Chuna Ram Choudhary

Chuna Ram Choudhary

professor, group leader


  1. Published

    Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. / Acosta-Alvear, Diego; Cho, Min Y; Wild, Thomas; Buchholz, Tonia J; Lerner, Alana G; Simakova, Olga; Hahn, Jamie; Korde, Neha; Landgren, Ola; Maric, Irina; Choudhary, Chuna Ram; Walter, Peter; Weissman, Jonathan S; Kampmann, Martin.

    In: eLife, Vol. 4, e08153, 01.09.2015, p. 1-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response. / Beli, Petra; Lukashchuk, Natalia; Wagner, Sebastian A; Weinert, Brian T; Olsen, Jesper V; Baskcomb, Linda; Mann, Matthias; Jackson, Stephen P; Choudhary, Chuna Ram.

    In: Molecular Cell, Vol. 46, No. 2, 2012, p. 212-25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response. / Blasius, Melanie; Wagner, Sebastian A; Choudhary, Chuna Ram; Bartek, Jiri; Jackson, Stephen P.

    In: Genes & Development, Vol. 28, No. 18, 04.09.2014, p. 1977-1982.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1. / Blasius, Melanie; Forment, Josep V; Thakkar, Neha; Wagner, Sebastian A; Choudhary, Chuna Ram; Jackson, Stephen P.

    In: Genome Biology (Online Edition), Vol. 12, No. 8, 2011, p. R78.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. / Borisova, Marina E; Voigt, Andrea; Tollenaere, Maxim A.X.; Sahu, Sanjeeb Kumar; Juretschke, Thomas; Kreim, Nastasja; Mailand, Niels; Choudhary, Chunaram; Bekker-Jensen, Simon; Akutsu, Masato; Wagner, Sebastian A; Beli, Petra.

    In: Nature Communications, Vol. 9, 1017, 2018, p. 1-16.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells. / Bursomanno, Sara; Beli, Petra; Khan, Asif M; Minocherhomji, Sheroy; Wagner, Sebastian Alexander; Bekker-Jensen, Simon; Mailand, Niels; Choudhary, Chuna Ram; Hickson, Ian D.; Liu, Ying.

    In: DNA Repair, Vol. 25, 01.2015, p. 84-96.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    STK3 is a therapeutic target for a subset of acute myeloid leukemias. / Camgoz, Aylin; Paszkowski-Rogacz, Maciej; Satpathy, Shankha; Wermke, Martin; Hamann, Martin V.; von Bonin, Malte; Choudhary, Chunaram; Knapp, Stefan; Buchholz, Frank.

    In: OncoTarget, Vol. 9, No. 39, 2018, p. 25458-25473.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    lncRNA Panct1 Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1. / Chakraborty, Debojyoti; Paszkowski-Rogacz, Maciej; Berger, Nicolas; Ding, Li; Mircetic, Jovan; Fu, Jun; Iesmantavicius, Vytautas; Choudhary, Chunaram; Anastassiadis, Konstantinos; Stewart, A Francis; Buchholz, Frank.

    In: Cell Reports, Vol. 21, No. 11, 12.12.2017, p. 3012-3021.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Lysine acetylation targets protein complexes and co-regulates major cellular functions. / Choudhary, Chuna Ram; Kumar, Chanchal; Gnad, Florian; Nielsen, Michael L; Rehman, Michael; Walther, Tobias C; Olsen, Jesper V; Mann, Matthias.

    In: Science, Vol. 325, No. 5942, 2009, p. 834-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Decoding signalling networks by mass spectrometry-based proteomics. / Choudhary, Chuna Ram; Mann, Matthias.

    In: Nature Reviews. Molecular Cell Biology, Vol. 11, No. 6, 01.06.2010, p. 427-39.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. / Choudhary, Chuna Ram; Olsen, Jesper V; Brandts, Christian; Cox, Jürgen; Reddy, Pavankumar N G; Böhmer, Frank D; Gerke, Volker; Schmidt-Arras, Dirk-E; Berdel, Wolfgang E; Müller-Tidow, Carsten; Mann, Matthias; Serve, Hubert.

    In: Molecular Cell, Vol. 36, No. 2, 2009, p. 326-39.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    The growing landscape of lysine acetylation links metabolism and cell signalling. / Choudhary, Chuna Ram; Weinert, Brian Tate; Nishida, Yuya; Verdin, Eric; Mann, Matthias.

    In: Nature Reviews. Molecular Cell Biology, Vol. 15, No. 8, 23.07.2014, p. 536-50.

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells. / Ding, Li; Paszkowski-Rogacz, Maciej; Winzi, Maria; Chakraborty, Debojyoti; Theis, Mirko; Singh, Sukhdeep; Ciotta, Giovanni; Poser, Ina; Roguev, Assen; Chu, Wai Kit; Choudhary, Chuna Ram; Mann, Matthias; Stewart, A Francis; Krogan, Nevan; Buchholz, Frank.

    In: Cell Systems, Vol. 1, No. 2, 26.08.2015, p. 141-151.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling. / Fiil, Berthe Katrine; Damgaard, Rune Busk; Wagner, Sebastian Alexander; Keusekotten, Kirstin; Fritsch, Melanie; Bekker-Jensen, Simon; Mailand, Niels; Choudhary, Chuna Ram; Komander, David; Gyrd-Hansen, Mads.

    In: Molecular Cell, Vol. 50, No. 6, 27.06.2013, p. 818-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage. / Gibbs-Seymour, Ian; Oka, Yasuyoshi; Rajendra, Eeson; Weinert, Brian Tate; Passmore, Lori A; Patel, Ketan J; Olsen, Jesper V; Choudhary, Chuna Ram; Bekker-Jensen, Simon; Mailand, Niels.

    In: Molecular Cell, Vol. 57, No. 1, 01.2015, p. 150-64.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Predicting post-translational lysine acetylation using support vector machines. / Gnad, Florian; Ren, Shubin; Choudhary, Chunaram; Cox, Jürgen; Mann, Matthias.

    In: Bioinformatics, Vol. 26, No. 13, 01.07.2010, p. 1666-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. / Gupta, Rajat; Somyajit, Kumar; Narita, Takeo; Maskey, Elina; Stanlie, Andre; Kremer, Magdalena; Typas, Dimitris; Lammers, Michael; Mailand, Niels; Nussenzweig, Andre; Lukas, Jiri; Choudhary, Chunaram.

    In: Cell, Vol. 173, No. 4, 2018, p. 972-988.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation. / Hansen, Bogi Karbech; Gupta, Rajat; Baldus, Linda; Lyon, David; Narita, Takeo; Lammers, Michael; Choudhary, Chunaram; Weinert, Brian T.

    In: Nature Communications, Vol. 10, 1055, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. / Henriksen, Peter; Wagner, Sebastian Alexander; Weinert, Brian Tate; Sharma, Satyan; Bacinskaja, Giedré; Rehman, Michael; Juffer, André H.; Walther, Tobias C.; Lisby, Michael; Choudhary, Chuna Ram.

    In: Molecular & Cellular Proteomics, Vol. 11, No. 11, 2012, p. 1510-1522.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Convergence of Ubiquitylation and Phosphorylation Signaling in Rapamycin-Treated Yeast Cells. / Iesmantavicius, Vytautas; Weinert, Brian Tate; Choudhary, Chuna Ram.

    In: Molecular & Cellular Proteomics, Vol. 13, No. 8, 24.06.2014, p. 1979-92.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Time-resolved dissection of early phosphoproteome and ensuing proteome changes in response to TGF-β. / J D'Souza, Rochelle C; Knittle, Anna M; Nagaraj, Nagarjuna; van Dinther, Maarten; Choudhary, Chuna Ram; Ten Dijke, Peter; Mann, Matthias; Sharma, Kirti.

    In: Science signaling, Vol. 7, No. 335, 07.2014, p. rs5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Specificity and commonality of the phosphoinositide-binding proteome analyzed by quantitative mass spectrometry. / Jungmichel, Stephanie; Sylvestersen, Kathrine B; Choudhary, Chuna Ram; Nguyen, Steve; Mann, Matthias; Nielsen, Michael L.

    In: Cell Reports, Vol. 6, No. 3, 13.02.2014, p. 578-91.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML). / Kindler, Thomas; Breitenbuecher, Frank; Kasper, Stefan; Estey, Eli; Giles, Francis; Feldman, Eric; Ehninger, Gerhard; Schiller, Gary; Klimek, Virginia; Nimer, Stephen D; Gratwohl, Alois; Choudhary, Chuna Ram; Mueller-Tidow, Constan; Serve, Hubert; Gschaidmeier, Harald; Cohen, Pamela S; Huber, Christoph; Fischer, Thomas.

    In: Blood, Vol. 105, No. 1, 2005, p. 335-40.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. / Lasko, Loren M; Jakob, Clarissa G; Edalji, Rohinton P; Qiu, Wei; Montgomery, Debra; Digiammarino, Enrico L; Hansen, T Matt; Risi, Roberto M; Frey, Robin; Manaves, Vlasios; Shaw, Bailin; Algire, Mikkel; Hessler, Paul; Lam, Lloyd T; Uziel, Tamar; Faivre, Emily; Ferguson, Debra; Buchanan, Fritz G; Martin, Ruth L; Torrent, Maricel; Chiang, Gary G; Karukurichi, Kannan; Langston, J William; Weinert, Brian T; Choudhary, Chunaram; de Vries, Peter; Van Drie, John H; McElligott, David; Kesicki, Ed; Marmorstein, Ronen; Sun, Chaohong; Cole, Philip A; Rosenberg, Saul H; Michaelides, Michael R; Lai, Albert; Bromberg, Kenneth D.

    In: Nature, Vol. 550, No. 7674, 05.10.2017, p. 128-132.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. / Lundby, Alicia; Hansen, Kasper Lage; Weinert, Brian Tate; Breinholt Bekker-Jensen, Dorte; Secher, Anna; Skovgaard, Tine; Kelstrup, Christian; Dmytriyev, Anatoliy; Choudhary, Chuna Ram; Lundby, Carsten; Olsen, Jesper Velgaard.

    In: Cell Reports, Vol. 2, No. 2, 30.08.2012, p. 419-431.

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 13781159