Effects of topical ropivacaine on eicosanoids and neurotransmitters in the rectum of patients with distal ulcerative colitis

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Standard

Effects of topical ropivacaine on eicosanoids and neurotransmitters in the rectum of patients with distal ulcerative colitis. / Hillingsø, J G; Kjeldsen, J; Schmidt, P T; Rasmussen, T N; Fisher-Hansen, B; Holst, Jens Juul; Lauristen, K; Bukhave, K; Rask-Madsen, J.

In: Scandinavian Journal of Gastroenterology, Vol. 37, No. 3, 03.2002, p. 325-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hillingsø, JG, Kjeldsen, J, Schmidt, PT, Rasmussen, TN, Fisher-Hansen, B, Holst, JJ, Lauristen, K, Bukhave, K & Rask-Madsen, J 2002, 'Effects of topical ropivacaine on eicosanoids and neurotransmitters in the rectum of patients with distal ulcerative colitis', Scandinavian Journal of Gastroenterology, vol. 37, no. 3, pp. 325-9.

APA

Hillingsø, J. G., Kjeldsen, J., Schmidt, P. T., Rasmussen, T. N., Fisher-Hansen, B., Holst, J. J., Lauristen, K., Bukhave, K., & Rask-Madsen, J. (2002). Effects of topical ropivacaine on eicosanoids and neurotransmitters in the rectum of patients with distal ulcerative colitis. Scandinavian Journal of Gastroenterology, 37(3), 325-9.

Vancouver

Hillingsø JG, Kjeldsen J, Schmidt PT, Rasmussen TN, Fisher-Hansen B, Holst JJ et al. Effects of topical ropivacaine on eicosanoids and neurotransmitters in the rectum of patients with distal ulcerative colitis. Scandinavian Journal of Gastroenterology. 2002 Mar;37(3):325-9.

Author

Hillingsø, J G ; Kjeldsen, J ; Schmidt, P T ; Rasmussen, T N ; Fisher-Hansen, B ; Holst, Jens Juul ; Lauristen, K ; Bukhave, K ; Rask-Madsen, J. / Effects of topical ropivacaine on eicosanoids and neurotransmitters in the rectum of patients with distal ulcerative colitis. In: Scandinavian Journal of Gastroenterology. 2002 ; Vol. 37, No. 3. pp. 325-9.

Bibtex

@article{c955978e7c8842aabf01056b4091d364,
title = "Effects of topical ropivacaine on eicosanoids and neurotransmitters in the rectum of patients with distal ulcerative colitis",
abstract = "BACKGROUND: Topical administration of lidocaine has been suggested to have beneficial clinical effects in patients with active ulcerative colitis, but the mechanism of action, if any, remains obscure. As local anaesthetics may exert anti-inflammatory actions through their inhibition of nervous reflexes, we have studied the local effects of a single rectal dose of ropivacaine gel on rectal concentrations of eicosanoids and neurotransmittors in patients with relapsing ulcerative colitis.METHODS: In a randomized, double-blind, placebo-controlled study, concentrations of leukotriene B4, thromboxane B2 and prostaglandin E2 in rectal dialysates and concentrations of substance P, neurokinin A, somatostatin, vasoactive intestinal polypeptide and calcitonin gene-related peptide in rectal biopsies from 19 patients with active, distally located, ulcerative colitis were measured before and after rectal administration of a 200-mg dose of ropivacaine- or placebo-gel by use of radioimmunoassays. For comparison with normal conditions, concentrations of neuropeptides were measured in another 19 patients with relapsing ulcerative colitis and 14 controls with non-inflamed colon.RESULTS: No significant changes in concentrations of eicosanoids or neuropeptides were observed after ropivacaine or placebo administration. Baseline concentrations of all neuropeptides, except somatostatin, were significantly lower in active ulcerative colitis than in controls with non-inflamed colon.CONCLUSIONS: These findings reveal no evidence of anti-inflammatory actions by ropivacaine in active ulcerative colitis and thus provide no rationale for topical treatment with local anaesthetics.",
keywords = "Administration, Rectal, Adult, Aged, Aged, 80 and over, Amides, Analysis of Variance, Anesthetics, Local, Biopsy, Needle, Colitis, Ulcerative, Double-Blind Method, Eicosanoids, Female, Humans, Intestinal Mucosa, Male, Middle Aged, Neuropeptides, Probability, Rectum, Reference Values, Statistics, Nonparametric, Treatment Outcome",
author = "Hillings{\o}, {J G} and J Kjeldsen and Schmidt, {P T} and Rasmussen, {T N} and B Fisher-Hansen and Holst, {Jens Juul} and K Lauristen and K Bukhave and J Rask-Madsen",
year = "2002",
month = mar,
language = "English",
volume = "37",
pages = "325--9",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Taylor & Francis",
number = "3",

}

RIS

TY - JOUR

T1 - Effects of topical ropivacaine on eicosanoids and neurotransmitters in the rectum of patients with distal ulcerative colitis

AU - Hillingsø, J G

AU - Kjeldsen, J

AU - Schmidt, P T

AU - Rasmussen, T N

AU - Fisher-Hansen, B

AU - Holst, Jens Juul

AU - Lauristen, K

AU - Bukhave, K

AU - Rask-Madsen, J

PY - 2002/3

Y1 - 2002/3

N2 - BACKGROUND: Topical administration of lidocaine has been suggested to have beneficial clinical effects in patients with active ulcerative colitis, but the mechanism of action, if any, remains obscure. As local anaesthetics may exert anti-inflammatory actions through their inhibition of nervous reflexes, we have studied the local effects of a single rectal dose of ropivacaine gel on rectal concentrations of eicosanoids and neurotransmittors in patients with relapsing ulcerative colitis.METHODS: In a randomized, double-blind, placebo-controlled study, concentrations of leukotriene B4, thromboxane B2 and prostaglandin E2 in rectal dialysates and concentrations of substance P, neurokinin A, somatostatin, vasoactive intestinal polypeptide and calcitonin gene-related peptide in rectal biopsies from 19 patients with active, distally located, ulcerative colitis were measured before and after rectal administration of a 200-mg dose of ropivacaine- or placebo-gel by use of radioimmunoassays. For comparison with normal conditions, concentrations of neuropeptides were measured in another 19 patients with relapsing ulcerative colitis and 14 controls with non-inflamed colon.RESULTS: No significant changes in concentrations of eicosanoids or neuropeptides were observed after ropivacaine or placebo administration. Baseline concentrations of all neuropeptides, except somatostatin, were significantly lower in active ulcerative colitis than in controls with non-inflamed colon.CONCLUSIONS: These findings reveal no evidence of anti-inflammatory actions by ropivacaine in active ulcerative colitis and thus provide no rationale for topical treatment with local anaesthetics.

AB - BACKGROUND: Topical administration of lidocaine has been suggested to have beneficial clinical effects in patients with active ulcerative colitis, but the mechanism of action, if any, remains obscure. As local anaesthetics may exert anti-inflammatory actions through their inhibition of nervous reflexes, we have studied the local effects of a single rectal dose of ropivacaine gel on rectal concentrations of eicosanoids and neurotransmittors in patients with relapsing ulcerative colitis.METHODS: In a randomized, double-blind, placebo-controlled study, concentrations of leukotriene B4, thromboxane B2 and prostaglandin E2 in rectal dialysates and concentrations of substance P, neurokinin A, somatostatin, vasoactive intestinal polypeptide and calcitonin gene-related peptide in rectal biopsies from 19 patients with active, distally located, ulcerative colitis were measured before and after rectal administration of a 200-mg dose of ropivacaine- or placebo-gel by use of radioimmunoassays. For comparison with normal conditions, concentrations of neuropeptides were measured in another 19 patients with relapsing ulcerative colitis and 14 controls with non-inflamed colon.RESULTS: No significant changes in concentrations of eicosanoids or neuropeptides were observed after ropivacaine or placebo administration. Baseline concentrations of all neuropeptides, except somatostatin, were significantly lower in active ulcerative colitis than in controls with non-inflamed colon.CONCLUSIONS: These findings reveal no evidence of anti-inflammatory actions by ropivacaine in active ulcerative colitis and thus provide no rationale for topical treatment with local anaesthetics.

KW - Administration, Rectal

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Amides

KW - Analysis of Variance

KW - Anesthetics, Local

KW - Biopsy, Needle

KW - Colitis, Ulcerative

KW - Double-Blind Method

KW - Eicosanoids

KW - Female

KW - Humans

KW - Intestinal Mucosa

KW - Male

KW - Middle Aged

KW - Neuropeptides

KW - Probability

KW - Rectum

KW - Reference Values

KW - Statistics, Nonparametric

KW - Treatment Outcome

M3 - Journal article

C2 - 11916195

VL - 37

SP - 325

EP - 329

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 3

ER -

ID: 132056610