Jens Juul Holst

Jens Juul Holst

Professor

ORCID: 0000-0001-6853-3805

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  1. Published

    Postprandial incretin and islet hormone responses and dipeptidyl-peptidase 4 enzymatic activity in patients with maturity onset diabetes of the young

    Østoft, S. H., Bagger, J. I., Hansen, Torben, Hartmann, Bolette, Pedersen, Oluf Borbye, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 1 Aug 2015, In: European Journal of Endocrinology. 173, 2, p. 205-215 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors.

    Ørskov, Cathrine, Hartmann, B., Poulsen, Steen Seier, Thulesen, J., Hare, K. J. & Holst, Jens Juul, 2005, In: Regulatory Peptides. 124, 1-3, p. 105-12 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide-1 in humans

    Ørskov, Cathrine, Rabenhøj, L., Wettergren, A., Kofod, H. & Holst, Jens Juul, 1994, In: Diabetes. 43, p. 535-539

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    All products of proglucagon are elevated in plasma from ureamic patients

    Ørskov, Cathrine, Andreasen, J. & Holst, Jens Juul, 1992, In: Journal of Clinical Endocrinology and Metabolism. 79, p. 379-383

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Production and secretion of amidated and glycine-extended glucagon-like peptide-1 (GLP) in man

    Ørskov, C., Rabenhøj, L., Kofod, H., Wettergren, A. & Holst, Jens Juul, 1994, In: Diabetes. 43, p. 535-39

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Biological effects and metabolic rates of GLP-1 7-36 amide and GLP-1 7-37 in healthy volunteers are indistinguishable

    Ørskov, Cathrine, Wettergren, A. & Holst, Jens Juul, 1993, In: Diabetes. 42, p. 658-661

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting-state and after oral glucose and intravenous arginine

    Ørskov, C., Jeppesen, J., Madsbad, J. & Holst, Jens Juul, 1991, In: J. Clin. Invest.. 87, p. 415-423

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Proglucagon products in plasma of uraemic patients and normals in the fasting state

    Ørskov, C., Andreasen, J. & Holst, Jens Juul, 1992, In: J. Clin. Endocrinol. Metab.. 74, p. 379-384

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Neurogenic nitric oxide and exocrine secretion in the gastrointestinal tract

    Ørskov, Cathrine & Holst, Jens Juul, 2000, Nitric Oxide and the Peripheral Nervous System. London, UK: Portland Press Ltd., p. 131

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  10. Published

    Secretion and effects of glucagon-like peptide-1 (GLP-1) in healthy volunteers and NIDDM subjects.

    Ørskov, C. & Holst, Jens Juul, 1995, Diabetes 1994. Elsevier Sci. Intl. Congress Series 1100, p. 513-516

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  11. Published

    The role of somatostatin in GLP-1-induced inhibition of glucagon secretion in mice

    Ørgaard, A. & Holst, Jens Juul, Sep 2017, In: Diabetologia. 60, 9, p. 1731-1739 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Short-chain fatty acids and regulation of pancreatic endocrine secretion in mice

    Ørgaard, A., Jepsen, Sara Lind & Holst, Jens Juul, 2019, In: Islets. 11, 5, p. 103-111

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    The effect of glucose on the plasma concentration of somatostatin during caloric deficiency in man

    Øktedalen, O., Opstad, P. K. & Holst, Jens Juul, 1993, In: Scandinavian Journal of Gastroenterology. 28, p. 652-656

    Research output: Contribution to journal › Journal article › Research

  14. Published

    Counterregulatory responses to postprandial hypoglycemia after Roux-en-Y gastric bypass

    Øhrstrøm, C. C., Hansen, D. L., Kielgast, U. L., Bergmann, M. L., Veedfald, Simon, Holst, Jens Juul & Worm, Dorte, 2021, In: Surgery for Obesity and Related Diseases. 17, 1, p. 55-63 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Evidence for Relationship Between Early Dumping and Postprandial Hypoglycemia After Roux-en-Y Gastric Bypass

    Øhrstrøm, C. C., Worm, Dorte, Kielgast, U. L., Holst, Jens Juul & Hansen, D. L., 2020, In: Obesity Surgery. 30, 3, p. 1038-1045

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Endurance training improves GLP-1 sensitivity and glucose tolerance in overweight women

    Åkerström, T., Stolpe, Malene Norup, Widmer, R., Dejgaard, T. F., Højberg, J. M., Møller, Kirsten, Hansen, J. S., Trinh, B., Holst, Jens Juul, Thomsen, C., Pedersen, Bente Klarlund & Ellingsgaard, H., 2022, In: Journal of the Endocrine Society. 6, 9, p. 1-8 8 p., bvac111.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

    van der Velden, W. J. C., Smit, F. X., Christiansen, Charlotte Bayer, Møller, T. C., Hjortø, Gertrud Malene, Larsen, Olav, Schiellerup, S. P., Bräuner, Hans, Holst, Jens Juul, Hartmann, Bolette, Frimurer, Thomas Michael & Rosenkilde, Mette, 2021, In: ACS Pharmacology & Translational Science. 4, 1, p. 296-313 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Molecular and in vivo phenotyping of missense variants of the human glucagon receptor

    van der Velden, W. J. C., Lindquist, Peter, Madsen, Jakob Sture, Stassen, R. H. M. J., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Hauser, Alexander Sebastian & Rosenkilde, M. M., 2022, In: Journal of Biological Chemistry. 298, 2, 101413.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Chenodeoxycholic acid reduces intestinal permeability in newly weaned piglets

    van der Meer, Y., Gerrits, W. J. J., van den Bosch, M., Holst, Jens Juul, Moreto, M., Buurman, W. A., Kulik, W. & van Kempen, T. A. T. G., Dec 2012, In: Journal of Animal Science. 90 Suppl 4, p. 302-4 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    The prebiotic inulin improves substrate metabolism and promotes short-chain fatty acid production in overweight to obese men

    van der Beek, C. M., Canfora, E. E., Kip, A. M., Gorissen, S. H. M., Damink, S. W. M. O., van Eijk, H. M., Holst, Jens Juul, Blaak, E. E., Dejong, C. H. C. & Lenaerts, K., Oct 2018, In: Metabolism. 87, p. 25-35

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men

    van der Beek, C. M., Canfora, E. E., Lenaerts, K., Troost, F. J., Damink, S. W. M. O., Holst, Jens Juul, Masclee, A. A. M., Dejong, C. H. C. & Blaak, E. E., 11 Oct 2016, In: Clinical Science. 130, 22, p. 2073-2082 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Islet-cell dysfunction induced by glucocorticoid treatment: potential role for altered sympathovagal balance?

    van Raalte, D. H., Kwa, K. A. A., van Genugten, R. E., Tushuizen, M. E., Holst, Jens Juul, Deacon, Carolyn F., Karemaker, J. M., Heine, R. J., Mari, A. & Diamant, M., 2013, In: Metabolism. 62, 4, p. 568-577 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The interleukin-1 receptor antagonist anakinra improves first-phase insulin secretion and insulinogenic index in subjects with impaired glucose tolerance

    van Poppel, P. C. M., van Asseldonk, E. J. P., Holst, Jens Juul, Vilsbøll, Tina, Netea, M. G. & Tack, C. J., Dec 2014, In: Diabetes, Obesity and Metabolism. 16, 12, p. 1269-73 5 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  24. Published

    Cerebral effects of glucagon-like peptide-1 receptor blockade before and after Roux-en-Y gastric bypass surgery in obese women: A proof-of-concept resting-state functional MRI study

    van Duinkerken, E., Bernardes, G., van Bloemendaal, L., Veltman, D. J., Barkhof, F., Mograbi, D. C., Gerdes, V. E. A., Deacon, Carolyn F., Holst, Jens Juul, Drent, M. L., Diamant, M., ten Kulve, J. & Ijzerman, R. G., 2021, In: Diabetes, Obesity and Metabolism. 23, 2, p. 415-424 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Butyrate and hexanoate-enriched triglycerides increase postprandrial systemic butyrate and hexanoate in men with overweight/obesity: A double-blind placebo-controlled randomized crossover trial

    van Deuren, T., Smolders, L., Hartog, A., Bouwman, F. G., Holst, Jens Juul, Venema, K., Blaak, E. E. & Canfora, E. E., 2023, In: Frontiers in Nutrition. 9, 19 p., 1066950.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Exogenous GLP-2 has only marginal effects on weaning-induced intestinal adaption in piglets

    le Huërou-Luron, I., Petersen, Y. M., Hartmann, B., Holst, Jens Juul & Sangild, Per Torp, 2003, Ikke angivet. R.O. Ball (ed.). 2 ed. University of Alberta Press, p. 164-166 3 p.

    Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research

  27. Published

    Sulfonylurea compounds uncouple the glucose dependence of the insulinotropic effect of glucagon-like peptide 1.

    de Heer, J. & Holst, Jens Juul, 2007, In: Diabetes. 56, 2, p. 438-43 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas

    de Heer, J., Rasmussen, C., Coy, D. H. & Holst, Jens Juul, Dec 2008, In: Diabetologia. 51, 12, p. 2263-70 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas

    de Heer, J., Pedersen, J., Ørskov, Cathrine & Holst, Jens Juul, Oct 2007, In: Diabetologia. 50, 10, p. 2135-42 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Bile acid mediated effects on gut integrity and performance of early-weaned piglets

    de Diego-Cabero, N., Mereu, A., Menoyo, D., Holst, Jens Juul & Ipharraguerre, I. R., 2015, In: B M C Veterinary Research. 11, 1, p. 1-8 8 p., 111.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas

    de, H. J., Rasmussen, C., Coy, D. H. & Holst, Jens Juul, 2008, In: Diabetologia. 51, 12, p. 2263-2270 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Circulating leptin and thyroid dysfunction.

    Zimmermann-Belsing, T., Brabant, G., Holst, Jens Juul & Feldt-Rasmussen, Ulla, 2003, In: European Journal of Endocrinology. 149, 4, p. 257-71 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Changes in serum leptin do not correlate to total fat mass in patients with thyrotoxicosis

    Zimmermann-Belsing, T., Dreyer, M., Holst, Jens Juul & Feldt-Rasmussen, U., 1998, In: J. Endocrinol.. 49, p. 589-595

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Effect of viscosity on appetite and gastro-intestinal hormones

    Zijlstra, N., Mars, M., de Wijk, R. A., Westerterp-Plantenga, M. S., Holst, Jens Juul & de Graaf, C., 2009, In: Physiology & Behavior. 97, 1, p. 68-75 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

    Zhu, X., Zhou, A., Dey, A., Norrbom, C., Carroll, R., Zhang, C., Laurent, V., Lindberg, I., Ugleholdt, Randi Kjærsgaard, Holst, Jens Juul & Steiner, D. F., 6 Aug 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 16, p. 10293-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Gain-of-function mutation in the voltage-gated potassium channel gene KCNQ1 and glucose-stimulated hypoinsulinemia - case report

    Zhang, J., Juhl, C. R., Hylten-Cavallius, L., Olesen, Morten Steen Salling, Linneberg, Allan René, Holst, Jens Juul, Hansen, Torben, Kanters, Jørgen K. & Torekov, Signe Sørensen, 2020, In: B M C Endocrine Disorders. 20, 5 p., 38.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study.

    Olsen, Ane Mette Zander, Madsbad, Sten, Madsen, J. L. & Holst, Jens Juul, 2002, In: Lancet. 359, 9309, p. 824-30 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Additive effects of glucagon-like peptide 1 and pioglitazone in patients with type 2 diabetes.

    Olsen, Ane Mette Zander, Christiansen, A., Madsbad, Sten & Holst, Jens Juul, 2004, In: Diabetes Care. 27, 8, p. 1910-4 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Additive glucose-lowering effects of glucagon-like peptide- 1 and metformin type 2 diabetes

    Zander, M., Taskiran, M., Toft-Nielsen, M. B. & Holst, Jens Juul, 2001, In: Diabetes Care. 24, p. 720-725

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetes

    Zander, M., Madsbad, S., Deacon, Carolyn F. & Holst, Jens Juul, 2006, In: Diabetologia. 49, 2, p. 369-374 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetes

    Zander, M., Madsbad, Sten, Deacon, Carolyn F. & Holst, Jens Juul, Feb 2006, In: Diabetologia. 49, 2, p. 369-74 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Effects of Gastric Bypass and Gastric Banding on Bone Remodeling in Obese Patients with Type 2 Diabetes

    Yu, E. W., Wewalka, M., Ding, S., Simonson, D. C., Foster, K., Holst, Jens Juul, Vernon, A., Goldfine, A. B. & Halperin, F., Feb 2016, In: Journal of Clinical Endocrinology and Metabolism. 101, 2, p. 714–722

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Preserved glucagon-like peptide-1 responses to oral glucose, but reduced incretin effect, insulin secretion and sensitivity in young Asians with type 2 diabetes mellitus

    Yeow, T. P., Pacini, G., Tura, A., Hor, C. P., Lim, S. L., Tan, F. H. S., Tong, C. V., Hong, J. Y. H., Md Zain, F., Holst, Jens Juul & Wan Mohamud, W. N., 2017, In: BMJ open diabetes research & care. 5, 1, 9 p., e000352.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Dipeptidyl peptidase expression during experimental colitis in mice

    Yazbeck, R., Sulda, M. L., Howarth, G. S., Bleich, A., Raber, K., von Hörsten, S., Holst, Jens Juul & Abbott, C. A., 1 Aug 2010, In: Inflammatory Bowel Diseases. 16, 8, p. 1340-1351 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls

    Yabe, D., Kuroe, A., Lee, S., Watanabe, K., Hyo, T., Hishizawa, M., Kurose, T., Deacon, Carolyn F., Holst, Jens Juul, Hirano, T., Inagaki, N. & Seino, Y., 22 Apr 2010, In: Journal of Diabetes Investigation. 1, 1-2, p. 56-9 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients

    Yabe, D., Kuroe, A., Watanabe, K., Iwasaki, M., Hamasaki, A., Hamamoto, Y., Harada, N., Yamane, S., Lee, S., Murotani, K., Deacon, Carolyn F., Holst, Jens Juul, Hirano, T., Inagaki, N., Kurose, T. & Seino, Y., 2015, In: Journal of Diabetes and its Complications. 29, p. 413-421 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls

    Yabe, D., Kuroe, A., Lee, S., Watanabe, K., Hyo, T., Hishizawa, M., Kurose, T., Deacon, Carolyn F., Holst, Jens Juul, Hirano, T., Inagaki, N. & Seino, Y., Jan 2010, In: Journal of Diabetes Investigation. 1, 1/2, p. 56-59

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    In the rat pancreas, somatostatin tonically inhibits glucagon secretion and is required for glucose-induced inhibition of glucagon secretion

    Xu, S. F. S., Andersen, Daniel Bjørklund, Izarzugaza, J. M. G., Kuhre, Rune Ehrenreich & Holst, Jens Juul, 2020, In: Acta Physiologica. 229, 3, 15 p., e13464.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition

    Xiao, W., Feng, Y., Holst, Jens Juul, Hartmann, Bolette, Yang, H. & Teitelbaum, D. H., May 2014, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28, 5, p. 2073-87 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Human gastric lipase secretion is inhibited by intraduodenal perfusion of dietary fat.

    Wøjdemann, M., Riber, C., Bisgaard, T., Sternby, B., Larsen, S., Rehfeld, J. F., Holst, Jens Juul & Olesen, O., 1999, In: Regulatory Peptides. 80, p. 101-106

    Research output: Contribution to journal › Journal article › Research › peer-review

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