Laura Frendrup McNair
Natural Products and Peptides
Jagtvej 162, 2100 København Ø
Introductory remarks on publicationslist
My latest results include identification and characterization of a new antifungal peptide in fermented milk product containing bioprotective Lactobacillus cultures (McNair et al. 2018 FEMS Yeast). A project conducted in tight collaboration with a food company. I am currently continuing this line of work and expect to present new exciting findings in the near future.
The work from my PhD include thorough characterisation of cellular energy metabolism in acutely isolated hippocampal and cerebral cortical mouse brain slices using 13C-mapping, GC-MS and HPLC (McNair et al. 2017 Neurochem Res) and provides evidence of metabolic similarity of these two brain regions. Moreover, I propose new interesting approaches for interpreting 13C-mapping data. This work was followed-up by evaluating the specificity of 13C-substrates for assessing astrocytic and neuronal metabolism individually in acute brain slices (Andersen, McNair et al. 2017 J Neurosci Res). Other parts of my work in acute brain slices have contributed to a recent review discussing the role of glutamate dehydrogenase and amino transferases in connection to glutamate oxidation in astrocytes (McKenna, Stridt, McNair et al. 2016 J Neurosci Res).
As part of my PhD I also completed two large rodent ex vivo studies combining 13C-mapping with GC-MS and 13C/1H NMR, in collaboration with excellent researchers at Yale University and Harvard Medical School (USA), respectively. I reveal significant brain regional differences in the rate of pyruvate carboxylase, an astrocytic enzyme essential for de novo synthesis of the excitatory neurotransmitter glutamate (manuscript in progress). Furthermore, I provide data suggesting that the glutamate transporter GLT-1 expressed in neurons is important for glutamate homeostasis and synaptoc energy metabolism (submitted to J Neurosci).
Results from my undergraduate research (2011-2012) at Bath University (UK) provide indications of differential changes in neural plasticity induced by addictive drug exposure with and without the context of a place-preference learning task, measured as long-term potentiation in hippocampal slices. This work was presented on scientific poster at the British Pharmacology Society meeting in 2012 and my data formed the basis for further work within Prof. C. Bailey's group.
Finally, my Master’s thesis elucidates the significant impact of pre-natal exposure to nicotine on brain function, measured as calcium responses to glutamatergic stimulation in brain slice from pubs born of nicotine treated mice (McNair & Kohlmeier 2015 J Dev Orig Health Dis).
Glutamate oxidation in astrocytes: Roles of glutamate dehydrogenase and aminotransferases. / McKenna, Mary C; Stridh, Malin H; McNair, Laura Frendrup; Sonnewald, Ursula; Waagepetersen, Helle S.; Schousboe, Arne.In: Journal of Neuroscience Research, Vol. 94, No. 12, 15.09.2016, p. 1561-1571.
Research output: Contribution to journal › Journal article › Research › peer-review