Human and rodent muscle Na(+)-K(+)-ATPase in diabetes related to insulin, starvation, and training
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As determined by vanadate-facilitated [3H]ouabain binding to intact samples, semistarvation and untreated streptozotocin- or partial pancreatectomy-induced diabetes reduced rat soleus muscle Na(+)-K(+)-adenosinetriphosphatase (Na(+)-K(+)-ATPase) concentration by 12-21% (P < 0.05). Conversely, insulin treatment of rats with streptozotocin-induced diabetes induced an increase of 18-26% above control (P < 0.05). Treadmill training diminished the reduction in muscle [3H]ouabain binding site concentration induced by untreated diabetes to only 2-5%. No significant variation was observed in rat cerebral cortex Na(+)-K(+)-ATPase concentration as a result of diabetes, semistarvation, or insulin treatment. In human subjects, Na(+)-K(+)-ATPase concentration in vastus lateralis muscle biopsies was 17 and 22% greater (P < 0.05), respectively, in patients with treated non-insulin-dependent diabetes mellitus (n = 24) and insulin-dependent diabetes mellitus (n = 7) than in control subjects (n = 8). A positive linear correlation between muscle Na(+)-K(+)-ATPase and plasma insulin concentrations was observed (r = 0.50, P = 0.006; n = 29). Thus, insulin seems a regulator of muscle Na(+)-K(+)-ATPase concentration, reduction of muscle Na(+)-K(+)-ATPase concentration with untreated diabetes bears similarities with undernourishment, and physical conditioning may ameliorate the muscle Na(+)-K(+)-ATPase concentration decrease induced by diabetes.
Original language | English |
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Journal | Journal of Applied Physiology |
Volume | 76 |
Issue number | 5 |
Pages (from-to) | 2140-6 |
Number of pages | 7 |
ISSN | 8750-7587 |
Publication status | Published - 1994 |
- Adult, Animals, Cerebral Cortex, Diabetes Mellitus, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Humans, Insulin, Male, Middle Aged, Muscles, Ouabain, Pancreatectomy, Physical Conditioning, Animal, Rats, Rats, Sprague-Dawley, Rats, Wistar, Sodium-Potassium-Exchanging ATPase, Starvation, Streptozocin
Research areas
ID: 150332747