Pontus Emanuel Gourdon

Pontus Emanuel Gourdon

Associate Professor

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    ORCID: 0000-0002-8631-3539

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    1. Published

      Dynein regulates Kv7.4 channel trafficking from the cell membrane

      van der Horst, Jennifer, Rognant, Salomé, Abbott, G. W., Ozhathil, Lijo Cherian, Hägglund, Per Mårten, Barrese, V., Chuang, Christine, Jespersen, Thomas, Davies, Michael J., Greenwood, I. A., Gourdon, Pontus Emanuel, Aalkjær, Christian & Jepps, Thomas Andrew Qvistgaard, 2021, In: Journal of General Physiology. 153, 3, 19 p., e202012760.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function

      Zhang, L., Simonsen, C., Zimova, L., Wang, Kaituo, Moparthi, L., Gaudet, R., Ekoff, M., Nilsson, G., Hellmich, U. A., Vlachova, V., Gourdon, Pontus Emanuel & Zygmunt, P. M., 2022, In: Nature Communications. 13, 1, 18 p., 7483.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Isolation and Crystallization of the D156C Form of Optogenetic ChR2

      Zhang, L., Wang, Kaituo, Ning, S., Pedersen, Per Amstrup, Duelli, A. S. & Gourdon, Pontus Emanuel, 2022, In: Cells. 11, 5, 11 p., 895.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Purification of Functional Human TRP Channels Recombinantly Produced in Yeast

      Zhang, L., Wang, Kaituo, Klærke, Dan Arne, Callø, Kirstine, Lowrey, L., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel & Gotfryd, K., 2019, In: Cells. 8, 2, p. 1-20 148.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      The two-domain elevator-type mechanism of zinc-transporting ZIP proteins

      Wiuf, A., Steffen, Jonas Hyld, Becares, E. R., Gronberg, C., Mahato, D. R., Rasmussen, Søren Gøgsig Faarup, Andersson, M., Croll, T., Gotfryd, K. & Gourdon, Pontus Emanuel, 2022, In: Science Advances. 8, 28, 13 p., 4331.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Structure and mechanism of Zn2+-transporting P-type ATPases

      Wang, Kaituo, Sitsel, O., Meloni, G., Autzen, Henriette Elisabeth, Andersson, M., Klymchuk, T., Nielsen, A. M., Rees, D. C., Nissen, P. & Gourdon, Pontus Emanuel, 23 Oct 2014, In: Nature. 514, 7523, p. 518-22 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding

      Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, S. K., Spliid, C. B., Wang, Yong, Gustavsson, Tobias, Sandoval, D. R., Vidal-Calvo, E. E., Choudhary, Swati, Agerbæk, Mette Ørskov, Lindorff-Larsen, Kresten, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sharp, J. S., Clausen, Thomas Mandel, Gourdon, Pontus Emanuel & Salanti, Ali, 2021, In: Nature Communications. 12, 1, 10 p., 2956.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Structure of the human ClC-1 chloride channel

      Wang, Kaituo, Preisler, Sarah Spruce, Zhang, L., Cui, Y., Missel, Julie Winkel, Grønberg, C., Gotfryd, K., Lindahl, E., Andersson, M., Callø, Kirstine, Egea, P. F., Klærke, Dan Arne, Pusch, M., Pedersen, Per Amstrup, Zhou, Z. H. & Gourdon, Pontus Emanuel, 2019, In: PLOS Biology. 17, 4, p. 1-20 e3000218.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      The role of water coordination in the pH-dependent gating of hAQP10

      Truelsen, S. F., Missel, Julie Winkel, Gotfryd, K., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel, Lindorff-Larsen, Kresten & Hélix-Nielsen, C., 2022, In: B B A - Biomembranes. 1864, 1, 13 p., 183809.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Identification of bile acid-CoA:amino acid N-acyltransferase as the hepatic N-acyl taurine synthase for polyunsaturated fatty acids

      Trammell, Sam, Gamon, Luke Francis, Gotfryd, K., Michler, Katja Thorøe, Alrehaili, B. D., Rix, I., Knop, Filip Krag, Gourdon, Pontus Emanuel, Lee, Y. K., Davies, Michael J., Gillum, M. P. & Grevengoed, Trisha Jean, 2023, In: Journal of Lipid Research. 64, 9, 9 p., 100361.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist

      Toernroth-Horsefield, S., Gourdon, Pontus Emanuel, Horsefield, R., Brive, L., Yamamoto, N., Mori, H., Snijder, A. & Neutze, R., Dec 2007, In: Structure. 15, 12, p. 1663-1673

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Assessing water permeability of aquaporins in a proteoliposome-based stopped-flow setup

      Steffen, Jonas Hyld, Missel, Julie Winkel, Al-Jubair, T., Kitchen, P., Salman, M. M., Bill, R. M., Törnroth-Horsefield, S. & Gourdon, Pontus Emanuel, 2022, In: STAR Protocols. 3, 2, 11 p., 101312.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Identifying Heterozipper β-Sheet in Twisted Amyloid Aggregation

      Song, Y., Dai, B., Wang, Yong, Wang, Y., Liu, C., Gourdon, Pontus Emanuel, Liu, L., Wang, Kaituo & Dong, M., 2022, In: Nano Letters. 22, 9, p. 3707–3712

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Characterization of ATP7A missense mutants suggests a correlation between intracellular trafficking and severity of Menkes disease

      Skjørringe, T., Pedersen, Per Amstrup, Thorborg, S. S., Nissen, P., Gourdon, Pontus Emanuel & Møller, L. B., 7 Apr 2017, In: Scientific Reports. 7, 18 p., 757.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Crystallization of P-type ATPases by the High Lipid-Detergent (HiLiDe) Method

      Sitsel, O., Wang, Kaituo, Liu, X. & Gourdon, Pontus Emanuel, 2016, P-Type ATPases: Methods and Protocols. Bublitz, M. (ed.). Springer, Vol. 1377. p. 413-420 8 p. (Methods in Molecular Biology, Vol. 1377).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    16. Published

      Structure and Function of Cu(I)- and Zn(II)-ATPases

      Sitsel, O., Grønberg, C., Autzen, Henriette Elisabeth, Wang, Kaituo, Meloni, G., Nissen, P. & Gourdon, Pontus Emanuel, 22 Sep 2015, In: Biochemistry. 54, 37, p. 5673-5683 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Structural basis of ion uptake in copper-transporting P1B-type ATPases

      Salustros, N., Gronberg, C., Abeyrathna, N. S., Lyu, Pin, Oradd, F., Wang, Kaituo, Andersson, M., Meloni, G. & Gourdon, Pontus Emanuel, 2022, In: Nature Communications. 13, 1, 11 p., 5121.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Mechanisms of a Mycobacterium tuberculosis Active Peptide

      Rao, K. U., Li, P., Welinder, C., Tenland, E., Gourdon, Pontus Emanuel, Sturegård, E., Ho, J. C. S. & Godaly, G., 2023, In: Pharmaceutics. 15, 2, 16 p., 540.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Endothelial protein C receptor binding induces conformational changes to severe malaria-associated group A PfEMP1

      Raghavan, Sai Sundar Rajan, Turner, Louise, Jensen, R. W., Johansen, Nicolai Tidemand, Jensen, D. S., Gourdon, Pontus Emanuel, Zhang, J., Wang, Y., Theander, Thor Grundtvig, Wang, Kaituo & Lavstsen, Thomas, 2023, In: Structure. 31, 10, p. 1174-1183.e4

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA

      Raghavan, Sai Sundar Rajan, Dagil, Robert, Lopez-Perez, Mary, Conrad, J., Bassi, Maria Rosaria, Quintana Varon, Maria del Pilar, Choudhary, Swati, Gustavsson, Tobias, Wang, Yong, Gourdon, Pontus Emanuel, Ofori, M. F., Christensen, S. B., Minja, D. T. R., Schmiegelow, Christentze, Nielsen, Morten Agertoug, Barfod, Lea Klingenberg, Hviid, Lars, Salanti, Ali, Lavstsen, Thomas & Wang, Kaituo, 2022, In: PLoS Pathogens. 18, 11, e1010924.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Saccharomyces cerevisiae as a superior host for overproduction of prokaryotic integral membrane proteins

      Preisler, Sarah Spruce, Wiuf, A. D., Friis, M., Kjaergaard, L., Hurd, M., Becares, E. R., Nurup, C. N., Bjoerkskov, F. B., Szathmáry, Z., Gourdon, Pontus Emanuel, Callø, Kirstine, Klærke, Dan Arne, Gotfryd, K. & Pedersen, Per Amstrup, 2021, In: Current research in structural biology. 3, p. 51-71 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Initiating Heavy-atom Based Phasing by Multi-Dimensional Molecular Replacement

      Pedersen, B. P., Gourdon, Pontus Emanuel, Liu, X., Karlsen, J. L. & Nissen, P., 28 Mar 2014, In: arXiv. p. 1-19 19 p.

      Research output: Contribution to journal › Journal article › Research

    23. Initiating heavy-atom-based phasing by multi-dimensional molecular replacement

      Pedersen, B. P., Gourdon, Pontus Emanuel, Liu, X., Karlsen, J. L. & Nissen, P., 1 Mar 2016, In: Acta crystallographica Section D: Structural biology . 72, 3, p. 440-445 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Copper binding leads to increased dynamics in the regulatory N-terminal domain of full-length human copper transporter ATP7B

      Orädd, F., Steffen, Jonas Hyld, Gourdon, Pontus Emanuel & Andersson, M., 2022, In: PLOS Computational Biology. 18, 9 September, 21 p., e1010074.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Crystal Structure of Na+, K+-ATPase in the Na+-Bound State

      Nyblom, M., Poulsen, H., Gourdon, Pontus Emanuel, Reinhard, L., Andersson, M., Lindahl, E., Fedosova, N. & Nissen, P., 4 Oct 2013, In: Science. 342, 6154, p. 123-127

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Principles to recover copper-conducting CTR proteins for the purpose of structural and functional studies

      Nayeri, N., Li, P., Górecki, K., Lindkvist-Petersson, K. & Gourdon, Pontus Emanuel, 2023, In: Protein Expression and Purification. 203, 8 p., 106213.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Cyclohexyl-alpha maltoside as a highly efficient tool for membrane protein studies

      Missel, Julie Winkel, Salustros, N., Becares, E. R., Steffen, Jonas Hyld, Laursen, A. G., Garcia, A. S., Garcia-Alai, M. M., Kolar, C., Gourdon, Pontus Emanuel & Gotfryd, K., 2021, In: Current Research in Structural Biology. 3, p. 85-94 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      On Allosteric Modulation of P-Type Cu+-ATPases

      Mattle, D., Sitsel, O., Autzen, Henriette Elisabeth, Meloni, G., Gourdon, Pontus Emanuel & Nissen, P., 10 Jul 2013, In: Journal of Molecular Biology. 425, 13, p. 2299-2308

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. A sulfur-based transport pathway in Cu+-ATPases

      Mattle, D., Zhang, L., Sitsel, O., Pedersen, L. T., Moncelli, M. R., Tadini-Buoninsegni, F., Gourdon, Pontus Emanuel, Rees, D. C., Nissen, P. & Meloni, G., 1 Jun 2015, In: E M B O Reports. 16, 6, p. 728-470 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      The transport mechanism of P4 ATPase lipid flippases

      Lopez Marques, Rosa Laura, Gourdon, Pontus Emanuel, Pomorski, Thomas Guenther & Palmgren, Michael, 2020, In: Biochemical Journal. 477, 19, p. 3769-3790 22 p.

      Research output: Contribution to journal › Review › Research › peer-review

    31. Published

      Isolation and Characterization of Nanobodies against a Zinc-Transporting P-Type ATPase

      Longhin, E., Gronberg, C., Hu, Q., Duelli, A. S., Andersen, K. R., Laursen, N. S. & Gourdon, Pontus Emanuel, 2018, In: Antibodies. 7, 4, 15 p., 39.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Overproduction of PIB-Type ATPases

      Liu, X., Sitsel, O., Wang, Kaituo & Gourdon, Pontus Emanuel, 2016, P-Type ATPases: Methods and Protocols. Bublitz, M. (ed.). Springer, Vol. 1377. p. 29-36 8 p. (Methods in Molecular Biology, Vol. 1377).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    33. Published

      Permeability and ammonia selectivity in aquaporin TIP2;1: linking structure to function

      Lindahl, V., Gourdon, Pontus Emanuel, Andersson, M. & Hess, B., 2018, In: Scientific Reports. 8, 13 p., 2995 .

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Structures of Atm1 provide insight into [2Fe-2S] cluster export from mitochondria

      Li, P., Hendricks, A. L., Wang, Yong, Villones, R. L. E., Lindkvist-Petersson, K., Meloni, G., Cowan, J. A., Wang, Kaituo & Gourdon, Pontus Emanuel, 2022, In: Nature Communications. 13, 1, 12 p., 4339.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Structure and transport mechanism of P5B-ATPases

      Li, P., Wang, Kaituo, Salustros, N., Grønberg, C. & Gourdon, Pontus Emanuel, 2021, In: Nature Communications. 12, 1, 8 p., 3973.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      PcoB is a defense outer membrane protein that facilitates cellular uptake of copper

      Li, P., Nayeri, N., Górecki, K., Becares, E. R., Wang, Kaituo, Mahato, D. R., Andersson, M., Abeyrathna, S. S., Lindkvist-Petersson, K., Meloni, G., Missel, Julie Winkel & Gourdon, Pontus Emanuel, 2022, In: Protein Science. 31, 7, p. 1-16 e4364.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Heterologous expression and purification of an active human TRPV3 ion channel

      Kol, S., Braun, C. S., Thiel, G., Doyle, D. A., Sundström, M., Gourdon, Pontus Emanuel & Nissen, P., 1 Dec 2013, In: The F E B S Journal (Online). 280, 23, p. 6010-6021 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

      Kitchen, P., Salman, M. M., Halsey, A. M., Clarke-Bland, C., MacDonald, J. A., Ishida, H., Vogel, H. J., Almutiri, S., Logan, A., Kreida, S., Al-Jubair, T., Missel, Julie Winkel, Gourdon, Pontus Emanuel, Törnroth-Horsefield, S., Conner, M. T., Ahmed, Z., Conner, A. C. & Bill, R. M., 2020, In: Cell. 181, 4, p. 784-799

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Crystal Structure of an Ammonia-Permeable Aquaporin

      Kirscht, A., Kaptan, S. S., Bienert, G. P., Chaumont, F., Nissen, P., de Groot, B. L., Kjellbom, P., Gourdon, Pontus Emanuel & Johanson, U., Mar 2016, In: PLoS Biology. 14, 3, 19 p., e1002411.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Conformational regulation of charge recombination reactions in a photosynthetic bacterial reaction center

      Katona, G., Snijder, A., Gourdon, Pontus Emanuel, Andréasson, U., Hansson, O., Andréasson, L. & Neutze, R., Jul 2005, In: Nature Structural and Molecular Biology. 12, 7, p. 630-1 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Phospholipid flipping involves a central cavity in P4 ATPases

      Jensen, M. S., Costa, S., Duelli, A. S., Andersen, P. A., Poulsen, L. R., Stanchev, L. D., Gourdon, Pontus Emanuel, Palmgren, Michael, Pomorski, Thomas Guenther & Lopez Marques, Rosa Laura, 2017, In: Scientific Reports. 7, 13 p., 17621.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Cryo-EM structure supports a role of AQP7 as a junction protein

      Huang, P., Venskutonytė, R., Prasad, R. B., Ardalani, H., de Maré, S. W., Fan, X., Li, P., Spégel, P., Yan, N., Gourdon, Pontus Emanuel, Artner, I. & Lindkvist-Petersson, K., 2023, In: Nature Communications. 14, 1, 12 p., 600.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Aquaglyceroporins and orthodox aquaporins in human adipocytes

      Huang, P., Hansen, J. S., Saba, K. H., Bergman, A., Negoita, F., Gourdon, Pontus Emanuel, Hagström-Andersson, A. & Lindkvist-Petersson, K., 1 Feb 2022, In: B B A - Biomembranes. 1864, 1, 183795.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      FK506-Binding Protein 2 Participates in Proinsulin Folding

      Hoefner, C., Bryde, T. H., Pihl, C., Tiedemann, S. N., Bresson, S. E., Hotiana, H. A., Khilji, M. S., Santos, T. D., Puglia, M., Pisano, P., Majewska, M., Durzynska, J., Klindt, K., Klusek, J., Perone, M. J., Bucki, R., Hägglund, P. M., Gourdon, P. E., Gotfryd, K., Urbaniak, E. & 5 others, Borowiak, M., Wierer, M., MacDonald, P. E., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, 2023, In: Biomolecules. 13, 1, 20 p., 152.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      The rapid “teabag” method for high-end purification of membrane proteins

      Hering, J., Missel, Julie Winkel, Zhang, L., Gunnarsson, A., Castaldo, M., Pedersen, Per Amstrup, Ek, M., Gourdon, Pontus Emanuel & Snijder, H. J., 2020, In: Scientific Reports. 10, 11 p., 16167.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Peroxynitrous acid (ONOOH) modifies the structure of anastellin and influences its capacity to polymerize fibronectin

      He, Jianfei, Becares, E. R., Thulstrup, Peter Waaben, Gamon, Luke Francis, Pedersen, J. N., Otzen, D., Gourdon, Pontus Emanuel, Davies, Michael J. & Hägglund, Per Mårten, 2020, In: Redox Biology. 36, 11 p., 101631.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells

      He, Jianfei, Steffen, Jonas Hyld, Thulstrup, Peter Waaben, Pedersen, J. N., Sauerland, Max Benjamin, Otzen, D. E., Hawkins, Clare Louise, Gourdon, Pontus Emanuel, Davies, Michael J. & Hägglund, Per Mårten, 2022, In: Scientific Reports. 12, 1, 15 p., 22051.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Structural and functional analysis of aquaporin-2 mutants involved in nephrogenic diabetes insipidus

      Hagströmer, C. J., Steffen, Jonas Hyld, Kreida, S., Al-Jubair, T., Frick, A., Gourdon, Pontus Emanuel & Törnroth-Horsefield, S., Dec 2023, In: Scientific Reports. 13, 1, 15 p., 14674.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Diverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases

      Guo, Zongxin, Orädd, F., Bågenholm, Viktoria, Grønberg, C., Ma, J. F., Ott, P., Wang, Y., Andersson, M., Pedersen, Per Amstrup, Wang, Kaituo & Gourdon, Pontus Emanuel, 2024, In: Nature Communications. 15, 1, 16 p., 2690.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Structure and ion-release mechanism of PIB-4-type ATPases

      Grønberg, C., Hu, Q., Mahato, D. R., Longhin, E., Salustros, N., Duelli, A., Lyu, P., Bågenholm, Viktoria, Eriksson, J., Rao, K. U., Henderson, D. I., Meloni, G., Andersson, M., Croll, T., Godaly, G., Wang, Kaituo & Gourdon, Pontus Emanuel, Dec 2021, In: eLife. 10, e73124.

      Research output: Contribution to journal › Journal article › Research › peer-review

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