Vilhelm Bohr
Affiliate professor, Affiliate Professor
Molecular Aging Program
Panum Instituttet, Blegdamsvej 3, 2200 København N, 07 Bygning 7, Building: 07-3-13
Member of:
- Published
DNA damage invokes mitophagy through a pathway involving Spata18
Dan, X., Babbar, M., Moore, A., Wechter, N., Tian, J., Mohanty, J. G., Croteau, D. L. & Bohr, Vilhelm, 2020, In: Nucleic Acids Research. 48, 12, p. 6611-6623 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease
Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., Rocktäschel, P., Croteau, D. L., Akbari, M., Greig, N. H., Fladby, T., Nilsen, H., Cader, M. Z., Mattson, M. P., Tavernarakis, N. & Bohr, Vilhelm, 2019, In: Nature Neuroscience. 22, p. 401-412Research output: Contribution to journal › Journal article › Research › peer-review
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Bohr på ny
Bohr, Vilhelm, Bohr, T., Topsøe, H., Bruun, L., Knudsen, H., Nielsen, H., Aaserud, Finn, Grandin, K., von Bülow, H., Kragh, H., Andersen, Anja C., Mølmer, K., Favrholdt, D., Faye, J. & Zinkernagel, H., 2 May 2013, København: Forlaget Epsilon.Dk.Research output: Book/Report › Book › Communication
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Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms
Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, Vilhelm & Fang, E. F., 2017, In: Trends in Neurosciences. 40, 3, p. 151-166 16 p.Research output: Contribution to journal › Review › Research › peer-review
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NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Fang, E. F., Hou, Y., Lautrup, S., Jensen, M. B., Yang, B., SenGupta, T., Caponio, D., Khezri, R., Demarest, T. G., Aman, Y., Figueroa, D., Morevati, M., Lee, H-J., Kato, H., Kassahun, H., Lee, J-H., Filippelli, D., Okur, M. N., Mangerich, A., Croteau, D. L. & 9 others, , 2019, In: Nature Communications. 10, 1, 18 p., 5284.Research output: Contribution to journal › Journal article › Research › peer-review
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Mitochondrial OGG1 expression reduces age-associated neuroinflammation by regulating cytosolic mitochondrial DNA
Hussain, M., Chu, X., Duan Sahbaz, B., Gray, S., Pekhale, K., Park, J. H., Croteau, D. L. & Bohr, Vilhelm, 2023, In: Free Radical Biology and Medicine. 203, p. 34-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mitochondria in the signaling pathways that control longevity and health span
Akbari, M., Kirkwood, T. B. L. & Bohr, Vilhelm, 2019, In: Ageing Research Reviews. 54, 100940.Research output: Contribution to journal › Review › Research › peer-review
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Metabolism, genomics, and DNA repair in the mouse aging liver
Lebel, M., de Souza-Pinto, N. C. & Bohr, Vilhelm, 1 Jan 2011, In: Current Gerontology and Geriatrics Research. 2011, p. 859415Research output: Contribution to journal › Journal article › Research › peer-review
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DNA repair deficiency in neurodegeneration
Jeppesen, D. K., Bohr, Vilhelm & Stevnsner, T. V., 30 Apr 2011, In: Progress in Neurobiology. 94, 2, p. 166-200 35 p.Research output: Contribution to journal › Journal article › Research › peer-review
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RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks
Lu, H., Shamanna, R. A., Keijzers, G., Anand, R., Rasmussen, Lene Juel, Cejka, P., Croteau, D. L. & Bohr, Vilhelm, 28 Jun 2016, In: Cell Reports. 16, 1, p. 161-173 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients
Maynard, S., Hejl, Anne-Mette, Dinh, T. T. S., Keijzers, G., Hansen, Åse Marie, Desler, Claus, Moreno-Villanueva, M., Bürkle, A., Rasmussen, Lene Juel, Waldemar, Gunhild & Bohr, Vilhelm, Oct 2015, In: Aging. 7, 10, p. 793-815 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline
Desler, Claus, Frederiksen, J. H., Olsen, M. N. A., Maynard, S., Keijzers, G., Fagerlund, Birgitte, Mortensen, Erik Lykke, Osler, Merete, Lauritzen, Martin, Bohr, Vilhelm & Rasmussen, Lene Juel, Nov 2015, In: Mitochondrion. 25, p. 34-7 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cockayne syndrome group A and B proteins function in rRNA transcription through nucleolin regulation
Okur, M. N., Lee, J., Osmani, W., Kimura, R., Demarest, T. G., Croteau, D. L. & Bohr, Vilhelm, 18 Mar 2020, In: Nucleic Acids Research. 48, 5, p. 2473-2485 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Toward understanding genomic instability, mitochondrial dysfunction and aging
Fakouri, N. B., Hou, Y., Demarest, T. G., Christiansen, L. S., Okur, M. N., Mohanty, J. G., Croteau, D. L. & Bohr, Vilhelm, 2019, In: F E B S Journal. 286, 6, p. 1058-1073 16 p.Research output: Contribution to journal › Review › Research › peer-review
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CDK2 phosphorylation of Werner protein (WRN) contributes to WRN’s DNA double-strand break repair pathway choice
Lee, J. H., Shamanna, R. A., Kulikowicz, T., Fakouri, N. B., Kim, E. W., Christiansen, L. S., Croteau, D. L. & Bohr, Vilhelm, 2021, In: Aging Cell. 20, 11, 14 p., e13484.Research output: Contribution to journal › Journal article › Research › peer-review
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NAD+ supplementation prevents STING-induced senescence in ataxia telangiectasia by improving mitophagy
Yang, B., Dan, X., Hou, Y., Lee, J. H., Wechter, N., Krishnamurthy, S., Kimura, R., Babbar, M., Demarest, T., McDevitt, R., Zhang, S., Zhang, Y., Mattson, M. P., Croteau, D. L. & Bohr, Vilhelm, 2021, In: Aging Cell. 20, 4, 14 p., e13329.Research output: Contribution to journal › Journal article › Research › peer-review
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NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING
Hou, Y., Wei, Y., Lautrup, S., Yang, B., Wang, Y., Cordonnier, S., Mattson, M. P., Croteau, D. L. & Bohr, Vilhelm, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 37, e2011226118.Research output: Contribution to journal › Journal article › Research › peer-review
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Roles of NAD+ in Health and Aging
Lautrup, S., Hou, Y., Fang, E. F. & Bohr, Vilhelm, 2024, In: Cold Spring Harbor Perspectives in Medicine. 14, 1, 27 p., a041193.Research output: Contribution to journal › Journal article › Research › peer-review
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Roles of Werner syndrome protein in protection of genome integrity
Rossi, M. L., Ghosh, A. K. & Bohr, Vilhelm, 2 Mar 2010, In: DNA Repair. 9, 3, p. 331-44 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population
Berquist, B. R., Singh, D. K., Fan, J., Kim, D., Gillenwater, E., Kulkarni, A., Bohr, Vilhelm, Ackerman, E. J., Tomkinson, A. E. & Wilson, D. M., 1 Aug 2010, In: Nucleic Acids Symposium Series. 38, 15, p. 5023-35 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease
Diaz, R. G., Weissman, L., Yang, J., Bohr, Vilhelm & Stevnsner, T. V., 12 Aug 2010, In: Neurobiology of Aging.Research output: Contribution to journal › Journal article › Research › peer-review
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Modulation of DNA base excision repair during neuronal differentiation
Sykora, P., Yang, J., Ferrarelli, L. K., Tian, J., Tadokoro, T., Kulkarni, A., Weissman, L., Keijzers, G., Wilson, D. M., Mattson, M. P. & Bohr, Vilhelm, Jul 2013, In: Neurobiology of Aging. 34, 7, p. 1717-27 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis
Li, X., Fang, E. F., Scheibye-Knudsen, Morten, Cui, H., Qiu, L., Li, J., He, Y., Huang, J., Bohr, Vilhelm, Ng, T. B. & Guo, H., 2014, In: Scientific Reports. 4, 6434.Research output: Contribution to journal › Journal article › Research › peer-review
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Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells
Zheng, Jin, Croteau, D. L., Bohr, Vilhelm & Akbari, M., 2019, In: Nucleic Acids Research. 47, 8, p. 4086–4110Research output: Contribution to journal › Journal article › Research › peer-review
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Sarcopenia, Aging and Prospective Interventional Strategies
Waltz, T. B., Fivenson, E. M., Morevati, M., Li, C., Becker, K. G., Bohr, Vilhelm & Fang, E. F., 2018, In: Current Medicinal Chemistry. 25, 40, p. 5588-5596 9 p.Research output: Contribution to journal › Review › Research › peer-review
ID: 4975983
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Mitochondria in the signaling pathways that control longevity and health span
Research output: Contribution to journal › Review › Research › peer-review
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281
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Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway
Research output: Contribution to journal › Journal article › Research › peer-review
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253
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Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis
Research output: Contribution to journal › Journal article › Research › peer-review
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