Activated T lymphocytes disappear from circulation during endotoxemia in humans
Research output: Contribution to journal › Journal article › Research › peer-review
Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.
Original language | Danish |
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Journal | Clinical and Vaccine Immunology |
Volume | 9 |
Issue number | 3 |
Pages (from-to) | 731-735 |
Number of pages | 5 |
ISSN | 1556-6811 |
Publication status | Published - 31 Dec 2002 |
ID: 162988992