Jens Juul Holst

Jens Juul Holst

Professor


  1. Published

    Insulin Resistance is Accompanied by Increased Fasting Glucagon and Delayed Glucagon Suppression in Individuals With Normal and Impaired Glucose Regulation

    Faerch, K., Vistisen, D., Pacini, G., Torekov, Signe Sørensen, Johansen, N. B., Witte, D. R., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Hansen, Torben, Lauritzen, T., Jørgensen, M. E., Ahrén, B. & Holst, Jens Juul, 8 Aug 2016, In: Diabetes. 65, 11, p. 3473-3481 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Actions of prolonged ghrelin infusion on gastrointestinal transit and glucose homeostasis in humans

    Falkén, Y., Hellström, P. M., Sanger, G. J., Dewit, O., Dukes, G., Grybäck, P., Holst, Jens Juul & Näslund, E., 1 Jun 2010, In: Neurogastroenterology and Motility. 22, 6, p. e192-200

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Changes in Glucose Homeostasis after Roux-en-Y Gastric Bypass Surgery for Obesity at Day Three, Two Months, and One Year after Surgery: Role of Gut Peptides

    Falkén, Y., Hellström, P. M., Holst, Jens Juul & Näslund, E., 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 7, p. 2227-35 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Gastrointestinal Hormones and β-Cell Function After Gastric Bypass and Sleeve Gastrectomy: A Randomized Controlled Trial (Oseberg)

    Fatima, F., Hjelmesæth, J., Birkeland, K. I., Hanne, G. L., Hertel, J. K., Svanevik, M., Sandbu, R., Småstuen, M. C., Hartmann, Bolette, Holst, Jens Juul & Hofsø, D., 2022, In: Journal of Clinical Endocrinology and Metabolism. 107, 2, p. e756-e766 11 p., dgab643.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Increased expression of glucagon-like peptide-1 receptors in psoriasis plaques

    Faurschou, A., Pedersen, Jens, Gyldenløve, M., Poulsen, Steen Seier, Holst, Jens Juul, Thyssen, Jacob Pontoppidan, Zachariae, Claus, Vilsbøll, Tina, Skov, Lone & Knop, Filip Krag, Feb 2013, In: Experimental Dermatology. 22, 2, p. 150-2 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    In vivo positron emission tomography imaging of decreased parasympathetic innervation in the gut of vagotomized patients

    Fedorova, T. D., Knudsen, K., Hartmann, Bolette, Holst, Jens Juul, Mortensen, F. V., Krogh, K. & Borghammer, P., 2020, In: Neurogastroenterology and Motility. 32, 3, 8 p., 13759.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Exenatide augments first and second phase insulin secretion in response to intravenous glucose in subjects with type 2 diabetes

    Fehse, F., Trautmann, M., Holst, Jens Juul, Halseth, A. E., Nanyakkara, N., Nielsen, L., Fineman, M. S. D., Kim, D. D. & Nauck, M. A., 2005, In: J. Clin. Endocrinol. Metab.. 90, p. 5991-5997

    Research output: Contribution to journalJournal articleResearch

  8. Published

    Exenatide augments first- and second-phase insulin secretion in response to intravenous glucose in subjects with type 2 diabetes

    Fehse, F., Trautmann, M., Holst, Jens Juul, Halseth, A. E., Nanayakkara, N., Nielsen, L. L., Fineman, M. S., Kim, D. D. & Nauck, M. A., Nov 2005, In: The Journal of clinical endocrinology and metabolism. 90, 11, p. 5991-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition

    Feng, Y., Demehri, F. R., Xiao, W., Tsai, Y., Jones, J. C., Brindley, C. D., Threadgill, D. W., Holst, Jens Juul, Hartmann, Bolette, Barrett, T. A., Teitelbaum, D. H. & Dempsey, P. J., May 2017, In: Cellular and Molecular Gastroenterology and Hepatology. 3, 3, p. 447-468 22 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Response to Comment on Færch et al. GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study. Diabetes 2015;64:2513–2525

    Ferch, K., Torekov, Signe Sørensen, Vistisen, D., Johansen, N. B., Witte, D. R., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Hansen, Torben, Lauritzen, T., Sandbek, A., Holst, Jens Juul & Jørgensen, M. E., 1 Sep 2015, In: Diabetes. 64, 9, p. e30-e31

    Research output: Contribution to journalComment/debateResearchpeer-review

  11. Published

    Individuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells

    Ferreira, F. P., Pereira, S. S., Costa, M. M., Guimarães, M., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Nora, M. & Monteiro, M. P., 2023, In: Molecular and Cellular Biochemistry. 478, 12, p. 2779-2787

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Physiological augmentation of amino acid-induced insulin secretion by GIP and GLP-I but not by CCK-8

    Fieseler, P., Bridenbaugh, S., Nustede, R., Martell, J., Nauck, M. A., Ørskov, Cathrine & Holst, Jens Juul, 1995, In: Am. J. Physiol.. Vol 268, p. E949-E955

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Pituitary adenylate-cyclase-activating polypeptide stimulates insulin and glucagon secretion in humans.

    Filipson, K., Tornøe, K., Holst, Jens Juul & Ahrén, B., 1997, In: J. Clin. Endocrinol. Metab.. 82, p. 3093-3098

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    PACAP contributes to insulin secretion after gastric glucose gavage in mice

    Filipsson, K., Holst, Jens Juul & Ahrén, B., 2000, In: Am. J. Physiol.. 279, p. R424-432

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    The effect of glucagon-like peptide-1 on energy expenditure and substrate metabolism in humans

    Flint, A., Raben, A., Rehfeld, J. F., Holst, Jens Juul & Astrup, A., 2000, In: International Journal of Obesity. 24, p. 288-298

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Glucagon-like peptide-1 promotes satiety and suppresses energy intake in humans

    Flint, A., Raben, A., Holst, Jens Juul & Astrup, A., 1997, International journal of obesity. 21 ed. European Association for the Study of Obesity, p. 16 1 p.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearch

  17. Published

    Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans

    Flint, A., Raben, Anne, Astrup, A. & Holst, Jens Juul, 1998, In: Journal of Clinical Investigation. 101, 3, p. 515-520 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Glucagon-like peptide-1 suppresses energy expenditure in obese humans

    Flint, A., Raben, A., Holst, Jens Juul & Astrup, A., 1999, International journal of obesity. Després, J-P. & Macdonald, I. (eds.). 23 ed. European Association for the Study of Obesity, p. S35 1 p.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearch

  19. Published

    The ¤use of glycaemic index tables to predict glycaemic index of composite breakfast meals

    Flint, A., Møller, B. K., Raben, Anne, Pedersen, D., Tetens, I., Holst, Jens Juul & Astrup, A., 2004, In: British Journal of Nutrition. 91, 6, p. 979-989 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    The use of glycaemic index tables to predict glycaemic index of breakfast meals

    Flint, A., Møller, B. K., Raben, Anne, Tetens, Inge , Holst, Jens Juul & Astrup, A., 2005, In: British Journal of Nutrition. 94, 1, p. 135-136 2 p.

    Research output: Contribution to journalLetterResearchpeer-review

  21. Published

    Glycemic and insulinemic responses as determinants of appetite in humans

    Flint, A., Møller, B. K., Raben, Anne, Sloth, B., Pedersen, D., Tetens, Inge , Holst, Jens Juul & Astrup, A., 2006, In: American Journal of Clinical Nutrition. 84, 6, p. 1365-1373 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published
  23. Published

    Nonalcoholic Fatty Liver Disease Is Prevalent in Women With Prior Gestational Diabetes Mellitus and Independently Associated With Insulin Resistance and Waist Circumference

    Foghsgaard, S., Andreasen, C., Vedtofte, L., Andersen, E. S., Bahne, E., Strandberg, C., Buhl, T., Holst, Jens Juul, Svare, J. A., Clausen, Tine Dalsgaard, Mathiesen, Elisabeth, Damm, Peter, Gluud, Lise Lotte, Knop, Filip Krag & Vilsbøll, Tina, Jan 2017, In: Diabetes Care. 40, 1, p. 109-116 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Liraglutide treatment for the prevention of glucose tolerance deterioration in women with prior gestational diabetes mellitus: A 52-week randomized controlled clinical trial

    Foghsgaard, S., Vedtofte, L., Andersen, E. S., Bahne, E., Andreasen, C., Sørensen, A. L., Forman, Julie Lyng, Mathiesen, Elisabeth, Svare, J. A., Clausen, Tine Dalsgaard, Damm, Peter, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2023, In: Diabetes, Obesity and Metabolism. 26, 1, p. 201-214 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Women with prior gestational diabetes mellitus and prediabetes are characterised by a decreased incretin effect

    Foghsgaard, S., Vedtofte, L., Andreasen, C., Andersen, E. S., Bahne, E., Bagger, J. I., Svare, J. A., Holst, Jens Juul, Clausen, Tine Dalsgaard, Mathiesen, Elisabeth, Damm, Peter, Knop, Filip Krag & Vilsbøll, Tina, Jul 2017, In: Diabetologia. 60, 7, p. 1344-1353 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Effect of vildagliptin on glucagon concentration during meals in patients with type 1 diabetes

    Foley, J. E., Ligueros-Saylan, M., He, Y., Holst, Jens Juul, Deacon, Carolyn F., Dunning, B. E., Leone-Jones, A., Yu, T. & Kelley, D. E., Oct 2008, In: Hormone and Metabolic Research. Supplement. 40, 10, p. 727-30 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Effect of Vildagliptin on Glucagon Concentration During Meals in Patients with Type 1 Diabetes

    Foley, J. E., Ligueros-Saylan, M., He, Y. L., Holst, Jens Juul, Deacon, Carolyn F., Dunning, B. E., Leone-Jones, A., Yu, T. & Kelley, D. E., 2008, In: Hormone and Metabolic Research. 40, 10, p. 727-730 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Combinatorial, additive and dose-dependent drug–microbiome associations

    Forslund, S. K., Chakaroun, R., Zimmermann-Kogadeeva, M., Markó, L., Aron-Wisnewsky, J., Nielsen, T., Moitinho-Silva, L., Schmidt, T. S. B., Falony, G., Vieira-Silva, S., Adriouch, S., Alves, R. J., Assmann, K., Bastard, J. P., Birkner, T., Caesar, R., Chilloux, J., Coelho, L. P., Fezeu, L., Galleron, N. & 23 others, Helft, G., Isnard, R., Ji, B., Kuhn, M., Le Chatelier, E., Myridakis, A., Olsson, L., Pons, N., Prifti, E., Quinquis, B., Roume, H., Lewinter, C., Søndertoft, N. B., Pedersen, H. K., Hansen, T. H., Hartmann, Bolette, Holst, Jens Juul, Hornbak, M., Jørgensen, Niklas Rye, Justesen, Johanne Marie, Krarup, N., Svendstrup, M. & The MetaCardis Consortium*, T. M. C., 2021, In: Nature. 600, p. 500-517 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Circulating Levels of the Soluble Receptor for AGE (sRAGE) during Escalating Oral Glucose Dosages and Corresponding Isoglycaemic i.v. Glucose Infusions in Individuals with and without Type 2 Diabetes

    Fotheringham, A. K., Bagger, J. I., Borg, D. J., McCarthy, D. A., Holst, Jens Juul, Vilsbøll, Tina, Knop, Filip Krag & Forbes, J. M., 2020, In: Nutrients. 12, 10, 12 p., 2928.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Twelve-Week Treatment With Liraglutide as Add-on to Insulin in Normal-Weight Patients With Poorly Controlled Type 1 Diabetes: A Randomized, Placebo-Controlled, Double-Blind Parallel Study

    Frandsen, C. S., Dejgaard, T. F., Holst, Jens Juul, Andersen, H. U., Thorsteinsson, B. & Madsbad, Sten, Dec 2015, In: Diabetes Care. 38, 12, p. 2250-7 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Non-insulin pharmacological therapies for treating type 1 diabetes

    Frandsen, C. S., Dejgaard, T. F., Madsbad, Sten & Holst, Jens Juul, 2018, In: Expert Opinion on Pharmacotherapy. 19, 9, p. 947-960

    Research output: Contribution to journalReviewResearchpeer-review

  32. Published

    Liraglutide as adjunct to insulin treatment in type 1 diabetes does not interfere with glycaemic recovery or gastric emptying rate during hypoglycaemia: a randomised, placebo-controlled, double-blind, parallel-group study

    Frandsen, C. S., Dejgaard, T. F., Andersen, H. U., Holst, Jens Juul, Hartmann, Bolette, Thorsteinsson, B. & Madsbad, Sten, 17 Mar 2017, In: Diabetes, Obesity and Metabolism. 19, 6, p. 773-782 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Extreme duration exercise affects old and younger men differently

    Frandsen, J., Sahl, R. E., Rømer, T., Thunestvedt Hansen, M., Nielsen, A. B., Lie-Olesen, M. M., Rasmusen, H. K., Søgaard, D., Ingersen, A., Rosenkilde, M., Westerterp, K., Holst, J. J., Andersen, J. L., Markowski, A. R., Blachnio-Zabielska, A., Clemmensen, C., Sacchetti, M., Cataldo, A., Traina, M., Larsen, S. & 2 others, Dela, Flemming & Helge, Jørn Wulff, 2022, In: Acta Physiologica. 235, 3, e13816.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    The influence of glucagon on postprandial hyperglycaemia in children 5 years after onset of type 1 diabetes

    Fredheim, S., Andersen, M. M., Pörksen, S., Nielsen, L. B., Pipper, C., Hansen, L., Holst, Jens Juul, Thomsen, J., Johannesen, Jesper, Mortensen, H. B. & Svensson, Jannet, 2015, In: Diabetologia. 58, 4, p. 828-34 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Effect of whey on blood glucose and insulin responses to composite breakfast and lunch meals in type 2 diabetic subjects.

    Frid, A. H., Nilsson, M., Holst, Jens Juul & Björck, I. M. E., 2005, In: American Journal of Clinical Nutrition. 82, 1, p. 69-75 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Attenuated processing of proglucagon and glucagon-like peptide- 1 in carboxypeptidase E-deficient mice

    Friis-Hansen, L., Lacourse, K. A., Samuelson, L. C. & Holst, Jens Juul, 2001, In: J. Endocrinol.. 169, p. 595-602

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Adult glucose metabolism in extremely birthweight-discordant monozygotic twins

    Frost, M., Petersen, I., Brixen, K., Beck-Nielsen, H., Holst, Jens Juul, Christiansen, L., Højlund, K. & Christensen, K., Dec 2012, In: Diabetologia. 55, 12, p. 3204-12 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Effect of liraglutide on ectopic fat in polycystic ovary syndrome: A randomized clinical trial

    Frøssing, S., Nylander, M., Chabanova, E., Frystyk, J., Holst, Jens Juul, Kistorp, Caroline Michaela Nervil, Skouby, Sven O. & Faber, Jens, Jan 2018, In: Diabetes, Obesity and Metabolism. 20, 1, p. 215-218

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Effects of whey protein and dietary fiber intake on insulin sensitivity, body composition, energy expenditure, blood pressure, and appetite in subjects with abdominal obesity

    Fuglsang-Nielsen, R., Rakvaag, E., Langdahl, B., Knudsen, K. E. B., Hartmann, Bolette, Holst, Jens Juul, Hermansen, K. & Gregersen, S., 2021, In: European Journal of Clinical Nutrition. 75, p. 611–619

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Consumption of nutrients and insulin resistance suppress markers of bone turnover in subjects with abdominal obesity

    Fuglsang-Nielsen, R., Rakvaag, E., Vestergaard, P., Hartmann, Bolette, Holst, Jens Juul, Hermansen, K., Gregersen, S. & Starup-Linde, J., 2020, In: Bone. 133, 9 p., 115230.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.

    Furuta, M., Yano, H., Zhou, A., Rouille, Y., Holst, Jens Juul, Carroll, R., Ravazzolla, M., Orci, L. & Steiner, D. F., 1997, In: Proc. Natl. Acad. Sci.. 94, p. 6646-6651

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Glucagon-Like Peptide-1 (GLP-1) Response to Oral Glucose is Reduced in Pre-diabetes, Screen-detected Type 2 Diabetes and Obesity, and Influenced by Sex: The ADDITION-PRO Study

    Færch, K., Torekov, Signe Sørensen, Vistisen, D., Johansen, N. B., Witte, D. R., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Hansen, Torben, Lauritzen, T., Sandbæk, A., Holst, Jens Juul & Jørgensen, M. E., Jul 2015, In: Diabetes. 64, p. 2513-25 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Effects of angiotensin II receptor blockade on cerebral, cardiovascular, counter-regulatory, and symptomatic responses during hypoglycaemia in patients with type 1 diabetes

    Færch, L. H., Thorsteinsson, B., Tarnow, L., Holst, Jens Juul, Kjær, T. W., Kanters, Jørgen K., Larroude, C., Dela, Flemming & Pedersen-Bjergaard, Ulrik, Dec 2015, In: Journal of the Renin-Angiotensin-Aldosterone System. 16, 4, p. 1036-1045 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    GIP and GLP-2 together improve bone turnover in humans supporting GIPR-GLP-2R co-agonists as future osteoporosis treatment

    Gabe, M. B. N., Skov-Jeppesen, Kirsa, Gasbjerg, Lærke Smidt, Schiellerup, S. P., Martinussen, C., Gadgaard, S., Boer, G. A., Oeke, J., Pedersen, Lola Julie Torz, Veedfald, Simon, Svane, M. S., Bojsen-Møller, K. N., Madsbad, Sten, Holst, Jens Juul, Hartmann, Bolette & Rosenkilde, M. M., 2022, In: Pharmacological Research. 176, 106058.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Biased GLP-2 agonist with strong G protein-coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice

    Gabe, M. B. N., Christensen, Liv von Voss, Dal, Jenna Elizabeth Hunt, Gadgaard, S., Gasbjerg, Lærke Smidt, Holst, Jens Juul, Kissow, Hannelouise, Hartmann, Bolette & Rosenkilde, Mette, Jan 2023, In: British Journal of Pharmacology. 180, 13, p. 1674-1689

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 receptor selectivity towards more GLP-1 receptor interaction

    Gabe, M. B. N., Gasbjerg, Lærke Smidt, Gadgaard, S., Lindquist, Peter, Holst, Jens Juul & Rosenkilde, Mette, 2022, In: British Journal of Pharmacology. 179, 18, p. 4473-4485

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Novel agonist- and antagonist-based radioligands for the GLP-2 receptor - useful tools for studies of basic GLP-2R pharmacology

    Gadgaard, S., van der Velden, W. J. C., Schiellerup, S. P., Dal, Jenna Elizabeth Hunt, Gabe, M. B. N., Windeløv, Johanne Agerlin, Boer, G. A., Kissow, Hannelouise, Ørskov, Cathrine, Holst, Jens Juul, Hartmann, Bolette & Rosenkilde, M. M., 2022, In: British Journal of Pharmacology. 179, 9, p. 1998-2015

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Long-acting agonists of human and rodent GLP-2 receptors for studies of the physiology and pharmacological potential of the GLP-2 system

    Gadgaard, S., Windeløv, Johanne Agerlin, Schiellerup, S. P., Holst, Jens Juul, Hartmann, Bolette & Rosenkilde, Mette, 2023, In: Biomedicine and Pharmacotherapy. 160, 13 p., 114383.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Glucagon promotes hepatic autophagy by AMPK-mediated mTORC1 inhibition

    Galsgaard, Katrine Douglas, Lee, J., Hubbard, B. T., Zhang, X. -., Cline, G. W., Nasiri, A. R., Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Pertersen, K. F. & Shulman, G. I., 2020, In: Diabetologia. 63, SUPPL 1, p. S231-S232

    Research output: Contribution to journalConference abstract in journalResearch

  50. Published

    Glucagon Receptor Signaling and Lipid Metabolism

    Galsgaard, Katrine Douglas, Pedersen, Jens, Knop, Filip Krag, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2019, In: Frontiers in Physiology. 10, 11 p., 413.

    Research output: Contribution to journalJournal articleResearchpeer-review

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