N-3 polyunsaturated fatty acids do not affect the cytokine response to strenuous exercise
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N-3 polyunsaturated fatty acids do not affect the cytokine response to strenuous exercise. / Toft, A.D.; Thorn, Mette; Ostrowski, Kenneth; Asp, Svend; Møller, Kirsten; Iversen, Susanne; Hermann, Claus; Søndergaard, S R; Pedersen, Bente Klarlund.
In: Journal of Applied Physiology, Vol. 89, No. 6, 31.12.2000, p. 2401-2406.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - N-3 polyunsaturated fatty acids do not affect the cytokine response to strenuous exercise
AU - Toft, A.D.
AU - Thorn, Mette
AU - Ostrowski, Kenneth
AU - Asp, Svend
AU - Møller, Kirsten
AU - Iversen, Susanne
AU - Hermann, Claus
AU - Søndergaard, S R
AU - Pedersen, Bente Klarlund
PY - 2000/12/31
Y1 - 2000/12/31
N2 - The aim of the present study was to investigate whether fish oil supplementation was able to modulate the acute-phase response to strenuous exercise. Twenty male runners were randomized to receive supplementation (n = 10) with 6.0 g fish oil daily, containing 3.6 g n-3 polyunsaturated fatty acids (PUFA), for 6 wk or to receive no supplementation (n = 10) before participating in The Copenhagen Marathon 1998. Blood samples were collected before the race, immediately after, and 1.5 and 3 h postexercise. The fatty acid composition in blood mononuclear cells (BMNC) differed between the fish oil-supplemented and the control group, showing incorporation of n-3 PUFA and less arachidonic acid in BMNC in the supplemented group. The plasma levels of tumor necrosis factor-alpha, interleukin-6, and transforming growth factor-beta(1) peaked immediately after the run, the increase being 3-, 92-, and 1.1-fold, respectively, compared with resting samples. The level of interleukin-1 receptor antagonist peaked 1.5 h after exercise, with the increase being 87-fold. However, the cytokine levels did not differ among the two groups. Furthermore, supplementation with fish oil did not influence exercise-induced increases in leucocytes and creatine kinase. In conclusion, 6 wk of fish oil supplementation had no influence on the acute-phase response to strenuous exercise.
AB - The aim of the present study was to investigate whether fish oil supplementation was able to modulate the acute-phase response to strenuous exercise. Twenty male runners were randomized to receive supplementation (n = 10) with 6.0 g fish oil daily, containing 3.6 g n-3 polyunsaturated fatty acids (PUFA), for 6 wk or to receive no supplementation (n = 10) before participating in The Copenhagen Marathon 1998. Blood samples were collected before the race, immediately after, and 1.5 and 3 h postexercise. The fatty acid composition in blood mononuclear cells (BMNC) differed between the fish oil-supplemented and the control group, showing incorporation of n-3 PUFA and less arachidonic acid in BMNC in the supplemented group. The plasma levels of tumor necrosis factor-alpha, interleukin-6, and transforming growth factor-beta(1) peaked immediately after the run, the increase being 3-, 92-, and 1.1-fold, respectively, compared with resting samples. The level of interleukin-1 receptor antagonist peaked 1.5 h after exercise, with the increase being 87-fold. However, the cytokine levels did not differ among the two groups. Furthermore, supplementation with fish oil did not influence exercise-induced increases in leucocytes and creatine kinase. In conclusion, 6 wk of fish oil supplementation had no influence on the acute-phase response to strenuous exercise.
M3 - Journal article
VL - 89
SP - 2401
EP - 2406
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 6
ER -
ID: 162952488