Thomas Werge

Thomas Werge

Clinical Professor

Member of:

  • Psychiatry


  1. Published

    Effect of Routine Cytochrome P450 2D6 and 2C19 Genotyping on Antipsychotic Drug Persistence in Patients With Schizophrenia: A Randomized Clinical Trial

    Jürgens, Gesche, Andersen, Stig Ejdrup, Rasmussen, H. B., Werge, Thomas, Jensen, H. D., Kaas-Hansen, Benjamin Skov & Nordentoft, Merete, 1 Dec 2020, In: JAMA Network Open. 3, 12, p. e2027909

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Immunity and mental illness: findings from a Danish population-based immunogenetic study of seven psychiatric and neurodevelopmental disorders

    Nudel, R., Benros, Michael Eriksen, Krebs, M. D., Allesøe, R. L., Lemvigh, C. K., Bybjerg-Grauholm, J., Børglum, A. D., Daly, M. J., Nordentoft, Merete, Mors, O., Hougaard, D. M., Mortensen, P. B., Buil, A., Werge, Thomas, Rasmussen, Simon & Thompson, W. K., 2019, In: European Journal of Human Genetics. 27, p. 1445-1455

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

    McLaughlin, R. L., Schijven, D., Van Rheenen, W., Van Eijk, K. R., O'Brien, M., Kahn, R. S., Ophoff, R. A., Goris, A., Bradley, D. G., Al-Chalabi, A., Van Den Berg, L. H., Luykx, J. J., Hardiman, O., Veldink, J. H., Shatunov, A., Dekker, A. M., Diekstra, F. P., Pulit, S. L., Van Der Spek, R. A. A., Van Doormaal, P. T. C. & 31 others, Sproviero, W., Jones, A. R., Nicholson, G. A., Rowe, D. B., Pamphlett, R., Kiernan, M. C., Bauer, D., Kahlke, T., Williams, K., Eftimov, F., Fogh, I., Ticozzi, N., Lin, K., Millecamps, S., Salachas, F., Meininger, V., Carvalho, M. D., Pinto, S., Mora, J. S., Rojas-Garcyá, R., Polak, M., Chandran, S., Andersen, P. M., Pers, Tune H, Hansen, M., Hansen, T., Li, T., Olsen, L., Rasmussen, H. B., Werge, Thomas & Project MinE GWAS Consortium & Schizophrenia Working Group of the Psychiatric Genomics Consortium, P. M. G. C. &. S. W. G. O. T. P. G. C., 2017, In: Nature Communications. 8, 14774.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Elevated polygenic burden for autism is associated with differential DNA methylation at birth

    Hannon, E., Schendel, D., Ladd-Acosta, C., Grove, J., Hansen, C. S., Andrews, S. V., Hougaard, D. M., Bresnahan, M., Mors, O., Hollegaard, M. V., Bækvad-Hansen, M., Hornig, M., Mortensen, P. B., Børglum, A. D., Werge, T., Pedersen, M. G., Nordentoft, M., Buxbaum, J., Fallin, M. D., Bybjerg-Grauholm, J. & 2 others, Reichenberg, A. & Mill, J., 28 Mar 2018, In: Genome Medicine. 10, 13 p., 19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The effect of COMT Val158Met genotype on neural response and performance during spatial working memory in remitted patients with bipolar disorder

    Miskowiak, Kamilla, Kjærstad, H. L., Støttrup, M. M., Vinberg, Maj, Carvalho, A. F., Vieta, E., Høffding, L. K., Werge, Thomas, Kessing, Lars Vedel & Macoveanu, J., Oct 2016, In: European Neuropsychopharmacology. 26, Supplement 2, p. S440-S440 1 p., P.2.d.035.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  6. Published

    Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: A study in male mice

    Didriksen, M., Fejgin, K., Nilsson, S. R. O., Birknow, M. R., Grayton, H. M., Larsen, P. H., Lauridsen, J. B., Nielsen, V., Celada, P., Santana, N., Kallunki, P., Christensen, K. V., Werge, Thomas, Stensbøl, T. B., Egebjerg, J., Gastambide, F., Artigas, F., Bastlund, J. F. & Nielsen, J., 2017, In: Journal of Psychiatry and Neuroscience. 42, 1, p. 48-58 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Evidence for Genetic Overlap Between Schizophrenia and Age at First Birth in Women

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, S. W. G. O. T. P. G. C., LifeLines Cohort Study, L. C. S., TwinsUK, T. & Werge, Thomas, 2016, In: J A M A Psychiatry. 73, 5, p. 497-505 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders

    Isles, A. R., Ingason, A., Lowther, C., Walters, J. T. R., Gawlick, M., Stöber, G., Rees, E., Martin, J., Little, R. B., Potter, H., Georgieva, L., Pizzo, L., Ozaki, N., Aleksic, B., Kushima, I., Ikeda, M., Iwata, N., Levinson, D. F., Gejman, P. V., Shi, J. & 20 others, Sanders, A. R., Duan, J., Willis, J., Sisodiya, S. M., Costain, G., Werge, Thomas, Degenhardt, F., Giegling, I., Rujescu, D., Hreidarsson, S. J., Saemundsen, E., Ahn, J. W., Ogilvie, C. M., Girirajan, S. D., Stefansson, H., Stefansson, K., O'Donovan, M. C., Owen, M. J., Bassett, A. & Kirov, G., May 2016, In: P L o S Genetics. 12, 5, e1005993.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Risk of psychiatric disorders among individuals with the 22q11.2 deletion or duplication: A Danish nationwide, register-based study

    Hoeffding, L. K., Trabjerg, B. B., Olsen, L., Mazin, W., Sparsø, T., Vangkilde, A., Mortensen, P. B., Pedersen, C. B. & Werge, Thomas, 1 Mar 2017, In: JAMA Psychiatry. 74, 3, p. 282-290 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Associations between social cognition, skills, and function and subclinical negative and positive symptoms in 22q11.2 deletion syndrome

    Vangkilde, A., Jepsen, J. M. R., Schmock, H., Olesen, C., Arnarsdóttir, S., Baaré, W. F. C., Plessen, K. J., Didriksen, M., Siebner, Hartwig Roman, Werge, Thomas & Olsen, L., 2016, In: Journal of Neurodevelopmental Disorders. 8, 13 p., 42.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Variable DNA methylation in neonates mediates the association between prenatal smoking and birth weight

    iPSYCH-Broad ASD Group, I. A. G., 15 Apr 2019, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 374, 1770, 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome

    Lahrouchi, N., Tadros, R., Crotti, L., Mizusawa, Y., Postema, P. G., Beekman, L., Walsh, R., Hasegawa, K., Barc, J., Ernsting, M., Turkowski, K. L., Mazzanti, A., Beckmann, B. M., Shimamoto, K., Diamant, U-B., Wijeyeratne, Y. D., Kucho, Y., Robyns, T., Ishikawa, T., Arbelo, E. & 86 others, Christiansen, M., Winbo, A., Jabbari, R., Lubitz, S. A., Steinfurt, J., Rudic, B., Loeys, B., Shoemaker, M. B., Weeke, P. E., Pfeiffer, R., Davies, B., Andorin, A., Hofman, N., Dagradi, F., Pedrazzini, M., Tester, D. J., Bos, J. M., Sarquella-Brugada, G., Campuzano, Ó., Platonov, P. G., Stallmeyer, B., Zumhagen, S., Nannenberg, E. A., Veldink, J. H., van den Berg, L. H., Al-Chalabi, A., Shaw, C. E., Shaw, P. J., Morrison, K. E., Andersen, P. M., Müller-Nurasyid, M., Cusi, D., Barlassina, C., Galan, P., Lathrop, M., Munter, M., Werge, Thomas, Ribasés, M., Aung, T., Khor, C. C., Ozaki, M., Lichtner, P., Meitinger, T., van Tintelen, J. P., Hoedemaekers, Y., Denjoy, I., Leenhardt, A., Napolitano, C., Shimizu, W., Schott, J., Gourraud, J., Makiyama, T., Ohno, S., Itoh, H., Krahn, A. D., Antzelevitch, C., Roden, D. M., Saenen, J., Borggrefe, M., Odening, K. E., Ellinor, P. T., Tfelt-Hansen, Jacob, Skinner, J. R., van den Berg, M. P., Olesen, Morten Steen Salling, Brugada, J., Brugada, R., Makita, N., Breckpot, J., Yoshinaga, M., Behr, E. R., Rydberg, A., Aiba, T., Kääb, S., Priori, S. G., Guicheney, P., Tan, H. L., Newton-Cheh, C., Ackerman, M. J., Schwartz, P. J., Schulze-Bahr, E., Probst, V., Horie, M., Wilde, A. A., Tanck, M. W. T. & Bezzina, C. R., 2020, In: Circulation. 142, 4, p. 324-338

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness

    Nudel, R., Appadurai, V., Schork, A. J., Buil, A., Bybjerg-Grauholm, J., Børglum, A. D., Daly, M. J., Mors, O., Hougaard, D. M., Mortensen, P. B., Werge, Thomas, Nordentoft, Merete, Thompson, W. K. & Benros, Michael Eriksen, Mar 2020, In: Human Genetics. 139, p. 593-604

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Genetic assortative mating for schizophrenia and bipolar disorder

    Jefsen, O. H., Nudel, R., Wang, Y., Bybjerg-Grauholm, J., Hemager, N., Christiani, C. A. J., Burton, B. K., Spang, K. S., Ellersgaard, D., Gantriis, D. L., Plessen, K. J., Jepsen, J. R. M., Thorup, Anne, Werge, Thomas, Nordentoft, Merete, Mors, O. & Greve, A. N., 2022, In: European Psychiatry. 65, 1, 7 p., e53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Accounting for age of onset and family history improves power in genome-wide association studies

    Pedersen, E. M., Agerbo, E., Plana-Ripoll, O., Grove, J., Dreier, J. W., Musliner, K. L., Bækvad-Hansen, M., Athanasiadis, G., Schork, A., Bybjerg-Grauholm, J., Hougaard, D. M., Werge, T., Nordentoft, M., Mors, O., Dalsgaard, S., Christensen, J., Børglum, A. D., Mortensen, P. B., McGrath, J. J., Privé, F. & 1 others, Vilhjálmsson, B. J., 2022, In: American Journal of Human Genetics. 109, 3, p. 417-432 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth

    Beaumont, R. N., Flatley, C., Vaudel, M., Wu, X., Chen, J., Moen, G. H., Skotte, L., Helgeland, Ø., Solé-Navais, P., Banasik, K., Albiñana, C., Ronkainen, J., Fadista, J., Stinson, S. E., Trajanoska, K., Wang, C. A., Westergaard, D., Srinivasan, S., Sánchez-Soriano, C., Bilbao, J. R. & 68 others, Allard, C., Groleau, M., Kuulasmaa, T., Leirer, D. J., White, F., Jacques, P. É., Cheng, H., Hao, K., Andreassen, O. A., Åsvold, B. O., Atalay, M., Bhatta, L., Bouchard, L., Brumpton, B. M., Brunak, Søren, Bybjerg-Grauholm, J., Ebbing, C., Elliott, P., pjx571, pjx571, Erikstrup, C., Estarlich, M., Franks, S., Gaillard, R., Geller, F., Grove, J., Hougaard, D. M., Kajantie, E., Morgen, C. S., Nohr, E. A., Nyegaard, Mette, Palmer, C. N. A., Pedersen, Ole Birger Vesterager, Rivadeneira, F., Sebert, S., Shields, B. M., Stoltenberg, C., Surakka, I., Thørner, L. W., Ullum, H., Vaarasmaki, M., Vilhjalmsson, B. J., Willer, C. J., Lakka, T. A., Gybel-Brask, D., Bustamante, M., Hansen, Torben, Pearson, E. R., Reynolds, R. M., Ostrowski, Sisse Rye, Pennell, C. E., Jaddoe, V. W. V., Felix, J. F., Hattersley, A. T., Melbye, M., Lawlor, D. A., Hveem, K., Werge, Thomas, Nielsen, Henriette Svarre, Magnus, P., Evans, D. M., Jacobsson, B., Järvelin, M. R., Zhang, G., Hivert, M. F., Johansson, S., Freathy, R. M., Feenstra, B. & Njølstad, P. R., 2023, In: Nature Genetics. 55, 11, p. 1807-1819 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    100 ancient genomes show repeated population turnovers in Neolithic Denmark

    Allentoft, M. E., Sikora, M., Fischer, A., Sjögren, K-G., Ingason, A., Macleod, R., Rosengren, A., Schulz Paulsson, B., Jørkov, M. L. S., Novosolov, M., Stenderup, J., Price, T. D., Mortensen, M. F., Nielsen, A. B., Hede, M. U., Sørensen, L., Nielsen, P. O., Rasmussen, P., Jensen, T. Z. T., Refoyo-Martínez, A. & 48 others, Irving-Pease, Evan, Barrie, William, Pearson, A., Sousa da Mota, B., Demeter, Fabrice, Henriksen, Rasmus Henrik Amund, Vimala, Tharsika, McColl, Hugh, Vaughn, Andrew Howland, Vinner, Lasse, Renaud, Gabriel, Stern, A., Johannsen, N. N., Ramsøe, Abigail Daisy, Schork, A. J., Ruter, Anthony Henry, Gotfredsen, Anne Birgitte, Nielsen, B. H., Petersen, Erik Brinch, Kannegaard, E., Hansen, J., Pedersen, K. B., Pedersen, L., Klassen, L., Meldgaard, Morten, Johansen, M., Uldum, O. C., Lotz, P., Lysdahl, P., Bangsgaard, Pernille, Petersen, P. V., Maring, R., Iversen, Rune, Wåhlin, S., Sørensen, S. A., Andersen, S. H., Jørgensen, T., Lynnerup, Niels, Lawson, D. J., Rasmussen, Simon, Korneliussen, Thorfinn Sand, Kjær, Kurt H., Durbin, R., Nielsen, Rasmus, Delaneau, O., Werge, Thomas, Kristiansen, Kristian & Willerslev, Eske, 2024, In: Nature. 625, 7994, p. 329-337 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction

    Sun, J., Wang, Y., Folkersen, L., Borné, Y., Amlien, I., Buil, A., Orho-Melander, M., Børglum, A. D., Hougaard, D. M., Lotta, L. A., Jones, M., Baras, A., Melander, O., Engström, G., Werge, Thomas, Lage, K. & Regeneron Genetics Center, R. G. C., 2021, In: Nature Communications. 12, 5276.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Circulating S100B levels at birth and risk of six major neuropsychiatric or neurological disorders: a two-sample Mendelian Randomization Study

    Pan, M., Roe, J. M., Nudel, R., Schork, A. J., Iakunchykova, O., Fjell, A. M., Walhovd, K. B., Werge, Thomas, Chen, C., Benros, Michael Eriksen & Wang, Y., 2023, In: Translational Psychiatry. 13, 174.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    DNA-methylation and immunological response in medication overuse headache

    Carlsen, L. N., Hansen, C. S., Kogelman, L. J. A., Werge, Thomas, Ullum, H., Bybjerg-Grauholm, J., Hansen, Thomas Folkmann & Jensen, Rigmor Højland, 2023, In: Cephalalgia. 43, 3, p. 1-11

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Genetic and epidemiological analyses of infection load and its relationship with psychiatric disorders

    Nudel, R., Hougaard, D. M., Werge, Thomas & Benros, Michael Eriksen, 2023, In: Epidemiology and Infection. 151, 11 p., e93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Elucidating the relationship between migraine risk and brain structure using genetic data

    International Headache Genetics Consortium, I. H. G. C., 1 Sep 2022, In: Brain. 145, 9, p. 3214-3224 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors

    Docherty, A. R., Mullins, N., Ashley-Koch, A. E., Qin, X., Coleman, J. R. I., Shabalin, A., Kang, J. E., Murnyak, B., Wendt, F., Adams, M., Campos, A. I., DiBlasi, E., Fullerton, J. M., Kranzler, H. R., Bakian, A. V., Monson, E. T., Rentería, M. E., Walss-Bass, C., Andreassen, O. A., Behera, C. & 228 others, Bulik, C. M., Edenberg, H. J., Kessler, R. C., John Mann, J., Nurnberger, J. I., Pistis, G., Streit, F., Ursano, R. J., Polimanti, R., Dennis, M., Garrett, M., Hair, L., Harvey, P., Hauser, E. R., Hauser, M. A., Huffman, J., Jacobson, D., Madduri, R., McMahon, B., Oslin, D. W., Trafton, J., Awasthi, S., Berrettini, W. H., Bohus, M., Chang, X., Chen, H. C., Chen, W. J., Christensen, E. D. M. D., Crow, S., Duriez, P., Edwards, A. C., Fernández-Aranda, F., Galfalvy, H., Gandal, M., Gorwood, P., Guo, Y., Hafferty, J. D., Hakonarson, H., Halmi, K. A., Hishimoto, A., Jain, S., Jamain, S., Jiménez-Murcia, S., Johnson, C., Kaplan, A. S., Kaye, W. H., Keel, P. K., Kennedy, J. L., Kim, M., Klump, K. L., Levey, D. F., Li, D., Liao, S. C., Lieb, K., Lilenfeld, L., Marshall, C. R., Mitchell, J. E., Okazaki, S., Otsuka, I., Pinto, D., Powers, A., Ramoz, N., Ripke, S., Roepke, S., Rozanov, V., Scherer, S. W., Schmahl, C., Sokolowski, M., Starnawska, A., Strober, M., Su, M. H., Thornton, L. M., Treasure, J., Ware, E. B., Watson, H. J., Witt, S. H., Blake Woodside, D., Yilmaz, Z., Zillich, L., Adolfsson, R., Agartz, I., Alda, M., Alfredsson, L., Appadurai, V., Artigas, M. S., Van Der Auwera, S., Helena Azevedo, M., Bass, N., Bau, C. H. D., Baune, B. T., Bellivier, F., Berger, K., Biernacka, J. M., Bigdeli, T. B., Binder, E. B., Boehnke, M., Boks, M. P., Braff, D. L., Bryant, R., Budde, M., Byrne, E. M., Cahn, W., Castelao, E., Cervilla, J. A., Chaumette, B., Corvin, A., Craddock, N., Djurovic, S., Foo, J. C., Forstner, A. J., Frye, M., Gatt, J. M., Giegling, I., Grabe, H. J., Green, M. J., Grevet, E. H., Grigoroiu-Serbanescu, M., Gutierrez, B., Guzman-Parra, J., Hamshere, M. L., Hartmann, A. M., Hauser, J., Heilmann-Heimbach, S., Hoffmann, P., Ising, M., Jones, I., Jones, L. A., Jonsson, L., Kahn, R. S., Kelsoe, J. R., Kendler, K. S., Kloiber, S., Koenen, K. C., Kogevinas, M., Krebs, M. O., Landén, M., Leboyer, M., Lee, P. H., Levinson, D. F., Liao, C., Lissowska, J., Mayoral, F., McElroy, S. L., McGrath, P., McGuffin, P., McQuillin, A., Mehta, D., Melle, I., Mitchell, P. B., Molina, E., Morken, G., Nievergelt, C., Nöthen, M. M., O'Donovan, M. C., Ophoff, R. A., Owen, M. J., Pato, C., Pato, M. T., Penninx, B. W. J. H., Potash, J. B., Power, R. A., Preisig, M., Quested, D., Ramos-Quiroga, J. A., Reif, A., Ribasés, M., Richarte, V., Rietschel, M., Rivera, M., Roberts, A., Roberts, G., Rouleau, G. A., Rovaris, D. L., Sanders, A. R., Schofield, P. R., Schulze, T. G., Scott, L. J., Serretti, A., Shi, J., Sirignano, L., Sklar, P., Smeland, O. B., Smoller, J. W., Sonuga-Barke, E. J. S., Trzaskowski, M., Tsuang, M. T., Turecki, G., Vilar-Ribó, L., Vincent, J. B., Völzke, H., Walters, J. T. R., Weickert, C. S., Weickert, T. W., Weissman, M. M., Williams, L. M., Wray, N. R., Zai, C. C., Agerbo, E., Børglum, A. D., Breen, G., Demontis, D., Erlangsen, A., Gelernter, J., Glatt, S. J., Hougaard, D. M., Hwu, H. G., Kuo, P. H., Lewis, C. M., Li, Q. S., Liu, C. M., Martin, N. G., McIntosh, A. M., Medland, S. E., Mors, O., Nordentoft, Merete, Olsen, C. M., Porteous, D., Smith, D. J., Stahl, E. A., Stein, M. B., Wasserman, D., Werge, Thomas, Whiteman, D. C., Willour, V., Coon, H., Beckham, J. C., Kimbrel, N. A. & Ruderfer, D. M., 2023, In: American Journal of Psychiatry. 180, 10, p. 723-738 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

    GERAD1 Consortium:, G. C., Jul 2019, In: Nature Genetics. 51, 7, p. 1193 1 p.

    Research output: Contribution to journalComment/debateResearch

  25. Published

    Association of Childhood Exposure to Nitrogen Dioxide and Polygenic Risk Score for Schizophrenia With the Risk of Developing Schizophrenia

    Horsdal, H. T., Agerbo, E., McGrath, J. J., Vilhjálmsson, B. J., Antonsen, S., Closter, A. M., Timmermann, A., Grove, J., Mok, P. L. H., Webb, R. T., Sabel, C. E., Hertel, O., Sigsgaard, T., Erikstrup, C., Hougaard, D. M., Werge, T., Nordentoft, M., Børglum, A. D., Mors, O., Mortensen, P. B. & 3 others, Brandt, J., Geels, C. & Pedersen, C. B., 2019, In: JAMA Network Open. 2, 11, 12 p., e1914401.

    Research output: Contribution to journalJournal articleResearchpeer-review

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