Holger Grohganz

Holger Grohganz

Associate Professor

ORCID: 0000-0002-0482-1397

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  1. Adsorption of the decapeptide Cetrorelix depends both on the composition of dissolution medium and the type of solid surface

    Grohganz, Holger, Rischer, M. & Brandl, M., 2004, In: European Journal of Pharmaceutical Sciences. 21, 2-3, p. 191-196

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Development and in vitro evaluation of a liposome based implant formulation for the decapeptide cetrorelix

    Grohganz, Holger, Tho, I. & Brandl, M., 2005, In: European Journal of Pharmaceutics and Biopharmaceutics. 59, 3, p. 439-448

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Development and validation of a HPLC method for routine quantification of the decapeptide Cetrorelix in liposome dispersions

    Grohganz, Holger, Schläfli, O., Rischer, M. & Brandl, M., 2004, In: Journal of Pharmaceutical and Biomedical Analysis. 34, 5, p. 963-969

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Quantification of various phosphatidylcholines in liposomes by enzymatic assay

    Grohganz, Holger, Ziroli, V., Massing, U. & Brandl, M., 2003, In: AAPS PharmSciTech. 4, 4

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    A Multivariate Approach for the Determination of the Optimal Mixing Ratio of the Non-Strong Interacting Co-Amorphous System Carvedilol-Tryptophan

    Di, Rong, Liu, J., Grohganz, Holger & Rades, Thomas, 2021, In: Molecules. 26, 4, 8 p., 801.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    A co-amorphous form of a substance and a protein

    Mishra, J., Bohr, A., Berg, T. H. A., Löbmann, Korbinian, Rades, Thomas, Grohganz, Holger & Water, J. J., 2019, Patent No. US201903078886A1

    Research output: Patent

  7. Published

    A theoretical and spectroscopic study of co-amorphous naproxen and indomethacin

    Löbmann, Korbinian, Laitinen, R., Grohganz, Holger, Strachan, C. J., Rades, Thomas & Gordon, K. C., 30 Aug 2013, In: International Journal of Pharmaceutics. 453, 1, p. 80-87 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Amino acids as co-amorphous excipients for simvastatin and glibenclamide: physical properties and stability

    Laitinen, R., Löbmann, Korbinian, Grohganz, Holger, Strachan, C. & Rades, Thomas, 7 Jul 2014, In: Molecular Pharmaceutics. 11, 7, p. 2381-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Amino acids as co-amorphous stabilizers for poorly water soluble drugs--Part 1: preparation, stability and dissolution enhancement

    Löbmann, Korbinian, Grohganz, Holger, Laitinen, R., Strachan, C. & Rades, Thomas, Nov 2013, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 85, 3 Pt B, p. 873-81 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Amino acids as co-amorphous stabilizers for poorly water-soluble drugs - Part 2: Molecular interactions

    Löbmann, Korbinian, Laitinen, R., Strachan, C., Rades, Thomas & Grohganz, Holger, 1 Jan 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 3, Part B, p. 882-888

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Amorphization within the tablet: Using microwave irradiation to form a glass solution in situ

    Doreth, M., Hussein, M. A., Priemel, P. A., Grohganz, Holger, Holm, R., Lopez de Diego, H., Rades, Thomas & Löbmann, Korbinian, 15 Mar 2017, In: International Journal of Pharmaceutics. 519, 1-2, p. 343-351 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Amorphous drugs and dosage forms

    Grohganz, Holger, Löbmann, Korbinian, Priemel, P., Jensen, K. B. T., Graeser, K., Strachan, C. & Rades, Thomas, 1 Jul 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 403-408 6 p.

    Research output: Contribution to journal › Review › Research

  13. Published

    Amorphous drugs and dosage forms

    Grohganz, Holger, Löbmann, Korbinian, Priemel, P., Tarp Jensen, K., Graeser, K., Strachan, C. & Rades, Thomas, 2013, In: Journal of Drug Delivery Science and Technology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine

    Ueda, H., Wu, W., Löbmann, Korbinian, Grohganz, Holger, Mullertz, Anette & Rades, Thomas, May 2018, In: Molecular Pharmaceutics. 15, 5, p. 2036-2044

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Aspartame as a co-former in co-amorphous systems

    Wu, W., Löbmann, Korbinian, Schnitzkewitz, J., Knuhtsen, A., Pedersen, D. S., Grohganz, Holger & Rades, Thomas, 5 Oct 2018, In: International Journal of Pharmaceutics. 549, 1-2, p. 380-387

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Characterising glass transition temperatures and glass dynamics in mesoporous silica-based amorphous drugs

    Kissi, E. O., Ruggiero, M. T., Hempel, N. J., Song, Z., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, 1 Jan 2019, In: Physical Chemistry Chemical Physics. 21, 35, p. 19686-19694 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Characterization of Amorphous and Co-Amorphous Simvastatin Formulations Prepared by Spray Drying

    Craye, G., Löbmann, Korbinian, Grohganz, Holger, Rades, Thomas & Laitinen, R., 2015, In: Molecules. 20, 12, p. 21532-48 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Classification of lyophilised mixtures using multivariate analysis of NIR spectra

    Grohganz, Holger, Fonteyne, M., Skibsted, E., Falck, T., Palmqvist, B. & Rantanen, Jukka, 2010, In: European Journal of Pharmaceutics and Biopharmaceutics. 74, p. 406-412

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Co-Amorphous Drug Formulations in Numbers: Recent Advances in Co-Amorphous Drug Formulations with Focus on Co-Formability, Molar Ratio, Preparation Methods, Physical Stability, In Vitro and In Vivo Performance, and New Formulation Strategies

    Liu, J., Grohganz, Holger, Löbmann, Korbinian, Rades, Thomas & Hempel, N., 2021, In: Pharmaceutics. 13, 3, 43 p., 389.

    Research output: Contribution to journal › Review › Research

  20. Published

    Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions

    Löbmann, Korbinian, Strachan, C., Grohganz, Holger, Rades, Thomas, Korhonen, O. & Laitinen, R., 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 81, 1, p. 159-69 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Co-former selection for co-amorphous drug-amino acid formulations

    Kasten, G., Löbmann, Korbinian, Grohganz, Holger & Rades, Thomas, 2019, In: International Journal of Pharmaceutics. 557, p. 366-373

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Coamorphous drug systems: enhanced physical stability and dissolution rate of indomethacin and naproxen

    Löbmann, Korbinian, Laitinen, R., Grohganz, Holger, Gordon, K. C., Strachan, C. & Rades, Thomas, 2011, In: Molecular Pharmaceutics. 8, 5, p. 1919-28 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Coaxial electrospinning of polycaprolactone: A design of experiments approach

    Gürtler, Anna-Lena, Linseisen, I., Grohganz, Holger & Heinz, Andrea, 2024, In: European Polymer Journal. 208, 11 p., 112886.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Compaction Behavior of Co-Amorphous Systems

    Sørensen, C. M., Rantanen, Jukka & Grohganz, Holger, 2023, In: Pharmaceutics. 15, 3, 12 p., 858.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Comparison of co-former performance in co-amorphous formulations: Single amino acids, amino acid physical mixtures, amino acid salts and dipeptides as co-formers

    Wu, W., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, 2021, In: European Journal of Pharmaceutical Sciences. 156, 8 p., 105582.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Considerations on the Kinetic Processes in the Preparation of Ternary Co-Amorphous Systems by Milling

    Wang, Y., Rades, Thomas & Grohganz, Holger, 2023, In: Pharmaceutics. 15, 1, 14 p., 172.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Controlling production process: incorporating analytical methods

    Grohganz, Holger & Rantanen, Jukka, 2008, In: Pharma focus Asia. 8, p. 82-83

    Research output: Contribution to journal › Journal article › Communication

  28. Published

    Correlation between calculated molecular descriptors of excipient amino acids and experimentally observed thermal stability of lysozyme

    Meng-Lund, H., Friis, N., van de Weert, Marco, Rantanen, Jukka, Poso, A., Grohganz, Holger & Jørgensen, Lene, 15 May 2017, In: International Journal of Pharmaceutics. 523, 1, p. 238-245 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Design of experiments approach on the compaction properties of co-amorphous tablets

    Engelsing, F., Buchart, L. & Grohganz, Holger, 2023, In: Pharmaceutical Development and Technology. 28, 9, p. 907-914

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy

    Maltesen, M. J., van de Weert, Marco & Grohganz, Holger, 2012, In: A A P S PharmSciTech. 13, 3, p. 747-55 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Design space approach in the optimization of the spray-drying process

    Lebrun, P., Krier, F., Mantanus, J., Grohganz, Holger, Yang, Mingshi, Rozet, E., Boulanger, B., Evrard, B., Rantanen, Jukka & Hubert, P., 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 80, 1

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Destabilization of Indomethacin-Paracetamol Co-Amorphous Systems by Mechanical Stress

    Di, Rong, Grohganz, Holger & Rades, Thomas, 2024, In: Pharmaceutics. 16, 15 p., 67.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Detecting phase separation of freeze-dried binary amorphous systems using pair-wise distribution function and multivariate data analysis

    Chieng, N., Trnka, H., Bøtker, Johan Peter, Pikal, M., Rantanen, Jukka & Grohganz, Holger, 18 Jul 2013, In: International Journal of Pharmaceutics. 454, 1, p. 167-173 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Determination of the Optimal Molar Ratio in Amino Acid-Based Coamorphous Systems

    Liu, J., Rades, Thomas & Grohganz, Holger, 2020, In: Molecular Pharmaceutics. 17, 4, p. 1335-1342 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Development of a screening method for co-amorphous formulations of drugs and amino acids

    Kasten, G., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, Dec 2016, In: European Journal of Pharmaceutical Sciences. 95, p. 28-35 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Dipeptides as co-formers in co-amorphous systems

    Wu, W., Löbmann, Korbinian, Schnitzkewitz, J., Knuhtsen, A., Pedersen, D. S., Rades, Thomas & Grohganz, Holger, 1 Jan 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 134, p. 68-76 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Dissolution properties of co-amorphous drug-amino acid formulations in buffer and biorelevant media

    Heikkinen, A. T., DeClerck, L., Löbmann, Korbinian, Grohganz, Holger, Rades, Thomas & Laitinen, R., Jul 2015, In: Pharmazie. 70, 7, p. 452-457 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Effects of polymer addition on the non-strongly interacting binary co-amorphous system carvedilol-tryptophan

    Wang, Y., Grohganz, Holger & Rades, Thomas, 2022, In: International Journal of Pharmaceutics. 617, 9 p., 121625.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Efflux Inhibitor Bicalutamide Increases Oral Bioavailability of the Poorly Soluble Efflux Substrate Docetaxel in Co-Amorphous Anti-Cancer Combination Therapy

    Bohr, A., Nascimento, T. L., Harmankaya, N., Weisser, J. J., Wang, Y., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, 2019, In: Molecules. 24, 2, 13 p., 266.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Emerging trends in the stabilization of amorphous drugs

    Laitinen, R., Löbmann, Korbinian, Strachan, C. J., Grohganz, Holger & Rades, Thomas, 30 Aug 2013, In: International Journal of Pharmaceutics. 453, 1, p. 65-79 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Erratum to: Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy

    Maltesen, M. J., van de Weert, Marco & Grohganz, Holger, 21 Feb 2013, In: A A P S PharmSciTech. 14, 2, p. 901 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  42. Published

    Exploring the chemical space for freeze-drying excipients

    Meng-Lund, H., Holm, T. P., Poso, A., Jørgensen, Lene, Rantanen, Jukka & Grohganz, Holger, 2019, In: International Journal of Pharmaceutics. 566, p. 254-263 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Formation mechanism of coamorphous drug−amino acid mixtures

    Jensen, K. B. T., Larsen, F. H., Cornett, Claus, Löbmann, Korbinian, Grohganz, Holger & Rades, Thomas, 2015, In: Molecular Pharmaceutics. 12, 7, p. 2484−2492 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Formation of mannitol hemihydrate in freeze-dried protein formulations-A design of experiment approach

    Larsen, H. M. L., Trnka, H. & Grohganz, Holger, 2 Jan 2014, In: International Journal of Pharmaceutics. 460, 1-2, p. 45-52 8 p.

    Research output: Contribution to journal › Journal article › Research

  45. Published

    Formulating Amorphous Drug Delivery System Using Low-Molecular-Weight Components as Stabilizers

    Löbmann, Korbinian, Laitinen, R., Grohganz, Holger & Rades, Thomas, 2014, In: CRS Newsletter. 31, 3, p. 16-17

    Research output: Contribution to journal › Journal article › Communication

  46. Published

    Formulation of co-amorphous systems from naproxen and naproxen sodium and in situ monitoring of physicochemical state changes during dissolution testing by Raman spectroscopy

    Ueda, H., Bøtker, Johan Peter, Edinger, M., Löbmann, Korbinian, Grohganz, Holger, Mullertz, Anette , Rades, Thomas & Østergaard, Jesper, 2020, In: International Journal of Pharmaceutics. 587, 119662.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Fuzzy Logic-based expert system for evaluating cake quality of freeze-dried formulations

    Trnka, H., Wu, J., van de Weert, Marco, Grohganz, Holger & Rantanen, Jukka, Dec 2013, In: Journal of Pharmaceutical Sciences. 102, 12, p. 4364-74 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Glass forming ability of amorphous drugs investigated by continuous cooling- and isothermal transformation

    Blaabjerg, L. I., Lindenberg, E., Löbmann, Korbinian, Grohganz, Holger & Rades, Thomas, 2016, In: Molecular Pharmaceutics. 13, 9, p. 3318-3325 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Glass solution formation in water - In situ amorphization of naproxen and ibuprofen with Eudragit® E PO

    Doreth, M., Löbmann, Korbinian, Grohganz, Holger, Holm, R., Lopez De Diego, H., Rades, Thomas & Priemel, P. A., 1 Feb 2016, In: Journal of Drug Delivery Science and Technology. 34, p. 32–40 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Glass-Transition Temperature of the β-Relaxation as the Major Predictive Parameter for Recrystallization of Neat Amorphous Drugs

    Kissi, E. O., Grohganz, Holger, Löbmann, Korbinian, Ruggiero, M. T., Zeitler, J. A. & Rades, Thomas, 15 Mar 2018, In: Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 122, 10, p. 2803-2808 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    INFLUENCE OF THE COOLING RATE AND THE BLEND RATIO ON THE PHYSICAL STABILTIY OF CO-AMORPHOUS NAPROXEN/INDOMETHACIN

    Beyer, A., Grohganz, Holger, Löbmann, Korbinian, Rades, Thomas & Leopold, C. S., 13 Oct 2016, In: European Journal of Pharmaceutics and Biopharmaceutics. 109, p. 140-148 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Impact of Molecular Surface Diffusion on the Physical Stability of Co-Amorphous Systems

    Liu, J., Hwu, E., Bannow, J., Grohganz, Holger & Rades, Thomas, 2022, In: Molecular Pharmaceutics. 19, 4, p. 1183-1190

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Improvement of the physicochemical properties of Co-amorphous naproxen-indomethacin by naproxen-sodium

    Beyer, A., Grohganz, Holger, Löbmann, Korbinian, Rades, Thomas & Leopold, C. S., 30 Jun 2017, In: International Journal of Pharmaceutics. 526, 1-2, p. 88-94 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Improving co-amorphous drug formulations by the addition of the highly water soluble amino acid proline

    Jensen, K. B. T., Löbmann, Korbinian, Rades, Thomas & Grohganz, Holger, 2014, In: Pharmaceutics. 6, 3, p. 416-435 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    In situ amorphisation of indomethacin with Eudragit® E during dissolution

    Priemel, P. A., Laitinen, R., Grohganz, Holger, Rades, Thomas & Strachan, C. J., Nov 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 3 Pt B, p. 1259-65 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    In situ co-amorphisation in coated tablets – The combination of carvedilol with aspartic acid during immersion in an acidic medium

    Petry, I., Löbmann, Korbinian, Grohganz, Holger, Rades, Thomas & Leopold, C. S., 10 Mar 2019, In: International Journal of Pharmaceutics. 558, p. 357-366 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    In situ co-amorphisation of arginine with indomethacin or furosemide during immersion in an acidic medium – A proof of concept study

    Petry, I., Löbmann, Korbinian, Grohganz, Holger, Rades, Thomas & Leopold, C. S., 1 Dec 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 133, p. 151-160 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    In vitro and in vivo comparison between crystalline and co-amorphous salts of naproxen-arginine

    Kasten, G., Lobo, L., Dengale, S., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, 1 Nov 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 132, p. 192-199 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Influence of Glass Forming Ability on the Physical Stability of Supersaturated Amorphous Solid Dispersions

    Blaabjerg, L. I., Bulduk, B., Lindenberg, E., Löbmann, Korbinian, Rades, Thomas & Grohganz, Holger, 1 Jan 2019, In: Journal of Pharmaceutical Sciences. 108, 8, p. 2561-2569

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    Influence of PVP molecular weight on the microwave assisted in situ amorphization of indomethacin

    Doreth, M., Löbmann, Korbinian, Priemel, P., Grohganz, Holger, Taylor, R., Holm, R., Lopez de Diego, H. & Rades, Thomas, Jan 2018, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 122, p. 62-69

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    Influence of Solvent Composition on the Performance of Spray-Dried Co-Amorphous Formulations

    Mishra, J., Rades, Thomas, Löbmann, Korbinian & Grohganz, Holger, 12 Apr 2018, In: Pharmaceutics. 10, 2, p. 1-13

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. Published

    Influence of Water on Amorphous Lidocaine

    Xu, X., Grohganz, Holger & Rades, Thomas, 2022, In: Molecular Pharmaceutics. 19, 9, p. 3199–3205

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Influence of polymer addition on the amorphization, dissolution and physical stability of co-amorphous systems

    Liu, J., Grohganz, Holger & Rades, Thomas, 2020, In: International Journal of Pharmaceutics. 588, p. 1-9 9 p., 119768.

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Influence of preparation pathway on the glass forming ability

    Blaabjerg, L. I., Lindenberg, E., Rades, Thomas, Grohganz, Holger & Löbmann, Korbinian, 21 Apr 2017, In: International Journal of Pharmaceutics. 521, 1-2, p. 232-238

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. Published

    Influence of preparation technique on co-amorphization of carvedilol with acidic amino acids

    Mishra, J., Löbmann, Korbinian, Grohganz, Holger & Rades, Thomas, 1 Dec 2018, In: International Journal of Pharmaceutics. 552, 1-2, p. 407-413

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    Influence of variation in molar ratio on co-amorphous drug-amino acid systems

    Jensen, K. B. T., Larsen, F. H., Löbmann, Korbinian, Rades, Thomas & Grohganz, Holger, 2016, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 107, p. 32-39 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Influence of water and trehalose on α- and β-relaxation of freeze-dried lysozyme formulations

    Vallaster, B., Engelsing, F. & Grohganz, Holger, 2024, In: European Journal of Pharmaceutics and Biopharmaceutics. 194, p. 1-8

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. Published

    Inhibition of surface crystallisation of amorphous indomethacin particles in physical drug-polymer mixtures

    Priemel, P. A., Laitinen, R., Barthold, S., Grohganz, Holger, Lehto, V., Rades, Thomas & Strachan, C. J., 18 Nov 2013, In: International Journal of Pharmaceutics. 456, 2, p. 301-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    Interaction of liposomes with bile salts investigated by asymmetric flow field-flow fractionation (AF4): A novel approach for stability assessment of oral drug carriers

    Bohsen, M. S., Tychsen, S. T., Kadhim, A. A. H., Grohganz, Holger, Treusch, A. H. & Brandl, M., 2023, In: European Journal of Pharmaceutical Sciences. 182, 10 p., 106384.

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. Published

    Investigation of physical properties and stability of indomethacin-cimetidine and naproxen-cimetidine co-amorphous systems prepared by quench cooling, coprecipitation and ball milling

    Lim, A. W., Löbmann, Korbinian, Grohganz, Holger, Rades, Thomas & Chieng, N., Jan 2016, In: Journal of Pharmacy and Pharmacology. 68, 1, p. 36-45 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  71. Published

    Is there a correlation between the glass forming ability of a drug and its supersaturation propensity?

    Blaabjerg, L. I., Lindenberg, E., Löbmann, Korbinian, Grohganz, Holger & Rades, Thomas, 1 Mar 2018, In: International Journal of Pharmaceutics. 538, 1-2, p. 243-249

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    Large-scale biophysical evaluation of protein PEGylation effects: in vitro properties of 61 protein entities

    Vernet, E., Popa, G., Pozdnyakova, I., Rasmussen, J. E., Grohganz, Holger, Giehm, L., Jensen, M. H., Wang, H., Plesner, B., Nielsen, Hanne Mørck, Jensen, Knud Jørgen, Berthelsen, J., Sundström, M. & van de Weert, Marco, 2016, In: Molecular Pharmaceutics. 13, 5, p. 1587-1598 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. Published

    Molecular interactions of hydrated co-amorphous systems of prilocaine and lidocaine

    Xu, X., Rades, Thomas & Grohganz, Holger, 2024, In: International Journal of Pharmaceutics. 651, 7 p., 123807.

    Research output: Contribution to journal › Journal article › Research › peer-review

  74. Published

    Multivariate Quantification of the Solid State Phase Composition of Co-Amorphous Naproxen-Indomethacin

    Beyer, A., Grohganz, Holger, Löbmann, Korbinian, Rades, Thomas & Leopold, C. S., 2015, In: Molecules. 20, 10, p. 19571-87 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  75. Published

    Multivariate analysis of phenol in freeze-dried and spray-dried insulin formulations by NIR and FTIR

    Maltesen, M. J., Bjerregaard, S., Hovgaard, L., Havelund, S., van de Weert, Marco & Grohganz, Holger, 2011, In: A A P S PharmSciTech. 12, 2, p. 627-635

    Research output: Contribution to journal › Journal article › Research › peer-review

  76. Published

    Near-Infrared Imaging for High-Throughput Screening of Moisture-Induced Changes in Freeze-Dried Formulations

    Trnka, H., Palou, A., Panouillot, P. E., Kauppinen, A., Toiviainen, M., Grohganz, Holger, Alcalà, M., Juuti, M., Ketolainen, J. & Rantanen, Jukka, 24 Mar 2014, In: Journal of Pharmaceutical Sciences. 103, 9, p. 2839–2846 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. Published

    Near-infrared (NIR) spectroscopy – a versatile tool for pharmaceutical research and production

    Grohganz, Holger, 2011, In: European Pharmaceutical Review. 16, 2, p. 57-60

    Research output: Contribution to journal › Journal article › Communication

  78. Published

    On the role of salt formation and structural similarity of co-formers in co-amorphous drug delivery systems

    Wu, W., Löbmann, Korbinian, Rades, Thomas & Grohganz, Holger, 15 Jan 2018, In: International Journal of Pharmaceutics. 535, 1-2, p. 86-94

    Research output: Contribution to journal › Journal article › Research › peer-review

  79. Published

    Ordnung muss (nicht) sein

    Löbmann, Korbinian, Jensen, K. B. T., Grohganz, Holger & Rades, Thomas, 2012, In: Lægemiddelforskning. 2012, p. 34-36

    Research output: Contribution to journal › Journal article › Communication

  80. Published

    Organic acids as co-formers for co-amorphous systems - Influence of variation in molar ratio on the physicochemical properties of the co-amorphous systems

    Wu, W., Ueda, H., Lobmann, K., Rades, Thomas & Grohganz, Holger, Oct 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 131, p. 25-32

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    Performance comparison between crystalline and co-amorphous salts of indomethacin-lysine

    Kasten, G., Nouri, K., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, 25 Nov 2017, In: International Journal of Pharmaceutics. 533, 1, p. 138-144 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  82. Published

    Predictive identification of co-formers in co-amorphous systems

    Chambers, L. I., Grohganz, Holger, Palmelund, H., Löbmann, Korbinian, Rades, Thomas, Musa, O. M. & Steed, J. W., 2021, In: European Journal of Pharmaceutical Sciences. 157, 9 p., 105636.

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    Preparation and characterization of spray-dried co-amorphous drug-amino acid salts

    Jensen, K. B. T., Blaabjerg, L. I., Lenz, E., Bohr, A., Grohganz, Holger, Kleinebudde, P., Rades, Thomas & Löbmann, Korbinian, May 2016, In: The Journal of pharmacy and pharmacology. 68, 5, p. 615–624 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  84. Published

    Preparation and recrystallization behavior of spray-dried co-amorphous naproxen-indomethacin

    Beyer, A., Radi, L., Grohganz, Holger, Löbmann, Korbinian, Rades, Thomas & Leopold, C. S., Jul 2016, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 104, p. 72-81 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    Preparation of Co-Amorphous Levofloxacin Systems for Pulmonary Application

    Gabelmann, A., Lehr, C. M. & Grohganz, Holger, 2023, In: Pharmaceutics. 15, 6, 15 p., 1574.

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    Preparation of Co-Amorphous Systems by Freeze-Drying

    Wostry, M., Plappert, H. & Grohganz, Holger, 2020, In: Pharmaceutics. 12, 10, 12 p., 941.

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    Probing Pharmaceutical Mixtures during Milling: The Potency of Low-Frequency Raman Spectroscopy in Identifying Disorder

    Walker, G., Römann, P., Poller, B., Löbmann, Korbinian, Grohganz, Holger, Rooney, J. S., Huff, G. S., Smith, G. P. S., Rades, Thomas, Gordon, K. C., Strachan, C. J. & Fraser-Miller, S. J., 2017, In: Molecular Pharmaceutics. 14, 12, p. 4675-4684 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. Published

    Process Optimization and Upscaling of Spray-Dried Drug-Amino acid Co-Amorphous Formulations

    Kasten, G., Duarte, Í., Paisana, M., Löbmann, Korbinian, Rades, Thomas & Grohganz, Holger, 9 Jan 2019, In: Pharmaceutics. 11, 1, 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. Published

    Properties of the Sodium Naproxen-Lactose-Tetrahydrate Co-Crystal upon Processing and Storage

    Sovago, I., Wang, W., Qiu, D., Raijada, D. K., Rantanen, Jukka, Grohganz, Holger, Rades, Thomas, Bond, A. D. & Löbmann, Korbinian, 2016, In: Molecules. 21, 4, p. 1-13 13 p., 509.

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    Quality by design approach in the optimization of the spray-drying process

    Baldinger, A., Clerdent, L., Rantanen, Jukka, Yang, Mingshi & Grohganz, Holger, 2012, In: Pharmaceutical Development and Technology. 17, 4, p. 389-397

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Published

    Rapid solid-state analysis of freeze-dried protein formulations using NIR and raman spectroscopies

    Grohganz, Holger, Gildemyn, D., Skibsted, E., Flink, J. M. & Rantanen, Jukka, 2011, In: Journal of Pharmaceutical Sciences. 100, 7

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    Recent advances in co-amorphous drug formulations

    Dengale, S. J., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, 1 May 2016, In: Advanced Drug Delivery Reviews. 100, p. 116-125 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    Recent trends in stabilising peptides and proteins in pharmaceutical formulation - considerations in the choice of excipients

    Jørgensen, Lene, Hostrup, S., Møller, E. H. & Grohganz, Holger, 2009, In: Expert Opinion on Drug Delivery. 6, 11, p. 1219-1230

    Research output: Contribution to journal › Review › Research

  94. Published

    Refining stability and dissolution rate of amorphous drug formulations

    Grohganz, Holger, Priemel, P. A., Löbmann, Korbinian, Nielsen, L. H., Laitinen, R., Mullertz, Anette , Van den Mooter, G. & Rades, Thomas, Jun 2014, In: Expert Opinion on Drug Delivery. 11, 6, p. 977-89 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    Role of excipients in the quantification of water in lyophilised mixtures using NIR spectroscopy

    Grohganz, Holger, Fonteyne, M., Skibsted, E., Falck, T., Palmqvist, B. & Rantanen, Jukka, 2009, In: Journal of Pharmaceutical and Biomedical Analysis. 49, p. 901-907

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. Published

    Role of polymeric excipients in the stabilization of olanzapine when exposed to aqueous environments

    Paisana, M., Wahl, M., Pinto, J., Rades, Thomas (ed.), Grohganz, Holger (ed.) & Löbmann, Korbinian (ed.), 2015, In: Molecules. 20, 12, p. 22634-223282 200649.

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    Screening of novel excipients for freeze-dried protein formulations

    Holm, T. P., Meng-Lund, H., Rantanen, Jukka, Jørgensen, Lene & Grohganz, Holger, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 160, p. 55-64 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    Solid state properties and drug release behavior of co-amorphous indomethacin-arginine tablets coated with Kollicoat® Protect

    Petry, I., Löbmann, Korbinian, Grohganz, Holger, Rades, Thomas & Leopold, C. S., Oct 2017, In: European Journal of Pharmaceutics and Biopharmaceutics. 119, p. 150-160 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Published

    Solid-state properties and dissolution behaviour of tablets containing co-amorphous indomethacin-arginine

    Lenz, E., Jensen, K. B. T., Blaabjerg, L. I., Knop, K., Grohganz, Holger, Löbmann, Korbinian, Rades, Thomas & Kleinebudde, P., Oct 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 96, p. 44–52 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  100. Published

    Solvent free amorphisation for pediatric formulations (minitablets) using mesoporous silica

    Monsuur, F., Choudhari, Y., Reddy, U., McCarthy, W., Sadek, I., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, 25 Sep 2016, In: International Journal of Pharmaceutics. 511, 2, p. 1135-1136

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

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