Thomas Werge
Clinical Professor
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Effect of Routine Cytochrome P450 2D6 and 2C19 Genotyping on Antipsychotic Drug Persistence in Patients With Schizophrenia: A Randomized Clinical Trial
Jürgens, Gesche, Andersen, Stig Ejdrup, Rasmussen, H. B., Werge, Thomas, Jensen, H. D., Kaas-Hansen, Benjamin Skov & Nordentoft, Merete, 1 Dec 2020, In: JAMA Network Open. 3, 12, p. e2027909Research output: Contribution to journal › Journal article › Research › peer-review
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Immunity and mental illness: findings from a Danish population-based immunogenetic study of seven psychiatric and neurodevelopmental disorders
Nudel, R., Benros, Michael Eriksen, Krebs, M. D., Allesøe, R. L., Lemvigh, C. K., Bybjerg-Grauholm, J., Børglum, A. D., Daly, M. J., Nordentoft, Merete, Mors, O., Hougaard, D. M., Mortensen, P. B., Buil, A., Werge, Thomas, Rasmussen, Simon & Thompson, W. K., 2019, In: European Journal of Human Genetics. 27, p. 1445-1455Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
McLaughlin, R. L., Schijven, D., Van Rheenen, W., Van Eijk, K. R., O'Brien, M., Kahn, R. S., Ophoff, R. A., Goris, A., Bradley, D. G., Al-Chalabi, A., Van Den Berg, L. H., Luykx, J. J., Hardiman, O., Veldink, J. H., Shatunov, A., Dekker, A. M., Diekstra, F. P., Pulit, S. L., Van Der Spek, R. A. A., Van Doormaal, P. T. C. & 31 others, , 2017, In: Nature Communications. 8, 14774.Research output: Contribution to journal › Journal article › Research › peer-review
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Elevated polygenic burden for autism is associated with differential DNA methylation at birth
Hannon, E., Schendel, D., Ladd-Acosta, C., Grove, J., Hansen, C. S., Andrews, S. V., Hougaard, D. M., Bresnahan, M., Mors, O., Hollegaard, M. V., Bækvad-Hansen, M., Hornig, M., Mortensen, P. B., Børglum, A. D., Werge, T., Pedersen, M. G., Nordentoft, M., Buxbaum, J., Fallin, M. D., Bybjerg-Grauholm, J. & 2 others, , 28 Mar 2018, In: Genome Medicine. 10, 13 p., 19.Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of COMT Val158Met genotype on neural response and performance during spatial working memory in remitted patients with bipolar disorder
Miskowiak, Kamilla, Kjærstad, H. L., Støttrup, M. M., Vinberg, Maj, Carvalho, A. F., Vieta, E., Høffding, L. K., Werge, Thomas, Kessing, Lars Vedel & Macoveanu, J., Oct 2016, In: European Neuropsychopharmacology. 26, Supplement 2, p. S440-S440 1 p., P.2.d.035.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: A study in male mice
Didriksen, M., Fejgin, K., Nilsson, S. R. O., Birknow, M. R., Grayton, H. M., Larsen, P. H., Lauridsen, J. B., Nielsen, V., Celada, P., Santana, N., Kallunki, P., Christensen, K. V., Werge, Thomas, Stensbøl, T. B., Egebjerg, J., Gastambide, F., Artigas, F., Bastlund, J. F. & Nielsen, J., 2017, In: Journal of Psychiatry and Neuroscience. 42, 1, p. 48-58 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Evidence for Genetic Overlap Between Schizophrenia and Age at First Birth in Women
Schizophrenia Working Group of the Psychiatric Genomics Consortium, S. W. G. O. T. P. G. C., LifeLines Cohort Study, L. C. S., TwinsUK, T. & Werge, Thomas, 2016, In: J A M A Psychiatry. 73, 5, p. 497-505 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders
Isles, A. R., Ingason, A., Lowther, C., Walters, J. T. R., Gawlick, M., Stöber, G., Rees, E., Martin, J., Little, R. B., Potter, H., Georgieva, L., Pizzo, L., Ozaki, N., Aleksic, B., Kushima, I., Ikeda, M., Iwata, N., Levinson, D. F., Gejman, P. V., Shi, J. & 20 others, , May 2016, In: P L o S Genetics. 12, 5, e1005993.Research output: Contribution to journal › Journal article › Research › peer-review
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Risk of psychiatric disorders among individuals with the 22q11.2 deletion or duplication: A Danish nationwide, register-based study
Hoeffding, L. K., Trabjerg, B. B., Olsen, L., Mazin, W., Sparsø, T., Vangkilde, A., Mortensen, P. B., Pedersen, C. B. & Werge, Thomas, 1 Mar 2017, In: JAMA Psychiatry. 74, 3, p. 282-290 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Associations between social cognition, skills, and function and subclinical negative and positive symptoms in 22q11.2 deletion syndrome
Vangkilde, A., Jepsen, J. M. R., Schmock, H., Olesen, C., Arnarsdóttir, S., Baaré, W. F. C., Plessen, K. J., Didriksen, M., Siebner, Hartwig Roman, Werge, Thomas & Olsen, L., 2016, In: Journal of Neurodevelopmental Disorders. 8, 13 p., 42.Research output: Contribution to journal › Journal article › Research › peer-review
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Variable DNA methylation in neonates mediates the association between prenatal smoking and birth weight
iPSYCH-Broad ASD Group, I. A. G., 15 Apr 2019, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 374, 1770, 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome
Lahrouchi, N., Tadros, R., Crotti, L., Mizusawa, Y., Postema, P. G., Beekman, L., Walsh, R., Hasegawa, K., Barc, J., Ernsting, M., Turkowski, K. L., Mazzanti, A., Beckmann, B. M., Shimamoto, K., Diamant, U-B., Wijeyeratne, Y. D., Kucho, Y., Robyns, T., Ishikawa, T., Arbelo, E. & 86 others, , 2020, In: Circulation. 142, 4, p. 324-338Research output: Contribution to journal › Journal article › Research › peer-review
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A large population-based investigation into the genetics of susceptibility to gastrointestinal infections and the link between gastrointestinal infections and mental illness
Nudel, R., Appadurai, V., Schork, A. J., Buil, A., Bybjerg-Grauholm, J., Børglum, A. D., Daly, M. J., Mors, O., Hougaard, D. M., Mortensen, P. B., Werge, Thomas, Nordentoft, Merete, Thompson, W. K. & Benros, Michael Eriksen, Mar 2020, In: Human Genetics. 139, p. 593-604Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic assortative mating for schizophrenia and bipolar disorder
Jefsen, O. H., Nudel, R., Wang, Y., Bybjerg-Grauholm, J., Hemager, N., Christiani, C. A. J., Burton, B. K., Spang, K. S., Ellersgaard, D., Gantriis, D. L., Plessen, K. J., Jepsen, J. R. M., Thorup, Anne, Werge, Thomas, Nordentoft, Merete, Mors, O. & Greve, A. N., 2022, In: European Psychiatry. 65, 1, 7 p., e53.Research output: Contribution to journal › Journal article › Research › peer-review
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Accounting for age of onset and family history improves power in genome-wide association studies
Pedersen, E. M., Agerbo, E., Plana-Ripoll, O., Grove, J., Dreier, J. W., Musliner, K. L., Bækvad-Hansen, M., Athanasiadis, G., Schork, A., Bybjerg-Grauholm, J., Hougaard, D. M., Werge, T., Nordentoft, M., Mors, O., Dalsgaard, S., Christensen, J., Børglum, A. D., Mortensen, P. B., McGrath, J. J., Privé, F. & 1 others, , 2022, In: American Journal of Human Genetics. 109, 3, p. 417-432 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
Beaumont, R. N., Flatley, C., Vaudel, M., Wu, X., Chen, J., Moen, G. H., Skotte, L., Helgeland, Ø., Solé-Navais, P., Banasik, K., Albiñana, C., Ronkainen, J., Fadista, J., Stinson, S. E., Trajanoska, K., Wang, C. A., Westergaard, D., Srinivasan, S., Sánchez-Soriano, C., Bilbao, J. R. & 68 others, , 2023, In: Nature Genetics. 55, 11, p. 1807-1819 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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100 ancient genomes show repeated population turnovers in Neolithic Denmark
Allentoft, M. E., Sikora, M., Fischer, A., Sjögren, K-G., Ingason, A., Macleod, R., Rosengren, A., Schulz Paulsson, B., Jørkov, M. L. S., Novosolov, M., Stenderup, J., Price, T. D., Mortensen, M. F., Nielsen, A. B., Hede, M. U., Sørensen, L., Nielsen, P. O., Rasmussen, P., Jensen, T. Z. T., Refoyo-Martínez, A. & 48 others, , 2024, In: Nature. 625, 7994, p. 329-337 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction
Sun, J., Wang, Y., Folkersen, L., Borné, Y., Amlien, I., Buil, A., Orho-Melander, M., Børglum, A. D., Hougaard, D. M., Lotta, L. A., Jones, M., Baras, A., Melander, O., Engström, G., Werge, Thomas, Lage, K. & Regeneron Genetics Center, R. G. C., 2021, In: Nature Communications. 12, 5276.Research output: Contribution to journal › Journal article › Research › peer-review
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Circulating S100B levels at birth and risk of six major neuropsychiatric or neurological disorders: a two-sample Mendelian Randomization Study
Pan, M., Roe, J. M., Nudel, R., Schork, A. J., Iakunchykova, O., Fjell, A. M., Walhovd, K. B., Werge, Thomas, Chen, C., Benros, Michael Eriksen & Wang, Y., 2023, In: Translational Psychiatry. 13, 174.Research output: Contribution to journal › Journal article › Research › peer-review
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DNA-methylation and immunological response in medication overuse headache
Carlsen, L. N., Hansen, C. S., Kogelman, L. J. A., Werge, Thomas, Ullum, H., Bybjerg-Grauholm, J., Hansen, Thomas Folkmann & Jensen, Rigmor Højland, 2023, In: Cephalalgia. 43, 3, p. 1-11Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic and epidemiological analyses of infection load and its relationship with psychiatric disorders
Nudel, R., Hougaard, D. M., Werge, Thomas & Benros, Michael Eriksen, 2023, In: Epidemiology and Infection. 151, 11 p., e93.Research output: Contribution to journal › Journal article › Research › peer-review
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Elucidating the relationship between migraine risk and brain structure using genetic data
International Headache Genetics Consortium, I. H. G. C., 1 Sep 2022, In: Brain. 145, 9, p. 3214-3224 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors
Docherty, A. R., Mullins, N., Ashley-Koch, A. E., Qin, X., Coleman, J. R. I., Shabalin, A., Kang, J. E., Murnyak, B., Wendt, F., Adams, M., Campos, A. I., DiBlasi, E., Fullerton, J. M., Kranzler, H. R., Bakian, A. V., Monson, E. T., Rentería, M. E., Walss-Bass, C., Andreassen, O. A., Behera, C. & 228 others, , 2023, In: American Journal of Psychiatry. 180, 10, p. 723-738 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
GERAD1 Consortium:, G. C., Jul 2019, In: Nature Genetics. 51, 7, p. 1193 1 p.Research output: Contribution to journal › Comment/debate › Research
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Association of Childhood Exposure to Nitrogen Dioxide and Polygenic Risk Score for Schizophrenia With the Risk of Developing Schizophrenia
Horsdal, H. T., Agerbo, E., McGrath, J. J., Vilhjálmsson, B. J., Antonsen, S., Closter, A. M., Timmermann, A., Grove, J., Mok, P. L. H., Webb, R. T., Sabel, C. E., Hertel, O., Sigsgaard, T., Erikstrup, C., Hougaard, D. M., Werge, T., Nordentoft, M., Børglum, A. D., Mors, O., Mortensen, P. B. & 3 others, , 2019, In: JAMA Network Open. 2, 11, 12 p., e1914401.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 34394780
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Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression
Research output: Contribution to journal › Journal article › Research › peer-review
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590
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Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders
Research output: Contribution to journal › Journal article › Research › peer-review
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Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia
Research output: Contribution to journal › Journal article › Research › peer-review
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