Lene Juel Rasmussen

Lene Juel Rasmussen

Managing director of centre, professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 1: Modifiable pathways of damage and repair in aging


  1. Published

    14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. / Andersen, Sofie Dabros; Keijzers, Guido; Rampakakis, Emmanouil; Engels, Kim; Luhn, Patricia; El-Shemerly, Mahmoud; Nielsen, Finn Cilius; Du, Yuhong; May, Alfred; Bohr, Vilhelm A; Ferrari, Stefano; Zannis-Hadjopoulos, Maria; Fu, Haian; Rasmussen, Lene Juel.

    In: D N A Repair, Vol. 11, No. 3, 03.2012, p. 267-77.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Functional characterization of MLH1 missense variants identified in Lynch Syndrome patients. / Andersen, Sofie Dabros; Liberti, Sascha Emilie; Lützen, Anne; Drost, Mark; Bernstein, Inge; Nilbert, Mef; Dominguez, Mev; Nyström, Minna; Hansen, Thomas Van Overeem; Christoffersen, Janus Wiese; Jäger, Anne Charlotte; de Wind, Niels; Nielsen, Finn Cilius; Tørring, Pernille M; Rasmussen, Lene Juel.

    In: Human Mutation, Vol. 33, No. 12, 12.2012, p. 1647-1655.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli. / Bendtsen, Kristian Moss; Jensen, Martin Borch; May, Alfred; Rasmussen, Lene Juel; Trusina, Ala; Bohr, Vilhelm; Jensen, Mogens Høgh.

    In: European Biophysics Journal, Vol. 43, No. 10-11, 14.11.2014, p. 509-516.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Analysis of the antimicrobial susceptibility of the ionizing radiation-resistant bacterium Deinococcus radiodurans: implications for bioremediation of radioactive waste. / Bouchami, Ons; Sghaier, Haïtham; Madsen, Claus Desler; Lazim, Hadeer; Saidi, Mouldi; Rasmussen, Lene Juel; Ben Hassan, Assia .

    In: Annals of Microbiology, 2011.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia. / Bundgaard, Amanda; Qvortrup, Klaus; Rasmussen, Lene Juel; Fago, Angela.

    In: Journal of Experimental Biology, Vol. 222, No. 11, jeb200410, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells. / Cheng, Chang; Edin, Nina F Jeppesen; Lauritzen, Knut H; Aspmodal, Ida; Christoffersen, Stine; Jian, Liu; Rasmussen, Lene Juel; Pettersen, Erik O; Xiaoqun, Gao; Bergersen, Linda H.

    In: Cellular oncology (Dordrecht), Vol. 35, No. 3, 06.2012, p. 217-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published
  8. The role of mitochondrial dNTP levels in cells with reduced TK2 activity. / Desler, C; Munch-Petersen, B; Rasmussen, L J.

    In: Nucleosides, nucleotides & nucleic acids, Vol. 25, No. 9-11, 2006, p. 1171-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The role of mitochondrial dysfunction in the progression of Alzheimer’s disease. / Desler, Claus; Lillenes, Meryl S.; Tønjum, Tone; Rasmussen, Lene Juel.

    In: Current Medicinal Chemistry, Vol. 25, No. 40, 2018, p. 5578 - 5587.

    Research output: Contribution to journalReviewResearchpeer-review

  10. Mitochondria as determinant of nucleotide pools and chromosomal stability. / Desler, Claus; Munch-Petersen, Birgitte; Stevnsner, Tinna; Matsui, Sei-Ichi; Kulawiec, Mariola; Singh, Keshav K; Rasmussen, Lene Juel.

    In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 625, No. 1-2, 01.12.2007, p. 112-24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    In Silico screening for functional candidates amongst hypothetical proteins. / Desler, Claus; Suravajhala, Prashanth; Sanderhoff, May; Rasmussen, Merete; Rasmussen, Lene Juel.

    In: BMC Bioinformatics, Vol. 10, 2009, p. 289.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair. / Dherin, Claudine; Gueneau, Emeric; Francin, Mathilde; Nunez, Marcela; Miron, Simona; Liberti, Sascha Emilie; Rasmussen, Lene Juel; Zinn-Justin, Sophie; Gilquin, Bernard; Charbonnier, Jean-Baptiste; Boiteux, Serge.

    In: Molecular and Cellular Biology, Vol. 29, No. 3, 2009, p. 907-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein. / Dominguez-Valentin, Mev; Drost, Mark; Therkildsen, Christina; Rambech, Eva; Ehrencrona, Hans; Angleys, Maria; Lau Hansen, Thomas; de Wind, Niels; Nilbert, Mef; Juel Rasmussen, Lene.

    In: Molecular Genetics & Genomic Medicine, Vol. 2, No. 4, 07.2014, p. 352-355.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. E-pub ahead of print

    A functional assay–based procedure to classify mismatch repair gene variants in Lynch syndrome. / Drost, Mark; Tiersma, Yvonne; Thompson, Bryony A.; Frederiksen, Jane H.; Keijzers, Guido; Glubb, Dylan; Kathe, Scott; Osinga, Jan; Westers, Helga; Pappas, Lisa; Boucher, Kenneth M.; Molenkamp, Siska; Zonneveld, José B.; van Asperen, Christi J.; Goldgar, David E.; Wallace, Susan S.; Sijmons, Rolf H.; Spurdle, Amanda B.; Rasmussen, Lene J.; Greenblatt, Marc S.; de Wind, Niels; Tavtigian, Sean V.

    In: Genetics in Medicine, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome. / Drost, Mark; Lützen, Anne; van Hees, Sandrine; Ferreira, Daniel; Calléja, Fabienne; Zonneveld, José B M; Nielsen, Finn Cilius; Rasmussen, Lene Juel; de Wind, Niels.

    In: Proceedings of the National Academy of Science of the United States of America, Vol. 110, No. 23, 04.06.2013, p. 9403-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants. / Drost, Mark; Zonneveld, José B M; van Hees, Sandrine; Rasmussen, Lene Juel; Hofstra, Robert M W; de Wind, Niels.

    In: Human Mutation, Vol. 33, No. 3, 2012, p. 488-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome. / Drost, Mark; Lützen, Anne; van Hees, Sandrine; Ferreira, Daniel; Calléja, Fabienne; Zonneveld, José B M; Nielsen, Finn Cilius; Rasmussen, Lene Juel; de Wind, Niels.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 23, 2013, p. 9403-9408.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published
  19. Published

    From powerhouse to perpetrator—mitochondria in health and disease. / Fakouri, Nima B.; Hansen, Thomas Lau; Desler, Claus; Anugula, Sharath; Rasmussen, Lene Juel.

    In: Biology, Vol. 8, No. 2, 35, 2019.

    Research output: Contribution to journalReviewResearchpeer-review

  20. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis. / Fakouri, Nima Borhan; Durhuus, Jon Ambaek; Regnell, Christine Elisabeth; Angleys, Maria; Desler, Claus; Hasan-Olive, Mahdi; Martin-Pardillos, Ana; Tsaalbi-Shtylik, Anastasia; Thomsen, Kirsten; Lauritzen, Martin; Bohr, Vilhelm A.; de Wind, Niels; Bergersen, Linda Hildegard; Rasmussen, Lene Juel.

    In: Scientific Reports, Vol. 7, 12480, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Interventions for age-related diseases : Shifting the paradigm. / Figueira, Inês; Fernandes, Adelaide; Mladenovic Djordjevic, Aleksandra; Lopez-Contreras, Andres; Henriques, Catarina M; Selman, Colin; Ferreiro, Elisabete; Gonos, Efstathios S; Trejo, José Luis; Misra, Juhi; Rasmussen, Lene Juel; Xapelli, Sara; Ellam, Timothy; Bellantuono, Ilaria.

    In: Mechanisms of Ageing and Development, Vol. 160, 12.2016, p. 69-92.

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? / Hansen, Thomas Lau; Rasmussen, Lene Juel; Madsen, Claus Desler; Frederiksen, Jane Bruun; Espersen, Maiken Lise Marcker; Singh, Keshav K.

    In: Journal of Aging Research, Vol. 2012, 2012, p. 192503.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis. / Hasan-Olive, Md Mahdi; Lauritzen, Knut H.; Ali, Mohammad; Rasmussen, Lene Juel; Storm-Mathisen, Jon; Bergersen, Linda H.

    In: Neurochemical Research, Vol. 44, No. 1, 2019, p. 22-37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays. / Heinen, Christopher D; Juel Rasmussen, Lene.

    In: Hereditary Cancer in Clinical Practice, Vol. 10, No. 1, 07.2012, p. 9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Bioenergetic Changes during Differentiation of Human Embryonic Stem Cells along the Hepatic Lineage. / Hopkinson, Branden M; Madsen, Claus Desler; Kalisz, Mark; Vestentoft, Peter Siig; Juel Rasmussen, Lene; Bisgaard, Hanne Cathrine.

    In: Oxidative Medicine and Cellular Longevity, Vol. 2017, 5080128, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

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