Jens Juul Holst

Jens Juul Holst

Professor

ORCID: 0000-0001-6853-3805

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  1. Published

    Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials

    Madsbad, Sten, Krarup, T., Deacon, Carolyn F. & Holst, Jens Juul, Jul 2008, In: Current Opinion in Clinical Nutrition and Metabolic Care. 11, 4, p. 491-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    GLP-1 suppresses gastrointestinal motility and inhibits the migrating motor complex in healthy subjects and patients with irritable bowel syndrome

    Hellström, P. M., Näslund, E., Edholm, T., Schmidt, P. T., Kristensen, J., Theodorsson, E., Holst, Jens Juul & Efendic, S., Jun 2008, In: Neurogastroenterology and Motility Online. 20, 6, p. 649-59 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans

    Meier, J. J., Gethmann, A., Götze, O., Gallwitz, B., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., Mar 2006, In: Diabetologia. 49, 3, p. 452-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency

    Jackson, R. S., Creemers, J. W. M., Farooqi, I. S., Raffin-Sanson, M-L., Varro, A., Dockray, G. J., Holst, J. J., Brubaker, P. L., Corvol, P., Polonsky, K. S., Ostrega, D., Becker, K. L., Bertagna, X., Hutton, J. C., White, A., Dattani, M. T., Hussain, K., Middleton, S. J., Nicole, T. M., Milla, P. J. & 2 others, Lindley, K. J. & O'Rahilly, S., Nov 2003, In: The Journal of Clinical Investigation. 112, 10, p. 1550-60 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Impact of cereal fibre on glucose-regulating factors

    Weickert, M. O., Mohlig, M., Koebnick, C., Holst, Jens Juul, Namsolleck, P., Ristow, M., Osterhoff, M., Rochlitz, H., Rudovich, N., Spranger, J. & Pfeiffer, A. F. H., Nov 2005, In: Diabetologia. 48, 11, p. 2343-53 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Feast or famine - are GLP-1 and ghrelin secretion intertwined?

    Djurhuus, C. B., Hansen, T. K., Holst, Jens Juul & Schmitz, O., Jul 2002, In: Hormone and Metabolic Research. Supplement. 34, 7, p. 353-4 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects

    Vilsbøll, T., Krarup, T., Madsbad, Sten & Holst, Jens Juul, 15 Jul 2003, In: Regulatory Peptides. 114, 2-3, p. 115-21 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects

    Sørensen, L. B., Flint, A., Raben, Anne, Hartmann, Bolette, Holst, Jens Juul & Astrup, A., Apr 2003, In: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 27, 4, p. 450-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Molecular Mechanisms of Glucose-Stimulated GLP-1 Secretion From Perfused Rat Small Intestine

    Kuhre, Rune Ehrenreich, Frost, C. R., Svendsen, B. & Holst, Jens Juul, Feb 2015, In: Diabetes. 64, 2, p. 370-382 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study

    Robertson, M. A., Sigalet, D. L., Holst, Jens Juul, Meddings, J. B., Wood, J. & Sharkey, K. A., Jul 2008, In: Journal of Autism and Developmental Disorders. 38, 6, p. 1066-71 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Incretin effect after oral amino Acid ingestion in humans

    Lindgren, O., Pacini, G., Tura, A., Holst, Jens Juul, Deacon, Carolyn F. & Ahrén, B., Mar 2015, In: The Journal of clinical endocrinology and metabolism. 100, 3, p. 1172-6 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Restoration of the insulinotropic effect of glucose-dependent insulinotropic polypeptide contributes to the antidiabetic effect of dipeptidyl peptidase-4 inhibitors

    Aaboe, K., Akram, S., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten & Krarup, T., Jan 2015, In: Diabetes, Obesity and Metabolism. 17, 1, p. 74-81 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    The glucagon-like peptide 2 receptor is expressed in enteric neurons and not in the epithelium of the intestine

    Pedersen, Jens, B. Pedersen, N., Brix, S. W., Grunddal, Kaare Villum, Rosenkilde, Mette, Hartmann, Bolette, Ørskov, Cathrine, Poulsen, Steen Seier & Holst, Jens Juul, May 2015, In: Peptides. 67, p. 20-28 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Incretins, insulin secretion and Type 2 diabetes mellitus

    Vilsbøll, T. & Holst, Jens Juul, Mar 2004, In: Diabetologia. 47, 3, p. 357-66 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects

    Vilsbøll, T., Agersø, H., Krarup, T. & Holst, Jens Juul, Jan 2003, In: The Journal of clinical endocrinology and metabolism. 88, 1, p. 220-4 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes

    Meier, J. J., Gallwitz, B., Salmen, S., Goetze, O., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., Jun 2003, In: The Journal of clinical endocrinology and metabolism. 88, 6, p. 2719-25 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Cocaine- and amphetamine-regulated transcript is present in hypothalamic neuroendocrine neurones and is released to the hypothalamic-pituitary portal circuit

    Larsen, P. J., Seier, V., Fink-Jensen, Anders, Holst, Jens Juul, Warberg, J. & Vrang, N., Mar 2003, In: Journal of Neuroendocrinology. 15, 3, p. 219-26 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    The effects of variations in dose and method of administration on glucagon like peptide-2 activity in the rat

    Kaji, T., Tanaka, H., Holst, Jens Juul, Redstone, H., Wallace, L., de Heuval, E. & Sigalet, D. L., 31 Oct 2008, In: European Journal of Pharmacology. 596, 1-3, p. 138-45 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes

    Nielsen, L. B., Ploug, K. B., Swift, P., Ørskov, Cathrine, Jansen-Olesen, I., Chiarelli, F., Holst, Jens Juul, Hougaard, P., Pörksen, S., Holl, R., de Beaufort, C., Gammeltoft, S., Rorsman, P., Mortensen, H. B. & Hansen, L., Jun 2007, In: European Journal of Endocrinology. Supplement. 156, 6, p. 663-71 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    A 25-year-old woman with type 2 diabetes and liver disease

    Junker, A. E., Gluud, Lise Lotte, Pedersen, J., Langhoff, J. L., Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, T., 2014, In: Case Reports in Gastroenterology. 8, 3, p. 398-403 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    GLP-2 levels in infants with intestinal dysfunction

    Sigalet, D. L., Martin, G., Meddings, J., Hartman, B. & Holst, Jens Juul, Sep 2004, In: Pediatric Research. 56, 3, p. 371-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers

    Nauck, M. A., Heimesaat, M. M., Behle, K., Holst, Jens Juul, Nauck, M. S., Ritzel, R., Hüfner, M. & Schmiegel, W. H., Mar 2002, In: The Journal of clinical endocrinology and metabolism. 87, 3, p. 1239-46 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Gastric inhibitory polypeptide does not inhibit gastric emptying in humans

    Meier, J. J., Goetze, O., Anstipp, J., Hagemann, D., Holst, Jens Juul, Schmidt, W. E., Gallwitz, B. & Nauck, M. A., Apr 2004, In: American Journal of Physiology: Endocrinology and Metabolism. 286, 4, p. E621-5

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia

    Mulla, C. M., Goldfine, A. B., Dreyfuss, J. M., Houten, S., Pan, H., Pober, D. M., Albrechtsen, Nicolai Jacob Wewer, Svane, M. S., Schmidt, J. B., Holst, Jens Juul, Craig, C. M., McLaughlin, T. L. & Patti, M., 2019, In: Obesity Surgery. 29, 7, p. 2092-2099

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans

    Muller, M., Hernandez, M. A. G., Goossens, G. H., Reijnders, D., Holst, Jens Juul, Jocken, J. W. E., van Eijk, H., Canfora, E. E. & Blaak, E. E., 2019, In: Scientific Reports. 9, 9 p., 12515.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Individual and combined glucose-lowering effects of glucagon receptor antagonism and sodium-glucose cotransporter 2 inhibition

    Haedersdal, S., Lund, A., Maagensen, H., Nielsen-Hannerup, E., Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2018, p. S312-S312.

    Research output: Contribution to conference › Poster › Research

  27. Published

    Gut-derived glucagon in man: [Meeting Abstract]

    Baekdal, M., Lund, A., Albrechtsen, Nicolai Jacob Wewer, Egholk, J., Jorsal, T., Black-Juel, C. T., Dal, Jenna Elizabeth Hunt, Galsgaard, Katrine Douglas, Rigbolt, K., Palnaes, C., Ørskov, Cathrine, Poulsen, Steen Seier, Holst, Jens Juul, Villsboll, T. & Knop, Filip Krag, 2019, In: Diabetologia. 62, Supl. 1/SI, p. S231-S231 472.

    Research output: Contribution to journal › Conference abstract in journal › Research

  28. Published

    Liraglutide preserved insulin secretion in adults with newly diagnosed type 1 diabetes: the NewLira trial: [Meeting Abstract}

    Dejgaard, T. F., Frandsen, C., Kielgast, U., Andersen, H. U., Thorsteinsson, B., Krarup, T., Holst, Jens Juul & Madsbad, Sten, 2019, In: Diabetologia. 62, Supl. 1/SI, p. S75-S75 145.

    Research output: Contribution to journal › Conference abstract in journal › Research

  29. Published

    Combined GLP-1, Oxyntomodulin, and Peptide YY Improves Body Weight and Glycemia in Obesity and Prediabetes/Type 2 Diabetes: A Randomized Single-Blinded Placebo Controlled Study

    Behary, P., Tharakan, G., Alexiadou, K., Johnson, N., Albrechtsen, N. J. W., Kenkre, J., Cuenco, J., Hope, D., Anyiam, O., Choudhury, S., Alessimii, H., Poddar, A., Minnion, J., Doyle, C., Frost, G., Le Roux, C., Purkayastha, S., Moorthy, K., Dhillo, W., Holst, J. J. & 4 others, Ahmed, A. R., Prevost, A. T., Bloom, S. R. & Tan, T. M., 2019, In: Diabetes Care. 42, 7, 8 p., dc190449.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Glucagon Receptor Signaling and Lipid Metabolism

    Galsgaard, Katrine Douglas, Pedersen, Jens, Knop, Filip Krag, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2019, In: Frontiers in Physiology. 10, 11 p., 413.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    A carbohydrate-reduced high-protein diet improves HbA1c and liver fat content in weight stable participants with type 2 diabetes: a randomised controlled trial

    fbg982, fbg982, Samkani, A., Petersen, A. D., Thomsen, M. N., Astrup, A., Chabanova, E., Frystyk, J., Holst, Jens Juul, Thomsen, Henrik S., Madsbad, Sten, Larsen, T. M., Haugaard, Steen Bendix & Krarup, T., 2019, In: Diabetologia. 62, 11, p. 2066-2078 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men

    Janus, C., Vistisen, D., Amadid, H., Witte, D. R., Lauritzen, T., Brage, S., Bjerregaard, A., Hansen, Torben, Holst, Jens Juul, Jørgensen, M. E., Pedersen, Oluf Borbye, Færch, K. & Torekov, Signe Sørensen, 2019, In: Endocrine Connections. 8, 12, p. 1607–1617 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Reduction of beta cell mass: partial insulin secretory compensation from the residual beta cell population in the nicotinamide-streptozotocin Göttingen minipig after oral glucose in vivo and in the perfused pancreas

    Larsen, M. O., Rolin, B., Gotfredsen, C. F., Carr, R. D. & Holst, Jens Juul, 2004, In: Diabetologia. 47, p. 1873-1878

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Teduglutide (ALX-0600), a dipeptidyl-peptidase-IV resistant glucagon-like-2 analog improves intestinal function in short bowel syndrome patients

    Jeppesen, P. B., Sanguinetti, E. L., Buckman, A., Howard, L., Scolapio, J. S., Ziegler, T. R., Gregory, M., Tappendent, K. A., Holst, Jens Juul & Mortensen, P. B., 2005, In: Gut. 54, p. 1224-1231

    Research output: Contribution to journal › Journal article › Research

  35. Published

    GLP-2 levels in human infants with intestinal dysfunction

    Sigalet, D. L., Martin, G., Meddings, J., Hartmann, B. & Holst, Jens Juul, 2004, In: Pediatric Research. 56, p. 371-376

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Insulin secretion and incretin hormones after oral glucose in impaired glucose tolerance

    Rask, E., Olsson, T., Söderberg, S., Holst, Jens Juul, Tura, A., Pacini, G. & Ahren, B., 2004, In: Metabolism. 53, p. 624-631

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Supplementation of total parenteral nutrition with butyrate acutely increases structural aspects of intestinal adaptation following and 80% jejunoileal resection in neonatal pigs

    Bartholome, A. L., Albin, D. M., Baker, D. H., Holst, Jens Juul & Tappenden, K. A., 2004, In: J Parenter Enteral Nutr. 28, p. 210-223

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors

    Hansotia, T., Baggio, L. L., Delmeire, D., Hinke, S. A., Yamada, Y., Tsukiyama, K., Seino, Y., Holst, Jens Juul, Schuit, F. & Drucker, D. J., 2004, In: Diabetes. 53, p. 1326-1335

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Postprandial GLP-1, norepinephrine, and reactive hypoglycemia in dumping syndrome

    Gebhard, B., Holst, Jens Juul & Biegelmayer, C., 2001, In: Digest Dis Sci. 46, p. 1915-1923

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes

    Meier, J. J., Huking, K., Holst, Jens Juul, Deacon, Carolyn F., Schmiegel, W. H. & Nauck, M. A., 2001, In: Diabetes. 50, p. 2497-2504

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Gastric myoelectrical activity and gut hormone secretion in myotonic dystrophy

    Ronnblom, A., Hellstrom, P. M. & Holst, Jens Juul, 2001, In: Eur J Gastroen Hepat. 13, p. 825-831

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Determinants of the effectiveness of glucagon-like peptide- 1 in type 2 diabetes

    Toft-Nielsen, M. B., Madsbad, S. & Holst, Jens Juul, 2001, In: J Clin Endocr Metab. 86, p. 3853-3860

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    GLP-1 inhibits gastric emptying of water but does not influence plasma vasopressin, sodium, or osmolality

    Naslund, E., Bogefors, J., Gryback, P. & Holst, Jens Juul, 2001, In: Scand J Gastroentero. 36, p. 156-162

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Regulatory peptides of the gastrointestinal tract

    Holst, Jens Juul, 2000, Small Bowel Disorders. London: Small Bowel Disorders, p. 96-115

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  45. Published

    Short-term treatment with GLP-1 increases pulsatile secretion in type 2 diabetes with no effect on orderliness.

    Juhl, C. B., Schmitz, O., Holst, Jens Juul, Vedhuis, J. & Pørksen, N., 2000, In: Diabetologia. 43, p. 583-588

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Increased intensity of physical activity stimulates subsequent fat intake

    Klausen, B., Toubro, S., Ranneries, C., Rehfeld, J. F., Holst, Jens Juul, Christensen, N. J. & Astrup, A., 1999, In: International Journal of Obesity. 23, p. 1282-1287

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Secretion of trophic gut peptides is not different in bolus- and continuously fed piglets

    Goudoever, V., Stoll, B., Hartmann, B., Holst, Jens Juul, Reeds, P. J. & Burrin, D. G., 2001, In: J Nutr.. 131, p. 729-732

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    The hypothalamic satiety peptide CART is expressed in anorectic and non-anorectic pancreatic islet tumors and in the normal islet of Langerhans

    Jensen, P. B., Kristensen, P., Clausen, J. T., Judge, M. E., Hastrup, S., Thim, L., Wulff, B. S., Foged, C., Jensen, J., Holst, Jens Juul & Madsen, O. D., 1999, In: FEBS Letters. 447, p. 139-143

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Advances in non-peptide glucagon receptor antagonist

    Madsen, P., Knudsen, L. B., Brand, C. L. & Holst, Jens Juul, 1999, In: Curr. Pharm Design. 5, p. 683-691

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Glucagon-like peptide-1 slows solid gastric emptying and inhibits insulin, glucagon and peptide YY release in humans

    Näslund, E., Bogefors, J., Skogar, S., Grybäck, P., Jacobsen, H. L., Holst, Jens Juul & Helström, P. M., 1999, In: Am. J. Physiol.. 277, p. 910-916

    Research output: Contribution to journal › Journal article › Research › peer-review

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