Thomas Werge
Clinical Professor
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A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy
Athanasiadis, G., Meijsen, J. J., Helenius, D., Schork, A. J., Ingason, A., Thompson, W. K., Geschwind, D. H., Werge, Thomas & Buil, A., 2022, In: PNAS. 119, 6, 9 p., e2118688119.Research output: Contribution to journal › Journal article › Research › peer-review
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A family-based study of genetic and epigenetic effects across multiple neurocognitive, motor, social-cognitive and social-behavioral functions
Nudel, R., Zetterberg, R., Hemager, N., Christiani, C. A. J., Ohland, J., Burton, B. K., Greve, A. N., Spang, K. S., Ellersgaard, D., Gantriis, D. L., Bybjerg-Grauholm, J., Plessen, K. J., Jepsen, J. R. M., Thorup, Anne, Werge, Thomas, Mors, O. & Nordentoft, Merete, 2022, In: Behavioral and Brain Functions. 18, 14.Research output: Contribution to journal › Journal article › Research › peer-review
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A saturated map of common genetic variants associated with human height
Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., Miao, J., Arias, J. D., Graham, S. E., Mukamel, R. E., Spracklen, C. N., Yin, X., Chen, S-H., Ferreira, T., Highland, H. H., Ji, Y. & 37 others, , 2022, In: Nature. 610, p. 704–712Research output: Contribution to journal › Journal article › Research › peer-review
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Accounting for age of onset and family history improves power in genome-wide association studies
Pedersen, E. M., Agerbo, E., Plana-Ripoll, O., Grove, J., Dreier, J. W., Musliner, K. L., Bækvad-Hansen, M., Athanasiadis, G., Schork, A., Bybjerg-Grauholm, J., Hougaard, D. M., Werge, T., Nordentoft, M., Mors, O., Dalsgaard, S., Christensen, J., Børglum, A. D., Mortensen, P. B., McGrath, J. J., Privé, F. & 1 others, , 2022, In: American Journal of Human Genetics. 109, 3, p. 417-432 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Accumulation of Disadvantages Across Multiple Domains Amongst Subgroups of Children of Parents with Schizophrenia or Bipolar Disorder: Clustering Data from the Danish High Risk and Resilience Study VIA 7
Krantz, M. F., Ellersgaard, D., Andersen, K. K., Hemager, N., Christiani, C., Spang, K. S., Burton, B. K., Gregersen, M., Søndergaard, A., Greve, A., Gantriis, D. L., Ohland, J., Mortensen, P. B., Werge, T., Nudel, R., Wang, Y., Hougaard, D. M., Plessen, K. J., Bliksted, V., Jepsen, J. R. M. & 3 others, , 2022, In: Schizophrenia Bulletin Open. 3, 1, 16 p., sgac010.Research output: Contribution to journal › Journal article › Research › peer-review
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Accurate and Effective Detection of Recurrent Copy Number Variants in Large SNP Genotype Datasets
Montalbano, S., Sánchez, X. C., Vaez, M., Helenius, D., Werge, Thomas & Ingason, A., 2022, In: Current Protocols. 2, 12, 21 p., e621.Research output: Contribution to journal › Journal article › Research › peer-review
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Cohort Profile: COVIDMENT: COVID-19 cohorts on mental health across six nations
Unnarsdóttir, A. B., Lovik, A., Fawns-Ritchie, C., Ask, H., Kõiv, K., Hagen, K., Didriksen, M., Christoffersen, L. A. N., Garðarsson, A. B., McIntosh, A., Kähler, A. K., Campbell, A., Hauksdóttir, A., Erikstrup, C., Mikkelsen, D. H., Altschul, D., Thordardottir, E. B., Frans, E. M., Kvale, G., Tómasson, G. & 32 others, , 2022, In: International Journal of Epidemiology. 51, 3, p. e108–e122 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Common Genetic Variation and Age of Onset of Anorexia Nervosa
Watson, H. J., Thornton, L. M., Yilmaz, Z., Baker, J. H., Coleman, J. R. I., Adan, R. A. H., Alfredsson, L., Andreassen, O. A., Ask, H., Berrettini, W. H., Boehnke, M., Boehm, I., Boni, C., Buehren, K., Bulant, J., Burghardt, R., Chang, X., Cichon, S., Cone, R. D., Courtet, P. & 157 others, , 2022, In: Biological Psychiatry Global Open Science. 2, 4, p. 368-378 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparing Copy Number Variations in a Danish Case Cohort of Individuals with Psychiatric Disorders
Calle Sánchez, X., Helenius, D., Bybjerg-Grauholm, J., Pedersen, C., Hougaard, D. M., Børglum, A. D., Nordentoft, Merete, Mors, O., Mortensen, P. B., Geschwind, D. H., Montalbano, S., Raznahan, A., Thompson, W. K., Ingason, A. & Werge, Thomas, 2022, In: JAMA Psychiatry. 79, 1, p. 59-69Research output: Contribution to journal › Journal article › Research › peer-review
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Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci
Fadista, J., Skotte, L., Karjalainen, J., Abner, E., Sørensen, E., Ullum, H., Werge, Thomas, Esko, T., Milani, L., Palotie, A., Daly, M., Melbye, M., Feenstra, B., Geller, F., IPSYCH Grp, I. G. & FinnGen Consortium, F. C., 2022, In: Nature Communications. 13, 11 p., 3200.Research output: Contribution to journal › Journal article › Research › peer-review
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Cross-trait assortative mating is widespread and inflates genetic correlation estimates
Border, R., Athanasiadis, G., Buil Demur, Alfonso Alberto, Schork, A. J., Cai, N., Young, A. I., Werge, Thomas, Flint, J., Kendler, K. S., Sankararaman, S., Dahl, A. W. & Zaitlen, N. A., 2022, In: Science. 378, 6621, p. 754-761 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Current advancements of modelling schizophrenia using patient-derived induced pluripotent stem cells
Dubonyte, Ugne, Asenjo-Martinez, A., Werge, Thomas, Lage, K. & Kirkeby, Agnete, 2022, In: Acta Neuropathologica Communications. 10, 1, 20 p., 183.Research output: Contribution to journal › Review › Research › peer-review
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Deep learning-based integration of genetics with registry data for stratification of schizophrenia and depression
Allesøe, R. L., Nudel, R., Thompson, W. K., Wang, Y., Nordentoft, Merete, Børglum, A. D., Hougaard, D. M., Werge, Thomas, Rasmussen, Simon & Benros, Michael Eriksen, 2022, In: Science Advances. 8, 26, eabi7293.Research output: Contribution to journal › Journal article › Research › peer-review
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Differences in the genetic architecture of common and rare variants in childhood, persistent and late-diagnosed attention-deficit hyperactivity disorder
Rajagopal, V. M., Duan, J., Vilar-Ribó, L., Grove, J., Zayats, T., Ramos-Quiroga, J. A., Satterstrom, F. K., Artigas, M. S., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Als, T. D., Rosengren, A., Daly, M. J., Neale, B. M., Nordentoft, M., Werge, T., Mors, O., Hougaard, D. M., Mortensen, P. B., Ribasés, M. & 2 others, , 2022, In: Nature Genetics. 54, 8, p. 1117-1124 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
Mullins, N., Kang, J. E., Campos, A. I., Coleman, J. R. I., Edwards, A. C., Galfalvy, H., Levey, D. F., Lori, A., Shabalin, A., Starnawska, A., Su, M. H., Watson, H. J., Adams, M., Awasthi, S., Gandal, M., Hafferty, J. D., Hishimoto, A., Kim, M., Okazaki, S., Otsuka, I. & 36 others, , 2022, In: Biological Psychiatry. 91, 3, p. 313-327 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elucidating the relationship between migraine risk and brain structure using genetic data
International Headache Genetics Consortium, I. H. G. C., 1 Sep 2022, In: Brain. 145, 9, p. 3214-3224 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Enhancing discovery of genetic variants for PTSD through integration of quantitative phenotypes and trauma exposure information
Maihofer, A. X., Choi, K. W., Coleman, J. R. I., Daskalakis, N. P., Denckla, C. A., Ketema, E., Morey, R. A., Polimanti, R., Ratanatharathorn, A., Torres, K., Wingo, A. P., Zai, C. C., Aiello, A. E., Almli, L. M., Amstadter, A. B., Andersen, S. B., Andreassen, O. A., Arbisi, P. A., Ashley-Koch, A. E., Austin, S. B. & 161 others, , 1 Apr 2022, In: Biological Psychiatry. 91, 7, p. 626-636 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Evaluating the interrelations between the autism polygenic score and psychiatric family history in risk for autism
Schendel, D., Munk Laursen, T., Albiñana, C., Vilhjalmsson, B., Ladd-Acosta, C., Fallin, M. D., Benke, K., Lee, B., Grove, J., Kalkbrenner, A., Ejlskov, L., Hougaard, D., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Børglum, A. D., Werge, Thomas, Nordentoft, Merete, Mortensen, P. B. & Agerbo, E., 2022, In: Autism Research. 15, 1, p. 171-182Research output: Contribution to journal › Journal article › Research › peer-review
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Family disadvantage, gender, and the returns to genetic human capital
Ronda, V., Agerbo, E., Bleses, D., Mortensen, P. B., Borglum, A., Mors, O., Rosholm, M., Hougaard, D. M., Nordentoft, Merete & Werge, Thomas, Apr 2022, In: Scandinavian Journal of Economics. 124, 2, p. 550-578 29 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic and psychosocial influence on the association between early childhood infections and later psychiatric disorders
Debost, J. P. G., Thorsteinsson, E., Trabjerg, B., Benros, Michael Eriksen, Albiñana, C., Vilhjalmsson, B. J., Børglum, A., Mors, O., Werge, Thomas, Mortensen, P. B., Agerbo, E. & Vogdrup, L., 2022, In: Acta Psychiatrica Scandinavica. 146, 5, p. 406-419 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic assortative mating for schizophrenia and bipolar disorder
Jefsen, O. H., Nudel, R., Wang, Y., Bybjerg-Grauholm, J., Hemager, N., Christiani, C. A. J., Burton, B. K., Spang, K. S., Ellersgaard, D., Gantriis, D. L., Plessen, K. J., Jepsen, J. R. M., Thorup, Anne, Werge, Thomas, Nordentoft, Merete, Mors, O. & Greve, A. N., 2022, In: European Psychiatry. 65, 1, 7 p., e53.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic correlates of phenotypic heterogeneity in autism
Warrier, V., Zhang, X., Reed, P., Havdahl, A., Moore, T. M., Cliquet, F., Leblond, C. S., Rolland, T., Rosengren, A., Caceres, A. S. J., Hayward, H., Crawley, D., Faulkner, J., Sabet, J., Ellis, C., Oakley, B., Loth, E., Charman, T., Murphy, D., Holt, R. & 33 others, , 2022, In: Nature Genetics. 54, 9, p. 1293-1304 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide association study of febrile seizures implicates fever response and neuronal excitability genes
Skotte, L., Fadista, J., Bybjerg-Grauholm, J., Appadurai, V., Hildebrand, M. S., Hansen, T. F., Banasik, K., Grove, J., Albiñana, C., Geller, F., Bjurström, C. F., Vilhjálmsson, B. J., Coleman, M., Damiano, J. A., Burgess, R., Scheffer, I. E., Pedersen, O. B. V., Erikstrup, C., Westergaard, D., Nielsen, K. R. & 19 others, , 2022, In: Brain. 145, 2, p. 555–568Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB
Eliasen, A. U., Pedersen, C. E. T., Rasmussen, M. A., Wang, N., Soverini, M., Fritz, A., Stokholm, J., Chawes, B. L., Morin, A., Bork-Jensen, J., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Mortensen, P. B., Hougaard, D. M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Mors, O., Nordentoft, M. & 14 others, , 2022, In: Journal of Allergy and Clinical Immunology. 150, 3, p. 622-630Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups
Mattheisen, M., Grove, J., Als, T. D., Martin, J., Voloudakis, G., Meier, S., Demontis, D., Bendl, J., Walters, R., Carey, C. E., Rosengren, A., Strom, N. I., Hauberg, M. E., Zeng, B., Hoffman, G., Zhang, W., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Agerbo, E., Cormand, B. & 14 others, , 2022, In: Nature Genetics. 54, p. 1470–1478Research output: Contribution to journal › Journal article › Research › peer-review
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Infection Polygenic Factors Account for a Small Proportion of the Relationship Between Infections and Mental Disorders
Shorter, J. R., Meijsen, J., Nudel, R., Krebs, M., Gådin, J., Mikkelsen, D. H., Nogueira Avelar e Silva, R., Benros, Michael Eriksen, Thompson, W. K., Ingason, A. & Werge, Thomas, 2022, In: Biological Psychiatry. 92, 4, p. 283-290Research output: Contribution to journal › Journal article › Research › peer-review
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Is the CYP2D6 Genotype Associated with Antipsychotic-Induced Weight Gain?
Jürgens, Gesche, Kaas-Hansen, Benjamin Skov, Nordentoft, Merete, Werge, Thomas & Andersen, Stig Ejdrup, Oct 2022, In: Journal of Personalized Medicine. 12, 10, 12 p., 1728.Research output: Contribution to journal › Journal article › Research › peer-review
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Life-time Actionable Pharmacogenetic Drug Use: A Population-based Cohort Study in 86 040 Young People with and without Mental Disorders in Denmark
Lunenburg, C. A. T. C., Ishtiak-Ahmed, K., Werge, Thomas & Gasse, C., 2022, In: Pharmacopsychiatry. 55, 2, p. 95-107Research output: Contribution to journal › Journal article › Research › peer-review
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Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Trubetskoy, V., Pardiñas, A. F., Qi, T., Panagiotaropoulou, G., Awasthi, S., Bigdeli, T. B., Bryois, J., Chen, C. Y., Dennison, C. A., Hall, L. S., Lam, M., Watanabe, K., Frei, O., Ge, T., Harwood, J. C., Koopmans, F., Magnusson, S., Richards, A. L., Sidorenko, J., Wu, Y. & 35 others, , 2022, In: Nature. 604, 7906, p. 502-508 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Maternal pregnancy-related infections and autism spectrum disorder—the genetic perspective
Nudel, R., Thompson, W. K., Børglum, A. D., Hougaard, D. M., Mortensen, P. B., Werge, Thomas, Nordentoft, Merete & Benros, Michael Eriksen, Dec 2022, In: Translational Psychiatry. 12, 1, 9 p., 334.Research output: Contribution to journal › Journal article › Research › peer-review
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Population Genomics of Stone Age Eurasia
Allentoft, M. E., Sikora, M., Refoyo-Martínez, A., Irving-Pease, E. K., Fischer, A., Barrie, W., Ingason, A., Stenderup, J., Sjögren, K-G., Pearson, A., Mota, B., Paulsson, B. S., Halgren, A., Macleod, R., Schjellerup Jørkov, M. L., Demeter, F., Novosolov, M., Sørensen, L., Nielsen, P-O., Henriksen, R. H. A. & 143 others, , 2022, p. 1-71, (bioRxiv).Research output: Working paper › Preprint › Research
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Prevalence of major depressive disorder in 51,658 otherwise healthy adult Danes: Sex differences in symptomatology and prediction of future anti-depressive medication
Mikkelsen, Christina, Larsen, M. A. H., Sørensen, E., Hansen, Thomas Folkmann, Mikkelsen, S., Erikstrup, C., Nielsen, K. R., Bruun, M. T., Hjalgrim, Henrik, Kessing, Lars Vedel, Werge, Thomas, Ullum, H., Ostrowski, Sisse Rye, Pedersen, Ole Birger Vesterager, Thørner, L. W. & Didriksen, Maria, 2022, In: Psychiatry Research. 318, 7 p., 114944.Research output: Contribution to journal › Journal article › Research › peer-review
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Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology
Bjornsdottir, G., Stefansdottir, L., Thorleifsson, G., Sulem, P., Norland, K., Ferkingstad, E., Oddsson, A., Zink, F., Lund, S. H., Nawaz, M. S., Bragi Walters, G., Skuladottir, A. T., Gudjonsson, S. A., Einarsson, G., Halldorsson, G. H., Bjarnadottir, V., Sveinbjornsson, G., Helgadottir, A., Styrkarsdottir, U., Gudmundsson, L. J. & 26 others, , 2022, In: Nature Communications. 13, 13 p., 634.Research output: Contribution to journal › Journal article › Research › peer-review
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Rare coding variants in ten genes confer substantial risk for schizophrenia
Singh, T., Poterba, T., Curtis, D., Akil, H., Al Eissa, M., Barchas, J. D., Bass, N., Bigdeli, T. B., Breen, G., Bromet, E. J., Buckley, P. F., Bunney, W. E., Bybjerg-Grauholm, J., Byerley, W. F., Chapman, S. B., Chen, W. J., Churchhouse, C., Craddock, N., Cusick, C. M., DeLisi, L. & 91 others, , 2022, In: Nature. 604, 7906, p. 509-516 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
Blokland, G. A. M., Grove, J., Chen, C. Y., Cotsapas, C., Tobet, S., Handa, R., Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M. & 35 others, , 2022, In: Biological Psychiatry. 91, 1, p. 107-117Research output: Contribution to journal › Journal article › Research › peer-review
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Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p
Weiner, D. J., Ling, E., Erdin, S., Tai, D. J. C., Yadav, R., Grove, J., Fu, J. M., Nadig, A., Carey, C., Baya, N., Bybjerg-Grauholm, J., Mortensen, P. B., Werge, T., Demontis, D., Mors, O., Nordentoft, M., Als, T. D., Baekvad-Hansen, M., Rosengren, A., Havdahl, A. & 33 others, , 2022, In: Nature Genetics. 54, p. 1630-1639Research output: Contribution to journal › Journal article › Research › peer-review
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Structural basis of organic cation transporter-3 inhibition
Khanppnavar, B., Maier, J., Herborg, Freja, Gradisch, R., Lazzarin, E., Luethi, D., Yang, J. W., Qi, C., Holy, M., Jäntsch, K., Kudlacek, O., Schicker, K., Werge, Thomas, Gether, Ulrik, Stockner, T., Korkhov, V. M. & Sitte, H. H., 2022, In: Nature Communications. 13, 1, 13 p., 6714.Research output: Contribution to journal › Journal article › Research › peer-review
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The Selection Landscape and Genetic Legacy of Ancient Eurasians
Irving-Pease, E., Refoyo Martínez, A., Ingason, A., Pearson, A., Fischer, A., Barrie, W., Sjögren, K-G., Halgren, A. S., Macleod, R., Demeter, F., Henriksen, R. H. A., Vimala, T., McColl, H., Vaughn, A., Stern, A. J., Speidel, L., Scorrano, G., Ramsøe, A., Schork, A. J., Rosengren, A. & 12 others, , 2022, bioRxiv, 26 p.Research output: Working paper › Preprint › Research
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The population genomic legacy of the second plague pandemic
Gopalakrishnan, S., Ebenesersdóttir, S. S., Lundstrøm, I. K. C., Turner-Walker, G., Moore, K. H. S., Luisi, P., Margaryan, A., Martin, M. D., Ellegaard, M. R., Magnússon, Ó., Sigurðsson, Á., Snorradóttir, S., Magnúsdóttir, D. N., Laffoon, J. E., van Dorp, L., Liu, X., Moltke, I., Ávila-Arcos, M. C., Schraiber, J. G., Rasmussen, S. & 40 others, , 2022, In: Current Biology. 32, 21, p. 4743-4751.e6Research output: Contribution to journal › Journal article › Research › peer-review
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The sequences of 150,119 genomes in the UK Biobank
Halldorsson, B. V., Eggertsson, H. P., Moore, K. H. S., Hauswedell, H., Eiriksson, O., Ulfarsson, M. O., Palsson, G., Hardarson, M. T., Oddsson, A., Jensson, B. O., Kristmundsdottir, S., Sigurpalsdottir, B. D., Stefansson, O. A., Beyter, D., Holley, G., Tragante, V., Gylfason, A., Olason, P. I., Zink, F., Asgeirsdottir, M. & 27 others, , 2022, In: Nature. 607Research output: Contribution to journal › Journal article › Research › peer-review
ID: 34394780
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Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression
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Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders
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Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia
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