Lene Juel Rasmussen

Lene Juel Rasmussen

Managing director of centre, professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 1: Modifiable pathways of damage and repair in aging


  1. Published

    14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. / Andersen, Sofie Dabros; Keijzers, Guido; Rampakakis, Emmanouil; Engels, Kim; Luhn, Patricia; El-Shemerly, Mahmoud; Nielsen, Finn Cilius; Du, Yuhong; May, Alfred; Bohr, Vilhelm A; Ferrari, Stefano; Zannis-Hadjopoulos, Maria; Fu, Haian; Rasmussen, Lene Juel.

    In: D N A Repair, Vol. 11, No. 3, 03.2012, p. 267-77.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells. / Machado, Ana Manuel Dantas; Desler, Claus; Boggild, Sisse; Strickertsson, Jesper A. B.; Friis-Hansen, Lennart; Figueiredo, Ceu; Seruca, Raquel; Rasmussen, Lene Juel.

    In: Mechanisms of Ageing and Development, Vol. 134, No. 10, 2013, p. 460-466.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis. / Hasan-Olive, Md Mahdi; Lauritzen, Knut H.; Ali, Mohammad; Rasmussen, Lene Juel; Storm-Mathisen, Jon; Bergersen, Linda H.

    In: Neurochemical Research, Vol. 44, No. 1, 2019, p. 22-37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression. / Syed, Salahuddin; Madsen, Claus Desler; Rasmussen, Lene J.; Schmidt, Kristina H.

    In: P L o S Genetics, Vol. 12, No. 12, e1006451, 12.2016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. E-pub ahead of print

    A functional assay–based procedure to classify mismatch repair gene variants in Lynch syndrome. / Drost, Mark; Tiersma, Yvonne; Thompson, Bryony A.; Frederiksen, Jane H.; Keijzers, Guido; Glubb, Dylan; Kathe, Scott; Osinga, Jan; Westers, Helga; Pappas, Lisa; Boucher, Kenneth M.; Molenkamp, Siska; Zonneveld, José B.; van Asperen, Christi J.; Goldgar, David E.; Wallace, Susan S.; Sijmons, Rolf H.; Spurdle, Amanda B.; Rasmussen, Lene J.; Greenblatt, Marc S.; de Wind, Niels; Tavtigian, Sean V.

    In: Genetics in Medicine, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants. / Drost, Mark; Zonneveld, José B M; van Hees, Sandrine; Rasmussen, Lene Juel; Hofstra, Robert M W; de Wind, Niels.

    In: Human Mutation, Vol. 33, No. 3, 2012, p. 488-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Acquired Localized Cutis Laxa due to Increased Elastin Turnover. / Nygaard, Rie Harboe; Maynard, Scott; Schjerling, Peter; Kjær, Michael; Qvortrup, Klaus; Bohr, Vilhelm A; Rasmussen, Lene J; Jemec, Gregor B E; Heidenheim, Michael.

    In: Case Reports in Dermatology, Vol. 8, No. 1, 14.06.2016, p. 42-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Aging, longevity and health. / Rasmussen, Lene Juel; Sander, Miriam; Wewer, Ulla M.; Bohr, Vilhelm A.

    In: Mechanisms of Ageing and Development, 23.07.2011, p. 522-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells. / Cheng, Chang; Edin, Nina F Jeppesen; Lauritzen, Knut H; Aspmodal, Ida; Christoffersen, Stine; Jian, Liu; Rasmussen, Lene Juel; Pettersen, Erik O; Xiaoqun, Gao; Bergersen, Linda H.

    In: Cellular oncology (Dordrecht), Vol. 35, No. 3, 06.2012, p. 217-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Analysis of the antimicrobial susceptibility of the ionizing radiation-resistant bacterium Deinococcus radiodurans: implications for bioremediation of radioactive waste. / Bouchami, Ons; Sghaier, Haïtham; Madsen, Claus Desler; Lazim, Hadeer; Saidi, Mouldi; Rasmussen, Lene Juel; Ben Hassan, Assia .

    In: Annals of Microbiology, 2011.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database. / Thompson, Bryony A; Spurdle, Amanda B; Plazzer, John-Paul; Greenblatt, Marc S; Akagi, Kiwamu; Al-Mulla, Fahd; Bapat, Bharati; Bernstein, Inge; Capellá, Gabriel; den Dunnen, Johan T; du Sart, Desiree; Fabre, Aurelie; Farrell, Michael P; Farrington, Susan M; Frayling, Ian M; Frebourg, Thierry; Goldgar, David E; Heinen, Christopher D; Holinski-Feder, Elke; Kohonen-Corish, Maija; Robinson, Kristina Lagerstedt; Leung, Suet Yi; Martins, Alexandra; Moller, Pal; Morak, Monika; Nystrom, Minna; Peltomaki, Paivi; Pineda, Marta; Qi, Ming; Ramesar, Rajkumar; Rasmussen, Lene Juel; Royer-Pokora, Brigitte; Scott, Rodney J; Sijmons, Rolf; Tavtigian, Sean V; Tops, Carli M; Weber, Thomas; Wijnen, Juul; Woods, Michael O; Macrae, Finlay; Genuardi, Maurizio; Castillejo, Adela; Sexton, Adrienne; Chan, Anthony K W; Viel, Alessandra; Blanco, Amie; French, Amy; Laner, Andreas; Wagner, Anja; van den Ouweland, Ans; on behalf of InSiGHT.

    In: Nature Genetics, Vol. 46, No. 2, 02.2014, p. 107-115.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Approaches to diagnose DNA mismatch repair gene defects in cancer. / Peña-Diaz, Javier; Rasmussen, Lene Juel.

    In: DNA Repair, Vol. 38, 02.2016, p. 147-154.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Assessing Genetic Variants of Uncertain Significance: The Example of Lynch Syndrome. / Rasmussen, Lene Juel; Heinen, Christopher D.

    2014, eLS.

    Research output: Other contributionNet publication - Internet publicationCommunication

  14. Published

    Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance. / Maynard, S; Keijzers, G; Hansen, Åse Marie; Osler, M; Molbo, D; Bendix, L; Møller, P; Loft, S; Moreno-Villanueva, M; Bürkle, A; Hvitby, Christina Poulsen; Schurman, S H; Stevnsner, Tinna V.; Rasmussen, L J; Avlund, K; Bohr, V A.

    In: Acta Physiologica (Print), Vol. 213, No. 1, 01.2015, p. 156-170.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Bacterial infection increases risk of carcinogenesis by targeting mitochondria. / Strickertsson, Jesper A.B.; Desler, Claus; Rasmussen, Lene Juel.

    In: Seminars in Cancer Biology, Vol. 47, 12.2017, p. 95-100.

    Research output: Contribution to journalReviewResearchpeer-review

  16. Published

    Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks. / Liberti, Sascha E; Andersen, Sofie Dabros; Wang, Jing; May, Alfred; Miron, Simona; Perderiset, Mylene; Keijzers, Guido; Nielsen, Finn C; Charbonnier, Jean-Baptiste; Bohr, Vilhelm A; Rasmussen, Lene J.

    In: DNA Repair, Vol. 10, No. 1, 02.01.2011, p. 73-86.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome. / Ou, Jianghua; Rasmussen, Merete; Westers, Helga; Andersen, Sofie D; Jager, Paul O; Kooi, Krista A; Niessen, Renée C; Eggen, Bart J L; Nielsen, Finn C; Kleibeuker, Jan H; Sijmons, Rolf H; Rasmussen, Lene J; Hofstra, Robert M W.

    In: Genes, Chromosomes & Cancer, Vol. 48, No. 4, 2009, p. 340-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Bioenergetic Changes during Differentiation of Human Embryonic Stem Cells along the Hepatic Lineage. / Hopkinson, Branden M; Madsen, Claus Desler; Kalisz, Mark; Vestentoft, Peter Siig; Juel Rasmussen, Lene; Bisgaard, Hanne Cathrine.

    In: Oxidative Medicine and Cellular Longevity, Vol. 2017, 5080128, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Cadmium inhibits human DNA mismatch repair in vivo. / Lützen, Anne; Liberti, Sascha Emilie; Rasmussen, Lene Juel.

    In: Biochemical and Biophysical Research Communications, Vol. 321, No. 1, 13.08.2004, p. 21-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair. / Dherin, Claudine; Gueneau, Emeric; Francin, Mathilde; Nunez, Marcela; Miron, Simona; Liberti, Sascha Emilie; Rasmussen, Lene Juel; Zinn-Justin, Sophie; Gilquin, Bernard; Charbonnier, Jean-Baptiste; Boiteux, Serge.

    In: Molecular and Cellular Biology, Vol. 29, No. 3, 2009, p. 907-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    DNA damage response, bioenergetics, and neurological disease : the challenge of maintaining brain health in an aging human population. / Rasmussen, Lene Juel; Shiloh, Yosef; Bergersen, Linda H; Sander, Miriam; Bohr, Vilhelm A; Tønjum, Tone.

    In: Mechanisms of Ageing and Development, Vol. 134, No. 10, 10.2013, p. 427-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    DNA mismatch repair and its many roles in eukaryotic cells. / Liu, Dekang; Keijzers, Guido; Rasmussen, Lene Juel.

    In: Mutation Research - Reviews in Mutation Research, Vol. 773, 07.2017, p. 174-187.

    Research output: Contribution to journalReviewResearchpeer-review

  23. Published

    Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients. / Maynard, Scott; Hejl, Anne-Mette; Dinh, Tran Thuan Son; Keijzers, Guido; Hansen, Åse M; Madsen, Claus Desler; Moreno-Villanueva, Maria; Bürkle, Alexander; Rasmussen, Lene J; Waldemar, Gunhild; Bohr, Vilhelm A.

    In: Aging, Vol. 7, No. 10, 10.2015, p. 793-815.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays. / Heinen, Christopher D; Juel Rasmussen, Lene.

    In: Hereditary Cancer in Clinical Practice, Vol. 10, No. 1, 07.2012, p. 9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Differential expression of hMLH1 in sporadic human colorectal cancer tumors and distant metastases. / Larsen, Nicolai Balle; Heiberg Engel, Peter Johan; Rasmussen, Merete; Rasmussen, Lene Juel.

    In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 117, No. 11, 2009, p. 839-48.

    Research output: Contribution to journalJournal articleResearchpeer-review

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