Ulrik Gether

Ulrik Gether

Head of Department, Professor


  1. 2024
  2. Published

    Transmembrane transporter proteins: Capturing transport in motion

    Loland, Claus Juul, Wellendorph, Petrine, Pedersen, Stine Helene Falsig & Gether, Ulrik, 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 2, p. 203-205 3 p.

    Research output: Contribution to journalEditorialpeer-review

  3. 2023
  4. Published

    Amphetamine-induced reverse transport of dopamine does not require cytosolic Ca2+

    Støier, J. F., Konomi Pilkati, Ainoa, Apuschkin, Mia, Herborg, Freja & Gether, Ulrik, 2023, In: Journal of Biological Chemistry. 299, 8, 14 p., 105063.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    Behavioral encoding across timescales by region-specific dopamine dynamics

    Jørgensen, Søren Heide, Ejdrup, Aske Lykke, Lycas, M. D., Posselt, Leonie Pauline, Madsen, Kenneth Lindegaard, Tian, L., Dreyer, J. K., Herborg, Freja, Sørensen, Andreas Toft & Gether, Ulrik, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 7, 10 p., e2215230120.

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    GLP-1 and nicotine combination therapy engages hypothalamic and mesolimbic pathways to reverse obesity

    Falk, S., Petersen, Jonas Odgaard, Svendsen, C. S. A., Leguizamon, Cesar Ramon Romero, Jørgensen, Søren Heide, Krauth, Nathalie, Ludwig, M. Q., Jørgensen, Kathrine Lundø, Roostalu, U., Hjort-Gregersen, G. S., Nielsen, D. A. G., Ejdrup, Aske Lykke, Pers, Tune H, Dmytriyeva, O., Hecksher-Soerensen, J., Gether, Ulrik, Kohlmeier, Kristi Anne & Clemmensen, Christoffer, 2023, In: Cell Reports. 42, 5, 18 p., 112466.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    Theory of visual attention (TVA) applied to rats performing the 5-choice serial reaction time task: differential effects of dopaminergic and noradrenergic manipulations

    Hervig, M. E. S., Toschi, C., Petersen, Anders, Vangkilde, Signe, Gether, Ulrik & Robbins, T. W., 2023, In: Psychopharmacology. 240, p. 41-58 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  8. Published

    Within-Mice Comparison of Microdialysis and Fiber Photometry-Recorded Dopamine Biosensor during Amphetamine Response

    Ejdrup, Aske Lykke, Wellbourne-Wood, J., Dreyer, J. K., Guldhammer, N., Lycas, M. D., Gether, Ulrik, Hall, B. J. & Sørensen, G., 2023, In: ACS Chemical Neuroscience. 14, 9, 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  9. 2022
  10. Published

    A density-based enrichment measure for assessing colocalization in single-molecule localization microscopy data

    Ejdrup, Aske Lykke, Lycas, M. D., Lorenzen, N., Konomi Pilkati, Ainoa, Herborg, Freja, Madsen, Kenneth Lindegaard & Gether, Ulrik, 2022, In: Nature Communications. 13, 1, 4388.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis

    Andersen, R. C., Schmidt, J. H., Rombach, J., Lycas, M. D., Christensen, N. R., Lund, V. K., Stapleton, D. S., Pedersen, S. S., Olsen, M. A., Stoklund, M., Noes-Holt, G., Nielsen, T. T. E., Keller, M. P., Jansen, A. M., Herlo, R., Pietropaolo, M., Simonsen, J. B., Kjærulff, O., Holst, B., Attie, A. D. & 2 others, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2022, In: Journal of Clinical Investigation. 132, 5, e144904.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution

    Schmidt, Solveig Gaarde, Gether, Ulrik & Loland, Claus Juul, 2022, In: Neurochemical Research. 47, p. 127–137 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors

    Klein Herenbrink, Carmen, Støier, J. F., Reith, W. D., Dagra, A., Gregorek, M. A. C., Cola, R. B., Patriarchi, T., Li, Y., Tian, L., Gether, Ulrik & Herborg, Freja, 2022, In: Communications Biology . 5, 1, 578.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity

    Lycas, M. D., Ejdrup, Aske Lykke, Sørensen, Andreas Toft, Haahr, N. O., Jørgensen, Søren Heide, Guthrie, D. A., Støier, J. F., Werner, C., Newman, A. H., Sauer, M., Herborg, Freja & Gether, Ulrik, 2022, In: Cell Reports. 40, 13, 27 p., 111431.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Structural basis of organic cation transporter-3 inhibition

    Khanppnavar, B., Maier, J., Herborg, Freja, Gradisch, R., Lazzarin, E., Luethi, D., Yang, J. W., Qi, C., Holy, M., Jäntsch, K., Kudlacek, O., Schicker, K., Werge, Thomas, Gether, Ulrik, Stockner, T., Korkhov, V. M. & Sitte, H. H., 2022, In: Nature Communications. 13, 1, 13 p., 6714.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    The Scaffold Protein PICK1 as a Target in Chronic Pain

    Sørensen, Andreas Toft, Rombach, J., Gether, Ulrik & Madsen, Kenneth Lindegaard, 2022, In: Cells. 11, 8, 1255.

    Research output: Contribution to journalReviewpeer-review

  17. 2021
  18. Published

    Adaptive aspects of impulsivity and interactions with effects of catecholaminergic agents in the 5-choice serial reaction time task: implications for ADHD

    Toschi, C., Hervig, M. E., Moazen, P., Parker, M. G., Dalley, J. W., Gether, Ulrik & Robbins, T. W., 2021, In: Psychopharmacology. 238, p. 2601–2615 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Direct-Pathway Spiny Projection Neuron Inhibition Evokes Transient Circuit Imbalance Manifested as Rotational Behavior

    Christensen, M., Nørr, Søren Emil, Gether, Ulrik & Rickhag, Karl Mattias, 2021, In: Neuroscience. 453, p. 32-42 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    Disruption of the PDZ domain-binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation

    Sørensen, G., Rickhag, Karl Mattias, Leo, D., Lycas, M. D., Ridderstrøm, P. H., Weikop, P., Lilja, J. H., Rifes, P., Herborg, Freja, Woldbye, David Paul Drucker, Wörtwein, Gitta, Gainetdinov, R. R., Fink-Jensen, Anders & Gether, Ulrik, 2021, In: Journal of Biological Chemistry. 297, 6, 101361.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals

    Ducrot, C., Bourque, M., Delmas, C. V. L., Racine, A., Guadarrama Bello, D., Delignat-Lavaud, B., Domenic Lycas, M., Fallon, A., Michaud-Tardif, C., Burke Nanni, S., Herborg, Freja, Gether, Ulrik, Nanci, A., Takahashi, H., Parent, M. & Trudeau, L., 2021, In: FASEB Journal. 35, 8, 24 p., 21791.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease

    Herborg, F., Jensen, K. L., Tolstoy, S., Arends, N., Posselt, L. P., Shekar, A., Aguilar, J., Lund, V. K., Erreger, K., Rickhag, M., Lycas, M. D., Lonsdale, M. N., Rahbek-Clemmensen, T., Sorensen, A. T., Newman, A. H., Lokkegaard, A., Kjaerulff, O., Werge, T., Moller, L. B., Matthies, H. J. G. & 4 others, Galli, A., Hjermind, L. E., Gether, Ulrik & IPSYCH Researchers, I. R., 2021, In: JCI insight. 6, 18, 21 p., 151496.

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    It takes two-or more-to tango: Revisiting the role of dopamine transporter oligomerization

    Gether, Ulrik & Sitte, H. H., 2021, In: Journal of Biological Chemistry. 296, 3 p., 100629.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    Rab2 drives axonal transport of dense core vesicles and lysosomal organelles

    Lund, Viktor Karlovich, Lycas, M. D., Schack, A., Andersen, Rita Chan, Gether, Ulrik & Kjærulff, Ole, 2021, In: Cell Reports. 35, 2, 26 p., 108973.

    Research output: Contribution to journalJournal articlepeer-review

  25. 2020
  26. Published

    A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain

    Christensen, N. R., De Luca, M., Lever, M. B., Richner, M., Hansen, A. B., Noes-Holt, G., Jensen, K. L., Rathje, M., Jensen, D. B., Erlendsson, S., Bartling, C. R. O., Ammendrup-Johnsen, I., Pedersen, S. E., Schönauer, M., Nissen, K. B., Midtgaard, S. R., Teilum, K., Arleth, L., Sørensen, A. T., Bach, A. & 5 others, Strømgaard, Kristian, Meehan, Claire Francesca, Vægter, C. B., Gether, Ulrik & Madsen, Kenneth Lindegaard, 2020, In: EMBO Molecular Medicine. 12, 6, 25 p., e11248.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    G protein-coupled receptor pharmacology-The next generation

    Bräuner, Hans, Rosenkilde, Mette, Gether, Ulrik & Gloriam, David E., 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, Supplement 6, p. 3-4 2 p.

    Research output: Contribution to journalEditorial

  28. Published

    Glucagon-like peptide-1 receptor regulation of basal dopamine transporter activity is species-dependent

    Jensen, M. E., Galli, A., Thomsen, M., Jensen, Kathrine Louise, Thomsen, G. K., Klausen, M. K., Vilsbøll, Tina, Christensen, Mikkel Bring, Holst, Jens Juul, Owens, A., Robertson, S., Daws, L., Zanella, D., Gether, Ulrik, Knudsen, Gitte Moos & Fink-Jensen, Anders, 2020, In: Neurochemistry International. 138, 9 p., 104772.

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter

    Guthrie, D. A., Klein Herenbrink, Carmen, Lycas, M. D., Ku, T., Bonifazi, A., Devree, B. T., Mathiasen, Signe, Javitch, J. A., Grimm, J. B., Lavis, L., Gether, Ulrik & Newman, A. H., 2020, In: ACS Chemical Neuroscience. 11, 20, p. 3288-3300 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  30. Published

    The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

    Plenge, P., Abramyan, A. M., Sørensen, G., Mork, A., Weikop, Pia, Gether, Ulrik, Bang-Andersen, B., Shi, L. & Loland, Claus Juul, 2020, In: Nature Communications. 11, 1, 12 p., 1491.

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

    Gotfryd, K., Boesen, T., Mortensen, Jonas Sigurd, Khelashvili, G., Quick, M., Terry, D. S., Missel, Julie Winkel, LeVine, M. V., Gourdon, Pontus Emanuel, Blanchard, S. C., Javitch, J. A., Weinstein, H., Loland, Claus Juul, Nissen, P. & Gether, Ulrik, 2020, In: Nature Communications. 11, 1, 14 p., 1005.

    Research output: Contribution to journalJournal articlepeer-review

  32. 2019
  33. Published

    Conformational dynamics of the human serotonin transporter during substrate and drug binding

    Möller, I. R., Slivacka, M., Nielsen, A. K., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 11 Apr 2019, In: Nature Communications. 10, 1, 1687.

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors

    DiCarlo, G. E., Aguilar, J. I., Matthies, H. J. G., Harrison, F. E., Bundschuh, K. E., West, A., Hashemi, P., Herborg, Freja, Rickhag, M., Chen, H., Gether, Ulrik, Wallace, M. T. & Galli, A., 2019, In: Journal of Clinical Investigation. 129, 8, p. 3407-3419 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    Chemogenetic Targeting of Dorsomedial Direct-pathway Striatal Projection Neurons Selectively Elicits Rotational Behavior in Mice

    Kønig, A. B., Ciriachi, C., Gether, Ulrik & Rickhag, Karl Mattias, 2019, In: Neuroscience. 401, p. 106-116

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    Differential effects of chemogenetic inhibition on dopamine and norepinephrine neurons in the mouse 5-choice serial reaction time task

    Fitzpatrick, C. M., Runegaard, A. H., Christiansen, S. H., Hansen, Nikolaj Winther, Jørgensen, Søren Heide, McGirr, J. C., de Diego Ajenjo, Amaia, Sørensen, Andreas Toft, Perrier, Jean-Francois Marie, Petersen, A., Gether, Ulrik, Woldbye, David Paul Drucker & Andreasen T., Jesper, 2019, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 90, 2, p. 264-276 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  37. Published

    G protein-coupled receptor signaling in VTA dopaminergic neurons bidirectionally regulates the acute locomotor response to amphetamine but does not affect behavioral sensitization

    Runegaard, A. H., Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2019, In: Neuropharmacology. 161, 107663.

    Research output: Contribution to journalReviewpeer-review

  38. Published

    Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout

    Giguère, N., Delignat-Lavaud, B., Herborg, Freja, Voisin, A., Li, Yuan, Jacquemet, V., Anand-Srivastava, M., Gether, Ulrik, Giros, B. & Trudeau, L., 2019, In: PLOS Genetics. 15, 8, 26 p., e1008352.

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    Initial rewarding effects of cocaine and amphetamine assessed in a day using the single-exposure place preference protocol

    Runegaard, A. H., Jensen, Kathrine Louise, Wörtwein, Gitta & Gether, Ulrik, 2019, In: European Journal of Neuroscience. 50, 3, p. 2156-2163 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  40. Published

    Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets

    Erlendsson, Simon, Thorsen, T. S., Vauquelin, G., Ammendrup-Johnsen, I., Wirth, V., Martinez, Karen Laurence, Teilum, Kaare, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2019, In: eLife. 8, p. 1-27 e39180.

    Research output: Contribution to journalJournal articlepeer-review

  41. Published

    Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges

    Runegaard, A. H., Fitzpatrick, C. M., Woldbye, David Paul Drucker, Andreasen T., Jesper, Sørensen, Andreas Toft & Gether, Ulrik, 2019, In: Pharmacological Reviews. 71, 2, p. 123-156 34 p.

    Research output: Contribution to journalReviewpeer-review

  42. 2018
  43. Published

    An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1

    Jensen, Rasmus Herlo Beenfeldt, Lund, Viktor Karlovich, Lycas, M. D., Jansen, A. M., Khelashvili, G., Andersen, Rita Chan, Bhatia, V., Pedersen, T. S., Albornoz, P. B. C., Johner, N., Ammendrup-Johnsen, I., Christensen, N. R., Erlendsson, Simon, Stoklund, M., Larsen, J. B., Weinstein, H., Kjærulff, Ole, Stamou, Dimitrios, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2018, In: Cell Reports. 23, 7, p. 2056-2069 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    An unsuspected role for organic cation transporter 3 in the actions of amphetamine

    Mayer, F. P., Schmid, D., Owens, W. A., Gould, G. G., Apuschkin, Mia, Kudlacek, O., Salzer, I., Boehm, S., Chiba, P., Williams, P. H., Wu, H., Gether, Ulrik, Koek, W., Daws, L. C. & Sitte, H. H., 2018, In: Neuropsychopharmacology. 43, p. 2408-2417 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  45. Published
  46. Published

    Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes

    Herborg, Freja, Andreassen, T. F., Berlin, F., Loland, Claus Juul & Gether, Ulrik, 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7250-7262 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  47. Published

    Obituary

    Brøsen, K., Simonsen, U. & Gether, Ulrik, 2018, In: Basic & clinical pharmacology & toxicology. 123, 5, p. 521-522 2 p.

    Research output: Contribution to journalComment/debate

  48. Published

    PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis

    Jensen, Kathrine Louise, Sørensen, G., Dencker, D., Owens, W. A., Rahbek-Clemmensen, T., Brett Lever, M., Runegaard, A. H., Riis Christensen, N., Weikop, Pia, Wörtwein, Gitta, Fink-Jensen, Anders, Madsen, Kenneth Lindegaard, Daws, L., Gether, Ulrik & Rickhag, Karl Mattias, 2018, In: eNeuro. 5, 3

    Research output: Contribution to journalJournal articlepeer-review

  49. Published

    Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT: Recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Robert Vandenberg

    Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 2018, In: Science Advances. 4, 5, 12 p., eaar6179.

    Research output: Contribution to journalJournal articlepeer-review

  50. 2017
  51. Published

    Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research

    Jørgensen, Søren Heide, Fitzpatrick, C. M., Gether, Ulrik, Woldbye, David Paul Drucker & Sørensen, Andreas Toft, Nov 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 5, p. 373-381 9 p.

    Research output: Contribution to journalReviewpeer-review

  52. Published

    Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake

    Jensen, Kathrine Louise, Runegaard, A. H., Weikop, Pia, Gether, Ulrik & Rickhag, Karl Mattias, Sep 2017, In: Journal of Visualized Experiments. 127, 10 p., e56093.

    Research output: Contribution to journalJournal articlepeer-review

  53. Published

    Partial Unwinding of Transmembrane Helices Facilitates Alternating Access in the Neurotransmitter: Sodium Symporter LeuT

    Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 28 Jun 2017

    Research output: Other contributionResearch

  54. Published

    Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice

    Thomsen, A. H. R., Jensen, Kathrine Louise, Fitzpatrick, C. M., Dencker, D., Weikop, Pia, Gether, Ulrik & Rickhag, Karl Mattias, Jan 2017, In: European Journal of Neuroscience. 45, 1, p. 121-128

    Research output: Contribution to journalJournal articlepeer-review

  55. Published

    Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

    Erlendsson, Simon, Gotfryd, K., Larsen, F. H., Mortensen, Jonas Sigurd, Geiger, M., van Rossum, B., Oschkinat, H., Gether, Ulrik, Teilum, Kaare & Loland, Claus Juul, 2017, In: eLife. 6, 9 p., e19314.

    Research output: Contribution to journalJournal articlepeer-review

  56. Published

    Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer

    Jacobsen, S. E., Gether, Ulrik & Bräuner, Hans, 2017, In: Scientific Reports. 7, 14 p., 46355.

    Research output: Contribution to journalJournal articlepeer-review

  57. Published

    Neurotransmitter Transporters: Structure, Function, and Drug Binding

    Loland, Claus Juul & Gether, Ulrik, 2017, Textbook of Drug Design and Discovery. Stromgaard, K., Krogsgaard-Larsen, P. & Madsen, U. (eds.). 5 ed. Boca Raton: CRC Press, p. 233-248 16 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  58. Published

    Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm

    Runegaard, A. H., Jensen, Kathrine Louise, Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2017, In: Journal of Neuroscience Methods. 289, p. 85-92 8 p.

    Research output: Contribution to journalJournal articlepeer-review

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