Birgitte Holst

Birgitte Holst

Guest Researcher


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  1. Published

    PHARMACOLOGICAL CHARACTERIZATION OF A GHRELIN RECEPTOR ANTAGONIST/ INVERSE AGONIST, PF-5190457, AND ITS MAJOR ACTIVE HYDROXY METABOLITE

    Deschaine, S. L., Hedegaard, M. A., Sulima, A., Moose, J., Stock, I. A., Hougland, J. L., Akhlaghi, F., Rice, K. C., Holst, Birgitte & Leggio, L., 2021, In: Alcoholism: Clinical and Experimental Research. 45, Supl. 1/SI, p. 146A-146A 1 p., 674.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  2. Published

    PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance

    Holst, Birgitte, Madsen, Kenneth Lindegaard, Jansen, A. M., Jin, C., Rickhag, Karl Mattias, Lund, Viktor Karlovich, Jensen, M., Bhatia, V., Sørensen, G., Madsen, A. N., Xue, Z., Møller, S. K., Woldbye, David Paul Drucker, Qvortrup, Klaus, Huganir, R., Stamou, Dimitrios, Kjærulff, Ole & Gether, Ulrik, Apr 2013, In: P L o S Biology (Online). 11, 4, p. 1-25 25 p., e1001542.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity

    Backe, M. B., Andersen, Rita Chan, Jensen, M., Jin, C., Hundahl, C., Dmytriyeva, O., Treebak, Jonas Thue, Hansen, J. B., Gerhart-Hines, Zach, Madsen, Kenneth Lindegaard & Holst, Birgitte, 2023, In: Journal of the endocrine society. 7, 6, p. 1-13 bvad057.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Pannexin-2-deficiency sensitizes pancreatic beta-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo

    Berchtold, L. A., Miani, M., Diep, T. A., Madsen, A. N., Cigliola, V., Colli, M., Miskovic Krivokapic, Jelena, Pociot, Flemming, Eizirik, D. L., Meda, P., Holst, Birgitte, Billestrup, Nils & Storling, J., 2017, In: Molecular and Cellular Endocrinology. 448, p. 108-121 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor

    Holst, Birgitte, Elling, C. E. & Schwartz, Thue W., 2000, In: Molecular Pharmacology. 58, 2, p. 263-70 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Peptide hormone isoforms: N-terminally branched PPY3-36 isoforms give improved lipid and fat-cell metabolism in diet-induced obese mice

    Pedersen, S. L., Sasikumar, P. G., Chelur, S., Holst, Birgitte, Artmann, A., Jensen, Knud Jørgen & Vrang, N., 2010, In: Journal of Peptide Science. 16, 11, p. 664-673 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation

    Valentin-Hansen, L., Holst, Birgitte, Frimurer, Thomas Michael, Schwartz, Thue W. & Hansen, L. V., 21 Dec 2012, In: Journal of Biological Chemistry. 287, 52, p. 43516-43526 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Physiological and Pathological Impact of Blood Sampling by Retro-Bulbar Sinus Puncture and Facial Vein Phlebotomy in Laboratory Mice

    Teilmann, A. C., Nygaard Madsen, A., Holst, Birgitte, Hau, Jann, Rozell, B. & Abelson, Klas, 26 Nov 2014, In: PloS one. 9, 11, p. 1-19 19 p., e113225.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine

    Deshmukh, A. S., Peijs, L., Beaudry, J. L., Jespersen, N. Z., Nielsen, C. H., Ma, T., Brunner, A. D., Larsen, T. J., Bayarri-Olmos, R., Prabhakar, B. S., Helgstrand, C., Severinsen, M. C. K., Holst, B., Kjaer, A., Tang-Christensen, M., Sanfridson, A., Garred, P., Privé, G. G., Pedersen, B. K., Gerhart-Hines, Z. & 4 others, Nielsen, S., Drucker, D. J., Mann, Matthias & Schéele, Camilla Charlotte Nielsen, 2019, In: Cell Metabolism. 30, 5, p. 963-975.e7 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    RhoA in tyrosine hydroxylase neurons regulates food intake and body weight via altered sensitivity to peripheral hormones

    Skov, Louise Julie, Ratner, C., Hansen, Nikolaj Winther, Thompson, J. J., Egerod, Kristoffer Lihme, Burm, Hayley Beth, Dalbøge, L. S., Hedegaard, M. A., Brakebusch, Cord Herbert, Pers, Tune H, Perrier, Jean-Francois Marie & Holst, Birgitte, 2019, In: Journal of Neuroendocrinology. 31, 7, 13 p., UNSP e12761.

    Research output: Contribution to journal › Conference article › Research › peer-review

  11. Published

    Risperidone treatment increases CB1 receptor binding in rat brain

    Secher, A., Husum, H., Holst, Birgitte, Egerod, Kristoffer Lihme & Mellerup, Erling Thyge, 2010, In: Neuroendocrinology. 91, 2, p. 155-68 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist

    Grunddal, K. V., Diep, T. A., Petersen, N., Tough, I. R., Skov, Louise Julie, Liu, L., Buijink, J. A., Mende, F., Jin, C., Jepsen, Sara Lind, Sørensen, L. M. E., Achiam, Michael Patrick, Strandby, R. B., Bach, Anders, Hartmann, Bolette, Frimurer, Thomas Michael, Hjorth, Siv Annegrethe, Bouvier, M., Cox, H. & Holst, Birgitte, 2021, In: Molecular Metabolism. 49, 14 p., 101207.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Short-term effects of dietary advanced glycation end products in rats

    Poulsen, M. W., Andersen, J. M., Hedegaard, R. S. V., Madsen, A. N., Krath, B. N., Monosik, R., Bak, M. J., Nielsen, J., Holst, Birgitte, Skibsted, Leif Horsfelt, Larsen, L. H. & Dragsted, Lars Ove, 2016, In: British Journal of Nutrition. 115, 4, p. 629-636 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Stability, liposome interaction, and in vivo pharmacology of ghrelin in liposomal suspensions

    Møller, E. H., Holst, Birgitte, Nielsen, L. H., Pedersen, P. S. & Østergaard, Jesper, 2010, In: Internation Journal of Pharmaceutics. 390, 1, p. 13-18

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Steric hindrance mutagenesis versus alanine scan in mapping of ligand binding sites in the tachykinin NK1 receptor

    Holst, Birgitte, Jensen, S. Z., Elling, C. E., Hjorth, S. A. & Schwartz, Thue W., 1998, In: Molecular Pharmacology. 53, no. 1, p. 166-175

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Studies of relationships between variation of the human G protein-coupled receptor 40 Gene and Type 2 diabetes and insulin release

    Hamid, Y. H., Vissing, H., Holst, Birgitte, Urhammer, S. A., Pyke, C., Hansen, S. K., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Schwartz, Thue W., Pedersen, O. & Hansen, Torben, 2005, In: Diabetic Medicine. 22, 1, p. 74-80 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice

    Wellner, N., Tsuboi, K., Madsen, A. N., Holst, Birgitte, Diep, T. A., Nakao, M., Tokumura, A., Burns, M. P., Deutsch, D. G., Ueda, N. & Hansen, Harald S., 1 Sep 2011, In: BBA General Subjects. 1811, 9, p. 508-12 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Synthesis and in Vitro Evaluation of Stabilized and Selective Neuromedin U-1 Receptor Agonists

    De Prins, A., Martin, C., Van Wanseele, Y., Tömböly, C., Tourwé, D., Caveliers, V., Holst, Birgitte, Van Eeckhaut, A., Rosenkilde, M. M., Smolders, I. & Ballet, S., 10 May 2018, In: ACS Medicinal Chemistry Letters. 9, 5, p. 496-501 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity

    Christoffersen, Christina, Federspiel, C. K., Borup, A., Christensen, P. M., Madsen, A. N., Heine, M., Nielsen, C. H., Kjaer, A., Holst, Birgitte, Heeren, J. & Nielsen, L. B., 2 Jan 2018, In: Cell Reports. 22, 1, p. 175-188

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    The Complex Signaling Pathways of the Ghrelin Receptor

    Hedegaard, M. A. & Holst, Birgitte, 2020, In: Molecular Endocrinology. 161, 4, 12 p., 020.

    Research output: Contribution to journal › Review › Research › peer-review

  21. Published

    The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis

    Backe, M. B., Jin, C., Andreone, L., Sankar, A., Agger, K., Helin, K., Madsen, A. N., Poulsen, Steen Seier, Bysani, M., Bacos, K., Ling, C., Javier Perone, M., Holst, Birgitte & Mandrup-Poulsen, Thomas, 2019, In: Journal of Diabetes Research. 2019, 15 p., 5451038.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    The Zinc-Sensing Receptor GPR39 in Physiology and as a Pharmacological Target

    Laitakari, Anna Isabella, Liu, L., Frimurer, Thomas Michael & Holst, Birgitte, 2021, In: International Journal of Molecular Sciences. 22, 8, 22 p., 3872.

    Research output: Contribution to journal › Review › Research › peer-review

  23. Published

    The dietary regulation of LEAP2 depends on meal composition in mice

    Gradel, Anna Katrina Jógvansdóttir, Holm, Stephanie Kjærulff, Byberg, Sarah, Merkestein, M., Hogendorf, W. F. J., Lund, M. L., Buijink, Jesse A., Damgaard, J., Lykkesfeldt, Jens & Holst, Birgitte, 2023, In: FASEB Journal. 37, 6, 21 p., 22923.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo

    Panaro, B. L., Tough, I. R., Engelstoft, M. S., Matthews, R. T., Digby, G. J., Møller, C. L., Svendsen, B., Gribble, F., Reimann, F., Holst, Jens Juul, Holst, Birgitte, Schwartz, Thue W., Cox, H. M. & Cone, R. D., 2 Dec 2014, In: Cell Metabolism. 20, 6, p. 1018-29 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    The metabolic actions of neurotensin secreted from the gut

    Ratner, C., Johnsen, Cecilie Hundahl & Holst, Birgitte, Sep 2016, In: Cardiovascular Endocrinology. 5, 3, p. 102-111

    Research output: Contribution to journal › Review › Research › peer-review

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