Exercise and health — emerging roles of IL-6

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Exercise and health — emerging roles of IL-6. / Ellingsgaard, Helga; Hojman, Pernille; Pedersen, Bente Klarlund.

In: Current Opinion in Physiology, Vol. 10, 2019, p. 49-54.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Ellingsgaard, H, Hojman, P & Pedersen, BK 2019, 'Exercise and health — emerging roles of IL-6', Current Opinion in Physiology, vol. 10, pp. 49-54. https://doi.org/10.1016/j.cophys.2019.03.009

APA

Ellingsgaard, H., Hojman, P., & Pedersen, B. K. (2019). Exercise and health — emerging roles of IL-6. Current Opinion in Physiology, 10, 49-54. https://doi.org/10.1016/j.cophys.2019.03.009

Vancouver

Ellingsgaard H, Hojman P, Pedersen BK. Exercise and health — emerging roles of IL-6. Current Opinion in Physiology. 2019;10:49-54. https://doi.org/10.1016/j.cophys.2019.03.009

Author

Ellingsgaard, Helga ; Hojman, Pernille ; Pedersen, Bente Klarlund. / Exercise and health — emerging roles of IL-6. In: Current Opinion in Physiology. 2019 ; Vol. 10. pp. 49-54.

Bibtex

@article{0fe4fcb0b98b4124a9315906a10993b5,
title = "Exercise and health — emerging roles of IL-6",
abstract = "Skeletal muscle works as a secretory organ with the capacity to produce hundreds of myokines. This finding provides a conceptual basis for understanding how muscles communicate with other organs such as adipose tissue, liver, pancreas, bones, and brain. The myokine IL-6 is released into the blood during exercise and it has been shown that IL-6 has multiple immunologic and metabolic effects. Here, we discuss recent advances regarding the physiology of IL-6. Human studies show that IL-6 infusion delays gastric emptying, reduces postprandial glucose concentrations and reduces insulin secretion, whereas experimental studies suggest a role for IL-6 in appetite regulation. Evidence is also accumulating for a central role of IL-6 in training-induced loss of visceral adipose tissue mass in humans. Moreover, recent experimental studies in mice show that voluntary exercise suppresses tumor growth through epinephrine-dependent and IL-6-dependent mobilization and redistribution of cytotoxic NK cells. It has been known for a while that IL-6 is a pleiotropic molecule; however, recent advances suggest that the physiological roles of IL-6 involve multiple aspects of metabolism as well as a role in tumor defense.",
author = "Helga Ellingsgaard and Pernille Hojman and Pedersen, {Bente Klarlund}",
year = "2019",
doi = "10.1016/j.cophys.2019.03.009",
language = "English",
volume = "10",
pages = "49--54",
journal = "Current Opinion in Physiology",
issn = "2468-8681",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Exercise and health — emerging roles of IL-6

AU - Ellingsgaard, Helga

AU - Hojman, Pernille

AU - Pedersen, Bente Klarlund

PY - 2019

Y1 - 2019

N2 - Skeletal muscle works as a secretory organ with the capacity to produce hundreds of myokines. This finding provides a conceptual basis for understanding how muscles communicate with other organs such as adipose tissue, liver, pancreas, bones, and brain. The myokine IL-6 is released into the blood during exercise and it has been shown that IL-6 has multiple immunologic and metabolic effects. Here, we discuss recent advances regarding the physiology of IL-6. Human studies show that IL-6 infusion delays gastric emptying, reduces postprandial glucose concentrations and reduces insulin secretion, whereas experimental studies suggest a role for IL-6 in appetite regulation. Evidence is also accumulating for a central role of IL-6 in training-induced loss of visceral adipose tissue mass in humans. Moreover, recent experimental studies in mice show that voluntary exercise suppresses tumor growth through epinephrine-dependent and IL-6-dependent mobilization and redistribution of cytotoxic NK cells. It has been known for a while that IL-6 is a pleiotropic molecule; however, recent advances suggest that the physiological roles of IL-6 involve multiple aspects of metabolism as well as a role in tumor defense.

AB - Skeletal muscle works as a secretory organ with the capacity to produce hundreds of myokines. This finding provides a conceptual basis for understanding how muscles communicate with other organs such as adipose tissue, liver, pancreas, bones, and brain. The myokine IL-6 is released into the blood during exercise and it has been shown that IL-6 has multiple immunologic and metabolic effects. Here, we discuss recent advances regarding the physiology of IL-6. Human studies show that IL-6 infusion delays gastric emptying, reduces postprandial glucose concentrations and reduces insulin secretion, whereas experimental studies suggest a role for IL-6 in appetite regulation. Evidence is also accumulating for a central role of IL-6 in training-induced loss of visceral adipose tissue mass in humans. Moreover, recent experimental studies in mice show that voluntary exercise suppresses tumor growth through epinephrine-dependent and IL-6-dependent mobilization and redistribution of cytotoxic NK cells. It has been known for a while that IL-6 is a pleiotropic molecule; however, recent advances suggest that the physiological roles of IL-6 involve multiple aspects of metabolism as well as a role in tumor defense.

U2 - 10.1016/j.cophys.2019.03.009

DO - 10.1016/j.cophys.2019.03.009

M3 - Review

AN - SCOPUS:85065835997

VL - 10

SP - 49

EP - 54

JO - Current Opinion in Physiology

JF - Current Opinion in Physiology

SN - 2468-8681

ER -

ID: 241160939