Lene Juel Rasmussen

Lene Juel Rasmussen

Managing director of centre, professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 1: Modifiable pathways of damage and repair in aging


  1. Published

    Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia. / Bundgaard, Amanda; Qvortrup, Klaus; Rasmussen, Lene Juel; Fago, Angela.

    In: Journal of Experimental Biology, Vol. 222, No. 11, jeb200410, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage. / Skovgaard, T; Rasmussen, Lene Juel; Munch-Petersen, Birgitte.

    In: Nucleosides, Nucleotides and Nucleic Acids, Vol. 29, No. 4-6, 2010, p. 347-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    The role of mitochondrial dysfunction in the progression of Alzheimer’s disease. / Desler, Claus; Lillenes, Meryl S.; Tønjum, Tone; Rasmussen, Lene Juel.

    In: Current Medicinal Chemistry, Vol. 25, No. 40, 2018, p. 5578 - 5587.

    Research output: Contribution to journalReviewResearchpeer-review

  4. The role of mitochondrial dNTP levels in cells with reduced TK2 activity. / Desler, C; Munch-Petersen, B; Rasmussen, L J.

    In: Nucleosides, nucleotides & nucleic acids, Vol. 25, No. 9-11, 2006, p. 1171-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The role of RecQ helicases in non-homologous end-joining. / Keijzers, Guido; Maynard, Scott; Shamanna, Raghavendra A; Rasmussen, Lene Juel; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Critical Reviews in Biochemistry and Molecular Biology, Vol. 49, No. 6, 11.2014, p. 463-472.

    Research output: Contribution to journalReviewResearchpeer-review

  6. Published

    The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms. / Jakobsen, Emil; Lange, Sofie C; Andersen, Jens Velde; Madsen, Claus Desler; Kihl, Henriette Filholm; Hohnholt, Michaela; Stridh, Malin H; Rasmussen, Lene Juel; Waagepetersen, Helle S.; Bak, Lasse Kristoffer.

    In: Biochemical Pharmacology, Vol. 155, 2018, p. 92-101.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The importance of mitochondrial DNA in aging and cancer. / Madsen, Claus Desler; Espersen, Maiken Lise Marcker; Singh, Keshav K; Rasmussen, Lene Juel.

    In: Journal of Aging Research, Vol. 2011, 30.03.2011, p. 407536.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients. / Jensen, Martin Borch; Dunn, Christopher A; Keijzers, Guido; Kulikowicz, Tomasz; Rasmussen, Lene Juel; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Aging, Vol. 4, No. 11, 11.2012, p. 790-802.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism. / Madsen, Claus Desler; Lykke, Anne; Rasmussen, Lene Juel.

    In: Journal of Nucleic Acids, Vol. 2010, 01.01.2010.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The challenges of human population ageing. / Sander, Miriam; Oxlund, Bjarke; Jespersen, Astrid; Krasnik, Allan; Mortensen, Erik Lykke; Westendorp, Rudi Gerardus Johannes; Rasmussen, Lene Juel.

    In: Age and Ageing, Vol. 44, No. 2, 03.2015, p. 185-7.

    Research output: Contribution to journalJournal articleCommunication

  11. Published

    The LipB protein is a negative regulator of dam gene expression in Escherichia coli. / Vaisvila, R; Rasmussen, L J; Lobner-Olesen, A; von Freiesleben, U; Marinus, M G.

    In: B B A - Reviews on Cancer, Vol. 1494, No. 1-2, 15.11.2000, p. 43-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis. / Fakouri, Nima Borhan; Durhuus, Jon Ambaek; Regnell, Christine Elisabeth; Angleys, Maria; Desler, Claus; Hasan-Olive, Mahdi; Martin-Pardillos, Ana; Tsaalbi-Shtylik, Anastasia; Thomsen, Kirsten; Lauritzen, Martin; Bohr, Vilhelm A.; de Wind, Niels; Bergersen, Linda Hildegard; Rasmussen, Lene Juel.

    In: Scientific Reports, Vol. 7, 12480, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Response to : Design of a core classification process for DNA mismatch repair variations of a priori unknown functional significance. / Rasmussen, Lene Juel; Heinen, Christopher D; Royer-Pokora, Brigitte; Drost, Mark; Tavtigian, Sean; Hofstra, Robert M W; de Wind, Niels.

    In: Human Mutation, Vol. 34, No. 6, 06.2013, p. 923-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Repair of DNA damage induced by anthanthrene, a polycyclic aromatic hydrocarbon (PAH) without bay or fjord regions. / Madsen, Claus Desler; Johannessen, Christian; Rasmussen, Lene Juel.

    In: Chemico-Biological Interactions, Vol. 177, No. 3, 2009, p. 212-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells. / Maynard, Scott; Keijzers, Guido; Gram, Martin; Madsen, Claus Desler; Bendix, Laila; Budtz-Jørgensen, Esben; Molbo, Drude; Croteau, Deborah L; Osler, Merete; Stevnsner, Tinna V.; Rasmussen, Lene Juel; Dela, Flemming; Avlund, Kirsten; Bohr, Vilhelm A.

    In: Aging, 30.11.2013, p. 850-864.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks. / Lu, Huiming; Shamanna, Raghavendra A; Keijzers, Guido; Anand, Roopesh; Rasmussen, Lene Juel; Cejka, Petr; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Cell Reports, Vol. 16, No. 1, 28.06.2016, p. 161-173.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations. / Nielsen, Sofie V,; Stein, Amelie; Dinitzen, Alexander B.; Papaleo, Elena; Tatham, Michael H.; Poulsen, Esben Guldahl; Kassem, Maher Mahmoud; Rasmussen, Lene Juel; Lindorff-Larsen, Kresten; Hartmann-Petersen, Rasmus.

    In: PLoS Genetics, Vol. 13, No. 4, e1006739, 19.04.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Pathological assessment of mismatch repair gene variants in Lynch syndrome : Past, present, and future. / Rasmussen, Lene Juel; Heinen, Christopher D; Royer-Pokora, Brigitte; Drost, Mark; Tavtigian, Sean; Hofstra, Robert M W; de Wind, Niels.

    In: Human Mutation, Vol. 33, No. 12, 12.2012, p. 1617-25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages. / Jantzen, Kim; Roursgaard, Martin; Madsen, Claus Desler; Loft, Steffen; Rasmussen, Lene Juel; Møller, Peter.

    In: Mutagenesis, Vol. 27, No. 6, 11.2012, p. 693-701.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Oxidative Stress-Induced Dysfunction of Muller Cells During Starvation. / Toft-Kehler, Anne Katrine; Gurubaran, Iswariyaraja Sridevi; Madsen, Claus Desler; Rasmussen, Lene J.; Skytt, Dorte Marie; Kolko, Miriam.

    In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 6, 05.2016, p. 2721-2728.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Nuclear translocation contributes to regulation of DNA excision repair activities. / Knudsen, Nina Østergaard; Andersen, Sofie Dabros; Lützen, Anne; Nielsen, Finn Cilius; Rasmussen, Lene Juel.

    In: DNA Repair, Vol. 8, No. 6, 2009, p. 682-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1). / Knudsen, Nina Østergaard; Nielsen, Finn Cilius; Vinther, Lena; Bertelsen, Ronni; Holten-Andersen, Steen; Liberti, Sascha Emilie; Hofstra, Robert; Kooi, Krista; Rasmussen, Lene Juel.

    In: Nucleic Acids Research, Vol. 35, No. 8, 2007, p. 2609-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Novel growth rate control of dam gene expression in Escherichia coli. / Rasmussen, L J; Marinus, M G; Løbner-Olesen, A.

    In: Molecular Microbiology, Vol. 12, No. 4, 05.1994, p. 631-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Novel DNA mismatch-repair activity involving YB-1 in human mitochondria. / de Souza-Pinto, Nadja C; Mason, Penelope A; Hashiguchi, Kazunari; Weissman, Lior; Tian, Jingyan; Guay, David; Lebel, Michel; Stevnsner, Tinna V; Rasmussen, Lene Juel; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 8, No. 6, 2009, p. 704-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Natural selection of mitochondria during somatic lifetime promotes healthy aging. / Rodell, Anders; Rasmussen, Lene J; Bergersen, Linda H; Singh, Keshav K; Gjedde, Albert.

    In: Frontiers in Neuroenergetics, Vol. 5, 2013, p. 1-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials : The role of autophagy and apoptosis. / Kermanizadeh, Ali; Jantzen, Kim; Ward, Michael B; Durhuus, Jon Ambæk; Juel Rasmussen, Lene; Loft, Steffen; Møller, Peter.

    In: Nanotoxicology, Vol. 11, No. 2, 03.2017, p. 184-200.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Mitochondrial oxidative phosphorylation capacity of cryopreserved cells. / Lauridsen, Poul Ejner; Rasmussen, Lene Juel; Desler, Claus.

    In: Mitochondrion, Vol. 47, 2019, p. 47-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published
  29. Published

    Mitochondria in biology and medicine--2012. / Madsen, Claus Desler; Rasmussen, Lene Juel.

    In: Mitochondrion, Vol. 16, 05.2014, p. 2-6.

    Research output: Contribution to journalReviewResearchpeer-review

  30. Published

    Mitochondria in biology and medicine. / Madsen, Claus Desler; Rasmussen, Lene Juel.

    In: Mitochondrion, Vol. 12, No. 4, 07.2012, p. 472-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Mitochondria as determinant of nucleotide pools and chromosomal stability. / Desler, Claus; Munch-Petersen, Birgitte; Stevnsner, Tinna; Matsui, Sei-Ichi; Kulawiec, Mariola; Singh, Keshav K; Rasmussen, Lene Juel.

    In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 625, No. 1-2, 01.12.2007, p. 112-24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    MERTK Acts as a costimulatory receptor on human cd8 t cells. / Peeters, Marlies J.W.; Dulkeviciute, Donata; Draghi, Arianna; Ritter, Cathrin; Rahbech, Anne; Skadborg, Signe K.; Seremet, Tina; Simoes, Ana Micaela Carnaz; Martinenaite, Evelina; Halldorsdottir, Holmfridur R.; Andersen, Mads Hald; Olofsson, Gitte Holmen; Svane, Inge Marie; Rasmussen, Lene Juel; Met, Ozcan; Becker, Jeurgen C.; Donia, Marco; Desler, Claus; Straten, Per Thor.

    In: Cancer Immunology Research, Vol. 7, No. 9, 2019, p. 1472-1484.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published
  34. Is hEXO1 a cancer predisposing gene? / Liberti, Sascha Emilie; Rasmussen, Lene Juel.

    In: Molecular Cancer Research, Vol. 2, No. 8, 08.2004, p. 427-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? / Hansen, Thomas Lau; Rasmussen, Lene Juel; Madsen, Claus Desler; Frederiksen, Jane Bruun; Espersen, Maiken Lise Marcker; Singh, Keshav K.

    In: Journal of Aging Research, Vol. 2012, 2012, p. 192503.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Involvement of the DNA mismatch repair system in cisplatin sensitivity of testicular germ cell tumours. / Rudolph, Christiane; Melau, Cecilie; Nielsen, John E.; Jensen, Kristina Vile; Liu, Dekang; Pena-Diaz, Javier; Meyts, Ewa Rajpert-De; Rasmussen, Lene Juel; Jorgensen, Anne.

    In: Cellular Oncology, Vol. 40, No. 4, 2017, p. 341-355.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Introducing the hypothome : a way to integrate predicted proteins in interactomes. / Madsen, Claus Desler; Zambach, Sine; Suravajhala, Prashanth; Rasmussen, Lene Juel.

    In: International Journal of Bioinformatics Research and Applications, Vol. 10, No. 6, 2014, p. 647-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Interventions for age-related diseases : Shifting the paradigm. / Figueira, Inês; Fernandes, Adelaide; Mladenovic Djordjevic, Aleksandra; Lopez-Contreras, Andres; Henriques, Catarina M; Selman, Colin; Ferreiro, Elisabete; Gonos, Efstathios S; Trejo, José Luis; Misra, Juhi; Rasmussen, Lene Juel; Xapelli, Sara; Ellam, Timothy; Bellantuono, Ilaria.

    In: Mechanisms of Ageing and Development, Vol. 160, 12.2016, p. 69-92.

    Research output: Contribution to journalReviewResearchpeer-review

  39. Published

    Initial brain aging : heterogeneity of mitochondrial size is associated with decline in complex I-linked respiration in cortex and hippocampus. / Thomsen, Kirsten; Yokota, Takashi; Hasan-Olive, Md Mahdi; Sherazi, Niloofar; Fakouri, Nima Borhan; Desler, Claus; Regnell, Christine Elisabeth; Larsen, Steen; Rasmussen, Lene Juel; Dela, Flemming; Bergersen, Linda Hildegard; Lauritzen, Martin.

    In: Neurobiology of Aging, Vol. 61, 2018, p. 215-224.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline. / Madsen, Claus Desler; Frederiksen, Jane H; Olsen, Maria Nathalie Angleys; Maynard, Scott; Keijzers, Guido; Fagerlund, Birgitte; Mortensen, Erik Lykke; Osler, Merete; Lauritzen, Martin; Bohr, Vilhelm A; Rasmussen, Lene Juel.

    In: Mitochondrion, Vol. 25, 11.2015, p. 34-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. / Lopez-Contreras, Andres J; Specks, Julia; Barlow, Jacqueline H; Ambrogio, Chiara; Madsen, Claus Desler; Vikingsson, Svante; Rodrigo-Perez, Sara; Green, Henrik; Rasmussen, Lene Juel; Murga, Matilde; Nussenzweig, André; Fernandez-Capetillo, Oscar.

    In: Genes & Development, Vol. 29, No. 7, 01.04.2015, p. 690-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    In Silico screening for functional candidates amongst hypothetical proteins. / Desler, Claus; Suravajhala, Prashanth; Sanderhoff, May; Rasmussen, Merete; Rasmussen, Lene Juel.

    In: BMC Bioinformatics, Vol. 10, 2009, p. 289.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure. / Lauritzen, Knut H.; Kleppa, Liv; Aronsen, Jan Magnus; Eide, Lars; Carlsen, Harald; Haugen, Oyvind P.; Sjaastad, Ivar; Klungland, Arne; Rasmussen, Lene Juel; Attramadal, Havard; Storm-Mathisen, Jon; Bergersen, Linda H.

    In: American Journal of Physiology: Heart and Circulatory Physiology, Vol. 309, No. 3, 01.08.2015, p. H434-H449.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Impact of bacterial infections on aging and cancer : Impairment of DNA repair and mitochondrial function of host cells. / Strickertsson, Jesper A B; Madsen, Claus Desler; Rasmussen, Lene Juel.

    In: Experimental Gerontology, Vol. 56, 08.2014, p. 164-174.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Human exonuclease 1 (EXO1) activity characterization and its function on FLAP structures. / Keijzers, Guido; Bohr, Vilhelm A; Juel Rasmussen, Lene.

    In: Bioscience Reports, Vol. 35, No. 3, e00206, 25.04.2015.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro. / Liu, Dekang; Frederiksen, Jane H; Liberti, Sascha E; Lützen, Anne; Keijzers, Guido; Pena-Diaz, Javier; Rasmussen, Lene Juel.

    In: Nucleic Acids Research, Vol. 45, No. 16, 19.09.2017, p. 9427-9440.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells. / Machado, Ana Manuel Dantas; Figueiredo, Ceu; Touati, Eliette; Máximo, Valdemar; Sousa, Sonia; Michel, Valérie; Carneiro, Fátima; Nielsen, Finn Cilius; Seruca, Raquel; Rasmussen, Lene Juel.

    In: Clinical Cancer Research, Vol. 15, No. 9, 2009, p. 2995-3002.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Helicobacter pylori infection generates genetic instability in gastric cells. / Machado, Ana Manuel Dantas; Figueiredo, Céu; Seruca, Raquel; Rasmussen, Lene Juel.

    In: BBA General Subjects, Vol. 1806, No. 1, 2010, p. 58-65.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Growth-rate-dependent transcription initiation from the dam P2 promoter. / Rasmussen, L J; Løbner-Olesen, A; Marinus, M G.

    In: Gene, Vol. 157, No. 1-2, 19.05.1995, p. 213-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions. / Martín-Pardillos, Ana; Tsaalbi-Shtylik, Anastasia; Chen, Si; Lazare, Seka; Van Os, Ronald P.; Dethmers-Ausema, Albertina; Fakouri, Nima Borhan; Bosshard, Matthias; Aprigliano, Rossana; Van Loon, Barbara; Salvatori, Daniela C.F.; Hashimoto, Keiji; Van Der Spek, Celia Dingemanse; Moriya, Masaaki; Rasmussen, Lene Juel; De Haan, Gerald; Raaijmakers, Marc H.G.P.; De Wind, Niels.

    In: Blood, Vol. 130, No. 13, 2017, p. 1523-1534.

    Research output: Contribution to journalJournal articleResearchpeer-review

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