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Carsten Geisler

Carsten Geisler

!!Professor, Institutleder

Primary fields of research

http://isim.ku.dk/units/t_cell_biology/

Current research

http://isim.ku.dk/units/t_cell_biology/

Selected publications

  1. Published

    Vitamin D controls T cell antigen receptor signaling and activation of human T cells

    von Essen, M. R., Kongsbak-Wismann, M., Schjerling, P., Ølgaard, K., Ødum, N. & Geisler, C. 2010 In : Nature Immunology. 11, 4, p. 344-349 5 p.

    Research output: Research - peer-reviewJournal article

  2. Published

    TCR down-regulation controls T cell homeostasis

    Boding, L., Bonefeld, C. M., Nielsen, B. L., Lauritsen, J. P. H., von Essen, M. R., Hansen, A. K., Larsen, J. M., Nielsen, M. M., Odum, N. & Geisler, C. 2009 In : Journal of Immunology. 183, 8, p. 4994-5005 11 p.

    Research output: Research - peer-reviewJournal article

  3. Published

    TCR Down-Regulation Controls Virus-Specific CD8+ T Cell Responses

    Bonefeld, C. M., Haks, M., Nielsen, B., von Essen, M., Boding, L., Hansen, A. K., Larsen, J. M., Odum, N., Krimpenfort, P., Kruisbeek, A., Christensen, J. P., Thomsen, A. R. & Geisler, C. 2008 In : Journal of Immunology. 181, 11, p. 7786-7799 13 p.

    Research output: Research - peer-reviewJournal article

  4. Published

    Protein kinase C (PKC) alpha and PKC theta are the major PKC isotypes involved in TCR down-regulation

    von Essen, M., Nielsen, M. W., Bonefeld, C. M., Boding, L., Larsen, J. M., Leitges, M., Baier, G., Odum, N. & Geisler, C. 2006 In : Journal of Immunology. 176, 12, p. 7502-10 8 p.

    Research output: Research - peer-reviewJournal article

  5. Published

    Constitutive and ligand-induced TCR degradation

    von Essen, M., Bonefeld, C. M., Siersma, V., Rasmussen, A. B., Lauritsen, J. P. H., Nielsen, B. L. & Geisler, C. 2004 In : Journal of Immunology. 173, 1, p. 384-93 9 p.

    Research output: Research - peer-reviewJournal article

  6. Published

    TCR trafficking in resting and stimulated T cells

    Geisler, C. 2004 In : Critical Reviews in Immunology. 24, 1, p. 67-86 19 p.

    Research output: Research - peer-reviewJournal article

  7. Published

    TCR comodulation of nonengaged TCR takes place by a protein kinase C and CD3 gamma di-leucine-based motif-dependent mechanism

    Bonefeld, C. M., Rasmussen, B. A., Lauritsen, J. P., von Essen, M., Odum, N., Andersen, P. S. & Geisler, C. 2003 In : Journal of Immunology. 171, 6, p. 3003-9 6 p.

    Research output: Research - peer-reviewJournal article

  8. Published

    Endo- and exocytic rate constants for spontaneous and protein kinase C-activated T cell receptor cycling

    Menné, C., Møller Sørensen, T., Siersma, V., von Essen, M., Ødum, N. & Geisler, C. 2002 In : European Journal of Immunology. 32, 3, p. 616-26 10 p.

    Research output: Research - peer-reviewJournal article

  9. Published

    Ligand-induced TCR down-regulation is not dependent on constitutive TCR cycling

    Dietrich, J., Menné, C., Lauritsen, J. P. H., von Essen, M., Rasmussen, B. A., Ødum, N. & Geisler, C. 2002 In : Journal of Immunology. 168, 11, p. 5434-40 6 p.

    Research output: Research - peer-reviewJournal article

  10. Published

    The CD3 gamma leucine-based receptor-sorting motif is required for efficient ligand-mediated TCR down-regulation

    von Essen, M., Menné, C., Nielsen, B. L., Lauritsen, J. P. H., Dietrich, J., Andersen, P. S., Karjalainen, K., Ødum, N. & Geisler, C. 2002 In : Journal of Immunology. 168, 9, p. 4519-23 4 p.

    Research output: Research - peer-reviewJournal article

  11. Published

    Leucine-based receptor sorting motifs are dependent on the spacing relative to the plasma membrane

    Geisler, C., Dietrich, J., Nielsen, B. L., Kastrup, J., Lauritsen, J. P. H., Odum, N. & Christensen, M. D. 1998 In : Journal of Biological Chemistry. 273, 33, p. 21316-23 7 p.

    Research output: Research - peer-reviewJournal article

  12. Published

    The phosphorylation state of CD3gamma influences T cell responsiveness and controls T cell receptor cycling

    Dietrich, J., Bäckström, T., Lauritsen, J. P., Kastrup, J., Christensen, M. D., von Bülow, F., Palmer, E. & Geisler, C. 1998 In : Journal of Biological Chemistry. 273, 37, p. 24232-8 6 p.

    Research output: Research - peer-reviewJournal article

  13. Published

    Two distinct pathways exist for down-regulation of the TCR

    Lauritsen, J. P., Christensen, M. D., Dietrich, J., Kastrup, J., Odum, N. & Geisler, C. 1998 In : Journal of Immunology. 161, 1, p. 260-7 7 p.

    Research output: Research - peer-reviewJournal article

  14. Published

    Regulation and function of the CD3¿ DxxxLL motif: a binding site for adaptor protein-1 and adaptor protein-2 in vitro

    Dietrich, J., Kastrup, J., Nielsen, B. L., Odum, N. & Geisler, C. 1997 In : Journal of Cell Biology. 138, 2, p. 271-81 10 p.

    Research output: Research - peer-reviewJournal article

  15. Published

    Molecular characterization of the di-leucine-based internalization motif of the T cell receptor

    Dietrich, J., Hou, X., Wegener, A. M., Pedersen, L. O., Odum, N. & Geisler, C. 1996 In : Journal of Biological Chemistry. 271, 19, p. 11441-8 7 p.

    Research output: Research - peer-reviewJournal article

  16. Published

    Role of CD3 gamma in T cell receptor assembly

    Dietrich, J., Neisig, A., Hou, X., Wegener, A. M., Gajhede, M. & Geisler, C. 1996 In : Journal of Cell Biology. 132, 3, p. 299-310 11 p.

    Research output: Research - peer-reviewJournal article

  17. Published

    Distinct domains of the CD3-gamma chain are involved in surface expression and function of the T cell antigen receptor

    Wegener, A. M., Hou, X., Dietrich, J. & Geisler, C. 1995 In : Journal of Biological Chemistry. 270, 9, p. 4675-80 5 p.

    Research output: Research - peer-reviewJournal article

  18. Published

    CD3 gamma contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor

    Dietrich, J., Hou, X., Wegener, A. M. & Geisler, C. 1994 In : EMBO Journal. 13, 9, p. 2156-66 10 p.

    Research output: Research - peer-reviewJournal article

  19. Published

    Failure to synthesize the CD3-gamma chain. Consequences for T cell antigen receptor assembly, processing, and expression

    Geisler, C. 1992 In : Journal of Immunology. 148, 8, p. 2437-45 8 p.

    Research output: Research - peer-reviewJournal article

ID: 10043