Holger Grohganz
Associate Professor
Solid State Pharmaceutics
Universitetsparken 2, 2100 København Ø
Pharmaceuticals, processes and products
Universitetsparken 2
2100 København Ø
- 2024
- Published
Anti-plasticizing effect of water on prilocaine and lidocaine: the role of the hydrogen bonding pattern
Xu, X., Grohganz, Holger & Rades, Thomas, 2024, In: Physical Chemistry Chemical Physics. 26, p. 14149-14159Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Coaxial electrospinning of polycaprolactone: A design of experiments approach
Gürtler, Anna-Lena, Linseisen, I., Grohganz, Holger & Heinz, Andrea, 2024, In: European Polymer Journal. 208, 11 p., 112886.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Destabilization of Indomethacin-Paracetamol Co-Amorphous Systems by Mechanical Stress
Di, Rong, Grohganz, Holger & Rades, Thomas, 2024, In: Pharmaceutics. 16, 15 p., 67.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Influence of water and trehalose on α- and β-relaxation of freeze-dried lysozyme formulations
Vallaster, B., Engelsing, F. & Grohganz, Holger, 2024, In: European Journal of Pharmaceutics and Biopharmaceutics. 194, p. 1-8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular interactions of hydrated co-amorphous systems of prilocaine and lidocaine
Xu, X., Rades, Thomas & Grohganz, Holger, 2024, In: International Journal of Pharmaceutics. 651, 7 p., 123807.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The interplay between trehalose and dextran as spray drying precursors for cationic liposomes
Lutta, A., Knopp, Matthias Manne, Tollemeto, M., Pedersen, Gabriel Kristian, Schmidt, S. T., Grohganz, Holger & Hagner Nielsen, L., 2024, In: International Journal of Pharmaceutics. 652, 10 p., 123798.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Utilizing the allyl-terminated copolymer methoxy(poly(ethylene glycol))-block-poly(jasmine lactone) in the development of amorphous solid dispersions: A comparative study of functionalized and non-functionalized polymer
Di, Rong, Bansal, K. K., Rosenholm, J. M., Grohganz, Holger & Rades, Thomas, 2024, In: International Journal of Pharmaceutics. 657, 12 p., 124175.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Compaction Behavior of Co-Amorphous Systems
Sørensen, C. M., Rantanen, Jukka & Grohganz, Holger, 2023, In: Pharmaceutics. 15, 3, 12 p., 858.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Considerations on the Kinetic Processes in the Preparation of Ternary Co-Amorphous Systems by Milling
Wang, Y., Rades, Thomas & Grohganz, Holger, 2023, In: Pharmaceutics. 15, 1, 14 p., 172.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design of experiments approach on the compaction properties of co-amorphous tablets
Engelsing, F., Buchart, L. & Grohganz, Holger, 2023, In: Pharmaceutical Development and Technology. 28, 9, p. 907-914Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction of liposomes with bile salts investigated by asymmetric flow field-flow fractionation (AF4): A novel approach for stability assessment of oral drug carriers
Bohsen, M. S., Tychsen, S. T., Kadhim, A. A. H., Grohganz, Holger, Treusch, A. H. & Brandl, M., 2023, In: European Journal of Pharmaceutical Sciences. 182, 10 p., 106384.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preparation of Co-Amorphous Levofloxacin Systems for Pulmonary Application
Gabelmann, A., Lehr, C. M. & Grohganz, Holger, 2023, In: Pharmaceutics. 15, 6, 15 p., 1574.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Thermal investigation on hydrated co-amorphous systems of nicotinamide and prilocaine
Xu, X., Rades, Thomas & Grohganz, Holger, 2023, In: European Journal of Pharmaceutics and Biopharmaceutics. 186, p. 1-6Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Wet granulation of co-amorphous indomethacin systems
Schütz, D., Timmerhaus, A. & Grohganz, Holger, 2023, In: International Journal of Pharmaceutics. 644, 9 p., 123318.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Effects of polymer addition on the non-strongly interacting binary co-amorphous system carvedilol-tryptophan
Wang, Y., Grohganz, Holger & Rades, Thomas, 2022, In: International Journal of Pharmaceutics. 617, 9 p., 121625.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of Molecular Surface Diffusion on the Physical Stability of Co-Amorphous Systems
Liu, J., Hwu, E., Bannow, J., Grohganz, Holger & Rades, Thomas, 2022, In: Molecular Pharmaceutics. 19, 4, p. 1183-1190Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Influence of Water on Amorphous Lidocaine
Xu, X., Grohganz, Holger & Rades, Thomas, 2022, In: Molecular Pharmaceutics. 19, 9, p. 3199–3205Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
A Multivariate Approach for the Determination of the Optimal Mixing Ratio of the Non-Strong Interacting Co-Amorphous System Carvedilol-Tryptophan
Di, Rong, Liu, J., Grohganz, Holger & Rades, Thomas, 2021, In: Molecules. 26, 4, 8 p., 801.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Co-Amorphous Drug Formulations in Numbers: Recent Advances in Co-Amorphous Drug Formulations with Focus on Co-Formability, Molar Ratio, Preparation Methods, Physical Stability, In Vitro and In Vivo Performance, and New Formulation Strategies
Liu, J., Grohganz, Holger, Löbmann, Korbinian, Rades, Thomas & Hempel, N., 2021, In: Pharmaceutics. 13, 3, 43 p., 389.Research output: Contribution to journal › Review › Research
- Published
Comparison of co-former performance in co-amorphous formulations: Single amino acids, amino acid physical mixtures, amino acid salts and dipeptides as co-formers
Wu, W., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, 2021, In: European Journal of Pharmaceutical Sciences. 156, 8 p., 105582.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Predictive identification of co-formers in co-amorphous systems
Chambers, L. I., Grohganz, Holger, Palmelund, H., Löbmann, Korbinian, Rades, Thomas, Musa, O. M. & Steed, J. W., 2021, In: European Journal of Pharmaceutical Sciences. 157, 9 p., 105636.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Screening of novel excipients for freeze-dried protein formulations
Holm, T. P., Meng-Lund, H., Rantanen, Jukka, Jørgensen, Lene & Grohganz, Holger, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 160, p. 55-64 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The influence of moisture on the storage stability of co-amorphous systems
Liu, J., Rades, Thomas & Grohganz, Holger, 2021, In: International Journal of Pharmaceutics. 605, 120802.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Determination of the Optimal Molar Ratio in Amino Acid-Based Coamorphous Systems
Liu, J., Rades, Thomas & Grohganz, Holger, 2020, In: Molecular Pharmaceutics. 17, 4, p. 1335-1342 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Formulation of co-amorphous systems from naproxen and naproxen sodium and in situ monitoring of physicochemical state changes during dissolution testing by Raman spectroscopy
Ueda, H., Bøtker, Johan Peter, Edinger, M., Löbmann, Korbinian, Grohganz, Holger, Mullertz, Anette , Rades, Thomas & Østergaard, Jesper, 2020, In: International Journal of Pharmaceutics. 587, 119662.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Influence of polymer addition on the amorphization, dissolution and physical stability of co-amorphous systems
Liu, J., Grohganz, Holger & Rades, Thomas, 2020, In: International Journal of Pharmaceutics. 588, p. 1-9 9 p., 119768.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preparation of Co-Amorphous Systems by Freeze-Drying
Wostry, M., Plappert, H. & Grohganz, Holger, 2020, In: Pharmaceutics. 12, 10, 12 p., 941.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
In situ co-amorphisation in coated tablets – The combination of carvedilol with aspartic acid during immersion in an acidic medium
Petry, I., Löbmann, Korbinian, Grohganz, Holger, Rades, Thomas & Leopold, C. S., 10 Mar 2019, In: International Journal of Pharmaceutics. 558, p. 357-366 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transformations between Co-Amorphous and Co-Crystal Systems and Their Influence on the Formation and Physical Stability of Co-Amorphous Systems
Wu, W., Wang, Y., Löbmann, Korbinian, Grohganz, Holger & Rades, Thomas, 4 Mar 2019, In: Molecular Pharmaceutics. 16, 3, p. 1294-1304 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Whey proteins as stabilizers in amorphous solid dispersions
Mishra, J., Bohr, A., Rades, Thomas, Grohganz, Holger & Löbmann, Korbinian, 1 Feb 2019, In: European Journal of Pharmaceutical Sciences. 128, p. 144-151 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Process Optimization and Upscaling of Spray-Dried Drug-Amino acid Co-Amorphous Formulations
Kasten, G., Duarte, Í., Paisana, M., Löbmann, Korbinian, Rades, Thomas & Grohganz, Holger, 9 Jan 2019, In: Pharmaceutics. 11, 1, 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterising glass transition temperatures and glass dynamics in mesoporous silica-based amorphous drugs
Kissi, E. O., Ruggiero, M. T., Hempel, N. J., Song, Z., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, 1 Jan 2019, In: Physical Chemistry Chemical Physics. 21, 35, p. 19686-19694 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dipeptides as co-formers in co-amorphous systems
Wu, W., Löbmann, Korbinian, Schnitzkewitz, J., Knuhtsen, A., Pedersen, D. S., Rades, Thomas & Grohganz, Holger, 1 Jan 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 134, p. 68-76 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Influence of Glass Forming Ability on the Physical Stability of Supersaturated Amorphous Solid Dispersions
Blaabjerg, L. I., Bulduk, B., Lindenberg, E., Löbmann, Korbinian, Rades, Thomas & Grohganz, Holger, 1 Jan 2019, In: Journal of Pharmaceutical Sciences. 108, 8, p. 2561-2569Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A co-amorphous form of a substance and a protein
Mishra, J., Bohr, A., Berg, T. H. A., Löbmann, Korbinian, Rades, Thomas, Grohganz, Holger & Water, J. J., 2019, Patent No. US201903078886A1Research output: Patent
- Published
Co-former selection for co-amorphous drug-amino acid formulations
Kasten, G., Löbmann, Korbinian, Grohganz, Holger & Rades, Thomas, 2019, In: International Journal of Pharmaceutics. 557, p. 366-373Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efflux Inhibitor Bicalutamide Increases Oral Bioavailability of the Poorly Soluble Efflux Substrate Docetaxel in Co-Amorphous Anti-Cancer Combination Therapy
Bohr, A., Nascimento, T. L., Harmankaya, N., Weisser, J. J., Wang, Y., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, 2019, In: Molecules. 24, 2, 13 p., 266.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploring the chemical space for freeze-drying excipients
Meng-Lund, H., Holm, T. P., Poso, A., Jørgensen, Lene, Rantanen, Jukka & Grohganz, Holger, 2019, In: International Journal of Pharmaceutics. 566, p. 254-263 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Using dextran of different molecular weights to achieve faster freeze-drying and improved storage stability of lactate dehydrogenase
Larsen, B. S., Skytte, J., Svagan, A. J., Meng-Lund, H., Grohganz, Holger & Löbmann, Korbinian, 2019, In: Pharmaceutical Development and Technology. 24, 3, p. 323-328Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
In situ co-amorphisation of arginine with indomethacin or furosemide during immersion in an acidic medium – A proof of concept study
Petry, I., Löbmann, Korbinian, Grohganz, Holger, Rades, Thomas & Leopold, C. S., 1 Dec 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 133, p. 151-160 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Influence of preparation technique on co-amorphization of carvedilol with acidic amino acids
Mishra, J., Löbmann, Korbinian, Grohganz, Holger & Rades, Thomas, 1 Dec 2018, In: International Journal of Pharmaceutics. 552, 1-2, p. 407-413Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vitro and in vivo comparison between crystalline and co-amorphous salts of naproxen-arginine
Kasten, G., Lobo, L., Dengale, S., Grohganz, Holger, Rades, Thomas & Löbmann, Korbinian, 1 Nov 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 132, p. 192-199 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aspartame as a co-former in co-amorphous systems
Wu, W., Löbmann, Korbinian, Schnitzkewitz, J., Knuhtsen, A., Pedersen, D. S., Grohganz, Holger & Rades, Thomas, 5 Oct 2018, In: International Journal of Pharmaceutics. 549, 1-2, p. 380-387Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Organic acids as co-formers for co-amorphous systems - Influence of variation in molar ratio on the physicochemical properties of the co-amorphous systems
Wu, W., Ueda, H., Lobmann, K., Rades, Thomas & Grohganz, Holger, Oct 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 131, p. 25-32Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers
Blaabjerg, L. I., Grohganz, Holger, Lindenberg, E., Löbmann, Korbinian, Mullertz, Anette & Rades, Thomas, 21 Sep 2018, In: Pharmaceutics. 10, 4, 14 p., 164.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Role of Glass Transition Temperatures in Coamorphous Drug-Amino Acid Formulations
Kissi, E. O., Kasten, G., Löbmann, Korbinian, Rades, Thomas & Grohganz, Holger, 4 Sep 2018, In: Molecular Pharmaceutics. 15, 9, p. 4247–4256Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The use of molecular descriptors in the development of co-amorphous formulations
Meng-Lund, H. M. L., Korgaard, G. K., Jensen, K. B. T., Poso, A., Pantsar, T., Rades, Thomas, Rantanen, Jukka & Grohganz, Holger, 1 Jul 2018, In: European Journal of Pharmaceutical Sciences. 119, p. 31 38 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine
Ueda, H., Wu, W., Löbmann, Korbinian, Grohganz, Holger, Mullertz, Anette & Rades, Thomas, May 2018, In: Molecular Pharmaceutics. 15, 5, p. 2036-2044Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Influence of Solvent Composition on the Performance of Spray-Dried Co-Amorphous Formulations
Mishra, J., Rades, Thomas, Löbmann, Korbinian & Grohganz, Holger, 12 Apr 2018, In: Pharmaceutics. 10, 2, p. 1-13Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glass-Transition Temperature of the β-Relaxation as the Major Predictive Parameter for Recrystallization of Neat Amorphous Drugs
Kissi, E. O., Grohganz, Holger, Löbmann, Korbinian, Ruggiero, M. T., Zeitler, J. A. & Rades, Thomas, 15 Mar 2018, In: Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 122, 10, p. 2803-2808 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1421411
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The significance of the amorphous potential energy landscape for dictating glassy dynamics and driving solid-state crystallisation
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
204
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Influence of Solvent Composition on the Performance of Spray-Dried Co-Amorphous Formulations
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
157
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The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers
Research output: Contribution to journal › Journal article › Research › peer-review
Published