John Robert Couchman

John Robert Couchman

Professor emeritus


  1. 2009
  2. Published

    Syndecans as receptors and organizers of the extracellular matrix. / Xian, Xiaojie; Gopal, Sandeep; Couchman, John.

    In: Cell and Tissue Research, 2009.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2008
  4. Published

    Cellular responses to the HEPII domain of fibronectin require N-sulphation of cell-surface heparan sulphate proteoglycan. / Mahalingam, Y.; Gallagher, J.T.; Couchman, John Robert.

    In: International Journal of Experimental Pathology, Vol. 89, No. 3, 2008.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Cellular roles of ADAM12 in health and disease. / Kveiborg, Marie; Albrechtsen, Reidar; Couchman, John R; Wewer, Ulla M.

    In: International Journal of Biochemistry & Cell Biology, Vol. 40, No. 9, 2008, p. 1685-702.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Commercial Antibodies: The Good, Bad, and Really Ugly. / Couchman, John R.

    In: Journal of Histochemistry and Cytochemistry, 2008.

    Research output: Contribution to journalComment/debateResearch

  7. Published

    Heparan sulfate regulates ADAM12 through a molecular switch mechanism. / Sørensen, Hans P; Vives, Romain R; Manetopoulos, Christina; Albrechtsen, Reidar; Lydolph, Magnus C; Jacobsen, Jonas; Couchman, John R; Wewer, Ulla M.

    In: Journal of Biological Chemistry, 2008.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Heparan sulfate regulates fibrillin-1 N- and C-terminal interactions. / Cain, Stuart A; Baldwin, Andrew K; Mahalingam, Yashithra; Raynal, Bertrand; Jowitt, Thomas A; Shuttleworth, C Adrian; Couchman, John R; Kielty, Cay M.

    In: Journal of Biological Chemistry, Vol. 283, No. 40, 2008, p. 27017-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Structural and cell adhesion properties of zebrafish syndecan-4 are shared with higher vertebrates. / Whiteford, James; Ko, Sunggeon; Lee, Weontae; Couchman, John R.

    In: Journal of Biological Chemistry, Vol. 283, No. 43, 2008, p. 29322-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The CMV early enhancer/chicken beta actin (CAG) promoter can be used to drive transgene expression during the differentiation of murine embryonic stem cells into vascular progenitors. / Alexopoulou, Annika N; Couchman, John R; Whiteford, James.

    In: BMC Cell Biology, Vol. 9, 2008, p. 2.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2007
  12. Published

    A rat monoclonal antibody that recognizes pro- and active MMP-7 indicates polarized expression in vivo. / Fingleton, Barbara; Powell, William C; Crawford, Howard C; Couchman, John R; Matrisian, Lynn M.

    In: Hybridoma: a journal of molecular immunology and experimental and clinical immunotherapy, Vol. 26, No. 1, 2007, p. 22-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation. / Bax, Daniel V; Mahalingam, Yashithra; Cain, Stuart; Mellody, Kieran; Freeman, Lyle; Younger, Kerri; Shuttleworth, C Adrian; Humphries, Martin J; Couchman, John R; Kielty, Cay M.

    In: Journal of Cell Science, Vol. 120, No. Pt 8, 2007, p. 1383-92.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Syndecans in wound healing, inflammation and vascular biology. / Alexopoulou, A.N.; Multhaupt, Hinke Arnolda B V H; Couchman, John Robert.

    In: International Journal of Biochemistry & Cell Biology, Vol. 39, No. 3, 2007, p. 505-528.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Syndecans promote integrin-mediated adhesion of mesenchymal cells in two distinct pathways. / Whiteford, James; Behrends, Volker; Kirby, Hishani; Kusche-Gullberg, Marion; Muramatsu, Takashi; Couchman, John R.

    In: Experimental Cell Research, Vol. 313, No. 18, 2007, p. 3902-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. 2006
  17. Published

    A conserved NXIP motif is required for cell adhesion properties of the syndecan-4 ectodomain. / Whiteford, James R; Couchman, John R.

    In: Journal of Biological Chemistry, Vol. 281, No. 43, 2006, p. 32156-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Cellular adhesion responses to the heparin-binding (HepII) domain of fibronectin require heparan sulfate with specific properties. / Mahalingam, Yashithra; Gallagher, John T; Couchman, John R.

    In: Journal of Biological Chemistry, Vol. 282, No. 5, 2006, p. 3221-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Fibronectin matrix assembly requires distinct contributions from Rho kinases I and -II. / Yoneda, Atsuko; Ushakov, Dmitriy; Multhaupt, Hinke A B; Couchman, John R.

    In: Molecular Biology of the Cell, Vol. 18, No. 1, 2006, p. 66-75.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    PKCbeta-dependent activation of RhoA by syndecan-4 during focal adhesion formation. / Dovas, Athanassios; Yoneda, Atsuko; Couchman, John R.

    In: Journal of Cell Science, Vol. 119, No. Pt 13, 2006, p. 2837-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. 2005
  22. Published

    Hierarchy of ADAM12 binding to integrins in tumor cells. / Thodeti, Charles Kumar; Fröhlich, Camilla; Nielsen, Christian Kamp; Holck, Peter; Sundberg, Christina; Kveiborg, Marie; Mahalingam, Yashithra; Albrechtsen, Reidar; Couchman, John R; Wewer, Ulla M.

    In: Experimental Cell Research, Vol. 309, No. 2, 2005, p. 438-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration. / Anilkumar, Narayanapanicker; Uekita, Takamasa; Couchman, John R; Nagase, Hideaki; Seiki, Motoharu; Itoh, Yoshifumi.

    In: The FASEB Journal, Vol. 19, No. 10, 2005, p. 1326-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    RhoGDI: multiple functions in the regulation of Rho family GTPase activities. / Dovas, Athanassios; Couchman, John R.

    In: Biochemical Journal, Vol. 390, No. Pt 1, 2005, p. 1-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Structural basis of syndecan-4 phosphorylation as a molecular switch to regulate signaling. / Koo, Bon-Kyung; Jung, Young Sang; Shin, Joon; Han, Innoc; Mortier, Eva; Zimmermann, Pascale; Whiteford, James R; Couchman, John R; Oh, Eok-Soo; Lee, Weontae.

    In: Journal of Molecular Biology, Vol. 355, No. 4, 2005, p. 651-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    The Rho kinases I and II regulate different aspects of myosin II activity. / Yoneda, Atsuko; Multhaupt, Hinke A B; Couchman, John R.

    In: Journal of Cell Biology, Vol. 170, No. 3, 2005, p. 443-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. 2004
  28. Published

    Essential contribution of tumor-derived perlecan to epidermal tumor growth and angiogenesis. / Jiang, Xinnong; Multhaupt, Hinke; Chan, En; Schaefer, Liliana; Schaefer, Roland M; Couchman, John R.

    In: Journal of Histochemistry and Cytochemistry, Vol. 52, No. 12, 2004, p. 1575-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Fibroblast invasive migration into fibronectin/fibrin gels requires a previously uncharacterized dermatan sulfate-CD44 proteoglycan. / Clark, Richard A F; Lin, Fubao; Greiling, Doris; An, Jianqang; Couchman, John R.

    In: Journal of Investigative Dermatology, Vol. 122, No. 2, 2004, p. 266-77.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Syndecans-2 and -4; close cousins, but not identical twins. / Oh, Eok-Soo; Couchman, John R.

    In: Molecules and Cells, Vol. 17, No. 2, 2004, p. 181-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. 2003
  32. Published

    Direct binding of syndecan-4 cytoplasmic domain to the catalytic domain of protein kinase C alpha (PKC alpha) increases focal adhesion localization of PKC alpha. / Lim, Ssang-Taek; Longley, Robert L; Couchman, John R; Woods, Anne.

    In: Journal of Biological Chemistry, Vol. 278, No. 16, 2003, p. 13795-802.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Nondébridement of laser char after two carbon dioxide laser passes results in faster reepithelialization. / Collawn, Sherry S; Woods, Anne; Couchman, John R.

    In: Plastic and Reconstructive Surgery, Vol. 111, No. 5, 2003, p. 1742-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Perlecan and tumor angiogenesis. / Jiang, Xinnong; Couchman, John R.

    In: Journal of Histochemistry and Cytochemistry, Vol. 51, No. 11, 2003, p. 1393-410.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Regulation of cytoskeletal organization by syndecan transmembrane proteoglycans. / Yoneda, Atsuko; Couchman, John R.

    In: Matrix Biology, Vol. 22, No. 1, 2003, p. 25-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Syndecans: proteoglycan regulators of cell-surface microdomains? / Couchman, John R.

    In: Nature Reviews. Molecular Cell Biology, Vol. 4, No. 12, 2003, p. 926-37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. 2002
  38. Published

    ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA. / Thodeti, Charles Kumar; Albrechtsen, Reidar; Grauslund, Morten; Asmar, Meena; Larsson, Christer; Takada, Yoshikazu; Mercurio, Arthur M; Couchman, John R; Wewer, Ulla M.

    In: Journal of Biological Chemistry, Vol. 278, No. 11, 2002, p. 9576-84.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Localization of the transmembrane proteoglycan syndecan-4 and its regulatory kinases in costameres of rat cardiomyocytes: a deconvolution microscopic study. / VanWinkle, W Barry; Snuggs, Mark B; De Hostos, Eugenio L; Buja, L Maximilian; Woods, Anne; Couchman, John R.

    In: Anatomical Record, Vol. 268, No. 1, 2002, p. 38-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Molecular characterization of chicken syndecan-2 proteoglycan. / Chen, Ligong; Couchman, John R; Smith, Jacqueline; Woods, Anne.

    In: Biochemical Journal, Vol. 366, No. Pt 2, 2002, p. 481-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Regulation of inositol phospholipid binding and signaling through syndecan-4. / Couchman, John R; Vogt, Susan; Lim, Ssang-Taek; Lim, Yangmi; Oh, Eok-Soo; Prestwich, Glenn D; Theibert, Anne; Lee, Weontae; Woods, Anne.

    In: Journal of Biological Chemistry, Vol. 277, No. 51, 2002, p. 49296-303.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Syndecan-4 associates with alpha-actinin. / Greene, Daniel K; Tumova, Sarka; Couchman, John R; Woods, Anne.

    In: Journal of Biological Chemistry, Vol. 278, No. 9, 2002, p. 7617-23.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. 2001
  44. Published

    Basement membrane and interstitial proteoglycans produced by MDCK cells correspond to those expressed in the kidney cortex. / Erickson, A C; Couchman, J R.

    In: Matrix Biology, Vol. 19, No. 8, 2001, p. 769-78.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Detection of proteoglycan core proteins with glycosaminoglycan lyases and antibodies. / Couchman, J R; Tapanadechopone, P.

    In: Methods in Molecular Biology, Vol. 171, 2001, p. 329-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    EphB/syndecan-2 signaling in dendritic spine morphogenesis. / Ethell, I M; Irie, F; Kalo, M S; Couchman, J R; Pasquale, E B; Yamaguchi, Y.

    In: Neuron, Vol. 31, No. 6, 2001, p. 1001-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Epidermal transformation leads to increased perlecan synthesis with heparin-binding-growth-factor affinity. / Tapanadechopone, P; Tumova, S; Jiang, X; Couchman, J R.

    In: Biochemical Journal, Vol. 355, No. Pt 2, 2001, p. 517-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Proteoglycan isolation and analysis. / Woods, A; Couchman, J R.

    In: Current Protocols in Cell Biology, Vol. Chapter 10, 2001, p. Unit 10.7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Rat embryo fibroblasts require both the cell-binding and the heparin-binding domains of fibronectin for survival. / Jeong, J; Han, I; Lim, Y; Kim, J; Park, I; Woods, A; Couchman, J R; Oh, E S.

    In: Biochemical Journal, Vol. 356, No. Pt 2, 2001, p. 531-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Solution structure of the dimeric cytoplasmic domain of syndecan-4. / Shin, J; Lee, W; Lee, D; Koo, B K; Han, I; Lim, Y; Woods, A; Couchman, J R; Oh, E S.

    In: Biochemistry, Vol. 40, No. 29, 2001, p. 8471-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Syndecan-4 and focal adhesion function. / Woods, A; Couchman, J R.

    In: Current Opinion in Cell Biology, Vol. 13, No. 5, 2001, p. 578-83.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Syndecan-4 up-regulation in proliferative renal disease is related to microfilament organization. / Yung, S; Woods, A; Chan, T M; Davies, M; Williams, J D; Couchman, J R.

    In: The FASEB Journal, Vol. 15, No. 9, 2001, p. 1631-3.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Syndecans and cell adhesion. / Couchman, J R; Chen, L; Woods, A.

    In: International Review of Cytology, Vol. 207, 2001, p. 113-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. 2000
  55. Published

    Control of extracellular matrix assembly by syndecan-2 proteoglycan. / Klass, C M; Couchman, J R; Woods, A.

    In: Journal of Cell Science, Vol. 113 ( Pt 3), 2000, p. 493-506.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Heparan sulfate chains from glypican and syndecans bind the Hep II domain of fibronectin similarly despite minor structural differences. / Tumova, S; Woods, A; Couchman, J R.

    In: Journal of Biological Chemistry, Vol. 275, No. 13, 2000, p. 9410-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions. / Tumova, S; Woods, A; Couchman, J R.

    In: International Journal of Biochemistry & Cell Biology, Vol. 32, No. 3, 2000, p. 269-88.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Integrin modulation by lateral association. / Woods, A; Couchman, J R.

    In: Journal of Biological Chemistry, Vol. 275, No. 32, 2000, p. 24233-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Still more complexity in mammalian basement membranes. / Erickson, A C; Couchman, J R.

    In: Journal of Histochemistry and Cytochemistry, Vol. 48, No. 10, 2000, p. 1291-306.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Syndecan-4 binding to the high affinity heparin-binding domain of fibronectin drives focal adhesion formation in fibroblasts. / Woods, A; Longley, R L; Tumova, S; Couchman, J R.

    In: Archives of Biochemistry and Biophysics, Vol. 374, No. 1, 2000, p. 66-72.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 916617