Holger Grohganz

Holger Grohganz

Associate Professor

ORCID: 0000-0002-0482-1397

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  1. Published

    Whey proteins as stabilizers in amorphous solid dispersions

    Mishra, J., Bohr, A., Rades, Thomas, Grohganz, Holger & Löbmann, Korbinian, 1 Feb 2019, In: European Journal of Pharmaceutical Sciences. 128, p. 144-151 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Wet granulation of co-amorphous indomethacin systems

    Schütz, D., Timmerhaus, A. & Grohganz, Holger, 2023, In: International Journal of Pharmaceutics. 644, 9 p., 123318.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Well-plate freeze-drying: a high throughput platform for screening of physical properties of freeze-dried formulations

    Trnka, H., Rantanen, Jukka & Grohganz, Holger, 2015, In: Pharmaceutical Development and Technology. 20, 1, p. 65-73 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Utilizing the allyl-terminated copolymer methoxy(poly(ethylene glycol))-block-poly(jasmine lactone) in the development of amorphous solid dispersions: A comparative study of functionalized and non-functionalized polymer

    Di, Rong, Bansal, K. K., Rosenholm, J. M., Grohganz, Holger & Rades, Thomas, 2024, In: International Journal of Pharmaceutics. 657, 12 p., 124175.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Using dextran of different molecular weights to achieve faster freeze-drying and improved storage stability of lactate dehydrogenase

    Larsen, B. S., Skytte, J., Svagan, A. J., Meng-Lund, H., Grohganz, Holger & Löbmann, Korbinian, 2019, In: Pharmaceutical Development and Technology. 24, 3, p. 323-328

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Unintended and in situ amorphisation of pharmaceuticals

    Priemel, P. A., Grohganz, Holger & Rades, Thomas, 1 May 2016, In: Advanced Drug Delivery Reviews. 100, p. 126-32 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Undesired co-amorphisation of indomethacin and arginine during combined storage at high humidity conditions

    Petry, I., Löbmann, Korbinian, Grohganz, Holger, Rades, Thomas & Leopold, C. S., 2018, In: International Journal of Pharmaceutics. 544, 1, p. 172-180 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Transformations between Co-Amorphous and Co-Crystal Systems and Their Influence on the Formation and Physical Stability of Co-Amorphous Systems

    Wu, W., Wang, Y., Löbmann, Korbinian, Grohganz, Holger & Rades, Thomas, 4 Mar 2019, In: Molecular Pharmaceutics. 16, 3, p. 1294-1304 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Towards a robust water content determination of freeze-dried samples by near-infrared spectroscopy

    Grohganz, Holger, Gildemyn, D., Skibsted, E., Fink, J. M. & Rantanen, Jukka, 2010, In: Analytica Chimica Acta. 676, p. 34-40

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Thermal investigation on hydrated co-amorphous systems of nicotinamide and prilocaine

    Xu, X., Rades, Thomas & Grohganz, Holger, 2023, In: European Journal of Pharmaceutics and Biopharmaceutics. 186, p. 1-6

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Theoretical Considerations in Developing Amorphous Solid Dispersions

    Laitinen, R., Priemel, P. A., Surwase, S., Graeser, K., Strachan, C. J., Grohganz, Holger & Rades, Thomas, 2014, Amorphous Solid Dispersions - Theory and Practice. Shah, N., Sandhu, H., Choi, D. S., Chokshi, H. & Malick, A. W. (eds.). New York: Springer Science+Business Media, p. 35-90 56 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  12. Published

    The use of molecular descriptors in the development of co-amorphous formulations

    Meng-Lund, H. M. L., Korgaard, G. K., Jensen, K. B. T., Poso, A., Pantsar, T., Rades, Thomas, Rantanen, Jukka & Grohganz, Holger, 1 Jul 2018, In: European Journal of Pharmaceutical Sciences. 119, p. 31 38 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    The significance of the amorphous potential energy landscape for dictating glassy dynamics and driving solid-state crystallisation

    Ruggiero, M. T., Krynski, M., Kissi, E. O., Sibik, J., Markl, D., Tan, N. Y., Arslanov, D., van der Zande, W., Redlich, B., Korter, T. M., Grohganz, Holger, Löbmann, Korbinian, Rades, Thomas, Elliott, S. R. & Zeitler, J. A., 2017, In: Physical chemistry chemical physics : PCCP. 19, 44, p. 30039-30047

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The interplay between trehalose and dextran as spray drying precursors for cationic liposomes

    Lutta, A., Knopp, Matthias Manne, Tollemeto, M., Pedersen, Gabriel Kristian, Schmidt, S. T., Grohganz, Holger & Hagner Nielsen, L., 2024, In: International Journal of Pharmaceutics. 652, 10 p., 123798.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The influence of moisture on the storage stability of co-amorphous systems

    Liu, J., Rades, Thomas & Grohganz, Holger, 2021, In: International Journal of Pharmaceutics. 605, 120802.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    The influence of lysozyme on mannitol polymorphism in freeze-dried and spray-dried formulations depends on the selection of the drying process

    Grohganz, Holger, Lee, Y., Rantanen, Jukka & Yang, Mingshi, 15 Apr 2013, In: International Journal of Pharmaceutics. 447, 1-2, p. 224-30 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    The impact of surface- and nano-crystallisation on the detected amorphous content and the dissolution behaviour of amorphous indomethacin

    Priemel, P. A., Grohganz, Holger, Gordon, K. C., Rades, Thomas & Strachan, C., 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 82, 1, p. 187-193

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    The Role of Glass Transition Temperatures in Coamorphous Drug-Amino Acid Formulations

    Kissi, E. O., Kasten, G., Löbmann, Korbinian, Rades, Thomas & Grohganz, Holger, 4 Sep 2018, In: Molecular Pharmaceutics. 15, 9, p. 4247–4256

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers

    Blaabjerg, L. I., Grohganz, Holger, Lindenberg, E., Löbmann, Korbinian, Mullertz, Anette & Rades, Thomas, 21 Sep 2018, In: Pharmaceutics. 10, 4, 14 p., 164.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Surface area, volume and shape descriptors as a novel tool for polymer lead design and discovery

    Christensen, J. R., Meng-Lund, H., Grohganz, Holger, Poso, A., Laitinen, T., Korhonen, O., Jørgensen, Lene & Pajander, J., 1 May 2017, In: European Journal of Pharmaceutical Sciences. 102, p. 188-195 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Supersaturating drug delivery systems: The potential of co-amorphous drug formulations

    Laitinen, R., Löbmann, Korbinian, Grohganz, Holger, Priemel, P., Strachan, C. J. & Rades, Thomas, 30 Oct 2017, In: International Journal of Pharmaceutics. 532, 1, p. 1-12 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Stabilized amorphous solid dispersions with small molecule excipients

    Löbmann, Korbinian, Jensen, K. B. T., Laitinen, R., Rades, Thomas, Strachan, C. & Grohganz, Holger, 2014, Amorphous Solid Dispersions - Theory and Practice. Shah, N., Sandhu, H., Choi, D. S., Chokshi, H. & Malick, A. W. (eds.). New York: Springer Science+Business Media, p. 613-626 24 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  23. Published

    Solvent free amorphisation for pediatric formulations (minitablets) using mesoporous silica

    Monsuur, F., Choudhari, Y., Reddy, U., McCarthy, W., Sadek, I., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, 25 Sep 2016, In: International Journal of Pharmaceutics. 511, 2, p. 1135-1136

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  24. Published

    Solid-state properties and dissolution behaviour of tablets containing co-amorphous indomethacin-arginine

    Lenz, E., Jensen, K. B. T., Blaabjerg, L. I., Knop, K., Grohganz, Holger, Löbmann, Korbinian, Rades, Thomas & Kleinebudde, P., Oct 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 96, p. 44–52 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Solid state properties and drug release behavior of co-amorphous indomethacin-arginine tablets coated with Kollicoat® Protect

    Petry, I., Löbmann, Korbinian, Grohganz, Holger, Rades, Thomas & Leopold, C. S., Oct 2017, In: European Journal of Pharmaceutics and Biopharmaceutics. 119, p. 150-160 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Screening of novel excipients for freeze-dried protein formulations

    Holm, T. P., Meng-Lund, H., Rantanen, Jukka, Jørgensen, Lene & Grohganz, Holger, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 160, p. 55-64 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Role of polymeric excipients in the stabilization of olanzapine when exposed to aqueous environments

    Paisana, M., Wahl, M., Pinto, J., Rades, Thomas (ed.), Grohganz, Holger (ed.) & Löbmann, Korbinian (ed.), 2015, In: Molecules. 20, 12, p. 22634-223282 200649.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Role of excipients in the quantification of water in lyophilised mixtures using NIR spectroscopy

    Grohganz, Holger, Fonteyne, M., Skibsted, E., Falck, T., Palmqvist, B. & Rantanen, Jukka, 2009, In: Journal of Pharmaceutical and Biomedical Analysis. 49, p. 901-907

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Refining stability and dissolution rate of amorphous drug formulations

    Grohganz, Holger, Priemel, P. A., Löbmann, Korbinian, Nielsen, L. H., Laitinen, R., Mullertz, Anette , Van den Mooter, G. & Rades, Thomas, Jun 2014, In: Expert Opinion on Drug Delivery. 11, 6, p. 977-89 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Recent trends in stabilising peptides and proteins in pharmaceutical formulation - considerations in the choice of excipients

    Jørgensen, Lene, Hostrup, S., Møller, E. H. & Grohganz, Holger, 2009, In: Expert Opinion on Drug Delivery. 6, 11, p. 1219-1230

    Research output: Contribution to journal › Review › Research

  31. Published

    Recent advances in co-amorphous drug formulations

    Dengale, S. J., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, 1 May 2016, In: Advanced Drug Delivery Reviews. 100, p. 116-125 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Rapid solid-state analysis of freeze-dried protein formulations using NIR and raman spectroscopies

    Grohganz, Holger, Gildemyn, D., Skibsted, E., Flink, J. M. & Rantanen, Jukka, 2011, In: Journal of Pharmaceutical Sciences. 100, 7

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Quality by design approach in the optimization of the spray-drying process

    Baldinger, A., Clerdent, L., Rantanen, Jukka, Yang, Mingshi & Grohganz, Holger, 2012, In: Pharmaceutical Development and Technology. 17, 4, p. 389-397

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Properties of the Sodium Naproxen-Lactose-Tetrahydrate Co-Crystal upon Processing and Storage

    Sovago, I., Wang, W., Qiu, D., Raijada, D. K., Rantanen, Jukka, Grohganz, Holger, Rades, Thomas, Bond, A. D. & Löbmann, Korbinian, 2016, In: Molecules. 21, 4, p. 1-13 13 p., 509.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Process Optimization and Upscaling of Spray-Dried Drug-Amino acid Co-Amorphous Formulations

    Kasten, G., Duarte, Í., Paisana, M., Löbmann, Korbinian, Rades, Thomas & Grohganz, Holger, 9 Jan 2019, In: Pharmaceutics. 11, 1, 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Probing Pharmaceutical Mixtures during Milling: The Potency of Low-Frequency Raman Spectroscopy in Identifying Disorder

    Walker, G., Römann, P., Poller, B., Löbmann, Korbinian, Grohganz, Holger, Rooney, J. S., Huff, G. S., Smith, G. P. S., Rades, Thomas, Gordon, K. C., Strachan, C. J. & Fraser-Miller, S. J., 2017, In: Molecular Pharmaceutics. 14, 12, p. 4675-4684 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Preparation of Co-Amorphous Systems by Freeze-Drying

    Wostry, M., Plappert, H. & Grohganz, Holger, 2020, In: Pharmaceutics. 12, 10, 12 p., 941.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Preparation of Co-Amorphous Levofloxacin Systems for Pulmonary Application

    Gabelmann, A., Lehr, C. M. & Grohganz, Holger, 2023, In: Pharmaceutics. 15, 6, 15 p., 1574.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Preparation and recrystallization behavior of spray-dried co-amorphous naproxen-indomethacin

    Beyer, A., Radi, L., Grohganz, Holger, Löbmann, Korbinian, Rades, Thomas & Leopold, C. S., Jul 2016, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 104, p. 72-81 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Preparation and characterization of spray-dried co-amorphous drug-amino acid salts

    Jensen, K. B. T., Blaabjerg, L. I., Lenz, E., Bohr, A., Grohganz, Holger, Kleinebudde, P., Rades, Thomas & Löbmann, Korbinian, May 2016, In: The Journal of pharmacy and pharmacology. 68, 5, p. 615–624 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Predictive identification of co-formers in co-amorphous systems

    Chambers, L. I., Grohganz, Holger, Palmelund, H., Löbmann, Korbinian, Rades, Thomas, Musa, O. M. & Steed, J. W., 2021, In: European Journal of Pharmaceutical Sciences. 157, 9 p., 105636.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Performance comparison between crystalline and co-amorphous salts of indomethacin-lysine

    Kasten, G., Nouri, K., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, 25 Nov 2017, In: International Journal of Pharmaceutics. 533, 1, p. 138-144 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Organic acids as co-formers for co-amorphous systems - Influence of variation in molar ratio on the physicochemical properties of the co-amorphous systems

    Wu, W., Ueda, H., Lobmann, K., Rades, Thomas & Grohganz, Holger, Oct 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 131, p. 25-32

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Ordnung muss (nicht) sein

    Löbmann, Korbinian, Jensen, K. B. T., Grohganz, Holger & Rades, Thomas, 2012, In: Lægemiddelforskning. 2012, p. 34-36

    Research output: Contribution to journal › Journal article › Communication

  45. Published

    On the role of salt formation and structural similarity of co-formers in co-amorphous drug delivery systems

    Wu, W., Löbmann, Korbinian, Rades, Thomas & Grohganz, Holger, 15 Jan 2018, In: International Journal of Pharmaceutics. 535, 1-2, p. 86-94

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Near-infrared (NIR) spectroscopy – a versatile tool for pharmaceutical research and production

    Grohganz, Holger, 2011, In: European Pharmaceutical Review. 16, 2, p. 57-60

    Research output: Contribution to journal › Journal article › Communication

  47. Published

    Near-Infrared Imaging for High-Throughput Screening of Moisture-Induced Changes in Freeze-Dried Formulations

    Trnka, H., Palou, A., Panouillot, P. E., Kauppinen, A., Toiviainen, M., Grohganz, Holger, Alcalà, M., Juuti, M., Ketolainen, J. & Rantanen, Jukka, 24 Mar 2014, In: Journal of Pharmaceutical Sciences. 103, 9, p. 2839–2846 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Multivariate analysis of phenol in freeze-dried and spray-dried insulin formulations by NIR and FTIR

    Maltesen, M. J., Bjerregaard, S., Hovgaard, L., Havelund, S., van de Weert, Marco & Grohganz, Holger, 2011, In: A A P S PharmSciTech. 12, 2, p. 627-635

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Multivariate Quantification of the Solid State Phase Composition of Co-Amorphous Naproxen-Indomethacin

    Beyer, A., Grohganz, Holger, Löbmann, Korbinian, Rades, Thomas & Leopold, C. S., 2015, In: Molecules. 20, 10, p. 19571-87 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Molecular interactions of hydrated co-amorphous systems of prilocaine and lidocaine

    Xu, X., Rades, Thomas & Grohganz, Holger, 2024, In: International Journal of Pharmaceutics. 651, 7 p., 123807.

    Research output: Contribution to journal › Journal article › Research › peer-review

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