Jens Juul Holst

Jens Juul Holst

Professor


  1. Published

    Individual and combined glucose-lowering effects of glucagon receptor antagonism and sodium-glucose cotransporter 2 inhibition

    Haedersdal, S., Lund, A., Maagensen, H., Nielsen-Hannerup, E., Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2018, p. S312-S312.

    Research output: Contribution to conferencePosterResearch

  2. Published

    Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine

    Petersen, N., Frimurer, Thomas Michael, Pedersen, M. T., Egerod, Kristoffer Lihme, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Grapin-Botton, A., Jensen, Kim Bak & Schwartz, Thue W., 2018, In: Gastroenterology. 155, 4, p. 1164-1176 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Restoration of enteroendocrine and pancreatic function after internal hernia and short bowel syndrome in a young woman with gastric bypass: a 2-year follow-up

    Borghede, M., Vinter-Jensen, L., Rasmussen, H. H., Veedfald, Simon, Rehfeld, Jens Frederik, Hartmann, Bolette, Holst, Jens Juul, Knop, Filip Krag & Sonne, D. P., 2018, In: Physiological Reports. 6, 9, 6 p., e13686.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Metformin-induced glucagon-like peptide-1 secretion contributes to the actions of metformin in type 2 diabetes

    Bahne, E., Sun, E. W. L., Young, R. L., Hansen, M., Sonne, D. P., Hansen, J. S., Rohde, U., Liou, A. P., Jackson, M. L., de Fontgalland, D., Rabbitt, P., Hollington, P., Sposato, L., Due, S., Wattchow, D. A., Rehfeld, Jens Frederik, Holst, Jens Juul, Keating, D. J., Vilsbøll, Tina & Knop, Filip Krag, 2018, In: JCI Insight. 3, 23, p. 1-16 e93936.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Hyperosmolar Duodenal Saline Infusion Lowers Circulating Ghrelin and Stimulates Intestinal Hormone Release in Young Men

    Veedfald, Simon, Wu, T., Bound, M., Grivell, J., Hartmann, Bolette, Rehfeld, Jens Frederik, Deacon, Carolyn F., Horowitz, M., Holst, Jens Juul & Rayner, C. K., 2018, In: Journal of Clinical Endocrinology & Metabolism. 103, 12, p. 4409-4418

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Reduced GLP-1 Secretion at 30 Minutes After a 75g Oral Glucose Load is Observed in Gestational Diabetes Mellitus: A Prospective Cohort Study

    Sukumar, N., Bagias, C., Goljan, I., Weldeselassie, Y., Gharanei, S., Tan, B. K., Holst, Jens Juul & Saravanan, P., 1 Dec 2018, In: Diabetes. 67, 12, p. 2650-2656

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published
  8. Published

    The bile acid-sequestering resin sevelamer eliminates the acute GLP-1 stimulatory effect of endogenously released bile acids in patients with type 2 diabetes

    Brønden, A., Albér, A., Rohde, U., Gasbjerg, Lærke Smidt, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Feb 2018, In: Diabetes, Obesity and Metabolism. 20, 2, p. 362-369

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Patient profiling for success after weight loss surgery (GO Bypass study): An interdisciplinary study protocol

    Christensen, Bodil Just, Schmidt, J. B., Nielsen, M. S., Tækker, L., Holm, Lotte, Lunn, Susanne, Bredie, Wender, Ritz, C., Holst, Jens Juul, Hansen, Torben, Hilbert, A., le Roux, C. W., Hulme, O. J., Siebner, Hartwig Roman, Morville, T., Naver, L., Floyd, A. K. & Sjödin, Anders Mikael, 2018, In: Contemporary Clinical Trials Communications. 10, p. 121-130 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The impact of short chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon

    Christiansen, Charlotte Bayer, Gabe, M. B. N., Svendsen, B., Dragsted, Lars Ove, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 315, 1, p. G53-G65 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course

    Mikkelsen, K. H., Vilsbøll, Tina, Holst, Jens Juul, Hartmann, Bolette, Knop, Filip Krag & Frost, M., 2018, In: BMC Endocrine Disorders. 18, 6 p., 60.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Glucose-lowering effects and mechanisms of the bile acid-sequestering resin sevelamer

    Brønden, A., Mikkelsen, K., Sonne, D. P., Hansen, M., Våben, C., Gabe, M. N., Rosenkilde, Mette, Tremaroli, V., Wu, H., Bäckhed, F., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Jul 2018, In: Diabetes, Obesity and Metabolism. 20, 7, p. 1623-1631

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Gastrointestinal Motility in Patients with End-Stage Renal Diease on Chronic Hemodialysis

    Broberg, B., Madsen, J., Fuglsang, S., Holst, Jens Juul, Christensen, Karl Bang, Rydahl, C., Idorn, T., Feldt-Rasmussen, Bo & Hornum, Mads, 1 Feb 2018, In: Nephrology Dialysis Transplantation. 33, Supplement 1, p. 318 1 p., SaO009 .

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  14. Published

    Separate effects of glucagon like peptide-2 (GLP-2) and glucose-dependent insulinotropic polypeptide (GIP) on bone remodelling

    Skov-Jeppesen, Kirsa, Svane, M., Martinussen, C., Gabe, M., Gasbjerg, Lærke Smidt, Madsbad, Sten, Holst, Jens Juul, Rosenkilde, Mette & Hartmann, Bolette, 2018, In: Diabetologia. 61, S1, p. S245-S245 501.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  15. Published

    Relationship between Optimum Mini‐doses of Glucagon and Insulin Levels when Treating Mild Hypoglycaemia in Patients with Type 1 Diabetes: A Simulation Study

    Ranjan, A., Wendt, S. L., Schmidt, S., Madsbad, Sten, Holst, Jens Juul, Madsen, H., Knudsen, C. B., Jørgensen, J. B. & Nørgaard, Kirsten, 2018, In: Basic & Clinical Pharmacology & Toxicology. 122, 3, p. 322-330

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Enteroendocrine K and L cells in healthy and type 2 diabetic individuals

    Jorsal, T., Rhee, N. A., Pedersen, Jens, Wahlgren, C. D., Mortensen, B., Jepsen, Sara Lind, Jelsing, J., Dalbøge, L. S., Vilmann, Peter, Hassan, H., Hendel, J. W., Poulsen, Steen Seier, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Feb 2018, In: Diabetologia. 61, 2, p. 284-294 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Treatment with GLP-1 Receptor Agonists

    Madsbad, Sten & Holst, Jens Juul, 2018, Diabetes: Epidemiology, Genetics, Pathogenesis, Diagnosis, Prevention, and Treatment. Bonora, E. & DeFronzo, R. (eds.). Springer, 45 p. (Endocrinology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  18. Published

    Older subjects with β-cell dysfunction have an accentuated incretin release

    De Jesús Garduno-Garcia, J., Gastaldelli, A., DeFronzo, R. A., Lertwattanarak, R., Holst, Jens Juul & Musi, N., 2018, In: Journal of Clinical Endocrinology and Metabolism. 103, 7, p. 2613-2619 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Is glucagon‐like peptide‐1 fully protected by the dipeptidyl peptidase 4 inhibitor sitagliptin when administered to patients with type 2 diabetes?

    Andersen, E. S., Lund, A., Bagger, J. I., Andreasen, C., Grøndahl, M., Deacon, Carolyn F., Hartmann, Bolette, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, Aug 2018, In: Diabetes, Obesity and Metabolism. 20, 8, p. 1937-1943

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Gut: a key player in the pathogenesis of type 2 diabetes?

    Muscogiuri, G., Balercia, G., Barrea, L., Cignarelli, A., Giorgino, F., Holst, Jens Juul, Laudisio, D., Orio, F., Tirabassi, G. & Colao, A., 2018, In: Critical Reviews in Food Science and Nutrition. 58, 8, p. 1294–1309

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published

    Stimulation of the Bile Acid Receptor Tgr5 Promotes Intestinal Growth

    Dal, Jenna Elizabeth Hunt, Hartmann, Bolette, Ullmer, C., Holst, Jens Juul & Kissow, Hannelouise, 1 May 2018, In: Gastroenterology. 154, 6 (S1), 1 p., S-333.

    Research output: Contribution to journalConference abstract in journalResearch

  22. Published

    The effect of DPP-4 protected GLP-1 (7-36) on coronary microcirculation in obese adults

    Nilsson, M., Bove, K., Suhrs, E., Hermann, T., Madsbad, Sten, Holst, Jens Juul, Prescott, Eva & Zander, M., 2018, In: Diabetologia. 61, S1, p. S354-S355 729.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  23. Published

    Insulin Secretion Depends on Intra-islet Glucagon Signaling

    Svendsen, B., Larsen, Olav, Gabe, M. B. N., Christiansen, Charlotte Bayer, Rosenkilde, M. M., Drucker, D. J. & Holst, Jens Juul, 2018, In: Cell Reports. 25, 5, p. 1127-1134.E2

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Determinants of Fasting Hyperglucagonemia in Patients with Type 2 Diabetes and Nondiabetic Control Subjects

    Demant, M., Bagger, J. I., Suppli, M. P., Lund, A., Gyldenløve, M., Hansen, K. B., Hare, Kristine Juul, Christensen, Mikkel Bring, Sonne, D. P., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Dec 2018, In: Metabolic Syndrome and Related Disorders. 16, 10, p. 530-536 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Do we know the true mechanism of action of the DPP-4 inhibitors?

    Andersen, E. S., Deacon, Carolyn F. & Holst, Jens Juul, 2018, In: Diabetes, Obesity and Metabolism. 20, 1, p. 34-41 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Ghrelin secretion in humans - a role for the vagus nerve?

    Veedfald, Simon, Plamboeck, A., Hartmann, Bolette, Vilsbøll, Tina, Knop, Filip Krag, Deacon, Carolyn F., Svendsen, Lars Bo & Holst, Jens Juul, Jun 2018, In: Neurogastroenterology and Motility. 30, 6, e13295.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Effect of liraglutide on ectopic fat in polycystic ovary syndrome: A randomized clinical trial

    Frøssing, S., Nylander, M., Chabanova, E., Frystyk, J., Holst, Jens Juul, Kistorp, Caroline Michaela Nervil, Skouby, Sven O. & Faber, Jens, Jan 2018, In: Diabetes, Obesity and Metabolism. 20, 1, p. 215-218

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Hyperglucagonemia correlates with plasma levels of non-branched-chain amino acids in patients with liver disease independent of type 2 diabetes

    Albrechtsen, Nicolai Jacob Wewer, Junker, A. E., Christensen, M., Hædersdal, S., Wibrand, F., Lund, A. M., Galsgaard, Katrine Douglas, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2018, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 314, 1, p. G91-G96

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published
  30. Published

    Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control

    Lehrskov, L. L., Lyngbaek, M. P., Soederlund, L., Legaard, G. E., Ehses, J. A., Heywood, S. E., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Karstoft, K., Pedersen, Bente Klarlund & Ellingsgaard, H., 2018, In: Cell Metabolism. 27, 6, p. 1201-1211

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Glucose Tolerance Tests and Osteocalcin Responses in Healthy People

    Starup-Linde, J., Westberg-Rasmussen, S., Lykkeboe, S., Handberg, A., Hartmann, Bolette, Holst, Jens Juul, Hermansen, K., Vestergaard, P. & Gregersen, S., 2018, In: Frontiers in Endocrinology. 9

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Hepatic Insulin Clearance in Regulation of Systemic Insulin Concentrations—Role of Carbohydrate and Energy Availability

    Bojsen-Møller, K. N., Lundsgaard, Anne-Marie, Madsbad, Sten, Kiens, Bente & Holst, Jens Juul, Nov 2018, In: Diabetes. 67, 11, p. 2129-2136 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Systems signatures reveal unique remission-path of Type 2 diabetes following Roux-en-Y gastric bypass surgery

    Li, Q-R., Wang, Z-M., Albrechtsen, N. J. W., Wang, D-D., Su, Z-D., Gao, X-F., Wu, Q-Q., Zhang, H-P., Zhu, L., Li, R-X., Jacobsen, S., Jørgensen, N. B., Dirksen, C., Bojsen-Møller, K. N., Petersen, J. S., Madsbad, S., Clausen, T. R., Diderichsen, B., Chen, L-N., Holst, J. J. & 2 others, Zeng, R. & Wu, J., 2018, In: EBioMedicine. 28, p. 234-240 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Evidence of a liver-alpha cell axis in humans: hepatic insulin resistance attenuates relationship between fasting plasma glucagon and glucagonotropic amino acids

    Albrechtsen, Nicolai Jacob Wewer, Færch, K., Jensen, T. M., Witte, D. R., Pedersen, Jens, Mahendran, Y., Jonsson, Anna Elisabet, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Torekov, Signe Sørensen, Lauritzen, T., Pedersen, Oluf Borbye, Knop, Filip Krag, Hansen, Torben, Jørgensen, M. E., Vistisen, D. & Holst, Jens Juul, 2018, In: Diabetologia. 61, 3, p. 671-680

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Cholecystokinin secretion is suppressed by glucagon-like peptide-1: clue to the mechanism of the adverse gallbladder events of GLP-1-derived drugs

    Rehfeld, Jens Frederik, Knop, Filip Krag, Asmar, A., Madsbad, Sten, Holst, Jens Juul & Asmar, M., 2018, In: Scandinavian Journal of Gastroenterology. 53, 12, p. 1429-1432

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Comparison of Glycomacropeptide with Phenylalanine Free-Synthetic Amino Acids in Test Meals to PKU Patients: No Significant Differences in Biomarkers, Including Plasma Phe Levels

    Ahring, K. K., Lund, A. M., Jensen, E., Jensen, T. G., Brondum-Nielsen, K., Pedersen, M., Bardow, A., Holst, Jens Juul, Rehfeld, Jens Frederik & Moller, L. B., 2018, In: Journal of Nutrition and Metabolism. 2018, p. 1-11 6352919.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Renoprotective effects of dulaglutide in patients with T2DM and CKD

    Sorensen, Charlotte Mehlin & Holst, Jens Juul, 2018, In: Nature Reviews. Nephrology. 14, 11, p. 659-660

    Research output: Contribution to journalComment/debateResearchpeer-review

  38. Published

    Response to Letter to the Editor: "Hemodynamic Effects of Glucagon: A Literature Review"

    Petersen, K. M., Bøgevig, S., Holst, Jens Juul, Knop, Filip Krag & Christensen, Mikkel Bring, 2018, In: The Journal of clinical endocrinology and metabolism. 103, 12, p. 4480-4481 2 p.

    Research output: Contribution to journalComment/debateResearch

  39. Published

    Effects of Smoking Versus Nonsmoking on Postprandial Glucose Metabolism in Heavy Smokers Compared With Nonsmokers

    Grøndahl, M. F., Bagger, J. I., Lund, A., Faurschou, A., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Jun 2018, In: Diabetes Care. 41, 6, p. 1260-1267

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    The role of the incretins in the postprandial bone remodelling

    Helsted, M. M., Gasbjerg, Lærke Smidt, Lanng, A. R., Stensen, S., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, M. M. & Knop, Filip Krag, 2018, In: Diabetologia. 61, S1, p. S221-S221 449.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  41. Published

    A carbohydrate-reduced high-protein diet acutely decreases postprandial and diurnal glucose excursions in type 2 diabetes patients

    Samkani, A., fbg982, fbg982, Kandel, D., Kjaer, S., Astrup, A., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten, Rehfeld, Jens Frederik, Haugaard, Steen Bendix & Krarup, T., 2018, In: British Journal of Nutrition. 119, 8, p. 910-917 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Patients with Obesity Caused by Melanocortin-4 Receptor Mutations Can Be Treated with a Glucagon-like Peptide-1 Receptor Agonist

    Iepsen, E. W., Zhang, J., Thomsen, Henrik S., Hansen, E. L., Hollensted, M., Madsbad, Sten, Hansen, Torben, Holst, Jens Juul, Holm, Jens-Christian & Torekov, Signe Sørensen, 2018, In: Cell Metabolism. 28, 1, p. 23-32.e3

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Glucagon-Like Peptide-1 Inhibits Prandial Gastrointestinal Motility Through Myenteric Neuronal Mechanisms in Humans

    Halim, M. A., Degerblad, M., Sundbom, M., Karlbom, U., Holst, Jens Juul, Webb, D. & Hellstrom, P. M., 2018, In: Journal of Clinical Endocrinology & Metabolism. 103, 2, p. 575-585

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Endogenous glucagon-like peptide- 1 and 2 are essential for regeneration after acute intestinal injury in mice

    Hytting-Andreasen, R., Balk-Møller, E., Hartmann, Bolette, Pedersen, Jens, Windeløv, Johanne Agerlin, Holst, Jens Juul & Kissow, Hannelouise, 2018, In: PLoS ONE. 13, 6, p. 1-14 e0198046.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    MODERATE EXERCISE DOES NOT IMPAIR THE EFFECT OF GLUCAGON IN INSULIN PUMP TREATED INDIVIDUALS WITH TYPE 1 DIABETES: A RANDOMIZED CROSSOVER STUDY: [Meeting Abstract}

    Steineck, I., Ranjan, A., Schmidt, S., Holst, Jens Juul & Norgaard, K., 2018, In: Diabetes Technology & Therapeutics. 20, p. A35-A35 072.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  46. Published

    Postprandial effects of individual and combined GIP and GLP-1 receptor antagonism in healthy subjects

    Gasbjerg, Lærke Smidt, Helsted, M. M., wbf943, wbf943, Lanng, A. R., Stensen, S., Jakobsen, M. H., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, M. M. & Knop, Filip Krag, 2018, In: Diabetologia. 61, S1, p. S246-S246 503.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  47. Published

    The prebiotic inulin improves substrate metabolism and promotes short-chain fatty acid production in overweight to obese men

    van der Beek, C. M., Canfora, E. E., Kip, A. M., Gorissen, S. H. M., Damink, S. W. M. O., van Eijk, H. M., Holst, Jens Juul, Blaak, E. E., Dejong, C. H. C. & Lenaerts, K., Oct 2018, In: Metabolism. 87, p. 25-35

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Impact of weight loss achieved through a multidisciplinary intervention on appetite in patients with severe obesity

    Coutinho, S. R., Rehfeld, Jens Frederik, Holst, Jens Juul, Kulseng, B. & Martins, C., Jul 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 315, 1, p. E91-E98

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Pre-Meal Effect of Whey Proteins on Metabolic Parameters in Subjects with and without Type 2 Diabetes: A Randomized, Crossover Trial

    Bjørnshave, A., Hermansen, K. & Holst, Jens Juul, 2018, In: Nutrients. 10, 2, p. 1-13 122.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses

    pjx571, pjx571, Mahendran, Y., Jonsson, Anna Elisabet, Gjesing, A. P., Weeke, P. E., Jørgensen, M. E., Færch, K., Witte, D. R., Holst, Jens Juul, Jørgensen, T., Grarup, Niels, Pedersen, Oluf Borbye, drb459, drb459, Torekov, Signe Sørensen, Kanters, Jørgen K. & Hansen, Torben, 2018, In: B M C Genetics. 19, 1, p. 1-9 9 p., 15.

    Research output: Contribution to journalJournal articleResearchpeer-review

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