Thomas Werge
Clinical Professor
- 2019
- Published
Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank
Barbu, M. C., Zeng, Y., Shen, X., Cox, S. R., Clarke, T., Gibson, J., Adams, M. J., Johnstone, M., Haley, C. S., Lawrie, S. M., Deary, I. J., Mcintosh, A. M., Whalley, H. C., Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J. & 216 others, , 2019, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 1, p. 91-100 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders
Bauer, A. E., Liu, X., Byrne, E. M., Sullivan, P. F., Wray, N. R., Agerbo, E., Nyegaard, M., Grove, J., Musliner, K. L., Ingstrup, K. G., Johannsen, B. M. W., Mægbæk, M. L., Wang, Y., Nordentoft, M., Mors, O., Børglum, A. D., Werge, T., Hougaard, D. M., Mortensen, P. B., Munk-Olsen, T. & 1 others, , 11 Nov 2019, In: Translational Psychiatry. 9, 1, 13 p., 288.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders
Burgdorf, K. S., Trabjerg, B., Giørtz Pedersen, M., Nissen, J., Banasik, K., Birger Pedersen, O., Sørensen, E., René Nielsen, K., Hørup Larsen, M., Erikstrup, C., Bruun-Rasmussen, P., Westergaard, D., Wegner Thørner, L., Hjalgrim, H., Martina Paarup, H., Brunak, S., Pedersen, C. B., Fuller Torrey, E., Werge, T., Bo Mortensen, P. & 2 others, , 2019, In: Brain, Behavior, and Immunity. 79, p. 152-158Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Assessment of bidirectional relationships between physical activity and depression among adults a 2-sample Mendelian randomization study
Choi, K. W., Chen, C. Y., Stein, M. B., Klimentidis, Y. C., Wang, M. J., Koenen, K. C., Smoller, J. W., Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M., Andlauer, T. F. M., Bacanu, S. A., Bækvad-Hansen, M., Beekman, A. T. F. & 31 others, , 2019, In: JAMA Psychiatry. 76, 4, p. 399-408 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, M. D. D. W. G. O. T. P. G. C., 2019, In: Nature Communications. 10, 1, 18 p., 2548.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clinical association to FKBP5 rs1360780 in patients with depression
Dam, H., Buch, J. O. D., Nielsen, A. B., Weikop, Pia, Werge, Thomas & Jørgensen, M. B., 2019, In: Psychiatric Genetics. 29, 6, p. 220-225 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
ADHD Working Group of the Psychiatric Genomics Consortium (PGC), A. W. G. O. T. P. G. C. (., Jan 2019, In: Nature Genetics. 51, 1, p. 63-75 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association study implicates CHRNA2 in cannabis use disorder
Demontis, D., Rajagopal, V. M., Thorgeirsson, T. E., Als, T. D., Grove, J., Leppälä, K., Gudbjartsson, D. F., Pallesen, J., Hjorthøj, C., Reginsson, G. W., Tyrfingsson, T., Runarsdottir, V., Qvist, P., Christensen, J. H., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Huckins, L. M., Stahl, E. A., Timmermann, A., Agerbo, E. & 10 others, , 2019, In: Nature Neuroscience. 22, 7, p. 1066-1074Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genomisk medicin som forbrugervare
Folkersen, L. & Werge, Thomas, 2019, In: Ugeskrift for Laeger. 181, 5 p., V11180789.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Can Animal Models of Copy Number Variants That Predispose to Schizophrenia Elucidate Underlying Biology?
Forsingdal, A., Jørgensen, T. N., Olsen, L., Werge, Thomas, Didriksen, M. & Nielsen, J., 2019, In: Biological Psychiatry. 85, 1, p. 13-24 12 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Schizophrenia polygenic risk scores, urbanicity and treatment-resistant schizophrenia
Gasse, C., Wimberley, T., Wang, Y., Mors, O., Børglum, A., Als, T. D., Werge, Thomas, Nordentoft, Merete, Hougaard, D. M. & Horsdal, H. T., 2019, In: Schizophrenia Research. 212, p. 79-85 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interactive effects between hemizygous 15q13.3 microdeletion and peripubertal stress on adult behavioral functions
Giovanoli, S., Werge, Thomas, Mortensen, P. B., Didriksen, M. & Meyer, U., 2019, In: Neuropsychopharmacology. 44, 4, p. 703-710 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of common genetic risk variants for autism spectrum disorder
Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, A. S. D. W. G. O. T. P. G. C., Mar 2019, In: Nature Genetics. 51, 3, p. 431-444Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variable DNA methylation in neonates mediates the association between prenatal smoking and birth weight
iPSYCH-Broad ASD Group, I. A. G., 15 Apr 2019, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 374, 1770, 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors
Hansen, T. F., Banasik, K., Erikstrup, C., Pedersen, O. B., Westergaard, D., Chmura, P. J., Nielsen, K., Thørner, L., Hjalgrim, H., Paarup, H., Larsen, M. A. H., Petersen, M., Jennum, P., Andersen, S., Nyegaard, M., Jemec, G. B. E., Olesen, J., Werge, T., Johansson, P. I., Sørensen, E. & 3 others, , 9 Jun 2019, In: BMJ Open. 9, 6, p. 1-7 7 p., e028401.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia
Harold, D., Connolly, S., Riley, B. P., Kendler, K. S., McCarthy, S. E., McCombie, W. R., Richards, A., Owen, M. J., O'Donovan, M. C., Walters, J., Donnelly, P., Bates, L., Barroso, I., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Deloukas, P., Duncanson, A. & 32 others, , 2019, In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 180, 3, p. 223-231 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of Childhood Exposure to Nitrogen Dioxide and Polygenic Risk Score for Schizophrenia With the Risk of Developing Schizophrenia
Horsdal, H. T., Agerbo, E., McGrath, J. J., Vilhjálmsson, B. J., Antonsen, S., Closter, A. M., Timmermann, A., Grove, J., Mok, P. L. H., Webb, R. T., Sabel, C. E., Hertel, O., Sigsgaard, T., Erikstrup, C., Hougaard, D. M., Werge, T., Nordentoft, M., Børglum, A. D., Mors, O., Mortensen, P. B. & 3 others, , 2019, In: JAMA Network Open. 2, 11, 12 p., e1914401.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
Huckins, L. M., Dobbyn, A., Ruderfer, D. M., Hoffman, G., Wang, W., Pardiñas, A. F., Rajagopal, V. M., Als, T. D., T. Nguyen, H., Girdhar, K., Boocock, J., Roussos, P., Fromer, M., Kramer, R., Domenici, E., Gamazon, E. R., Purcell, S., CommonMind Consortium, The Schizophrenia Working Group of the PsyUniversity of Copenhagenchiatric Genomics Consortium, iPSYCH-GEMS Schizophrenia Working Group & 15 others, , 2019, In: Nature Genetics. 51, p. 659-674Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Migraine polygenic risk score associates with efficacy of migraine-specific drugs
Kogelman, L. J. A., Esserlind, A-L., Christensen, A. F., Awasthi, S., Ripke, S., Ingason, A., Davidsson, O. B., Erikstrup, C., Hjalgrim, H., Ullum, H., Olesen, J., Hansen, T. F., Gudbjartsson, D., Gastafsson, O., Stefansson, K., Stefansson, H., Porsteinsdottir, U., Andersen, S., Banasik, K., Brunak, S. & 73 others, , 2019, In: Neurology: Genetics. 5, 6, 12 p., e364.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
BIOLOGICAL PREDICTORS OF PSYCHIATRIC TRAJECTORIES IN A DANISH POPULATION COHORT OF INDIVIDUALS WITH SCHIZOPHRENIA
Krebs, M., Themudo, G. E., Benros, Michael Eriksen, Werge, Thomas & Thompson, W., 2019, In: European Neuropsychopharmacology. 29, S5, p. S260-S260 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Individuals with 22q11.2 deletion syndrome show intact prediction but reduced adaptation in responses to repeated sounds: Evidence from Bayesian mapping
Larsen, K. M., Mørup, M., Birknow, M. R., Fischer, E., Olsen, L., Didriksen, M., Baaré, W. F. C., Werge, Thomas, Garrido, M. I. & Siebner, Hartwig Roman, 2019, In: NeuroImage: Clinical. 22, 101721.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, M. D. D. W. G. O. T. P. G. C., 2019, In: Cell. 179, 7, p. 1469-1482 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
Liu, X., Helenius, D., Skotte, L., Beaumont, R. N., Wielscher, M., Geller, F., Juodakis, J., Mahajan, A., Bradfield, J. P., Lin, F. T. J., Vogelezang, S., Bustamante, M., Ahluwalia, T. S., Pitkänen, N., Wang, C. A., Bacelis, J., Borges, M. C., Zhang, G., Bedell, B. A., Rossi, R. M. & 54 others, , 2 Sep 2019, In: Nature Communications. 10, 1, 13 p., 3927.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic Variants Associated with Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study
Meier, S. M., Trontti, K., Purves, K. L., Als, T. D., Grove, J., Laine, M., Pedersen, M. G., Bybjerg-Grauholm, J., Bækved-Hansen, M., Sokolowska, E., Mortensen, P. B., Hougaard, D. M., Werge, Thomas, Nordentoft, Merete, Breen, G., Børglum, A. D., Eley, T. C., Hovatta, I., Mattheisen, M. & Mors, O., 2019, In: JAMA Psychiatry. 76, 9, p. 924-932 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, M. D. D. W. G. O. T. P. G. C. B. D. W. G. O. T. P. G. C. S. W. G. O. T. P. G. C., Fanous, A. H., Kendler, K. S., McQuillin, A. & Lewis, C. M., 2019, In: American Journal of Psychiatry. 176, 8, p. 651-660Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia with Risk for Depression in the Danish Population
Musliner, K. L., Mortensen, P. B., McGrath, J. J., Suppli, N. P., Hougaard, D. M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Andreassen, O., Pedersen, C. B., Pedersen, M. G., Mors, O., Nordentoft, Merete, Børglum, A. D., Werge, Thomas & Agerbo, E., 2019, In: JAMA Psychiatry. 76, 5, p. 516-525 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
Nievergelt, C. M., Maihofer, A. X., Klengel, T., Atkinson, E. G., Chen, C-Y., Choi, K. W., Coleman, J. R. I., Dalvie, S., Duncan, L. E., Gelernter, J., Levey, D. F., Logue, M. W., Polimanti, R., Provost, A. C., Ratanatharathorn, A., Stein, M. B., Torres, K., Aiello, A. E., Almli, L. M., Amstadter, A. B. & 159 others, , 2019, In: Nature Communications. 10, 1, 4558.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population
Nissen, J., Trabjerg, B., Pedersen, M. G., Banasik, K., Pedersen, O. B., Sørensen, E., Nielsen, K. R., Erikstrup, C., Petersen, M. S., Paarup, H. M., Bruun-Rasmussen, P., Westergaard, D., Hansen, T. F., Pedersen, C. B., Werge, T., Torrey, F., Hjalgrim, H., Mortensen, P. B., Yolken, R., Brunak, S. & 2 others, , Oct 2019, In: Psychoneuroendocrinology. 108, p. 150-154Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Roadmap for a precision-medicine initiative in the Nordic region
Njølstad, P. R., Andreassen, O. A., Brunak, S., Børglum, A. D., Dillner, J., Esko, T., Franks, P. W., Freimer, N., Groop, L., Heimer, H., Hougaard, D. M., Hovig, E., Hveem, K., Jalanko, A., Kaprio, J., Knudsen, G. P., Melbye, M., Metspalu, A., Mortensen, P. B., Palmgren, J. & 11 others, , 2019, In: Nature Genetics. 51, p. 924-930Research output: Contribution to journal › Comment/debate › Research
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A large-scale genomic investigation of susceptibility to infection and its association with mental disorders in the Danish population
Nudel, R., Wang, Y., Appadurai, V., Schork, A. J., Buil, A., Agerbo, E., Bybjerg-Grauholm, J., Børglum, A. D., Daly, M. J., Mors, O., Hougaard, D. M., Mortensen, P. B., Werge, Thomas, Nordentoft, Merete, Thompson, W. K. & Benros, Michael Eriksen, 2019, In: Translational Psychiatry. 9, 1, 10 p., 283.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Immunity and mental illness: findings from a Danish population-based immunogenetic study of seven psychiatric and neurodevelopmental disorders
Nudel, R., Benros, Michael Eriksen, Krebs, M. D., Allesøe, R. L., Lemvigh, C. K., Bybjerg-Grauholm, J., Børglum, A. D., Daly, M. J., Nordentoft, Merete, Mors, O., Hougaard, D. M., Mortensen, P. B., Buil, A., Werge, Thomas, Rasmussen, Simon & Thompson, W. K., 2019, In: European Journal of Human Genetics. 27, p. 1445-1455Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
GERAD1 Consortium:, G. C., Jul 2019, In: Nature Genetics. 51, 7, p. 1193 1 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Exploring Comorbidity Within Mental Disorders among a Danish National Population
Plana-Ripoll, O., Pedersen, C. B., Holtz, Y., Benros, M. E., Dalsgaard, S., De Jonge, P., Fan, C. C., Degenhardt, L., Ganna, A., Greve, A. N., Gunn, J., Iburg, K. M., Kessing, L. V., Lee, B. K., Lim, C. C. W., Mors, O., Nordentoft, M., Prior, A., Roest, A. M., Saha, S. & 12 others, , 2019, In: JAMA Psychiatry. 76, 3, p. 259-270Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human Disease Variation in the Light of Population Genomics
Prohaska, Ana, Racimo, Fernando, Schork, A. J., Sikora, Martin, Stern, A. J., Ilardo, M., Allentoft, Morten Erik, Folkersen, L., Buil, A., Moreno Mayar, J. Víctor, Korneliussen, Thorfinn Sand, Geschwind, D., Ingason, A., Werge, Thomas, Nielsen, Rasmus & Willerslev, Eske, 2019, In: Cell. 177, 1, p. 115-131 17 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants
Satterstrom, F. K., Walters, R. K., Singh, T., Wigdor, E. M., Lescai, F., Demontis, D., Kosmicki, J. A., Grove, J., Stevens, C., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Palmer, D. S., Maller, J. B., Nordentoft, M., Mors, O., Robinson, E. B., Hougaard, D. M., Werge, T. M., Bo Mortensen, P., Neale, B. M. & 3 others, , 2019, In: Nature Neuroscience. 22, 12, p. 1961-1965Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment
Schork, A. J., Won, H., Appadurai, V., Nudel, R., Gandal, M., Delaneau, O., Revsbech Christiansen, M., Hougaard, D. M., Bækved-Hansen, M., Bybjerg-Grauholm, J., Giørtz Pedersen, M., Agerbo, E., Bøcker Pedersen, C., Neale, B. M., Daly, M. J., Wray, N. R., Nordentoft, M., Mors, O., Børglum, A. D., Bo Mortensen, P. & 4 others, , Mar 2019, In: Nature Neuroscience. 22, 3, p. 353-361Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reduced neonatal brain-derived neurotrophic factor is associated with autism spectrum disorders
Skogstrand, K., Hagen, C. M., Borbye-Lorenzen, N., Christiansen, M., Bybjerg-Grauholm, J., Baekvad-Hansen, M., Werge, Thomas, Borglum, A., Mors, O., Nordentoft, M., Mortensen, P. B. & Hougaard, D. M., 2019, In: Translational Psychiatry. 9, 9 p., 252.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association study identifies 30 loci associated with bipolar disorder
eQTLGen Consortium, E. C., May 2019, In: Nature Genetics. 51, 5, p. 793-803Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GENETIC SUBTYPES OF SCHIZOPHRENIA ELUCIDATED BY MULTISTATE DIAGNOSIS TRAJECTORIES
Themudo, G. E., Krebs, M., Benros, Michael Eriksen, Werge, Thomas & Thompson, W., 2019, p. 1338-1338.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Disentangling polygenic associations between attention-deficit/hyperactivity disorder, educational attainment, literacy and language
iPSYCH-Broad-PGC ADHD Consortium, I. A. C., 2019, In: Translational Psychiatry. 9, 1, 12 p., 35.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Post-traumatic stress following military deployment: Genetic associations and cross-disorder genetic correlations
Wang, Y., Karstoft, Karen-Inge, Nievergelt, C. M., Maihofer, A. X., Stein, M. B., Ursano, R. J., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Hougaard, D. M., Andreassen, O. A., Werge, Thomas, Thompson, W. K. & Andersen, S. B., 2019, In: Journal of Affective Disorders. 252, p. 350-357 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
Anorexia Nervosa Genetics Initiative, A. N. G. I., Aug 2019, In: Nature Genetics. 51, 8, p. 1207-1214Research output: Contribution to journal › Letter › Research › peer-review
ID: 34394780
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Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression
Research output: Contribution to journal › Journal article › Research › peer-review
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Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders
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340
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Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia
Research output: Contribution to journal › Journal article › Research › peer-review
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