Lene Juel Rasmussen

Lene Juel Rasmussen

Managing director of centre, professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 1: Modifiable pathways of damage and repair in aging


  1. Published

    14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. / Andersen, Sofie Dabros; Keijzers, Guido; Rampakakis, Emmanouil; Engels, Kim; Luhn, Patricia; El-Shemerly, Mahmoud; Nielsen, Finn Cilius; Du, Yuhong; May, Alfred; Bohr, Vilhelm A; Ferrari, Stefano; Zannis-Hadjopoulos, Maria; Fu, Haian; Rasmussen, Lene Juel.

    In: D N A Repair, Vol. 11, No. 3, 03.2012, p. 267-77.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells. / Machado, Ana Manuel Dantas; Desler, Claus; Boggild, Sisse; Strickertsson, Jesper A. B.; Friis-Hansen, Lennart; Figueiredo, Ceu; Seruca, Raquel; Rasmussen, Lene Juel.

    In: Mechanisms of Ageing and Development, Vol. 134, No. 10, 2013, p. 460-466.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis. / Hasan-Olive, Md Mahdi; Lauritzen, Knut H.; Ali, Mohammad; Rasmussen, Lene Juel; Storm-Mathisen, Jon; Bergersen, Linda H.

    In: Neurochemical Research, Vol. 44, No. 1, 2019, p. 22-37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression. / Syed, Salahuddin; Madsen, Claus Desler; Rasmussen, Lene J.; Schmidt, Kristina H.

    In: P L o S Genetics, Vol. 12, No. 12, e1006451, 12.2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. E-pub ahead of print

    A functional assay–based procedure to classify mismatch repair gene variants in Lynch syndrome. / Drost, Mark; Tiersma, Yvonne; Thompson, Bryony A.; Frederiksen, Jane H.; Keijzers, Guido; Glubb, Dylan; Kathe, Scott; Osinga, Jan; Westers, Helga; Pappas, Lisa; Boucher, Kenneth M.; Molenkamp, Siska; Zonneveld, José B.; van Asperen, Christi J.; Goldgar, David E.; Wallace, Susan S.; Sijmons, Rolf H.; Spurdle, Amanda B.; Rasmussen, Lene J.; Greenblatt, Marc S.; de Wind, Niels; Tavtigian, Sean V.

    In: Genetics in Medicine, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants. / Drost, Mark; Zonneveld, José B M; van Hees, Sandrine; Rasmussen, Lene Juel; Hofstra, Robert M W; de Wind, Niels.

    In: Human Mutation, Vol. 33, No. 3, 2012, p. 488-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Acquired Localized Cutis Laxa due to Increased Elastin Turnover. / Nygaard, Rie Harboe; Maynard, Scott; Schjerling, Peter; Kjær, Michael; Qvortrup, Klaus; Bohr, Vilhelm A; Rasmussen, Lene J; Jemec, Gregor B E; Heidenheim, Michael.

    In: Case Reports in Dermatology, Vol. 8, No. 1, 14.06.2016, p. 42-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Aging, longevity and health. / Rasmussen, Lene Juel; Sander, Miriam; Wewer, Ulla M.; Bohr, Vilhelm A.

    In: Mechanisms of Ageing and Development, 23.07.2011, p. 522-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells. / Cheng, Chang; Edin, Nina F Jeppesen; Lauritzen, Knut H; Aspmodal, Ida; Christoffersen, Stine; Jian, Liu; Rasmussen, Lene Juel; Pettersen, Erik O; Xiaoqun, Gao; Bergersen, Linda H.

    In: Cellular oncology (Dordrecht), Vol. 35, No. 3, 06.2012, p. 217-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Analysis of the antimicrobial susceptibility of the ionizing radiation-resistant bacterium Deinococcus radiodurans: implications for bioremediation of radioactive waste. / Bouchami, Ons; Sghaier, Haïtham; Madsen, Claus Desler; Lazim, Hadeer; Saidi, Mouldi; Rasmussen, Lene Juel; Ben Hassan, Assia .

    In: Annals of Microbiology, 2011.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database. / Thompson, Bryony A; Spurdle, Amanda B; Plazzer, John-Paul; Greenblatt, Marc S; Akagi, Kiwamu; Al-Mulla, Fahd; Bapat, Bharati; Bernstein, Inge; Capellá, Gabriel; den Dunnen, Johan T; du Sart, Desiree; Fabre, Aurelie; Farrell, Michael P; Farrington, Susan M; Frayling, Ian M; Frebourg, Thierry; Goldgar, David E; Heinen, Christopher D; Holinski-Feder, Elke; Kohonen-Corish, Maija; Robinson, Kristina Lagerstedt; Leung, Suet Yi; Martins, Alexandra; Moller, Pal; Morak, Monika; Nystrom, Minna; Peltomaki, Paivi; Pineda, Marta; Qi, Ming; Ramesar, Rajkumar; Rasmussen, Lene Juel; Royer-Pokora, Brigitte; Scott, Rodney J; Sijmons, Rolf; Tavtigian, Sean V; Tops, Carli M; Weber, Thomas; Wijnen, Juul; Woods, Michael O; Macrae, Finlay; Genuardi, Maurizio; Castillejo, Adela; Sexton, Adrienne; Chan, Anthony K W; Viel, Alessandra; Blanco, Amie; French, Amy; Laner, Andreas; Wagner, Anja; van den Ouweland, Ans; on behalf of InSiGHT.

    In: Nature Genetics, Vol. 46, No. 2, 02.2014, p. 107-115.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Approaches to diagnose DNA mismatch repair gene defects in cancer. / Peña-Diaz, Javier; Rasmussen, Lene Juel.

    In: DNA Repair, Vol. 38, 02.2016, p. 147-154.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Assessing Genetic Variants of Uncertain Significance: The Example of Lynch Syndrome. / Rasmussen, Lene Juel; Heinen, Christopher D.

    2014, eLS.

    Research output: Other contributionNet publication - Internet publicationCommunication

  14. Published

    Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance. / Maynard, S; Keijzers, G; Hansen, Åse Marie; Osler, M; Molbo, D; Bendix, L; Møller, P; Loft, S; Moreno-Villanueva, M; Bürkle, A; Hvitby, Christina Poulsen; Schurman, S H; Stevnsner, Tinna V.; Rasmussen, L J; Avlund, K; Bohr, V A.

    In: Acta Physiologica (Print), Vol. 213, No. 1, 01.2015, p. 156-170.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Bacterial infection increases risk of carcinogenesis by targeting mitochondria. / Strickertsson, Jesper A.B.; Desler, Claus; Rasmussen, Lene Juel.

    In: Seminars in Cancer Biology, Vol. 47, 12.2017, p. 95-100.

    Research output: Contribution to journalReviewResearchpeer-review

  16. Published

    Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks. / Liberti, Sascha E; Andersen, Sofie Dabros; Wang, Jing; May, Alfred; Miron, Simona; Perderiset, Mylene; Keijzers, Guido; Nielsen, Finn C; Charbonnier, Jean-Baptiste; Bohr, Vilhelm A; Rasmussen, Lene J.

    In: DNA Repair, Vol. 10, No. 1, 02.01.2011, p. 73-86.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome. / Ou, Jianghua; Rasmussen, Merete; Westers, Helga; Andersen, Sofie D; Jager, Paul O; Kooi, Krista A; Niessen, Renée C; Eggen, Bart J L; Nielsen, Finn C; Kleibeuker, Jan H; Sijmons, Rolf H; Rasmussen, Lene J; Hofstra, Robert M W.

    In: Genes, Chromosomes & Cancer, Vol. 48, No. 4, 2009, p. 340-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Bioenergetic Changes during Differentiation of Human Embryonic Stem Cells along the Hepatic Lineage. / Hopkinson, Branden M; Madsen, Claus Desler; Kalisz, Mark; Vestentoft, Peter Siig; Juel Rasmussen, Lene; Bisgaard, Hanne Cathrine.

    In: Oxidative Medicine and Cellular Longevity, Vol. 2017, 5080128, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Cadmium inhibits human DNA mismatch repair in vivo. / Lützen, Anne; Liberti, Sascha Emilie; Rasmussen, Lene Juel.

    In: Biochemical and Biophysical Research Communications, Vol. 321, No. 1, 13.08.2004, p. 21-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair. / Dherin, Claudine; Gueneau, Emeric; Francin, Mathilde; Nunez, Marcela; Miron, Simona; Liberti, Sascha Emilie; Rasmussen, Lene Juel; Zinn-Justin, Sophie; Gilquin, Bernard; Charbonnier, Jean-Baptiste; Boiteux, Serge.

    In: Molecular and Cellular Biology, Vol. 29, No. 3, 2009, p. 907-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    DNA damage response, bioenergetics, and neurological disease : the challenge of maintaining brain health in an aging human population. / Rasmussen, Lene Juel; Shiloh, Yosef; Bergersen, Linda H; Sander, Miriam; Bohr, Vilhelm A; Tønjum, Tone.

    In: Mechanisms of Ageing and Development, Vol. 134, No. 10, 10.2013, p. 427-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    DNA mismatch repair and its many roles in eukaryotic cells. / Liu, Dekang; Keijzers, Guido; Rasmussen, Lene Juel.

    In: Mutation Research - Reviews in Mutation Research, Vol. 773, 07.2017, p. 174-187.

    Research output: Contribution to journalReviewResearchpeer-review

  23. Published

    Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients. / Maynard, Scott; Hejl, Anne-Mette; Dinh, Tran Thuan Son; Keijzers, Guido; Hansen, Åse M; Madsen, Claus Desler; Moreno-Villanueva, Maria; Bürkle, Alexander; Rasmussen, Lene J; Waldemar, Gunhild; Bohr, Vilhelm A.

    In: Aging, Vol. 7, No. 10, 10.2015, p. 793-815.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays. / Heinen, Christopher D; Juel Rasmussen, Lene.

    In: Hereditary Cancer in Clinical Practice, Vol. 10, No. 1, 07.2012, p. 9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Differential expression of hMLH1 in sporadic human colorectal cancer tumors and distant metastases. / Larsen, Nicolai Balle; Heiberg Engel, Peter Johan; Rasmussen, Merete; Rasmussen, Lene Juel.

    In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 117, No. 11, 2009, p. 839-48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Disturbed mitochondrial function restricts glutamate uptake in the human Müller glia cell line, MIO-M1. / Vohra, Rupali; Gurubaran, Iswariyaraja Sridevi; Henriksen, Ulrik ; Bergersen, Linda Hildegaard; Rasmussen, Lene Juel; Desler, Claus; Skytt, Dorte Marie; Kolko, Miriam.

    In: Mitochondrion, Vol. 36, 2017, p. 52-59.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli. / Bendtsen, Kristian Moss; Jensen, Martin Borch; May, Alfred; Rasmussen, Lene Juel; Trusina, Ala; Bohr, Vilhelm; Jensen, Mogens Høgh.

    In: European Biophysics Journal, Vol. 43, No. 10-11, 14.11.2014, p. 509-516.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    EXO1 (Exonuclease 1). / Rasmussen, Lene Juel; Keijzers, Guido.

    Encyclopedia of Signaling Molecules . ed. / Sangdun Choi. New York : Springer, 2017.

    Research output: Chapter in Book/Report/Conference proceedingEncyclopedia chapterResearch

  29. Published

    Enterococcus faecalis Infection and Reactive Oxygen Species Down-Regulates the miR-17-92 Cluster in Gastric Adenocarcinoma Cell Culture. / Strickertsson, Jesper A B; Rasmussen, Lene Juel; Friis-Hansen, Lennart.

    In: Genes, Vol. 5, No. 3, 28.08.2014, p. 726-38.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells. / Strickertsson, Jesper A B; Madsen, Claus Desler; Martin-Bertelsen, Tomas; Machado, Ana Manuel Dantas; Wadstrøm, Torkel; Winther, Ole; Rasmussen, Lene Juel; Friis-Hansen, Lennart.

    In: PLOS ONE, Vol. 8, No. 4, e63147, 2013, p. 1-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Exonuclease 1 and its versatile roles in DNA repair. / Keijzers, Guido; Liu, Dekang; Rasmussen, Lene Juel.

    In: Critical Reviews in Biochemistry and Molecular Biology, Vol. 51, No. 6, 05.08.2016, p. 440–451.

    Research output: Contribution to journalReviewResearchpeer-review

  32. Published

    From powerhouse to perpetrator—mitochondria in health and disease. / Fakouri, Nima B.; Hansen, Thomas Lau; Desler, Claus; Anugula, Sharath; Rasmussen, Lene Juel.

    In: Biology, Vol. 8, No. 2, 35, 2019.

    Research output: Contribution to journalReviewResearchpeer-review

  33. Published

    Functional analysis of HNPCC-related missense mutations in MSH2. / Lützen, Anne; de Wind, Niels; Georgijevic, Dubravka; Nielsen, Finn Cilius; Rasmussen, Lene Juel.

    In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 645, No. 1-2, 14.10.2008, p. 44-55.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Functional characterization of MLH1 missense variants identified in Lynch Syndrome patients. / Andersen, Sofie Dabros; Liberti, Sascha Emilie; Lützen, Anne; Drost, Mark; Bernstein, Inge; Nilbert, Mef; Dominguez, Mev; Nyström, Minna; Hansen, Thomas Van Overeem; Christoffersen, Janus Wiese; Jäger, Anne Charlotte; de Wind, Niels; Nielsen, Finn Cilius; Tørring, Pernille M; Rasmussen, Lene Juel.

    In: Human Mutation, Vol. 33, No. 12, 12.2012, p. 1647-1655.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Functional examination of MLH1, MSH2, and MSH6 intronic mutations identified in Danish colorectal cancer patients. / Petersen, Sanne M; Dandanell, Mette; Rasmussen, Lene J; Gerdes, Anne-Marie; Krogh, Lotte Nylandsted; Bernstein, Inge; Okkels, Henrik; Wikman, Friedrik; Nielsen, Finn C; Hansen, Thomas V O.

    In: BMC Medical Genetics, Vol. 14, 2013, p. 103.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein. / Dominguez-Valentin, Mev; Drost, Mark; Therkildsen, Christina; Rambech, Eva; Ehrencrona, Hans; Angleys, Maria; Lau Hansen, Thomas; de Wind, Niels; Nilbert, Mef; Juel Rasmussen, Lene.

    In: Molecular Genetics & Genomic Medicine, Vol. 2, No. 4, 07.2014, p. 352-355.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome. / Drost, Mark; Lützen, Anne; van Hees, Sandrine; Ferreira, Daniel; Calléja, Fabienne; Zonneveld, José B M; Nielsen, Finn Cilius; Rasmussen, Lene Juel; de Wind, Niels.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 23, 2013, p. 9403-9408.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome. / Drost, Mark; Lützen, Anne; van Hees, Sandrine; Ferreira, Daniel; Calléja, Fabienne; Zonneveld, José B M; Nielsen, Finn Cilius; Rasmussen, Lene Juel; de Wind, Niels.

    In: Proceedings of the National Academy of Science of the United States of America, Vol. 110, No. 23, 04.06.2013, p. 9403-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Genome-wide screens for expressed hypothetical proteins. / Madsen, Claus Desler; Durhuus, Jon Ambæk; Rasmussen, Lene Juel.

    In: Methods in molecular biology (Clifton, N.J.), Vol. 815, 2012, p. 25-38.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions. / Martín-Pardillos, Ana; Tsaalbi-Shtylik, Anastasia; Chen, Si; Lazare, Seka; Van Os, Ronald P.; Dethmers-Ausema, Albertina; Fakouri, Nima Borhan; Bosshard, Matthias; Aprigliano, Rossana; Van Loon, Barbara; Salvatori, Daniela C.F.; Hashimoto, Keiji; Van Der Spek, Celia Dingemanse; Moriya, Masaaki; Rasmussen, Lene Juel; De Haan, Gerald; Raaijmakers, Marc H.G.P.; De Wind, Niels.

    In: Blood, Vol. 130, No. 13, 2017, p. 1523-1534.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Growth-rate-dependent transcription initiation from the dam P2 promoter. / Rasmussen, L J; Løbner-Olesen, A; Marinus, M G.

    In: Gene, Vol. 157, No. 1-2, 19.05.1995, p. 213-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Helicobacter pylori infection generates genetic instability in gastric cells. / Machado, Ana Manuel Dantas; Figueiredo, Céu; Seruca, Raquel; Rasmussen, Lene Juel.

    In: BBA General Subjects, Vol. 1806, No. 1, 2010, p. 58-65.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells. / Machado, Ana Manuel Dantas; Figueiredo, Ceu; Touati, Eliette; Máximo, Valdemar; Sousa, Sonia; Michel, Valérie; Carneiro, Fátima; Nielsen, Finn Cilius; Seruca, Raquel; Rasmussen, Lene Juel.

    In: Clinical Cancer Research, Vol. 15, No. 9, 2009, p. 2995-3002.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro. / Liu, Dekang; Frederiksen, Jane H; Liberti, Sascha E; Lützen, Anne; Keijzers, Guido; Pena-Diaz, Javier; Rasmussen, Lene Juel.

    In: Nucleic Acids Research, Vol. 45, No. 16, 19.09.2017, p. 9427-9440.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Human exonuclease 1 (EXO1) activity characterization and its function on FLAP structures. / Keijzers, Guido; Bohr, Vilhelm A; Juel Rasmussen, Lene.

    In: Bioscience Reports, Vol. 35, No. 3, e00206, 25.04.2015.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Impact of bacterial infections on aging and cancer : Impairment of DNA repair and mitochondrial function of host cells. / Strickertsson, Jesper A B; Madsen, Claus Desler; Rasmussen, Lene Juel.

    In: Experimental Gerontology, Vol. 56, 08.2014, p. 164-174.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure. / Lauritzen, Knut H.; Kleppa, Liv; Aronsen, Jan Magnus; Eide, Lars; Carlsen, Harald; Haugen, Oyvind P.; Sjaastad, Ivar; Klungland, Arne; Rasmussen, Lene Juel; Attramadal, Havard; Storm-Mathisen, Jon; Bergersen, Linda H.

    In: American Journal of Physiology: Heart and Circulatory Physiology, Vol. 309, No. 3, 01.08.2015, p. H434-H449.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    In Silico screening for functional candidates amongst hypothetical proteins. / Desler, Claus; Suravajhala, Prashanth; Sanderhoff, May; Rasmussen, Merete; Rasmussen, Lene Juel.

    In: BMC Bioinformatics, Vol. 10, 2009, p. 289.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. / Lopez-Contreras, Andres J; Specks, Julia; Barlow, Jacqueline H; Ambrogio, Chiara; Madsen, Claus Desler; Vikingsson, Svante; Rodrigo-Perez, Sara; Green, Henrik; Rasmussen, Lene Juel; Murga, Matilde; Nussenzweig, André; Fernandez-Capetillo, Oscar.

    In: Genes & Development, Vol. 29, No. 7, 01.04.2015, p. 690-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline. / Madsen, Claus Desler; Frederiksen, Jane H; Olsen, Maria Nathalie Angleys; Maynard, Scott; Keijzers, Guido; Fagerlund, Birgitte; Mortensen, Erik Lykke; Osler, Merete; Lauritzen, Martin; Bohr, Vilhelm A; Rasmussen, Lene Juel.

    In: Mitochondrion, Vol. 25, 11.2015, p. 34-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Initial brain aging : heterogeneity of mitochondrial size is associated with decline in complex I-linked respiration in cortex and hippocampus. / Thomsen, Kirsten; Yokota, Takashi; Hasan-Olive, Md Mahdi; Sherazi, Niloofar; Fakouri, Nima Borhan; Desler, Claus; Regnell, Christine Elisabeth; Larsen, Steen; Rasmussen, Lene Juel; Dela, Flemming; Bergersen, Linda Hildegard; Lauritzen, Martin.

    In: Neurobiology of Aging, Vol. 61, 2018, p. 215-224.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Interventions for age-related diseases : Shifting the paradigm. / Figueira, Inês; Fernandes, Adelaide; Mladenovic Djordjevic, Aleksandra; Lopez-Contreras, Andres; Henriques, Catarina M; Selman, Colin; Ferreiro, Elisabete; Gonos, Efstathios S; Trejo, José Luis; Misra, Juhi; Rasmussen, Lene Juel; Xapelli, Sara; Ellam, Timothy; Bellantuono, Ilaria.

    In: Mechanisms of Ageing and Development, Vol. 160, 12.2016, p. 69-92.

    Research output: Contribution to journalReviewResearchpeer-review

  53. Published

    Introducing the hypothome : a way to integrate predicted proteins in interactomes. / Madsen, Claus Desler; Zambach, Sine; Suravajhala, Prashanth; Rasmussen, Lene Juel.

    In: International Journal of Bioinformatics Research and Applications, Vol. 10, No. 6, 2014, p. 647-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Involvement of the DNA mismatch repair system in cisplatin sensitivity of testicular germ cell tumours. / Rudolph, Christiane; Melau, Cecilie; Nielsen, John E.; Jensen, Kristina Vile; Liu, Dekang; Pena-Diaz, Javier; Meyts, Ewa Rajpert-De; Rasmussen, Lene Juel; Jorgensen, Anne.

    In: Cellular Oncology, Vol. 40, No. 4, 2017, p. 341-355.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? / Hansen, Thomas Lau; Rasmussen, Lene Juel; Madsen, Claus Desler; Frederiksen, Jane Bruun; Espersen, Maiken Lise Marcker; Singh, Keshav K.

    In: Journal of Aging Research, Vol. 2012, 2012, p. 192503.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Is hEXO1 a cancer predisposing gene? / Liberti, Sascha Emilie; Rasmussen, Lene Juel.

    In: Molecular Cancer Research, Vol. 2, No. 8, 08.2004, p. 427-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published
  58. Published

    MERTK Acts as a costimulatory receptor on human cd8 t cells. / Peeters, Marlies J.W.; Dulkeviciute, Donata; Draghi, Arianna; Ritter, Cathrin; Rahbech, Anne; Skadborg, Signe K.; Seremet, Tina; Simoes, Ana Micaela Carnaz; Martinenaite, Evelina; Halldorsdottir, Holmfridur R.; Andersen, Mads Hald; Olofsson, Gitte Holmen; Svane, Inge Marie; Rasmussen, Lene Juel; Met, Ozcan; Becker, Jeurgen C.; Donia, Marco; Desler, Claus; Straten, Per Thor.

    In: Cancer Immunology Research, Vol. 7, No. 9, 2019, p. 1472-1484.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Mitochondria as determinant of nucleotide pools and chromosomal stability. / Desler, Claus; Munch-Petersen, Birgitte; Stevnsner, Tinna; Matsui, Sei-Ichi; Kulawiec, Mariola; Singh, Keshav K; Rasmussen, Lene Juel.

    In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 625, No. 1-2, 01.12.2007, p. 112-24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Mitochondria in biology and medicine. / Madsen, Claus Desler; Rasmussen, Lene Juel.

    In: Mitochondrion, Vol. 12, No. 4, 07.2012, p. 472-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Mitochondria in biology and medicine--2012. / Madsen, Claus Desler; Rasmussen, Lene Juel.

    In: Mitochondrion, Vol. 16, 05.2014, p. 2-6.

    Research output: Contribution to journalReviewResearchpeer-review

  62. Published
  63. Published

    Mitochondrial oxidative phosphorylation capacity of cryopreserved cells. / Lauridsen, Poul Ejner; Rasmussen, Lene Juel; Desler, Claus.

    In: Mitochondrion, Vol. 47, 2019, p. 47-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials : The role of autophagy and apoptosis. / Kermanizadeh, Ali; Jantzen, Kim; Ward, Michael B; Durhuus, Jon Ambæk; Juel Rasmussen, Lene; Loft, Steffen; Møller, Peter.

    In: Nanotoxicology, Vol. 11, No. 2, 03.2017, p. 184-200.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Natural selection of mitochondria during somatic lifetime promotes healthy aging. / Rodell, Anders; Rasmussen, Lene J; Bergersen, Linda H; Singh, Keshav K; Gjedde, Albert.

    In: Frontiers in Neuroenergetics, Vol. 5, 2013, p. 1-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Novel DNA mismatch-repair activity involving YB-1 in human mitochondria. / de Souza-Pinto, Nadja C; Mason, Penelope A; Hashiguchi, Kazunari; Weissman, Lior; Tian, Jingyan; Guay, David; Lebel, Michel; Stevnsner, Tinna V; Rasmussen, Lene Juel; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 8, No. 6, 2009, p. 704-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Novel growth rate control of dam gene expression in Escherichia coli. / Rasmussen, L J; Marinus, M G; Løbner-Olesen, A.

    In: Molecular Microbiology, Vol. 12, No. 4, 05.1994, p. 631-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1). / Knudsen, Nina Østergaard; Nielsen, Finn Cilius; Vinther, Lena; Bertelsen, Ronni; Holten-Andersen, Steen; Liberti, Sascha Emilie; Hofstra, Robert; Kooi, Krista; Rasmussen, Lene Juel.

    In: Nucleic Acids Research, Vol. 35, No. 8, 2007, p. 2609-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    Nuclear translocation contributes to regulation of DNA excision repair activities. / Knudsen, Nina Østergaard; Andersen, Sofie Dabros; Lützen, Anne; Nielsen, Finn Cilius; Rasmussen, Lene Juel.

    In: DNA Repair, Vol. 8, No. 6, 2009, p. 682-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. Published

    Oxidative Stress-Induced Dysfunction of Muller Cells During Starvation. / Toft-Kehler, Anne Katrine; Gurubaran, Iswariyaraja Sridevi; Madsen, Claus Desler; Rasmussen, Lene J.; Skytt, Dorte Marie; Kolko, Miriam.

    In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 6, 05.2016, p. 2721-2728.

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages. / Jantzen, Kim; Roursgaard, Martin; Madsen, Claus Desler; Loft, Steffen; Rasmussen, Lene Juel; Møller, Peter.

    In: Mutagenesis, Vol. 27, No. 6, 11.2012, p. 693-701.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    Pathological assessment of mismatch repair gene variants in Lynch syndrome : Past, present, and future. / Rasmussen, Lene Juel; Heinen, Christopher D; Royer-Pokora, Brigitte; Drost, Mark; Tavtigian, Sean; Hofstra, Robert M W; de Wind, Niels.

    In: Human Mutation, Vol. 33, No. 12, 12.2012, p. 1617-25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations. / Nielsen, Sofie V,; Stein, Amelie; Dinitzen, Alexander B.; Papaleo, Elena; Tatham, Michael H.; Poulsen, Esben Guldahl; Kassem, Maher Mahmoud; Rasmussen, Lene Juel; Lindorff-Larsen, Kresten; Hartmann-Petersen, Rasmus.

    In: PLoS Genetics, Vol. 13, No. 4, e1006739, 19.04.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks. / Lu, Huiming; Shamanna, Raghavendra A; Keijzers, Guido; Anand, Roopesh; Rasmussen, Lene Juel; Cejka, Petr; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Cell Reports, Vol. 16, No. 1, 28.06.2016, p. 161-173.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells. / Maynard, Scott; Keijzers, Guido; Gram, Martin; Madsen, Claus Desler; Bendix, Laila; Budtz-Jørgensen, Esben; Molbo, Drude; Croteau, Deborah L; Osler, Merete; Stevnsner, Tinna V.; Rasmussen, Lene Juel; Dela, Flemming; Avlund, Kirsten; Bohr, Vilhelm A.

    In: Aging, 30.11.2013, p. 850-864.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Repair of DNA damage induced by anthanthrene, a polycyclic aromatic hydrocarbon (PAH) without bay or fjord regions. / Madsen, Claus Desler; Johannessen, Christian; Rasmussen, Lene Juel.

    In: Chemico-Biological Interactions, Vol. 177, No. 3, 2009, p. 212-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    Response to : Design of a core classification process for DNA mismatch repair variations of a priori unknown functional significance. / Rasmussen, Lene Juel; Heinen, Christopher D; Royer-Pokora, Brigitte; Drost, Mark; Tavtigian, Sean; Hofstra, Robert M W; de Wind, Niels.

    In: Human Mutation, Vol. 34, No. 6, 06.2013, p. 923-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis. / Fakouri, Nima Borhan; Durhuus, Jon Ambaek; Regnell, Christine Elisabeth; Angleys, Maria; Desler, Claus; Hasan-Olive, Mahdi; Martin-Pardillos, Ana; Tsaalbi-Shtylik, Anastasia; Thomsen, Kirsten; Lauritzen, Martin; Bohr, Vilhelm A.; de Wind, Niels; Bergersen, Linda Hildegard; Rasmussen, Lene Juel.

    In: Scientific Reports, Vol. 7, 12480, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    The LipB protein is a negative regulator of dam gene expression in Escherichia coli. / Vaisvila, R; Rasmussen, L J; Lobner-Olesen, A; von Freiesleben, U; Marinus, M G.

    In: B B A - Reviews on Cancer, Vol. 1494, No. 1-2, 15.11.2000, p. 43-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. Published

    The challenges of human population ageing. / Sander, Miriam; Oxlund, Bjarke; Jespersen, Astrid; Krasnik, Allan; Mortensen, Erik Lykke; Westendorp, Rudi Gerardus Johannes; Rasmussen, Lene Juel.

    In: Age and Ageing, Vol. 44, No. 2, 03.2015, p. 185-7.

    Research output: Contribution to journalJournal articleCommunication

  81. Published

    The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism. / Madsen, Claus Desler; Lykke, Anne; Rasmussen, Lene Juel.

    In: Journal of Nucleic Acids, Vol. 2010, 01.01.2010.

    Research output: Contribution to journalJournal articleResearchpeer-review

  82. Published

    The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients. / Jensen, Martin Borch; Dunn, Christopher A; Keijzers, Guido; Kulikowicz, Tomasz; Rasmussen, Lene Juel; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Aging, Vol. 4, No. 11, 11.2012, p. 790-802.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Published

    The importance of mitochondrial DNA in aging and cancer. / Madsen, Claus Desler; Espersen, Maiken Lise Marcker; Singh, Keshav K; Rasmussen, Lene Juel.

    In: Journal of Aging Research, Vol. 2011, 30.03.2011, p. 407536.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms. / Jakobsen, Emil; Lange, Sofie C; Andersen, Jens Velde; Madsen, Claus Desler; Kihl, Henriette Filholm; Hohnholt, Michaela; Stridh, Malin H; Rasmussen, Lene Juel; Waagepetersen, Helle S.; Bak, Lasse Kristoffer.

    In: Biochemical Pharmacology, Vol. 155, 2018, p. 92-101.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published

    The role of RecQ helicases in non-homologous end-joining. / Keijzers, Guido; Maynard, Scott; Shamanna, Raghavendra A; Rasmussen, Lene Juel; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Critical Reviews in Biochemistry and Molecular Biology, Vol. 49, No. 6, 11.2014, p. 463-472.

    Research output: Contribution to journalReviewResearchpeer-review

  86. The role of mitochondrial dNTP levels in cells with reduced TK2 activity. / Desler, C; Munch-Petersen, B; Rasmussen, L J.

    In: Nucleosides, nucleotides & nucleic acids, Vol. 25, No. 9-11, 2006, p. 1171-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    The role of mitochondrial dysfunction in the progression of Alzheimer’s disease. / Desler, Claus; Lillenes, Meryl S.; Tønjum, Tone; Rasmussen, Lene Juel.

    In: Current Medicinal Chemistry, Vol. 25, No. 40, 2018, p. 5578 - 5587.

    Research output: Contribution to journalReviewResearchpeer-review

  88. Published

    Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage. / Skovgaard, T; Rasmussen, Lene Juel; Munch-Petersen, Birgitte.

    In: Nucleosides, Nucleotides and Nucleic Acids, Vol. 29, No. 4-6, 2010, p. 347-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia. / Bundgaard, Amanda; Qvortrup, Klaus; Rasmussen, Lene Juel; Fago, Angela.

    In: Journal of Experimental Biology, Vol. 222, No. 11, jeb200410, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 13558388