Morphogenesis and Differentiation Program
Neuronal Signalling Lab
2200 København N
Primary research area
The mammalian brain consists of a large quantity of water which is continuously shifted between the circulating blood and the brain parenchyma as well as between different compartments and cellular structures within the brain tissue; i.e. cerebrospinal fluid secretion, brain extracellular fluid generation, activity-dependent glial cell swelling, and dendritic beading observed during spreading depolarization. We presume that the transport of water between these different compartments is under tight control since a disturbance in the cerebral water homeostasis (with associated changes in ion concentrations) may lead to neuronal dysfunction and/or brain edema. However, our incomplete knowledge of the molecular mechanisms responsible for the maintenance of cerebral water transport and their regulation currently prevents us from gaining a full understanding of this intricate and crucial (patho)physiological issue.
The focus of our laboratory is to elucidate the molecular mechanisms underlying water and ion homeostasis in the mammalian brain under both physiological and pathophysiological conditions. Our technical approach spans from molecular and biophysical properties of water transport proteins (including aquaporins and cotransporters) to their regulation at the cellular level and their integral function in acutely prepared brain slices.