Birgitte Holst

Birgitte Holst

Guest Researcher


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  1. Published

    FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver

    von Holstein-Rathlou, S., BonDurant, L. D., Peltekian, L., Naber, M. C., Yin, T. C., Claflin, K. E., Urizar, A. I., Madsen, A. N., Ratner, C., Holst, B., Karstoft, K., Vandenbeuch, A., Anderson, C. B., Cassell, M. D., Thompson, A. P., Solomon, T. P., Rahmouni, K., Kinnamon, S. C., Pieper, A. A., Gillum, M. P. & 1 others, Potthoff, M. J., 9 Feb 2016, In: Cell Metabolism. 23, 2, p. 335-43 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Ablation of Nampt in AgRP neurons leads to neurodegeneration and impairs fasting- and ghrelin-mediated food intake

    de Guia, R. M., Hassing, Anna Skab, Ma, Tao, Plucinska, Kaja, Holst, Birgitte, Gerhart-Hines, Zach, Emanuelli, Brice & Treebak, Jonas Thue, 2021, In: F A S E B Journal. 35, 5, e21450.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Fasting- and ghrelin-induced food intake is regulated by NAMPT in the hypothalamus

    de Guia, R. M., Hassing, Anna Skab, Skov, Louise Julie, Ratner, C., Plucinska, Kaja, Madsen, S., Diep, T. A., dela Cruz, Gelo, Trammell, Sam, Sustarsic, E. G., Emanuelli, Brice, Gillum, M. P., Gerhart-Hines, Zach, Holst, Birgitte & Treebak, Jonas Thue, 2020, In: Acta Physiologica. 228, 4

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Estrous Cycle Modulation of Feeding and Relaxin-3/Rxfp3 mRNA Expression: Implications for Estradiol Action

    de Avila, C., Chometton, S., Calvez, J., Guevremont, G., Kania, A., Pedersen, Lola Julie Torz, Lenglos, C., Blasiak, A., Rosenkilde, Mette, Holst, Birgitte, Conrad, C. D., Fyer, J. D., Timofeeva, E., Gundlach, A. L. & Cifani, C., 2021, In: Neuroendocrinology. 111, 12, p. 1201–1218

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice

    Wellner, N., Tsuboi, K., Madsen, A. N., Holst, Birgitte, Diep, T. A., Nakao, M., Tokumura, A., Burns, M. P., Deutsch, D. G., Ueda, N. & Hansen, Harald S., 1 Sep 2011, In: BBA General Subjects. 1811, 9, p. 508-12 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population

    Vestmar, M. A., Galijatovic, E. A. A., Christensen, C. R., Pedersen, M. H., Glümer, C., Linneberg, Allan René, Witte, D. R., Jørgensen, M. E., Christensen, C., Brandslund, I., Lauritzen, T., Pedersen, Oluf Borbye, Holst, Birgitte, Grarup, Niels, Schwartz, Thue W. & Hansen, Torben, Sep 2016, In: Journal of Medical Genetics. 53, 9, p. 616-23 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation

    Valentin-Hansen, L., Holst, Birgitte, Frimurer, Thomas Michael, Schwartz, Thue W. & Hansen, L. V., 21 Dec 2012, In: Journal of Biological Chemistry. 287, 52, p. 43516-43526 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Metabolic insights from a GHSR-A203E mutant mouse model

    Pedersen, Lola Julie Torz, Osborne-Lawrence, S., Rodriguez, J., He, Z., Paula Cornejo, M., Roman Mustafa, E., Jin, C., Petersen, N., Hedegaard, M. A., Nybo, Maja Lind, Martinez Damonte, V., Metzger, N. P., Mani, B. K., Williams, K. W., Raingo, J., Perello, M., Holst, Birgitte & Zigman, J. M., 2020, In: Molecular Metabolism. 39, 16 p., 101004.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice

    Thieme, V., Jolly, N., Madsen, A. N., Bellmann-Sickert, K., Schwartz, Thue W., Holst, Birgitte, Cox, H. M. & Beck-Sickinger, A. G., Nov 2016, In: British Journal of Pharmacology. 173, 22, p. 3208-3221 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Physiological and Pathological Impact of Blood Sampling by Retro-Bulbar Sinus Puncture and Facial Vein Phlebotomy in Laboratory Mice

    Teilmann, A. C., Nygaard Madsen, A., Holst, Birgitte, Hau, Jann, Rozell, B. & Abelson, Klas, 26 Nov 2014, In: PloS one. 9, 11, p. 1-19 19 p., e113225.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    New potential agents for cryopreservation of hematopoietic and adipose stromal cells

    Svalgaard, J., Haastrup, E., Brink, A., Clausen, C., Holst, Birgitte, Theilgaard-Mønch, Kim, Reckzeh, K. & Fischer-Nielsen, A., Apr 2014, In: Cytotherapy. 16, Supplement 4, p. S58

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  12. Published

    Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39

    Storjohann, L., Holst, Birgitte & Schwartz, Thue W., 2008, In: FEBS Letters. 582, 17, p. 2583-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39

    Storjohann, L., Holst, Birgitte & Schwartz, Thue W., 2008, In: Biochemistry. 47, 35, p. 9198-207 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Acute disruption of glucagon secretion or action does not improve glucose tolerance in an insulin-deficient mouse model of diabetes

    Steenberg, V. R., Jensen, S. M., Pedersen, Jens, Madsen, A. N., Windeløv, Johanne Agerlin, Holst, Birgitte, Quistorff, B., Poulsen, Steen Seier & Holst, Jens Juul, 2016, In: Diabetologia. 59, 2, p. 363-370 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    RhoA in tyrosine hydroxylase neurons regulates food intake and body weight via altered sensitivity to peripheral hormones

    Skov, Louise Julie, Ratner, C., Hansen, Nikolaj Winther, Thompson, J. J., Egerod, Kristoffer Lihme, Burm, Hayley Beth, Dalbøge, L. S., Hedegaard, M. A., Brakebusch, Cord Herbert, Pers, Tune H, Perrier, Jean-Francois Marie & Holst, Birgitte, 2019, In: Journal of Neuroendocrinology. 31, 7, 13 p., UNSP e12761.

    Research output: Contribution to journal › Conference article › Research › peer-review

  16. Published

    Exploring the Behavioral and Metabolic Phenotype Generated by Re-Introduction of the Ghrelin Receptor in the Ventral Tegmental Area

    Skov, Louise Julie, Jensen, M., Christiansen, S. H., Ratner, C., Woldbye, David Paul Drucker & Holst, Birgitte, 26 Apr 2017, In: International Journal of Molecular Sciences. 18, 5, 17 p., 914.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Unique interaction pattern for a functionally biased ghrelin receptor agonist

    Sivertsen, B. B., Lang, M., Frimurer, T. M., Holliday, N. D., Bach, Anders, Els, S., Engelstoft, M. S., Petersen, P. S., Madsen, A. N., Schwartz, Thue W., Beck-Sickinger, A. G. & Holst, Birgitte, 10 Jun 2011, In: The Journal of Biological Chemistry. 286, 23, p. 20845-20860 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Functionally biased signalling properties of 7TM receptors - opportunities for drug development for the ghrelin receptor

    Sivertsen, B., Holliday, N., Madsen, A. N. & Holst, Birgitte, Dec 2013, In: British Journal of Pharmacology. 170, 7, p. 1349-62 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    A systematic review and meta-analysis finds increased blood levels of all forms of ghrelin in both restricting and binge-eating/purging subtypes of anorexia nervosa

    Seidel, M., Jensen, S. M., Healy, D., Dureja, A., Watson, H. J., Holst, Birgitte, Bulik, C. M. & Sjögren, J. M., 2021, In: Nutrients. 13, 2, p. 1-19 19 p., 709.

    Research output: Contribution to journal › Review › Research › peer-review

  20. Published

    Risperidone treatment increases CB1 receptor binding in rat brain

    Secher, A., Husum, H., Holst, Birgitte, Egerod, Kristoffer Lihme & Mellerup, Erling Thyge, 2010, In: Neuroendocrinology. 91, 2, p. 155-68 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Molecular structure and function of 7TM/G-protein coupled receptors

    Schwartz, Thue W. & Holst, Birgitte, 2002, Textbook of receptor Pharmacology. p. 65-84

    Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research

  22. Published

    Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors

    Schwartz, Thue W. & Holst, Birgitte, 2006, In: Journal of Receptors and Signal Transduction. 26, 1-2, p. 107-28 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?

    Schwartz, Thue W. & Holst, Birgitte, 2007, In: TIPS - Trends in Pharmacological Sciences. 28, 8, p. 366-73 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Molecular mechanism of 7TM receptor activation--a global toggle switch model

    Schwartz, Thue W., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Elling, C. E., 2006, In: Annual Review of Pharmacology and Toxicology. 46, p. 481-519 38 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    An enteroendocrine full package solution

    Schwartz, Thue W. & Holst, Birgitte, 2010, In: Cell Metabolism. 11, 6, p. 445-7 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Ghrelin-mediated improvements in the metabolic phenotype in the R6/2 mouse model of Huntington's disease

    Rudenko, Olga, Springer, C., Skov, Louise Julie, Madsen, A. N., Hasholt, Lis Frydenreich, Nørremølle, Anne & Holst, Birgitte, 2019, In: Journal of Neuroendocrinology. 31, 7 (SI), 14 p., e12699.

    Research output: Contribution to journal › Conference article › Research › peer-review

  27. Published

    Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor

    Rosenkilde, Mette, Lucibello, M., Holst, Birgitte & Schwartz, Thue W., 1998, In: FEBS Letters. 439, 1-2, p. 35-40 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery

    Ratner, C., Skov, Louise Julie, Raida, Z., Bächler, T., Bellmann-Sickert, K., Le Foll, C., Sivertsen, B., Dalbøge, L. S., Hartmann, Bolette, Beck-Sickinger, A. G., Madsen, A. N., Jelsing, J., Holst, Jens Juul, Lutz, T. A., Andrews, Z. B. & Holst, Birgitte, Sep 2016, In: Endocrinology. 157, 9, p. 3482-92 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway

    Ratner, C., He, Z., Grunddal, Kaare Villum, Skov, Louise Julie, Hartmann, Bolette, Zhang, F., Feuchtinger, A., Bjerregaard, Anette, Christoffersen, Christina, Tschöp, M. H., Finan, B., DiMarchi, R. D., Leinninger, G. M., Williams, K. W., Clemmensen, Christoffer & Holst, Birgitte, 2019, In: Diabetes. 68, 6, p. 1329-1340

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Anorexia and fat aversion induced by vertical sleeve gastrectomy is attenuated in neurotensin receptor 1–Deficient mice

    Ratner, C., Shin, J. H., Dwibedi, C., Tremaroli, V., Bjerregaard, Anette, Hartmann, Bolette, Bäckhed, F., Leinninger, G., Seeley, R. J. & Holst, Birgitte, 2021, In: Endocrinology. 162, 9, 12 p., bqab130.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    The metabolic actions of neurotensin secreted from the gut

    Ratner, C., Johnsen, Cecilie Hundahl & Holst, Birgitte, Sep 2016, In: Cardiovascular Endocrinology. 5, 3, p. 102-111

    Research output: Contribution to journal › Review › Research › peer-review

  32. Published

    Impaired oxidative capacity due to decreased CPT1b levels as a contributing factor to fat accumulation in obesity

    Ratner, C., Madsen, A. N., Kristensen, L. V., Skov, Louise Julie, Pedersen, K. S., Mortensen, Ole Hartvig, Knudsen, Gitte Moos, Raun, K. & Holst, Birgitte, 8 Apr 2015, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 308, 11, p. R973-R982 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Short-term effects of dietary advanced glycation end products in rats

    Poulsen, M. W., Andersen, J. M., Hedegaard, R. S. V., Madsen, A. N., Krath, B. N., Monosik, R., Bak, M. J., Nielsen, J., Holst, Birgitte, Skibsted, Leif Horsfelt, Larsen, L. H. & Dragsted, Lars Ove, 2016, In: British Journal of Nutrition. 115, 4, p. 629-636 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    In vivo characterization of high Basal signaling from the ghrelin receptor

    Petersen, P. S., Woldbye, David Paul Drucker, Madsen, A. N., Egerod, Kristoffer Lihme, Jin, C., Lang, M., Rasmussen, M., Beck-Sickinger, A. G. & Holst, Birgitte, 2009, In: Endocrinology. 150, 11, p. 4920-30 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism

    Petersen, P. S., Jin, C., Madsen, A. N., Rasmussen, M., Kuhre, Rune Ehrenreich, Egerod, Kristoffer Lihme, Nielsen, L. B., Schwartz, Thue W. & Holst, Birgitte, 22 Jul 2011, In: FASEB Journal. p. 3803-3814 12 p., 4.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Modifying the conserved C-terminal tyrosine of the peptide hormone PYY3-36 to improve Y2 receptor selectivity

    Pedersen, S. L., Holst, Birgitte, Vrang, N. & Jensen, Knud Jørgen, 2009, In: Journal of Peptide Science. 15, 11, p. 753-759 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Peptide hormone isoforms: N-terminally branched PPY3-36 isoforms give improved lipid and fat-cell metabolism in diet-induced obese mice

    Pedersen, S. L., Sasikumar, P. G., Chelur, S., Holst, Birgitte, Artmann, A., Jensen, Knud Jørgen & Vrang, N., 2010, In: Journal of Peptide Science. 16, 11, p. 664-673 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helix variants of PYY3-36

    Pedersen, S. L., Bhatia, V. K., Jurt, S., Paulsson, J. F., Pedersen, M. H., Jørgensen, R., Holst, Birgitte, Stamou, Dimitrios, Vrang, N., Zerbe, O. & Jensen, Knud Jørgen, 2012, In: Journal of Peptide Science. 18, 9, p. 579-587 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo

    Pedersen, M. H., Bentsen, M. A., Husted, Anna Sofie, Ekberg, J. P., Wright, M. J., Di Salvo, J., Weinglass, A. B., Engelstoft, M. S., Madsen, A. N., Lückmann, Michael, Miller, M. W., Trujillo, M. E., Frimurer, Thomas Michael, Holst, Birgitte, Howard, A. D. & Schwartz, Thue W., Jan 2015, In: Molecular Metabolism. 4, 1, p. 3-14 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics

    Park, M., Sivertsen, B. B., Els-Heindl, S., Huber, T., Holst, Birgitte, Beck-Sickinger, A. G., Schwartz, Thue W. & Sakmar, T. P., 19 Nov 2015, In: Chemistry & Biology. 22, 11, p. 1431-1436 6 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  41. Published

    The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo

    Panaro, B. L., Tough, I. R., Engelstoft, M. S., Matthews, R. T., Digby, G. J., Møller, C. L., Svendsen, B., Gribble, F., Reimann, F., Holst, Jens Juul, Holst, Birgitte, Schwartz, Thue W., Cox, H. M. & Cone, R. D., 2 Dec 2014, In: Cell Metabolism. 20, 6, p. 1018-29 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Y5 neuropeptide Y receptor overexpression in mice neither affects anxiety- and depression-like behaviours nor seizures but confers moderate hyperactivity.

    Olesen, M. V., Christiansen, S. H. O., Gøtzsche, C. R., Holst, Birgitte, Kokaia, M. & Woldbye, David Paul Drucker, 2012, In: Neuropeptides (Sheffield). 46, 2, p. 71-9

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Ligand binding and micro-switches in 7TM receptor structures

    Nygaard, R., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Schwartz, Thue W., 2009, In: TIPS - Trends in Pharmacological Sciences. 30, 5, p. 249-59 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Immune malfunction in the GPR39 zinc receptor of knockout mice: Its relationship to depressive disorder

    Młyniec, K., Trojan, E., Ślusarczyk, J., Głombik, K., Basta-Kaim, A., Budziszewska, B., Skrzeszewski, J., Siwek, A., Holst, Birgitte & Nowak, G., 15 Feb 2016, In: Journal of Neuroimmunology. 291, p. 11-17 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    GPR39 Zn2+-sensing receptor: a new target in antidepressant development?

    Młyniec, K., Singewald, N., Holst, Birgitte & Nowak, G., 15 Mar 2015, In: Journal of Affective Disorders. 174, p. 89-100 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission

    Młyniec, K., Gaweł, M., Librowski, T., Reczyński, W., Bystrowska, B. & Holst, Birgitte, Jun 2015, In: Brain Research Bulletin. 115, p. 23-29 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    GPR39 (zinc receptor) knockout mice exhibit depression-like behavior and CREB/BDNF down-regulation in the hippocampus

    Młyniec, K., Budziszewska, B., Holst, Birgitte, Ostachowicz, B. & Nowak, G., 2015, In: International Journal of Neuropsychopharmacology. 18, 3, p. 1-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Stability, liposome interaction, and in vivo pharmacology of ghrelin in liposomal suspensions

    Møller, E. H., Holst, Birgitte, Nielsen, L. H., Pedersen, P. S. & Østergaard, Jesper, 2010, In: Internation Journal of Pharmaceutics. 390, 1, p. 13-18

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved

    Møller, C. L., Raun, K., Jacobsen, M. L., Pedersen, T. Å., Holst, Birgitte, Conde-Frieboes, K. W. & Wulff, B. S., 20 Jul 2011, In: Molecular and Cellular Endocrinology. 341, 1-2, p. 9-17 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Ghrelin

    Mueller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., Casanueva, F. F., D'Alessio, D., Depoortere, I., Geliebter, A., Ghigo, E., Cole, P. A., Cowley, M., Cummings, D. E., Dagher, A., Diano, S. & 37 others, Dickson, S. L., Dieguez, C., Granata, R., Grill, H. J., Grove, K., Habegger, K. M., Heppner, K., Heiman, M. L., Holsen, L., Holst, Birgitte, Inui, A., Jansson, J. O., Kirchner, H., Korbonits, M., Laferrere, B., LeRoux, C. W., Lopez, M., Morin, S., Nakazato, M., Nass, R., Perez-Tilve, D., Pfluger, P. T., Schwartz, Thue W., Seeley, R. J., Sleeman, M., Sun, Y., Sussel, L., Tong, J., Thorner, M. O., van der Lely, A. J., van der Ploeg, L. H. T., Zigman, J. M., Kojima, M., Kangawa, K., Smith, R. G., Horvath, T. & Tschoep, M. H., Jun 2015, In: Molecular Metabolism. 4, 6, p. 437-460 24 p.

    Research output: Contribution to journal › Review › Research › peer-review

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