Vilhelm Bohr

Vilhelm Bohr

Affiliate professor

Member of:


  1. 2024
  2. Published

    Roles of NAD+ in Health and Aging

    Lautrup, S., Hou, Y., Fang, E. F. & Bohr, Vilhelm, 2024, In: Cold Spring Harbor Perspectives in Medicine. 14, 1, 27 p., a041193.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    The cGAS-STING signaling pathway is modulated by urolithin A

    Madsen, Helena Borland, Park, J. H., Chu, X., Hou, Y., Li, Zhiquan, Rasmussen, Lene Juel, Croteau, D. L., Bohr, Vilhelm & Akbari, M., 2024, In: Mechanisms of Ageing and Development. 217, 11 p., 111897.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies

    Wang, H. L., Siow, R., Schmauck-Medina, T., Zhang, J., Sandset, P. M., Filshie, C., Lund, Ø., Partridge, L., Bergersen, L. H., Juel Rasmussen, L., Palikaras, K., Sotiropoulos, I., Storm-Mathisen, J., Rubinsztein, D. C., Spillantini, M. G., De Zeeuw, C. I., Watne, L. O., Vyhnalek, M., Veverova, K., Liang, K. X. & 18 others, Tavernarakis, N., Bohr, Vilhelm, Yokote, K., Saarela, J., Nilsen, H., Gonos, E. S., Scheibye-Knudsen, Morten, Chen, G., Kato, H., Selbæk, G., Fladby, T., Nilsson, P., Simonsen, A., Aarsland, D., Lautrup, S., Ottersen, O. P., Cox, L. S. & Fang, E. F., 2024, In: The journals of gerontology. Series A, Biological sciences and medical sciences. 79, 4, 10 p., glae029.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    Salidroside promotes healthy longevity by interfering with HSP90 activity

    Zhang, J., Li, Zhiquan, Song, J., Zhou, L., Chen, X., Ge, W., Dong, T., Luo, Y., Mao, T., Li, Z., Tan, D., Rasmussen, Lene Juel, Bohr, Vilhelm, Tong, X. & Dai, F., 2024, In: GeroScience. 46, p. 1641–1655 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  6. 2023
  7. Published

    Rev1 deficiency induces a metabolic shift in MEFs that can be manipulated by the NAD+ precursor nicotinamide riboside

    Anugula, Sharath, Li, Zhiquan, Li, Yuan, Hendriksen, A., Christensen, P. B., Wang, L., Monk, J. M., de Wind, N., Bohr, Vilhelm, Desler, Claus, Naviaux, R. K. & Rasmussen, Lene Juel, 2023, In: Heliyon. 9, 6, e17392.

    Research output: Contribution to journalJournal articlepeer-review

  8. Published

    Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice

    Dan, X., Yang, B., McDevitt, R. A., Gray, S., Chu, X., Claybourne, Q., Figueroa, D. M., Zhang, Y., Croteau, D. L. & Bohr, Vilhelm, 2023, In: Aging Cell. 22, 4, 13 p., e13793.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice

    Hou, Y., Park, J. H., Dan, X., Chu, X., Yang, B., Hussain, M., Croteau, D. L. & Bohr, Vilhelm, 2023, In: Neurobiology of Disease. 180, 11 p., 106092.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Mitochondrial OGG1 expression reduces age-associated neuroinflammation by regulating cytosolic mitochondrial DNA

    Hussain, M., Chu, X., Duan Sahbaz, B., Gray, S., Pekhale, K., Park, J. H., Croteau, D. L. & Bohr, Vilhelm, 2023, In: Free Radical Biology and Medicine. 203, p. 34-44 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    The DNA repair enzyme, aprataxin, plays a role in innate immune signaling

    Madsen, Helena Borland, Pease, L. I., Scanlan, R. L., Akbari, M., Rasmussen, Lene Juel, Shanley, D. P. & Bohr, Vilhelm, 2023, In: Frontiers in Aging Neuroscience. 15, 17 p., 1290681.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Long-term NAD+ supplementation prevents the progression of age-related hearing loss in mice

    Okur, M. N., Sahbaz, B. D., Kimura, R., Manor, U., Patel, J., Park, J. H., Andrade, L., Puligilla, C., Croteau, D. L. & Bohr, Vilhelm, 2023, In: Aging Cell. 22, 9, 14 p., e13909.

    Research output: Contribution to journalJournal articlepeer-review

  13. 2022
  14. Published

    Foreword

    Bohr, Vilhelm, 2022, Molecular, Cellular, and Metabolic Fundamentals of Human Aging. Academic Press, p. xi-xi

    Research output: Chapter in Book/Report/Conference proceedingPreface/postscriptResearch

  15. Published

    Mitochondrial PARP1 regulates NAD+-dependent poly ADP-ribosylation of mitochondrial nucleoids

    Lee, J., Hussain, M., Kim, E. W., Cheng, S., Leung, A. K. L., Fakouri, N. B., Croteau, D. L. & Bohr, Vilhelm, 2022, In: Experimental and Molecular Medicine. 54, p. 2135–2147 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1 and the NAMPT-NAD+ pathway

    Maynard, S., Hall, A., Galanos, P., Rizza, S., Yamamoto, T., Gram, H. H., Munk, S. H. N., Shoaib, Muhammad, Sørensen, Claus Storgaard, Bohr, Vilhelm, Lerdrup, Mads, Maya-Mendoza, A. & Bartek, J., 2022, In: Nucleic Acids Research. 50, 17, p. 9948-9965 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary

    Schmauck-Medina, T., Molière, A., Lautrup, S., Zhang, J., Chlopicki, S., Madsen, H. B., Cao, S., Soendenbroe, C., Mansell, E., Vestergaard, M. B., Li, Z., Shiloh, Y., Opresko, P. L., Egly, J. M., Kirkwood, T., Verdin, E., Bohr, V. A., Cox, L. S., Stevnsner, T., Rasmussen, L. J. & 1 others, Fang, E. F., 2022, In: Aging. 14, 16, p. 6829-6839 11 p.

    Research output: Contribution to journalReviewpeer-review

  18. 2021
  19. Published

    Cytosolic self-DNA—A potential source of chronic inflammation in aging

    Akbari, M., Shanley, D. P., Bohr, Vilhelm & Rasmussen, Lene Juel, 2021, In: Cells. 10, 12, 3544.

    Research output: Contribution to journalReviewpeer-review

  20. Published

    Olfactory dysfunction in aging and neurodegenerative diseases

    Dan, X., Wechter, N., Gray, S., Mohanty, J. G., Croteau, D. L. & Bohr, Vilhelm, 2021, In: Ageing Research Reviews. 70, 101416.

    Research output: Contribution to journalReviewpeer-review

  21. Published

    NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING

    Hou, Y., Wei, Y., Lautrup, S., Yang, B., Wang, Y., Cordonnier, S., Mattson, M. P., Croteau, D. L. & Bohr, Vilhelm, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 37, e2011226118.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    CDK2 phosphorylation of Werner protein (WRN) contributes to WRN’s DNA double-strand break repair pathway choice

    Lee, J. H., Shamanna, R. A., Kulikowicz, T., Fakouri, N. B., Kim, E. W., Christiansen, L. S., Croteau, D. L. & Bohr, Vilhelm, 2021, In: Aging Cell. 20, 11, 14 p., e13484.

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy

    Palikaras, K., Achanta, K., Choi, S., Akbari, M. & Bohr, Vilhelm, 2021, In: Aging. 13, 21, p. 23876-23894 19 p.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology

    SenGupta, T., Palikaras, K., Esbensen, Y. Q., Konstantinidis, G., Galindo, F. J. N., Achanta, K., Kassahun, H., Stavgiannoudaki, I., Bohr, Vilhelm, Akbari, M., Gaare, J., Tzoulis, C., Tavernarakis, N. & Nilsen, H., 2021, In: Cell Reports. 36, 10, 109668.

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    NAD+ supplementation prevents STING-induced senescence in ataxia telangiectasia by improving mitophagy

    Yang, B., Dan, X., Hou, Y., Lee, J. H., Wechter, N., Krishnamurthy, S., Kimura, R., Babbar, M., Demarest, T., McDevitt, R., Zhang, S., Zhang, Y., Mattson, M. P., Croteau, D. L. & Bohr, Vilhelm, 2021, In: Aging Cell. 20, 4, 14 p., e13329.

    Research output: Contribution to journalJournal articlepeer-review

  26. 2020
  27. Published

    The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

    Aman, Y., Frank, J., Lautrup, S. H., Matysek, A., Niu, Z., Yang, G., Shi, L., Bergersen, L. H., Storm-Mathisen, J., Rasmussen, Lene Juel, Bohr, Vilhelm, Nilsen, H. & Fang, E. F., 2020, In: Mechanisms of Ageing and Development. 185, 111194.

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    DNA damage invokes mitophagy through a pathway involving Spata18

    Dan, X., Babbar, M., Moore, A., Wechter, N., Tian, J., Mohanty, J. G., Croteau, D. L. & Bohr, Vilhelm, 2020, In: Nucleic Acids Research. 48, 12, p. 6611-6623 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase

    Duan, S., Han, X., Akbari, M., Croteau, D. L., Rasmussen, Lene Juel & Bohr, Vilhelm, 2020, In: Nucleic Acids Research. 48, 12, p. 6530–6546

    Research output: Contribution to journalJournal articlepeer-review

  30. Published

    Heterochromatin: an epigenetic point of view in aging

    Lee, J., Kim, E. W., Croteau, D. L. & Bohr, Vilhelm, 2020, In: Experimental & Molecular Medicine. 52, 9, p. 1466-1474 9 p.

    Research output: Contribution to journalReviewpeer-review

  31. Published

    Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease

    Navarro, J. F., Croteau, D. L., Jurek, A., Andrusivova, Z., Yang, B., Wang, Y., Ogedegbe, B., Riaz, T., Støen, M., Desler, Claus, Rasmussen, Lene Juel, Tønjum, T., Galas, M. C., Lundeberg, J. & Bohr, Vilhelm, 2020, In: iScience. 23, 10, 42 p., 101556.

    Research output: Contribution to journalJournal articlepeer-review

  32. Published

    Cockayne syndrome group A and B proteins function in rRNA transcription through nucleolin regulation

    Okur, M. N., Lee, J., Osmani, W., Kimura, R., Demarest, T. G., Croteau, D. L. & Bohr, Vilhelm, 18 Mar 2020, In: Nucleic Acids Research. 48, 5, p. 2473-2485 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD+ signaling

    Okur, M. N., Fang, E. F., Fivenson, E. M., Tiwari, V., Croteau, D. L. & Bohr, Vilhelm, Dec 2020, In: Aging Cell. 19, 12, p. e13268

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome

    Okur, M. N., Mao, B., Kimura, R., Haraczy, S., Fitzgerald, T., Edwards-Hollingsworth, K., Tian, J., Osmani, W., Croteau, D. L., Kelley, M. W. & Bohr, Vilhelm, Jan 2020, In: npj Aging and Mechanisms of Disease. 6, 10 p., 1.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

    Zheng, Jin, Akbari, M., Schirmer, C., Reynaert, M. L., Loyens, A., Lefebvre, B., Buée, L., Croteau, D. L., Galas, M. C. & Bohr, Vilhelm, 2020, In: Acta Neuropathologica Communications. 8, 1, 23 p., 25.

    Research output: Contribution to journalJournal articlepeer-review

  36. 2019
  37. Published

    Mitochondria in the signaling pathways that control longevity and health span

    Akbari, M., Kirkwood, T. B. L. & Bohr, Vilhelm, 2019, In: Ageing Research Reviews. 54, 100940.

    Research output: Contribution to journalReviewpeer-review

  38. Toward understanding genomic instability, mitochondrial dysfunction and aging

    Fakouri, N. B., Hou, Y., Demarest, T. G., Christiansen, L. S., Okur, M. N., Mohanty, J. G., Croteau, D. L. & Bohr, Vilhelm, 2019, In: F E B S Journal. 286, 6, p. 1058-1073 16 p.

    Research output: Contribution to journalReviewpeer-review

  39. Published

    Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease

    Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., Rocktäschel, P., Croteau, D. L., Akbari, M., Greig, N. H., Fladby, T., Nilsen, H., Cader, M. Z., Mattson, M. P., Tavernarakis, N. & Bohr, Vilhelm, 2019, In: Nature Neuroscience. 22, p. 401-412

    Research output: Contribution to journalJournal articlepeer-review

  40. Published

    NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

    Fang, E. F., Hou, Y., Lautrup, S., Jensen, M. B., Yang, B., SenGupta, T., Caponio, D., Khezri, R., Demarest, T. G., Aman, Y., Figueroa, D., Morevati, M., Lee, H-J., Kato, H., Kassahun, H., Lee, J-H., Filippelli, D., Okur, M. N., Mangerich, A., Croteau, D. L. & 9 others, Maezawa, Y., Lyssiotis, C. A., Tao, J., Yokote, K., Rusten, T. E., Mattson, M. P., Jasper, H., Nilsen, H. & Bohr, Vilhelm, 2019, In: Nature Communications. 10, 1, 18 p., 5284.

    Research output: Contribution to journalJournal articlepeer-review

  41. Emerging Antitumor Activities of the Bitter Melon (Momordica charantia)

    Fang, E. F., Froetscher, L., Scheibye-Knudsen, Morten, Bohr, Vilhelm, Wong, J. H. & Ng, T. B., 2019, In: Current Protein and Peptide Science. 20, 3, p. 296-301 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Ageing as a risk factor for neurodegenerative disease

    Hou, Y., Dan, X., Babbar, M., Wei, Y., Hasselbalch, Steen, Croteau, D. L. & Bohr, Vilhelm, 2019, In: Nature Reviews. Neurology. 15, 10, p. 565-581 17 p.

    Research output: Contribution to journalReviewpeer-review

  43. Published

    Cockayne syndrome group B deficiency reduces H3K9me3 chromatin remodeler SETDB1 and exacerbates cellular aging

    Lee, J., Demarest, T. G., Babbar, M., Kim, E. W., Okur, M. N., De, S., Croteau, D. L. & Bohr, Vilhelm, 2019, In: Nucleic Acids Research. 47, 16, p. 8548-8562

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Lamin A/C promotes DNA base excision repair

    Maynard, S., Keijzers, G., Akbari, M., Ben Ezra, Michael, Hall, A., Morevati, M., Scheibye-Knudsen, Morten, Gonzalo, S., Bartek, J. & Bohr, Vilhelm, 2019, In: Nucleic Acids Research. 47, 22, p. 11709–11728

    Research output: Contribution to journalJournal articlepeer-review

  45. Published

    NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress

    Yang, B., Figueroa, D. M., Hou, Y., Babbar, M., Baringer, S. L., Croteau, D. L. & Bohr, Vilhelm, 2019, In: Free Radical Biology and Medicine. 141, p. 47-58 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  46. Published

    Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells

    Zheng, Jin, Croteau, D. L., Bohr, Vilhelm & Akbari, M., 2019, In: Nucleic Acids Research. 47, 8, p. 4086–4110

    Research output: Contribution to journalJournal articlepeer-review

  47. 2018
  48. Published

    NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

    Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., Stevnsner, T. V., Mattson, M. P. & Bohr, Vilhelm, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 8, p. E1876-E1885

    Research output: Contribution to journalJournal articlepeer-review

  49. Published

    Sarcopenia, Aging and Prospective Interventional Strategies

    Waltz, T. B., Fivenson, E. M., Morevati, M., Li, C., Becker, K. G., Bohr, Vilhelm & Fang, E. F., 2018, In: Current Medicinal Chemistry. 25, 40, p. 5588-5596 9 p.

    Research output: Contribution to journalReviewpeer-review

  50. 2017
  51. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

    Fakouri, N. B., Durhuus, J. A., Regnell, C. E., Angleys, M., Desler, Claus, Hasan-Olive, M., Martin-Pardillos, A., Tsaalbi-Shtylik, A., Thomsen, Kirsten Joan, Lauritzen, Martin, Bohr, Vilhelm, de Wind, N., Bergersen, L. H. & Rasmussen, Lene Juel, 2017, In: Scientific Reports. 7, 14 p., 12480.

    Research output: Contribution to journalJournal articlepeer-review

  52. Published

    In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice

    Fang, E. F., Palikaras, K., Sun, N., Fivenson, E. M., Spangler, R. D., Kerr, J. S., Cordonnier, S. A., Hou, Y., Dombi, E., Kassahun, H., Tavernarakis, N., Poulton, J., Nilsen, H. & Bohr, Vilhelm, 2017, In: Journal of Visualized Experiments. 129, e56301.

    Research output: Contribution to journalJournal articlepeer-review

  53. Published

    NAD+ in Aging: Molecular Mechanisms and Translational Implications

    Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P. & Bohr, Vilhelm, 2017, In: Trends in Molecular Medicine. 23, 10, p. 899-916 18 p.

    Research output: Contribution to journalReviewpeer-review

  54. Published

    Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway

    Fang, E. F., Waltz, T. B., Kassahun, H., Lu, Q., Kerr, J. S., Morevati, M., Fivenson, E. M., Wollman, B. N., Marosi, K., Wilson, M. A., Iser, W. B., Eckley, D. M., Zhang, Y., Lehrmann, E., Goldberg, I. G., Scheibye-Knudsen, Morten, Mattson, M. P., Nilsen, H., Bohr, Vilhelm & Becker, K. G., 2017, In: Scientific Reports. 7, 46208.

    Research output: Contribution to journalJournal articlepeer-review

  55. Published

    Mitophagy in neurodegeneration and aging

    Fivenson, E. M., Lautrup, S., Sun, N., Scheibye-Knudsen, Morten, Stevnsner, T., Nilsen, H., Bohr, Vilhelm & Fang, E. F., 2017, In: Neurochemistry International. 109, p. 202-209

    Research output: Contribution to journalReviewpeer-review

  56. Published

    Genome instability in Alzheimer disease

    Hou, Y., Song, H., Croteau, D. L., Akbari, M. & Bohr, Vilhelm, Jan 2017, In: Mechanisms of Ageing and Development. 161, part A, p. 83-94 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  57. Published

    Cockayne syndrome: Clinical features, model systems and pathways

    Karikkineth, A. C., Scheibye-Knudsen, Morten, Fivenson, E., Croteau, D. L. & Bohr, Vilhelm, 2017, In: Ageing Research Reviews. 33, p. 3-17

    Research output: Contribution to journalReviewpeer-review

  58. Published

    Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms

    Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, Vilhelm & Fang, E. F., 2017, In: Trends in Neurosciences. 40, 3, p. 151-166 16 p.

    Research output: Contribution to journalReviewpeer-review

  59. Published

    DNA polymerase beta participates in mitochondrial DNA repair

    Sykora, P., Kanno, S., Akbari, M., Kulikowicz, T., Baptiste, B. A., Leandro, G. S., Lu, H., Tian, J., May, A., Becker, K. A., Croteau, D. L., Wilson, D. M., Sobol, R. W., Yasui, A. & Bohr, Vilhelm, Aug 2017, In: Molecular and Cellular Biology. 37, 16, e00237-17.

    Research output: Contribution to journalJournal articlepeer-review

  60. 2016
  61. Published

    NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

    Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, M., Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., Iser, W. B., Wollman, B. N., Morevati, M., Li, J., Kerr, J. S., Lu, Q., Waltz, T. B., Tian, J., Sinclair, D. A., Mattson, M. P. & 2 others, Nilsen, H. & Bohr, Vilhelm, 11 Oct 2016, In: Cell Metabolism. 24, 4, p. 566-581 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  62. Nuclear DNA damage signalling to mitochondria in ageing

    Fang, E. F., Scheibye-Knudsen, Morten, Chua, K. F., Mattson, M. P., Croteau, D. L. & Bohr, Vilhelm, May 2016, In: Nature Reviews. Molecular Cell Biology. 17, 5, p. 308-321 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  63. Published

    A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain

    Lauritzen, K. H., Hasan-Olive, M. M., Regnell, C. E., Kleppa, L., Scheibye-Knudsen, Morten, Gjedde, Albert, Klungland, A., Bohr, Vilhelm, Storm-Mathisen, J. & Bergersen, L. H., Dec 2016, In: Neurobiology of Aging. 48, p. 34-47

    Research output: Contribution to journalJournal articlepeer-review

  64. Published

    RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

    Lu, H., Shamanna, R. A., Keijzers, G., Anand, R., Rasmussen, Lene Juel, Cejka, P., Croteau, D. L. & Bohr, Vilhelm, 28 Jun 2016, In: Cell Reports. 16, 1, p. 161-173 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  65. Published

    Acquired Localized Cutis Laxa due to Increased Elastin Turnover

    Nygaard, R. H., Maynard, S., Schjerling, P., Kjær, M., Qvortrup, Klaus, Bohr, Vilhelm, Rasmussen, Lene Juel, Jemec, Gregor & Heidenheim, M., 14 Jun 2016, In: Case Reports in Dermatology. 8, 1, p. 42-51 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  66. Published

    Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA

    Scheibye-Knudsen, M., Tseng, A., Jensen, M. B., Scheibye-Alsing, K., Fang, E. F., Iyama, T., Bharti, S. K., Marosi, K., Froetscher, L., Kassahun, H., Eckley, D. M., Maul, R. W., Bastian, P., De, S., Ghosh, S., Nilsen, H., Goldberg, I. G., Mattson, M. P., Wilson, D. M. . III., Brosh, R. M. . J. & 2 others, Gorospe, M. & Bohr, Vilhelm, 1 Nov 2016, In: National Academy of Sciences. Proceedings. 113, 44, p. 12502-12507

    Research output: Contribution to journalJournal articlepeer-review

  67. 2015
  68. Published

    Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells

    Akbari, M., Sykora, P. & Bohr, Vilhelm, 10 Aug 2015, In: Scientific Reports. 5, 8 p., 12876 .

    Research output: Contribution to journalJournal articlepeer-review

  69. Published

    The role of DNA base excision repair in brain homeostasis and disease

    Akbari, M., Morevati, M., Croteau, D. & Bohr, Vilhelm, Aug 2015, In: DNA Repair. 32, p. 172-9 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  70. Loss of NEIL1 causes defects in olfactory function in mice

    Canugovi, C., Misiak, M., Scheibye-Knudsen, Morten, Croteau, D. L., Mattson, M. P. & Bohr, Vilhelm, 1 Feb 2015, In: Neurobiology of Aging. 36, 2, p. 1007-1012 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  71. A research agenda for aging in China in the 21st century

    Fang, E. F., Scheibye-Knudsen, Morten, Jahn, H. J., Li, J., Ling, L., Guo, H., Zhu, X., Preedy, V., Lu, H., Bohr, Vilhelm, Chan, W. Y., Liu, Y. & Ng, T. B., Nov 2015, In: Ageing Research Reviews. 24, Pt B, p. 197-205 9 p.

    Research output: Contribution to journalReviewpeer-review

  72. Published

    A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function

    Hey-Mogensen, M., Gram, M., Jensen, M. B., Lund, M. T., Hansen, C. N., Scheibye-Knudsen, Morten, Bohr, Vilhelm & Dela, Flemming, 1 Sep 2015, In: The Journal of Physiology. 593, 17, p. 3991-4010 20 p.

    Research output: Contribution to journalJournal articlepeer-review

  73. Published

    Human exonuclease 1 (EXO1) activity characterization and its function on FLAP structures

    Keijzers, G., Bohr, Vilhelm & Rasmussen, Lene Juel, 2015, In: Bioscience Reports. 35, 3, 13 p., e00206.

    Research output: Contribution to journalJournal articlepeer-review

  74. Published

    Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline

    Desler, Claus, Frederiksen, J. H., Olsen, M. N. A., Maynard, S., Keijzers, G., Fagerlund, Birgitte, Mortensen, Erik Lykke, Osler, Merete, Lauritzen, Martin, Bohr, Vilhelm & Rasmussen, Lene Juel, Nov 2015, In: Mitochondrion. 25, p. 34-7 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  75. Published

    Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance

    Maynard, S., Keijzers, G., Hansen, Åse Marie, Osler, Merete, Molbo, Drude, Bendix, L., Møller, Peter, Loft, Steffen, Moreno-Villanueva, M., Bürkle, A., Hvitby, C. P., Schurman, S. H., Stevnsner, T. V., Rasmussen, Lene Juel, Avlund, K. & Bohr, Vilhelm, Jan 2015, In: Acta Physiologica (Print). 213, 1, p. 156-170 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  76. Published

    DNA Damage, DNA Repair, Aging, and Neurodegeneration

    Maynard, S., Fang, E. F., Scheibye-Knudsen, Morten, Croteau, D. L. & Bohr, Vilhelm, Oct 2015, In: Cold Spring Harbor Perspectives in Medicine. 5, 10, a025130.

    Research output: Contribution to journalJournal articlepeer-review

  77. Published

    Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients

    Maynard, S., Hejl, Anne-Mette, Dinh, T. T. S., Keijzers, G., Hansen, Åse Marie, Desler, Claus, Moreno-Villanueva, M., Bürkle, A., Rasmussen, Lene Juel, Waldemar, Gunhild & Bohr, Vilhelm, Oct 2015, In: Aging. 7, 10, p. 793-815 23 p.

    Research output: Contribution to journalJournal articlepeer-review

  78. Protecting the mitochondrial powerhouse

    Scheibye-Knudsen, Morten, Fang, E. F., Croteau, D. L., Wilson, D. M. & Bohr, Vilhelm, 1 Mar 2015, In: Trends in Cell Biology. 25, 3, p. 158-170 13 p.

    Research output: Contribution to journalReviewpeer-review

  79. 2014
  80. Published

    Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity

    Aamann, M. D., Hvitby, C. P., Popuri, V., Muftuoglu, M., Lemminger, L. P. B., Skeby, C. K., Keijzers, G., Ahn, B., Bjørås, M., Bohr, Vilhelm & Stevnsner, T. V., Jan 2014, In: Mechanisms of Ageing and Development. 135, p. 1-14 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  81. Published

    Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair

    Akbari, M., Keijzers, G., Maynard, S., Scheibye-Knudsen, M., Desler, Claus, Hickson, Ian David & Bohr, Vilhelm, Apr 2014, In: DNA Repair. 16, p. 44-53 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  82. Published

    Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli

    Bendtsen, K. M., Jensen, M. B., May, A., Rasmussen, Lene Juel, Trusina, Ala, Bohr, Vilhelm & Jensen, Mogens Høgh, 14 Nov 2014, In: European Biophysics Journal. 43, 10-11, p. 509-516

    Research output: Contribution to journalJournal articlepeer-review

  83. Published

    Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction

    Fang, E. F., Scheibye-Knudsen, M., Brace, L. E., Kassahun, H., SenGupta, T., Nilsen, H., Mitchell, J. R., Croteau, D. L. & Bohr, Vilhelm, 8 May 2014, In: Cell. 157, 4, p. 882-96 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  84. Published

    The role of RecQ helicases in non-homologous end-joining

    Keijzers, G., Maynard, S., Shamanna, R. A., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In: Critical Reviews in Biochemistry and Molecular Biology. 49, 6, p. 463-472 10 p.

    Research output: Contribution to journalReviewpeer-review

  85. Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis

    Li, X., Fang, E. F., Scheibye-Knudsen, Morten, Cui, H., Qiu, L., Li, J., He, Y., Huang, J., Bohr, Vilhelm, Ng, T. B. & Guo, H., 2014, In: Scientific Reports. 4, 6434.

    Research output: Contribution to journalJournal articlepeer-review

  86. Published

    A high-fat diet and NAD+ activate sirt1 to rescue premature aging in cockayne syndrome

    Scheibye-Knudsen, M., Mitchell, S. J., Fang, E. F., Iyama, T., Ward, T., Wang, J., Dunn, C. A., Singh, N., Veith, S., Hasan-Olive, M. M., Mangerich, A., Wilson, M. A., Mattson, M. P., Bergersen, L. H., Cogger, V. C., Warren, A., Le Couteur, D. G., Moaddel, R., Wilson, D. M., Croteau, D. L. & 2 others, De Cabo, R. & Bohr, Vilhelm, 4 Nov 2014, In: Cell Metabolism. 20, 5, p. 840-855 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  87. Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders

    Scheibye-Knudsen, Morten, Fang, E. F., Croteau, D. L. & Bohr, Vilhelm, 2014, In: Autophagy. 10, 8, p. 1468-1469 2 p.

    Research output: Contribution to journalJournal articlepeer-review

  88. Published

    RECQ HELICASE RECQL4 PARTICIPATES IN NON-HOMOLOGOUS END JOINING AND INTERACTS WITH THE KU COMPLEX

    Shamanna, R. A., Singh, D. K., Lu, H., Mirey, G., Keijzers, G., Salles, B., Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In: Carcinogenesis. 35, 11, p. 2415-2424 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  89. 2013
  90. Published

    Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells

    Maynard, S., Keijzers, G., Gram, M., Desler, Claus, Bendix, L., Budtz-Joergensen, Esben, Molbo, Drude, Croteau, D. L., Osler, Merete, Stevnsner, T. V., Rasmussen, Lene Juel, Dela, Flemming, Avlund, K. & Bohr, Vilhelm, 30 Nov 2013, In: Aging. p. 850-864 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  91. Published

    A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells

    Nguyen, G. H., Dexheimer, T. S., Rosenthal, A. S., Chu, W. K., Singh, D. K., Mosedale, G., Bachrati, C. Z., Schultz, L., Sakurai, M., Savitsky, P., Abu, M., McHugh, P. J., Bohr, Vilhelm, Harris, C. C., Jadhav, A., Gileadi, O., Maloney, D. J., Simeonov, A. & Hickson, Ian David, 24 Jan 2013, In: Chemistry & Biology. 20, 1, p. 55-62 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  92. Published

    DNA damage response, bioenergetics, and neurological disease: the challenge of maintaining brain health in an aging human population

    Rasmussen, Lene Juel, Shiloh, Y., Bergersen, L. H., Sander, M., Bohr, Vilhelm & Tønjum, T., Oct 2013, In: Mechanisms of Ageing and Development. 134, 10, p. 427-33 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  93. Published

    Modulation of DNA base excision repair during neuronal differentiation

    Sykora, P., Yang, J., Ferrarelli, L. K., Tian, J., Tadokoro, T., Kulkarni, A., Weissman, L., Keijzers, G., Wilson, D. M., Mattson, M. P. & Bohr, Vilhelm, Jul 2013, In: Neurobiology of Aging. 34, 7, p. 1717-27 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  94. 2012
  95. Published

    14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif

    Andersen, S. D., Keijzers, G., Rampakakis, E., Engels, K., Luhn, P., El-Shemerly, M., Nielsen, Finn Cilius, Du, Y., May, A., Bohr, Vilhelm, Ferrari, S., Zannis-Hadjopoulos, M., Fu, H. & Rasmussen, Lene Juel, Mar 2012, In: D N A Repair. 11, 3, p. 267-77 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  96. Published

    RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity

    Croteau, D. L., Rossi, M. L., Canugovi, C., Tian, J., Sykora, P., Ramamoorthy, M., Wang, Z. M., Singh, D. K., Akbari, M., Kasiviswanathan, R., Copeland, W. C. & Bohr, Vilhelm, 2012, In: Aging Cell. 11, 3, p. 456-66 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  97. Published

    The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients

    Jensen, M. B., Dunn, C. A., Keijzers, G., Kulikowicz, T., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2012, In: Aging. 4, 11, p. 790-802 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  98. Published

    Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy

    Scheibye-Knudsen, M., Ramamoorthy, M., Sykora, P., Maynard, S., Lin, P., Minor, R. K., Wilson, D. M., Cooper, M., Spencer, R., de Cabo, R., Croteau, D. L. & Bohr, Vilhelm, Apr 2012, In: The Journal of Experimental Medicine. 209, 4, p. 855-69 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  99. 2011
  100. Published

    Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells

    Bacolla, A., Wang, G., Jain, A., Chuzhanova, N. A., Cer, R. Z., Collins, J. R., Cooper, D. N., Bohr, Vilhelm & Vasquez, K. M., 25 Mar 2011, In: The Journal of Biological Chemistry. 286, 12, p. 10017-26 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  101. Published

    Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein

    Bernier, M., Paul, R. K., Martin-Montalvo, A., Scheibye-Knudsen, M., Song, S., He, H., Armour, S. M., Hubbard, B. P., Bohr, Vilhelm, Wang, L., Zong, Y., Sinclair, D. A. & de Cabo, R., 3 Jun 2011, In: The Journal of Biological Chemistry. 286, 22, p. 19270-9 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  102. Published

    DNA repair deficiency in neurodegeneration

    Jeppesen, D. K., Bohr, Vilhelm & Stevnsner, T. V., 30 Apr 2011, In: Progress in Neurobiology. 94, 2, p. 166-200 35 p.

    Research output: Contribution to journalJournal articlepeer-review

  103. Published

    Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples

    Lachapelle, S., Gagné, J., Garand, C., Desbiens, M., Coulombe, Y., Bohr, Vilhelm, Hendzel, M. J., Masson, J., Poirier, G. G. & Lebel, M., 4 Mar 2011, In: Journal of Proteome Research. 10, 3, p. 1216-27 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  104. Published

    Metabolism, genomics, and DNA repair in the mouse aging liver

    Lebel, M., de Souza-Pinto, N. C. & Bohr, Vilhelm, 1 Jan 2011, In: Current Gerontology and Geriatrics Research. 2011, p. 859415

    Research output: Contribution to journalJournal articlepeer-review

  105. Published

    Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks

    Liberti, S. E., Andersen, S. D., Wang, J., May, A., Miron, S., Perderiset, M., Keijzers, G., Nielsen, Finn Cilius, Charbonnier, J., Bohr, Vilhelm & Rasmussen, Lene Juel, 2 Jan 2011, In: DNA Repair. 10, 1, p. 73-86 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  106. Published

    Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions

    Liu, D., Croteau, D. L., Souza-Pinto, N., Pitta, M., Tian, J., Wu, C., Jiang, H., Mustafa, K., Keijzers, G., Bohr, Vilhelm & Mattson, M. P., Feb 2011, In: Journal of Cerebral Blood Flow and Metabolism. 31, 2, p. 680-692 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  107. Published

    Aging, longevity and health

    Rasmussen, Lene Juel, Sander, M., Wewer, Ulla M. & Bohr, Vilhelm, 23 Jul 2011, In: Mechanisms of Ageing and Development. p. 522-32 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  108. Published

    Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1

    Rhee, D. B., Ghosh, A., Lu, J., Bohr, Vilhelm & Liu, Y., 2 Jan 2011, In: DNA Repair. 10, 1, p. 34-44 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  109. Published

    Aprataxin localizes to mitochondria and preserves mitochondrial function

    Sykora, P., Croteau, D. L., Bohr, Vilhelm & Wilson, D. M., 3 May 2011, In: Proceedings of the National Academy of Sciences USA (PNAS). 108, 18, p. 7437-42 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  110. 2010
  111. Published

    Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane

    Aamann, M. D., Sorensen, M. M., Hvitby, C. P., Berquist, B. R., Muftuoglu, M., Tian, J., de Souza-Pinto, N. C., Scheibye-Knudsen, M., Wilson, D. M., Stevnsner, T. V. & Bohr, Vilhelm, 1 Jul 2010, In: The FASEB Journal. 24, 7, p. 2334-46 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  112. Published

    Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population

    Berquist, B. R., Singh, D. K., Fan, J., Kim, D., Gillenwater, E., Kulkarni, A., Bohr, Vilhelm, Ackerman, E. J., Tomkinson, A. E. & Wilson, D. M., 1 Aug 2010, In: Nucleic Acids Symposium Series. 38, 15, p. 5023-35 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  113. Published

    Impact papers on aging in 2009

    Blagosklonny, M. V., Campisi, J., Sinclair, D. A., Bartke, A., Blasco, M. A., Bonner, W. M., Bohr, V. A., Brosh, R. M., Brunet, A., Depinho, R. A., Donehower, L. A., Finch, C. E., Finkel, T., Gorospe, M., Gudkov, A. V., Hall, M. N., Hekimi, S., Helfand, S. L., Karlseder, J., Kenyon, C. & 15 others, Kroemer, G., Longo, V., Nussenzweig, A., Osiewacz, H. D., Peeper, D. S., Rando, T. A., Rudolph, K. L., Sassone-Corsi, P., Serrano, M., Sharpless, N. E., Skulachev, V. P., Tilly, J. L., Tower, J., Verdin, E. & Vijg, J., 1 Mar 2010, In: Aging. 2, 3, p. 111-21 11 p.

    Research output: Contribution to journalReview

  114. Published

    Telomerer--begyndelsen og enden

    Bohr, Vilhelm, 4 Oct 2010, In: Ugeskrift for Laeger. 172, 40, p. 2744

    Research output: Contribution to journalJournal articlepeer-review

  115. Published

    The mitochondrial transcription factor A functions in mitochondrial base excision repair

    Canugovi, C., Maynard, S., Bayne, A. V., Sykora, P., Tian, J., de Souza-Pinto, N. C., Croteau, D. L. & Bohr, Vilhelm, 5 Oct 2010, In: DNA Repair. 9, 10, p. 1080-9 10 p.

    Research output: Contribution to journalJournal articlepeer-review

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