High incidence of multinodular toxic goitre in the elderly population in a low iodine intake area vs. high incidence of Graves' disease in the young in a high iodine intake area: comparative surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

High incidence of multinodular toxic goitre in the elderly population in a low iodine intake area vs. high incidence of Graves' disease in the young in a high iodine intake area : comparative surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland. / Laurberg, P; Pedersen, K M; Vestergaard, H; Sigurdsson, G.

In: Journal of Internal Medicine, Vol. 229, No. 5, 05.1991, p. 415-20.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Laurberg, P, Pedersen, KM, Vestergaard, H & Sigurdsson, G 1991, 'High incidence of multinodular toxic goitre in the elderly population in a low iodine intake area vs. high incidence of Graves' disease in the young in a high iodine intake area: comparative surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland', Journal of Internal Medicine, vol. 229, no. 5, pp. 415-20.

APA

Laurberg, P., Pedersen, K. M., Vestergaard, H., & Sigurdsson, G. (1991). High incidence of multinodular toxic goitre in the elderly population in a low iodine intake area vs. high incidence of Graves' disease in the young in a high iodine intake area: comparative surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland. Journal of Internal Medicine, 229(5), 415-20.

Vancouver

Laurberg P, Pedersen KM, Vestergaard H, Sigurdsson G. High incidence of multinodular toxic goitre in the elderly population in a low iodine intake area vs. high incidence of Graves' disease in the young in a high iodine intake area: comparative surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland. Journal of Internal Medicine. 1991 May;229(5):415-20.

Author

Laurberg, P ; Pedersen, K M ; Vestergaard, H ; Sigurdsson, G. / High incidence of multinodular toxic goitre in the elderly population in a low iodine intake area vs. high incidence of Graves' disease in the young in a high iodine intake area : comparative surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland. In: Journal of Internal Medicine. 1991 ; Vol. 229, No. 5. pp. 415-20.

Bibtex

@article{b786457101d2468c8ddce012fca4342c,
title = "High incidence of multinodular toxic goitre in the elderly population in a low iodine intake area vs. high incidence of Graves' disease in the young in a high iodine intake area: comparative surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland",
abstract = "Little is known about the optimum level of iodine intake for iodine supplementation programmes, or about the effects of the high levels of iodine intake that are found in some countries. We compared the incidence of different types of hyperthyroidism in East-Jutland Denmark with a low average iodine intake but no endemic goitre, and the incidence in Iceland with a relatively high iodine intake. Hyperthyroidism was more common in East-Jutland than in Iceland, due to a much higher incidence of multinodular toxic goitre and also of single toxic adenoma. Most of the patients with these diseases were over 50 years of age. By contrast, the incidence of Graves' disease was significantly higher in Iceland than in East-Jutland. This difference was most marked in the younger age groups, in which hyperthyroidism was more than twice as common in Iceland as in East-Jutland. These results demonstrate that even mild iodine deficiency has a significant effect on population health, since it leads to a high incidence of autonomous thyroid nodules with hyperthyroidism in the elderly population. However, population iodine intake probably should not exceed a level much higher than that necessary to avoid iodine deficiency, otherwise Graves' disease may be induced in the young population.",
keywords = "Adolescent, Adult, Aged, Child, Denmark, Graves Disease, Health Surveys, Humans, Hyperthyroidism, Iceland, Incidence, Iodine, Middle Aged, Thyrotoxicosis, Comparative Study, Journal Article",
author = "P Laurberg and Pedersen, {K M} and H Vestergaard and G Sigurdsson",
year = "1991",
month = may,
language = "English",
volume = "229",
pages = "415--20",
journal = "Acta Medica Scandinavica",
issn = "0955-7873",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - High incidence of multinodular toxic goitre in the elderly population in a low iodine intake area vs. high incidence of Graves' disease in the young in a high iodine intake area

T2 - comparative surveys of thyrotoxicosis epidemiology in East-Jutland Denmark and Iceland

AU - Laurberg, P

AU - Pedersen, K M

AU - Vestergaard, H

AU - Sigurdsson, G

PY - 1991/5

Y1 - 1991/5

N2 - Little is known about the optimum level of iodine intake for iodine supplementation programmes, or about the effects of the high levels of iodine intake that are found in some countries. We compared the incidence of different types of hyperthyroidism in East-Jutland Denmark with a low average iodine intake but no endemic goitre, and the incidence in Iceland with a relatively high iodine intake. Hyperthyroidism was more common in East-Jutland than in Iceland, due to a much higher incidence of multinodular toxic goitre and also of single toxic adenoma. Most of the patients with these diseases were over 50 years of age. By contrast, the incidence of Graves' disease was significantly higher in Iceland than in East-Jutland. This difference was most marked in the younger age groups, in which hyperthyroidism was more than twice as common in Iceland as in East-Jutland. These results demonstrate that even mild iodine deficiency has a significant effect on population health, since it leads to a high incidence of autonomous thyroid nodules with hyperthyroidism in the elderly population. However, population iodine intake probably should not exceed a level much higher than that necessary to avoid iodine deficiency, otherwise Graves' disease may be induced in the young population.

AB - Little is known about the optimum level of iodine intake for iodine supplementation programmes, or about the effects of the high levels of iodine intake that are found in some countries. We compared the incidence of different types of hyperthyroidism in East-Jutland Denmark with a low average iodine intake but no endemic goitre, and the incidence in Iceland with a relatively high iodine intake. Hyperthyroidism was more common in East-Jutland than in Iceland, due to a much higher incidence of multinodular toxic goitre and also of single toxic adenoma. Most of the patients with these diseases were over 50 years of age. By contrast, the incidence of Graves' disease was significantly higher in Iceland than in East-Jutland. This difference was most marked in the younger age groups, in which hyperthyroidism was more than twice as common in Iceland as in East-Jutland. These results demonstrate that even mild iodine deficiency has a significant effect on population health, since it leads to a high incidence of autonomous thyroid nodules with hyperthyroidism in the elderly population. However, population iodine intake probably should not exceed a level much higher than that necessary to avoid iodine deficiency, otherwise Graves' disease may be induced in the young population.

KW - Adolescent

KW - Adult

KW - Aged

KW - Child

KW - Denmark

KW - Graves Disease

KW - Health Surveys

KW - Humans

KW - Hyperthyroidism

KW - Iceland

KW - Incidence

KW - Iodine

KW - Middle Aged

KW - Thyrotoxicosis

KW - Comparative Study

KW - Journal Article

M3 - Journal article

C2 - 2040867

VL - 229

SP - 415

EP - 420

JO - Acta Medica Scandinavica

JF - Acta Medica Scandinavica

SN - 0955-7873

IS - 5

ER -

ID: 174866956