IL-6 has no acute effect on the regulation of urea synthesis in vivo in rats
Research output: Contribution to journal › Journal article › Research › peer-review
Clinical or experimentally induced, active inflammation up-regulates the in vivo capacity of urea synthesis (CUNS), which promotes nitrogen removal from the body and metabolic catabolism. We have shown that tumor necrosis factor a (TNF-a) up-regulates CUNS and increases interleukin 6 expression (IL-6) within hours of administration. The described effect of TNF-a on nitrogen homeostasis may, therefore, depend on IL-6.
| Original language | English |
|---|---|
| Journal | Scandinavian Journal of Clinical & Laboratory Investigation |
| Volume | 71 |
| Issue number | 2 |
| Pages (from-to) | 150-156 |
| Number of pages | 7 |
| ISSN | 0036-5513 |
| DOIs | |
| Publication status | Published - Apr 2011 |
- Acute-Phase Proteins, Animals, Blood Glucose, Corticosterone, Female, Gene Expression Regulation, Glucagon, Humans, Insulin, Interleukin-6, Liver, RNA, Messenger, Rats, Rats, Wistar, Somatomedins, Urea
Research areas
ID: 38531833