Abigail Mackey

Abigail Mackey

Clinical Professor

ORCID: 0000-0002-2017-4580

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  1. Published

    A RANDOMIZED, CROSS-OVER STUDY TO INVESTIGATE THE EFFECT OF WEIGHT-BEARING VS NON-WEIGHT-BEARING EXERCISE AND CARDIOVASCULAR STRESS ON TYPE II COLLAGEN TURNOVER IN PATIENTS WITH KNEE OSTEOARTHRITIS - SERUM BIOMARKER DATA FROM THE EFEX-OA-02 STUDY

    Bjerre-Bastos, J. J., Sejersen, Casper Aastrup, Nielsen, H. B., Boesen, M., Secher, Niels H., Distajo, G., Flood, V., Henrotin, Y., Uebelhoer, M., Mackey, Abigail, Krustrup, P., Kitchen, C. -., Petersen, E. E., Thudium, C. S., Andersen, J. R. & Bihlet, A. R., 2022, In: Osteoarthritis and Cartilage. 30, p. S102-S103 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  2. Published

    A biomarker perspective on the acute effect of exercise with and without impact on joint tissue turnover: an exploratory randomized cross-over study

    Bjerre-Bastos, J. J., Nielsen, H. B., Andersen, J. R., Karsdal, M., Boesen, Mikael Ploug, Mackey, Abigail, Byrjalsen, I., Thudium, C. S. & Bihlet, A. R., 2021, In: European Journal of Applied Physiology. 121, p. 2799–2809 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Activation of satellite cells and the regeneration of human skeletal muscle are expedited by ingestion of nonsteroidal anti-inflammatory medication

    Mackey, Abigail, Rasmussen, L. K., Kadi, F., Schjerling, Peter, Helmark, I. C., Ponsot, E., Aagaard, P., Durigan, J. L. Q. & Kjær, Michael, 2 Mar 2016, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30, 6, p. 2266-2281

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Adipocytes are present at human and murine myotendinous junctions

    Jakobsen, J. R., Jakobsen, N. R., Mackey, Abigail, Knudsen, A. B., Hannibal, Jens, Koch, M., Kjær, Michael & Krogsgaard, Michael R., 2021, In: Translational Sports Medicine. 4, 2, p. 223-230

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Age and prior exercise in vivo determine the subsequent in vitro molecular profile of myoblasts and non-myogenic cells derived from human skeletal muscle

    Bechshøft, C. J. L., Jensen, S. M., Schjerling, P., Andersen, J. L., Svensson, R. B., Eriksen, C. S., Mkumbuzi, N. S., Kjær, Michael & Mackey, Abigail, Jun 2019, In: American Journal of Physiology: Cell Physiology. 316, 6, p. C898-C912

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Age and prior exercise in vivo determine the subsequent in vitro molecular profile of myoblasts and nonmyogenic cells derived from human skeletal muscle

    Bechshøft, C. J. L., Jensen, S. M., Schjerling, Peter, Andersen, J. L., Svensson, R. B., Eriksen, C. S., Mkumbuzi, N. S., Kjær, Michael & Mackey, Abigail, 2019, In: American Journal of Physiology: Cell Physiology. 316, p. C898–C912 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Ageing is associated with diminished muscle re-growth and myogenic precursor cell expansion early after immobility-induced atrophy in human skeletal muscle

    Suetta, C., Frandsen, U., Mackey, Abigail, Jensen, L., Hvid, L. G., Bayer, M. L., Petersson, S. J., Schrøder, H. D., Andersen, J. L., Aagaard, P., Schjerling, P. & Kjaer, M., 2013, In: Journal of Physiology. 591, 15, p. 3789-3804 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Aging is associated with an altered macrophage response during human skeletal muscle regeneration

    Ahmadi, M., Karlsen, Anders, Mehling, J., Soendenbroe, C., Mackey, Abigail & Hyldahl, R. D., 2022, In: Experimental Gerontology. 7 p., 111974.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    An Estimate of Plasma Volume Changes Following Moderate-High Intensity Running and Cycling Exercise and Adrenaline Infusion

    Bjerre-Bastos, J. J., Sejersen, Casper Aastrup, Bihlet, A. R., Secher, Niels H., Mackey, Abigail, Kitchen, C., Drobinski, P., Thudium, C. S. & Nielsen, H. B., 2022, In: Frontiers in Physiology. 13, 8 p., 948097.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise

    Ziegler, A. K., Damgaard, A., Mackey, Abigail, Schjerling, Peter, Magnusson, Stig Peter, Olesen, A. T., Kjær, Michael & Schéele, Camilla Charlotte Nielsen, 2019, In: Scientific Reports. 9, 11 p., 12069.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Automated image segmentation of haematoxylin and eosin stained skeletal muscle cross-sections

    Liu, F., Mackey, Abigail, Srikuea, R., Esser, K. A. & Yang, L., Dec 2013, In: Journal of Microscopy. 252, 3, p. 275-85 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Behandling af akutte muskelskader

    Bayer, M. L., Mackey, Abigail, Magnusson, Stig Peter, Krogsgaard, Michael R. & Kjær, Michael, 18 Feb 2019, In: Ugeskrift for Laeger. 181, 8, 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    CHANGES IN PLASMA VOLUME WHEN MEASURING BIOCHEMICAL MARKERS OF JOINT TISSUE TURNOVER IN RELATION TO ACUTE PHYSICAL ACTIVITY

    Bjerre-Bastos, J., Sejersen, C., Nielsen, H. B., Secher, Niels H., Kitchen, C. C., Miller, C. P., Mackey, Abigail & Bihlet, A. R., 2022, In: Annals of the Rheumatic Diseases. 81, p. 1618-1618 1 p., AB0984.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  14. Published

    Cardiorespiratory fitness and physical performance after childhood hematopoietic stem cell transplantation: a systematic review and meta-analysis

    Fridh, M. K., Simonsen, C., Schmidt-andersen, P., Nissen, A. A., Christensen, J. F., Larsen, A., Mackey, Abigail, Larsen, Hanne Bækgaard & Muller, Klaus, 2021, In: Bone Marrow Transplantation. 56, 9, p. 2063–2078

    Research output: Contribution to journal › Review › Research › peer-review

  15. Published

    Collagens in primary frozen shoulder: expression of collagen mRNA isoforms in the different phases of the disease

    Marker, L., Schjerling, P., Mackey, Abigail, Hansen, T., Jakobsen, J., Kjær, Michael & Krogsgaard, Michael R., 2021, In: Rheumatology. 60, 8, p. 3879-3887

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Composition and adaptation of human myotendinous junction and neighboring muscle fibers to heavy resistance training

    Jakobsen, J. R., Mackey, Abigail, Knudsen, A. B., Kjær, Michael & Krogsgaard, Michael R., Dec 2017, In: Scandinavian Journal of Medicine & Science in Sports. 27, 12, p. 1547–1559

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Connective tissue regeneration in skeletal muscle after eccentric contraction-induced injury

    Mackey, Abigail & Kjær, Michael, Mar 2017, In: Journal of Applied Physiology. 122, 3, p. 533-540 8 p.

    Research output: Contribution to journal › Review › Research › peer-review

  18. Published

    Differential satellite cell density of type I and II fibres with lifelong endurance running in old men

    Mackey, Abigail, Karlsen, Anders, Couppé, Christian, Mikkelsen, U. R., Nielsen, R. H., Magnusson, Stig Peter & Kjær, Michael, Mar 2014, In: Acta Physiologica (Print). 210, 3, p. 612-27 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Differentially activated macrophages orchestrate myogenic precursor cell fate during human skeletal muscle regeneration

    Saclier, M., Yacoub-Youssef, H., Mackey, Abigail, Arnold, L., Ardjoune, H., Magnan, M., Sailhan, F., Chelly, J., Pavlath, G. K., Mounier, R., Kjær, Michael & Chazaud, B., Feb 2013, In: Stem Cells. 31, 2, p. 384-96 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Distinct myofibre domains of the human myotendinous junction revealed by single-nucleus RNA sequencing

    Karlsen, Anders, Yeung, Ching-Yan Chloé, Schjerling, Peter, Denz, L., Høgsbjerg, Christian, Jakobsen, J. R., Krogsgaard, Michael R., Koch, M., Schiaffino, S., Kjær, Michael & Mackey, Abigail, 2023, In: Journal of Cell Science. 136, 8, 14 p., jcs260913.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Distribution of myogenic progenitor cells and myonuclei is altered in women with vs. those without chronically painful trapezius muscle

    Mackey, Abigail, Andersen, L. L., Frandsen, U., Suetta, Charlotte & Sjøgaard, G., 1 Dec 2010, In: Journal of Applied Physiology. 109, 6, p. 1920-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Does an NSAID a Day Keep Satellite Cells at Bay?

    Mackey, Abigail, 16 May 2013, In: Journal of Applied Physiology. 115, 6, p. 900-908 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Does moderate intensity impact exercise and non-impact exercise induce acute changes in collagen biochemical markers related to osteoarthritis? An exploratory randomized cross-over trial

    Bjerre-bastos, J. J., Nielsen, H. B., Andersen, J. R., Karsdal, M., Bay-jensen, A., Boesen, Mikael Ploug, Mackey, Abigail, Byrjalsen, I. & Bihlet, A. R., 2021, In: Osteoarthritis and Cartilage. 29, 7, p. 986-994

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Dynamic adaptation of tendon and muscle connective tissue to mechanical loading

    Mackey, Abigail, Heinemeier, K. M., Koskinen, S. O. A. & Kjær, Michael, 2008, In: Connective Tissue Research. 49, 3, p. 165-8 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Effect of Losartan on the Acute Response of Human Elderly Skeletal Muscle to Exercise

    Heisterberg, M. F., Andersen, J. L., Schjerling, P., Bülow, J., Lauersen, J. B., Roeber, H. L., Kjær, Michael & Mackey, Abigail, 1 Feb 2018, In: Medicine and Science in Sports and Exercise. 50, 2, p. 225–235

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Enhanced satellite cell proliferation with resistance training in elderly men and women

    Mackey, Abigail, Esmarck, B., Kadi, F., Koskinen, S. O. A., Kongsgaard, M., Sylvestersen, A., Hansen, J. J., Larsen, G. & Kjær, Michael, 2007, In: Scandinavian Journal of Medicine & Science in Sports. 17, 1, p. 34-42 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Evaluation of serum ARGS neoepitope as an osteoarthritis biomarker using a standardized model for exercise-induced cartilage extra cellular matrix turnover

    Bjerre-bastos, J. J., Nielsen, H. B., Andersen, J. R., He, Y., Karsdal, M., Bay-jensen, A., Boesen, M., Mackey, Abigail & Bihlet, A. R., 1 Apr 2020, In: Osteoarthritis and Cartilage Open. 2, 8 p., 100060.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Evidence of skeletal muscle damage following electrically stimulated isometric muscle contractions in humans.

    Mackey, Abigail, Bojsen-Moller, J., Qvortrup, Klaus, Langberg, Henning, Suetta, Charlotte, Kalliokoski, K. K., Kjær, Michael & Magnusson, Stig Peter, 2008, In: Journal of Applied Physiology. 105, 5, p. 1620-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Fiber type specific response of skeletal muscle satellite cells to high-intensity resistance training in dialysis patients

    Molsted, S., Andersen, J. L., Harrison, Adrian Paul, Eidemak, I. & Mackey, Abigail, 6 Oct 2015, In: Muscle & Nerve. 52, 5, p. 736-745 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Fibre type differences in the organisation of mononuclear cells and myonuclei at the tips of human myofibres

    Høgsbjerg, Christian, Jørgensen, Ask Møbjerg, Yeung, Ching-Yan Chloé, Schjerling, Peter, Krogsgaard, Michael R., Koch, M., Kjær, Michael, Von Keudell, Arvind Gabriel & Mackey, Abigail, 1 Jan 2024, bioRxiv, 34 p. (bioRxiv).

    Research output: Working paper › Preprint › Research

  31. Published

    Fusion of myofibre branches is a physiological feature of healthy human skeletal muscle regeneration

    Højfeldt, Grith Stougaard, Sorenson, T., Gonzales, A., Kjær, Michael, Andersen, J. L. & Mackey, Abigail, 12 Aug 2023, In: Skeletal Muscle. 13, 1, p. 1-14 13.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    GH/IGF-I axis and matrix adaptation of the musculotendinous tissue to exercise in humans

    Heinemeier, K. M., Mackey, Abigail, Doessing, S., Hansen, M., Bayer, M. L., Nielsen, R. H., Herchenhan, A., Malmgaard-Clausen, N. M. & Kjær, Michael, Aug 2012, In: Scandinavian Journal of Medicine & Science in Sports. 22, 4, p. e1-7

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis

    Doessing, S., Heinemeier, K. M., Holm, L., Mackey, Abigail, Schjerling, Peter, Rennie, M., Petersen, K. S., Reitelseder, S., Kappelgaard, A., Rasmussen, M. H., Flyvbjerg, A. & Kjær, Michael, 15 Jan 2010, In: Journal of Physiology. 588, Pt 2, p. 341-51 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Human skeletal muscle acetylcholine receptor gene expression in elderly males performing heavy resistance exercise

    Soendenbroe, C., Flindt Heisterberg, M. F., Schjerling, Peter, Kjær, Michael, Andersen, J. L. & Mackey, Abigail, 2022, In: American journal of physiology. Cell physiology. 323, p. C159–C169

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Human skeletal muscle fibroblasts stimulate in vitro myogenesis and in vivo muscle regeneration

    Mackey, Abigail, Magnan, M., Chazaud, B. & Kjær, Michael, 2017, In: The Journal of Physiology. 595, 15, p. 5115-5127 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism

    Kristensen, D. M., Desdoits-Lethimonier, C., Mackey, Abigail, Dalgaard, M. D., De Masi, F., Munkbøl, C. H., Styrishave, Bjarne, Antignac, J., Le Bizec, B., Platel, C., Hay-Schmidt, Anders, Jensen, T. K., Lesné, L., Mazaud-Guittot, S., Kristiansen, Karsten, Brunak, Søren, Kjær, Michael, Juul, Anders & Jégou, B., 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. e715-e724 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Immunohistochemical changes in the expression of HSP27 in exercised human vastus lateralis muscle

    Folkesson, M., Mackey, Abigail, Holm, L., Kjær, Michael, Paulsen, G., Raastad, T., Henriksson, J. & Kadi, F., 2008, In: Acta Physiologica (Print Edition). 194, 3, p. 215-22 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Immunohistochemistry, Microscopy, and Image Analysis of Human Muscle Biopsies: Muscle Fiber Denervation as a Working Example

    Soendenbroe, C., Andersen, J. L. & Mackey, Abigail, 2023, Neuromuscular Assessments of Form and Function. Humana Press, p. 145-165 Chapter 9. (Neuromethods, Vol. 204).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  39. Published

    Impact of low-volume concurrent strength training distribution on muscular adaptation

    Kilen, Anders, Bay, J., Bejder, Jacob, Andersen, A. B., Bonne, T. C., Larsen, P. D., Carlsen, A., Egelund, J., Nybo, Lars, Mackey, Abigail, Olsen, N. V., Aachmann-Andersen, N. J., Andersen, J. L. & Nordsborg, Nikolai Baastrup, 2020, In: Journal of Science and Medicine in Sport. 23, 10, p. 999-1004 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Improved skeletal muscle mass and strength after heavy strength training in very old individuals

    Bechshøft, R. L., Malmgaard-Clausen, N. M., Gliese, B., Beyer, N., Mackey, Abigail, Andersen, J. L., Kjær, Michael & Holm, L., 2017, In: Experimental Gerontology. 92, p. 96-105 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Increased cellular proliferation in rat skeletal muscle and tendon in response to exercise: use of FLT and PET/CT

    Skovgaard, D., Bayer, M. L., Mackey, Abigail, Madsen, J., Kjær, Michael & Kjær, Andreas, 2010, In: Molecular Imaging and Biology. 12, 6, p. 626-634 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Increased myogenic precursor cell number in human skeletal muscle with 12 weeks of training at low intensity

    Mackey, Abigail, Holm, L., Reitelseder, S., Pedersen, T. G., Kadi, F., Dossing, S. & Kjær, Michael, Apr 2008.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  43. Published

    Integrated method for quantitative morphometry and oxygen transport modeling in striated muscle

    Al-Shammari, A. A., Kissane, R. W. P., Holbek, S., Mackey, Abigail, Andersen, T. R., Gaffney, E. A., Kjær, Michael & Egginton, S., 2019, In: Journal of Applied Physiology. 126, 3, p. 544-557 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Intramuscular connective tissue content and mechanical properties: Influence of aging and physical activity in mice

    Olesen, A. T., Malchow-møller, L., Bendixen, R. D., Kjær, Michael, Mackey, Abigail, Magnusson, Stig Peter & Svensson, R. B., 1 Jul 2022, In: Experimental Gerontology. p. 111893

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Key Components of Human Myofibre Denervation and Neuromuscular Junction Stability are Modulated by Age and Exercise

    Søndenbroe, C., Bechshøft, C. J. L., Heisterberg, M. F., Jensen, S. M., Bomme, E., Schjerling, Peter, Karlsen, Anders, Kjær, Michael, Andersen, J. L. & Mackey, Abigail, 2020, In: Cells. 9, 4, 893.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Lack of muscle fibre hypertrophy, myonuclear addition, and satellite cell pool expansion with resistance training in 83-94-year-old men and women

    Karlsen, Anders, Bechshøft, R. L., Malmgaard-Clausen, N. M., Andersen, J. L., Schjerling, P., Kjær, Michael & Mackey, Abigail, 3 Mar 2019, In: Acta Physiologica. 227, ja, e13271.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Larger interface area at the human myotendinous junction in type 1 compared to type 2 muscle fibers

    Rithamer Jakobsen, J., Mackey, Abigail, Koch, M., Imhof, T., Hannibal, Jens, Kjær, Michael & Rindom Krogsgaard, M., 2023, In: Scandinavian Journal of Medicine & Science in Sports. 33, 2, p. 136-145 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Life-long endurance exercise in humans: circulating levels of inflammatory markers and leg muscle size

    Mikkelsen, U. R., Couppé, Christian, Karlsen, Anders, Grosset, J. F., Schjerling, Peter, Mackey, Abigail, Klausen, H. H., Magnusson, Stig Peter & Kjær, Michael, 30 Nov 2013, In: Mechanisms of Ageing and Development. 134, 11-12, p. 531-40 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Local NSAID infusion inhibits satellite cell proliferation in human skeletal muscle after eccentric exercise

    Mikkelsen, U. R., Langberg, Henning, Helmark, I. C., Skovgaard, D., Andersen, L. L., Kjær, Michael & Mackey, Abigail, Nov 2009, In: Journal of Applied Physiology. 107, 5, p. 1600-1611 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Losartan has no additive effect on the response to heavy resistance exercise in human elderly skeletal muscle

    Heisterberg, M. F., Andersen, J. L., Schjerling, Peter, Lund, A., Dalskov, S., Overgård Jønsson, A., Warming, N., Fogelstrøm, M., Kjær, Michael & Mackey, Abigail, Nov 2018, In: Journal of Applied Physiology. 125, 5, p. 1536-1554 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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